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The map label for this gene is hisG

Identifier: 62390386

GI number: 62390386

Start: 1587067

End: 1587912

Strand: Reverse

Name: hisG

Synonym: cg1698

Alternate gene names: 62390386

Gene position: 1587912-1587067 (Counterclockwise)

Preceding gene: 62390387

Following gene: 62390385

Centisome position: 48.37

GC content: 57.21

Gene sequence:

>846_bases
ATGTTGAAAATCGCTGTCCCAAACAAAGGCTCGCTGTCCGAGCGCGCCATGGAAATCCTCGCCGAAGCAGGCTACGCAGG
CCGTGGAGATTCCAAATCCCTCAACGTTTTTGATGAAGCAAACAACGTTGAATTCTTCTTCCTTCGCCCTAAAGATATCG
CCATCTACGTTGCTGGTGGCCAGCTCGATTTGGGTATCACCGGCCGCGACCTTGCTCGCGATTCCCAGGCTGATGTCCAC
GAAGTTCTTTCCCTCGGCTTCGGTTCCTCCACTTTCCGTTACGCAGCACCAGCTGATGAAGAGTGGAGCATCGAAAAGCT
CGACGGCAAGCGCATCGCTACCTCTTACCCCAACCTTGTTCGCGATGACCTCGCAGCACGTGGGCTTTCCGCTGAGGTGC
TCCGCCTCGACGGTGCAGTAGAGGTATCCATCAAGCTTGGTGTCGCAGATGCCATCGCCGATGTTGTATCCACCGGCCGC
ACGCTGCGTCAGCAAGGTCTTGCACCTTTCGGCGAGGTTCTGTGCACCTCTGAGGCTGTCATTGTTGGCCGCAAGGATGA
AAAGGTCACCCCAGAGCAGCAGATCCTGCTTCGCCGCATCCAGGGAATTTTGCACGCGCAGAACTTCCTCATGCTGGATT
ACAACGTCGACCGCGACAACCTGGACGCTGCCACTGCAGTAACCCCAGGCTTATCCGGCCCAACGGTATCCCCACTGGCA
CGCGACAACTGGGTTGCTGTACGCGCCATGGTGCCACGCAGGTCAGCTAACGCCATCATGGATAAGCTTGCTGGACTCGG
CGCTGAAGCCATCCTGGCTTCTGAAATCCGCATCGCCCGCATCTAG

Upstream 100 bases:

>100_bases
GAAATCTCCCAGCTCATTTATTGGACCCAGGTCATCATGGTTGCTCGCGGCCTGAAGCCAGAAGATATCTACAAGAACCT
GTAGGAGTTTTAAAGCAATC

Downstream 100 bases:

>100_bases
TTTTAACTACCCCCGAAAATGTAGTGGGTAGTTCCACACTGCCTCTTACAAGTACGTAGGATAATCCACAGCACCATTGT
GATTTCCTTCAACTTGTGAG

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MLKIAVPNKGSLSERAMEILAEAGYAGRGDSKSLNVFDEANNVEFFFLRPKDIAIYVAGGQLDLGITGRDLARDSQADVH
EVLSLGFGSSTFRYAAPADEEWSIEKLDGKRIATSYPNLVRDDLAARGLSAEVLRLDGAVEVSIKLGVADAIADVVSTGR
TLRQQGLAPFGEVLCTSEAVIVGRKDEKVTPEQQILLRRIQGILHAQNFLMLDYNVDRDNLDAATAVTPGLSGPTVSPLA
RDNWVAVRAMVPRRSANAIMDKLAGLGAEAILASEIRIARI

Sequences:

>Translated_281_residues
MLKIAVPNKGSLSERAMEILAEAGYAGRGDSKSLNVFDEANNVEFFFLRPKDIAIYVAGGQLDLGITGRDLARDSQADVH
EVLSLGFGSSTFRYAAPADEEWSIEKLDGKRIATSYPNLVRDDLAARGLSAEVLRLDGAVEVSIKLGVADAIADVVSTGR
TLRQQGLAPFGEVLCTSEAVIVGRKDEKVTPEQQILLRRIQGILHAQNFLMLDYNVDRDNLDAATAVTPGLSGPTVSPLA
RDNWVAVRAMVPRRSANAIMDKLAGLGAEAILASEIRIARI
>Mature_281_residues
MLKIAVPNKGSLSERAMEILAEAGYAGRGDSKSLNVFDEANNVEFFFLRPKDIAIYVAGGQLDLGITGRDLARDSQADVH
EVLSLGFGSSTFRYAAPADEEWSIEKLDGKRIATSYPNLVRDDLAARGLSAEVLRLDGAVEVSIKLGVADAIADVVSTGR
TLRQQGLAPFGEVLCTSEAVIVGRKDEKVTPEQQILLRRIQGILHAQNFLMLDYNVDRDNLDAATAVTPGLSGPTVSPLA
RDNWVAVRAMVPRRSANAIMDKLAGLGAEAILASEIRIARI

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=289, Percent_Identity=35.6401384083045, Blast_Score=139, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320896, Length=287, Percent_Identity=32.7526132404181, Blast_Score=149, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_CORGB (A4QE90)

Other databases:

- EMBL:   AP009044
- RefSeq:   YP_001138458.1
- ProteinModelPortal:   A4QE90
- SMR:   A4QE90
- STRING:   A4QE90
- GeneID:   4993123
- GenomeReviews:   AP009044_GR
- KEGG:   cgt:cgR_1564
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- ProtClustDB:   PRK00489
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 30230; Mature: 30230

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKIAVPNKGSLSERAMEILAEAGYAGRGDSKSLNVFDEANNVEFFFLRPKDIAIYVAGG
CEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEEECCCEEEEEEECC
QLDLGITGRDLARDSQADVHEVLSLGFGSSTFRYAAPADEEWSIEKLDGKRIATSYPNLV
EEEECCCCHHHCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHCCCCEEECCCCHHH
RDDLAARGLSAEVLRLDGAVEVSIKLGVADAIADVVSTGRTLRQQGLAPFGEVLCTSEAV
HHHHHHCCCCEEEEEECCEEEEEEEECHHHHHHHHHHCCHHHHHHCCCCHHHHHHCCCEE
IVGRKDEKVTPEQQILLRRIQGILHAQNFLMLDYNVDRDNLDAATAVTPGLSGPTVSPLA
EEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHEECCCCCCCCCCCCC
RDNWVAVRAMVPRRSANAIMDKLAGLGAEAILASEIRIARI
CCCEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHCEEEECC
>Mature Secondary Structure
MLKIAVPNKGSLSERAMEILAEAGYAGRGDSKSLNVFDEANNVEFFFLRPKDIAIYVAGG
CEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEEECCCEEEEEEECC
QLDLGITGRDLARDSQADVHEVLSLGFGSSTFRYAAPADEEWSIEKLDGKRIATSYPNLV
EEEECCCCHHHCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHCCCCEEECCCCHHH
RDDLAARGLSAEVLRLDGAVEVSIKLGVADAIADVVSTGRTLRQQGLAPFGEVLCTSEAV
HHHHHHCCCCEEEEEECCEEEEEEEECHHHHHHHHHHCCHHHHHHCCCCHHHHHHCCCEE
IVGRKDEKVTPEQQILLRRIQGILHAQNFLMLDYNVDRDNLDAATAVTPGLSGPTVSPLA
EEECCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHEECCCCCCCCCCCCC
RDNWVAVRAMVPRRSANAIMDKLAGLGAEAILASEIRIARI
CCCEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA