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The map label for this gene is efpA [H]

Identifier: 62390238

GI number: 62390238

Start: 1417926

End: 1419326

Strand: Reverse

Name: efpA [H]

Synonym: cg1526

Alternate gene names: 62390238

Gene position: 1419326-1417926 (Counterclockwise)

Preceding gene: 62390241

Following gene: 62390236

Centisome position: 43.24

GC content: 55.53

Gene sequence:

>1401_bases
ATGATTTTAAGCATCGTCCTTTTGGGCTACTTCATGATTCTGCTTGACACCTCCATCGTCATTACGGGTCTACCTGCCAT
CGGCAGTGAACTTGGCATCGATCCCGTGCACCTGTCATGGGTGCAGAGTTCCTACACATTAGTCTTCGGCGCACTTCTTC
TGCTGGGAGCTCGTGCCGGTGATATCTTCGGCCGAAAGAAAGTGCTCTACATTGGTCTCGCGTTGTTTGCGGCTTCATCG
TTGGCAATTGCGCTTTCTCCAAATGCTGCGGTCCTCATTGGAGCACGCGTAGTTCAAGGCGCGGGAGCTGCGATTATCGC
TCCAGCGACACTTGCGTTGATTACTGAGTTCTTCCCCGAAGGCCCAGCTCGCCTTCGTGCTACCTCTGCTTATGGTGCTG
TTGCCGGCATCGGTGTGGCAGCAGGCCTAGTGATCGGCGGCGTATTTGCTGATCTTTTGTCGTGGCGCATCGGCTTCTTT
ATCAACGTCCCCATCGCCGCAGTGTTGGCCTACATAGTGCACAAAGCCATTCCCGCAACCTTCAGCAGGCCTGGATCACT
CGACATCTTCGGAGCAATTACCTCCACGGCAGGTATCGCCGCGGTGCTCTACGCAATTGTCCGCAGCGCCGATTACAGCT
GGACAGATCCGTTTGTGTTGATTTCCCTCGTGCTGGGCATCGCAGTGTTCATCTGGTTCCTGCGCCATGAATCCTCAGCC
AAAGAACCACTTCTGCCCCTGGGGCTCTTTAAAAACCGCAGGCGAAACACCATCTTGGCCAGCCGCTTTCTTCTGGTTGG
CTCCGTGATGTCATTCTTCTTCTTTGCCACCCAGCTGTTCCAGGACACCATGGGAATGAATGCTCTCCAGGCAGGCCTTG
CGTTCATGCCGCTATCTCTGCTGCAGTTTGCCAGCGCCGCGATGGTGCCACGGCTTTCCCGAGCAGGCGTATCTGATTCC
ATGCTCACCGTCATCGGTTTCGCCATCATGGTCATCGGCATGGCAGGCCTCGCATTTGTACCAAACACGATGATCGCGCT
GATCCTACCAATAGTTTTGGTGGGATTTGGCCAAGGCTTCGCTTTCGGACCAATGACAGCTCTGGCAGTTCAAGGTGCAC
CGAAGGACCAATCCGGCGCCGTTTCTGGCCTGGTGAATTCCCTTCACCAAATCGGCGGCACCTTCGGTTTGGGTGTGTTC
TCCTCCTTGGCTGTCGCTGTCATCGGACATGATGCAACATCAGAGATGATCAGCGACCGCGCACACTTCGGATTCTTGCT
CTCCACCGTGACGCTGACGCTGGCCACCATCTTTGCGGTCACACTGCTGAAGCGCCACGAAACCCGAAAGAGTAGCGAGC
GCCCAACCCAGCTCGTCGACGAAAAGGCAGTTACCTCTTAG

Upstream 100 bases:

>100_bases
CTTCAACATAGGCGTTGGGGCTGACTTTTAAACAGGTACCAGTAGTACCGGCATAAGCGATCACTGTTGCGTTTTCTTGC
TGCCATCAAAAATTAGTCAC

Downstream 100 bases:

>100_bases
TGCGCTGCAGCATCCCAGTTAACGCCATCACCAGCTGAAACTTCCAAAGGAACGGACAGCTTGATGGCGTTATCCATTTC
GCGTTCCAGAATCTCACGGA

Product: major facilitator superfamily permease

Products: NA

Alternate protein names: Efflux protein A [H]

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MILSIVLLGYFMILLDTSIVITGLPAIGSELGIDPVHLSWVQSSYTLVFGALLLLGARAGDIFGRKKVLYIGLALFAASS
LAIALSPNAAVLIGARVVQGAGAAIIAPATLALITEFFPEGPARLRATSAYGAVAGIGVAAGLVIGGVFADLLSWRIGFF
INVPIAAVLAYIVHKAIPATFSRPGSLDIFGAITSTAGIAAVLYAIVRSADYSWTDPFVLISLVLGIAVFIWFLRHESSA
KEPLLPLGLFKNRRRNTILASRFLLVGSVMSFFFFATQLFQDTMGMNALQAGLAFMPLSLLQFASAAMVPRLSRAGVSDS
MLTVIGFAIMVIGMAGLAFVPNTMIALILPIVLVGFGQGFAFGPMTALAVQGAPKDQSGAVSGLVNSLHQIGGTFGLGVF
SSLAVAVIGHDATSEMISDRAHFGFLLSTVTLTLATIFAVTLLKRHETRKSSERPTQLVDEKAVTS

Sequences:

>Translated_466_residues
MILSIVLLGYFMILLDTSIVITGLPAIGSELGIDPVHLSWVQSSYTLVFGALLLLGARAGDIFGRKKVLYIGLALFAASS
LAIALSPNAAVLIGARVVQGAGAAIIAPATLALITEFFPEGPARLRATSAYGAVAGIGVAAGLVIGGVFADLLSWRIGFF
INVPIAAVLAYIVHKAIPATFSRPGSLDIFGAITSTAGIAAVLYAIVRSADYSWTDPFVLISLVLGIAVFIWFLRHESSA
KEPLLPLGLFKNRRRNTILASRFLLVGSVMSFFFFATQLFQDTMGMNALQAGLAFMPLSLLQFASAAMVPRLSRAGVSDS
MLTVIGFAIMVIGMAGLAFVPNTMIALILPIVLVGFGQGFAFGPMTALAVQGAPKDQSGAVSGLVNSLHQIGGTFGLGVF
SSLAVAVIGHDATSEMISDRAHFGFLLSTVTLTLATIFAVTLLKRHETRKSSERPTQLVDEKAVTS
>Mature_466_residues
MILSIVLLGYFMILLDTSIVITGLPAIGSELGIDPVHLSWVQSSYTLVFGALLLