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The map label for this gene is gnd [H]

Identifier: 62390335

GI number: 62390335

Start: 1531805

End: 1533283

Strand: Reverse

Name: gnd [H]

Synonym: cg1643

Alternate gene names: 62390335

Gene position: 1533283-1531805 (Counterclockwise)

Preceding gene: 62390340

Following gene: 62390333

Centisome position: 46.71

GC content: 58.89

Gene sequence:

>1479_bases
ATGCCGTCAAGTACGATCAATAACATGACTAATGGAGATAATCTCGCACAGATCGGCGTTGTAGGCCTAGCAGTAATGGG
CTCAAACCTCGCCCGCAACTTCGCCCGCAACGGCAACACTGTCGCTGTCTACAACCGCAGCACTGACAAAACCGACAAGC
TCATCGCCGATCACGGCTCCGAAGGCAACTTCATCCCTTCTGCAACCGTCGAAGAGTTCGTAGCATCCCTGGAAAAGCCA
CGCCGCGCCATCATCATGGTTCAGGCTGGTAACGCCACCGACGCAGTCATCAACCAGCTGGCAGATGCCATGGACGAAGG
CGACATCATCATCGACGGCGGCAACGCCCTCTACACCGACACCATTCGTCGCGAGAAGGAAATCTCCGCACGCGGTCTCC
ACTTCGTCGGTGCTGGTATCTCCGGCGGCGAAGAAGGCGCACTCAACGGCCCATCCATCATGCCTGGTGGCCCAGCAAAG
TCCTACGAGTCCCTCGGACCACTGCTTGAGTCCATCGCTGCCAACGTTGACGGCACCCCATGTGTCACCCACATCGGCCC
AGACGGCGCCGGCCACTTCGTCAAGATGGTCCACAACGGCATCGAGTACGCCGACATGCAGGTCATCGGCGAGGCATACC
ACCTTCTCCGCTACGCAGCAGGCATGCAGCCAGCTGAAATCGCTGAGGTTTTCAAGGAATGGAACGCAGGCGACCTGGAT
TCCTACCTCATCGAAATCACCGCAGAGGTTCTCTCCCAGGTGGATGCTGAAACCGGCAAGCCACTAATCGACGTCATCGT
TGACGCTGCAGGTCAGAAGGGCACCGGACGTTGGACCGTCAAGGCTGCTCTTGATCTGGGTATTGCTACCACCGGCATCG
GCGAAGCTGTTTTCGCACGTGCACTCTCCGGCGCAACCAGCCAGCGCGCTGCAGCACAGGGCAACCTACCTGCAGGTGTC
CTCACCGATCTGGAAGCACTTGGCGTGGACAAGGCACAGTTCGTCGAAGACGTTCGCCGTGCACTGTACGCATCCAAGCT
TGTTGCTTACGCACAGGGCTTCGACGAGATCAAGGCTGGCTCCGACGAGAACAACTGGGACGTTGACCCTCGCGACCTCG
CTACCATCTGGCGCGGCGGCTGCATCATTCGCGCTAAGTTCCTCAACCGCATCGTCGAAGCATACGATGCAAACGCTGAA
CTTGAGTCCCTGCTGCTCGATCCTTACTTCAAGAGCGAGCTCGGCGACCTCATCGATTCATGGCGTCGCGTGATTGTCAC
CGCCACCCAGCTTGGCCTGCCAATCCCAGTGTTCGCTTCCTCCCTGTCCTACTACGACAGCCTGCGTGCAGAGCGTCTGC
CAGCAGCCCTGATCCAAGGACAGCGCGACTTCTTCGGTGCGCACACCTACAAGCGCATCGACAAGGATGGCTCCTTCCAC
ACCGAGTGGTCCGGCGACCGCTCCGAGGTTGAAGCTTAA

Upstream 100 bases:

>100_bases
CGGCCTAAAATGGTTGGATTTTCACCTCCTGTGACCTGGTAAAATCGCCACTACCCCCAAATGGTCACACCTTTTAGGCC
GATTTTGCTGACACCGGGCT

Downstream 100 bases:

>100_bases
AGGCTCTCCTTTTAACACAACGCCAAAACCCCTCACAGTCACCTTAGATTGTGAGGGGTTTTTCGCGTGCTGCCAGGGAT
TCGCCGGAGGTGGGCGTCGA

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MPSSTINNMTNGDNLAQIGVVGLAVMGSNLARNFARNGNTVAVYNRSTDKTDKLIADHGSEGNFIPSATVEEFVASLEKP
RRAIIMVQAGNATDAVINQLADAMDEGDIIIDGGNALYTDTIRREKEISARGLHFVGAGISGGEEGALNGPSIMPGGPAK
SYESLGPLLESIAANVDGTPCVTHIGPDGAGHFVKMVHNGIEYADMQVIGEAYHLLRYAAGMQPAEIAEVFKEWNAGDLD
SYLIEITAEVLSQVDAETGKPLIDVIVDAAGQKGTGRWTVKAALDLGIATTGIGEAVFARALSGATSQRAAAQGNLPAGV
LTDLEALGVDKAQFVEDVRRALYASKLVAYAQGFDEIKAGSDENNWDVDPRDLATIWRGGCIIRAKFLNRIVEAYDANAE
LESLLLDPYFKSELGDLIDSWRRVIVTATQLGLPIPVFASSLSYYDSLRAERLPAALIQGQRDFFGAHTYKRIDKDGSFH
TEWSGDRSEVEA

Sequences:

>Translated_492_residues
MPSSTINNMTNGDNLAQIGVVGLAVMGSNLARNFARNGNTVAVYNRSTDKTDKLIADHGSEGNFIPSATVEEFVASLEKP
RRAIIMVQAGNATDAVINQLADAMDEGDIIIDGGNALYTDTIRREKEISARGLHFVGAGISGGEEGALNGPSIMPGGPAK
SYESLGPLLESIAANVDGTPCVTHIGPDGAGHFVKMVHNGIEYADMQVIGEAYHLLRYAAGMQPAEIAEVFKEWNAGDLD
SYLIEITAEVLSQVDAETGKPLIDVIVDAAGQKGTGRWTVKAALDLGIATTGIGEAVFARALSGATSQRAAAQGNLPAGV
LTDLEALGVDKAQFVEDVRRALYASKLVAYAQGFDEIKAGSDENNWDVDPRDLATIWRGGCIIRAKFLNRIVEAYDANAE
LESLLLDPYFKSELGDLIDSWRRVIVTATQLGLPIPVFASSLSYYDSLRAERLPAALIQGQRDFFGAHTYKRIDKDGSFH
TEWSGDRSEVEA
>Mature_491_residues
PSSTINNMTNGDNLAQIGVVGLAVMGSNLARNFARNGNTVAVYNRSTDKTDKLIADHGSEGNFIPSATVEEFVASLEKPR
RAIIMVQAGNATDAVINQLADAMDEGDIIIDGGNALYTDTIRREKEISARGLHFVGAGISGGEEGALNGPSIMPGGPAKS
YESLGPLLESIAANVDGTPCVTHIGPDGAGHFVKMVHNGIEYADMQVIGEAYHLLRYAAGMQPAEIAEVFKEWNAGDLDS
YLIEITAEVLSQVDAETGKPLIDVIVDAAGQKGTGRWTVKAALDLGIATTGIGEAVFARALSGATSQRAAAQGNLPAGVL
TDLEALGVDKAQFVEDVRRALYASKLVAYAQGFDEIKAGSDENNWDVDPRDLATIWRGGCIIRAKFLNRIVEAYDANAEL
ESLLLDPYFKSELGDLIDSWRRVIVTATQLGLPIPVFASSLSYYDSLRAERLPAALIQGQRDFFGAHTYKRIDKDGSFHT
EWSGDRSEVEA

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=472, Percent_Identity=48.9406779661017, Blast_Score=450, Evalue=1e-126,
Organism=Escherichia coli, GI1788341, Length=474, Percent_Identity=54.4303797468354, Blast_Score=523, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17542558, Length=471, Percent_Identity=46.9214437367304, Blast_Score=462, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6321695, Length=478, Percent_Identity=46.8619246861925, Blast_Score=452, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6321977, Length=485, Percent_Identity=45.7731958762887, Blast_Score=433, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24639279, Length=478, Percent_Identity=45.397489539749, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24655230, Length=203, Percent_Identity=30.0492610837438, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19922568, Length=203, Percent_Identity=30.0492610837438, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52580; Mature: 52448

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSSTINNMTNGDNLAQIGVVGLAVMGSNLARNFARNGNTVAVYNRSTDKTDKLIADHGS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCC
EGNFIPSATVEEFVASLEKPRRAIIMVQAGNATDAVINQLADAMDEGDIIIDGGNALYTD
CCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCEEEHH
TIRREKEISARGLHFVGAGISGGEEGALNGPSIMPGGPAKSYESLGPLLESIAANVDGTP
HHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
CVTHIGPDGAGHFVKMVHNGIEYADMQVIGEAYHLLRYAAGMQPAEIAEVFKEWNAGDLD
EEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHH
SYLIEITAEVLSQVDAETGKPLIDVIVDAAGQKGTGRWTVKAALDLGIATTGIGEAVFAR
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEEHHHCHHHCCHHHHHHHH
ALSGATSQRAAAQGNLPAGVLTDLEALGVDKAQFVEDVRRALYASKLVAYAQGFDEIKAG
HHHCCHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHCC
SDENNWDVDPRDLATIWRGGCIIRAKFLNRIVEAYDANAELESLLLDPYFKSELGDLIDS
CCCCCCCCCHHHHHHHHCCCCEEHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHH
WRRVIVTATQLGLPIPVFASSLSYYDSLRAERLPAALIQGQRDFFGAHTYKRIDKDGSFH
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCCCCCC
TEWSGDRSEVEA
CCCCCCHHHCCC
>Mature Secondary Structure 
PSSTINNMTNGDNLAQIGVVGLAVMGSNLARNFARNGNTVAVYNRSTDKTDKLIADHGS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHCCCC
EGNFIPSATVEEFVASLEKPRRAIIMVQAGNATDAVINQLADAMDEGDIIIDGGNALYTD
CCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCEEEHH
TIRREKEISARGLHFVGAGISGGEEGALNGPSIMPGGPAKSYESLGPLLESIAANVDGTP
HHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
CVTHIGPDGAGHFVKMVHNGIEYADMQVIGEAYHLLRYAAGMQPAEIAEVFKEWNAGDLD
EEEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHH
SYLIEITAEVLSQVDAETGKPLIDVIVDAAGQKGTGRWTVKAALDLGIATTGIGEAVFAR
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEEHHHCHHHCCHHHHHHHH
ALSGATSQRAAAQGNLPAGVLTDLEALGVDKAQFVEDVRRALYASKLVAYAQGFDEIKAG
HHHCCHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHCC
SDENNWDVDPRDLATIWRGGCIIRAKFLNRIVEAYDANAELESLLLDPYFKSELGDLIDS
CCCCCCCCCHHHHHHHHCCCCEEHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHH
WRRVIVTATQLGLPIPVFASSLSYYDSLRAERLPAALIQGQRDFFGAHTYKRIDKDGSFH
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHCCCCCCC
TEWSGDRSEVEA
CCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]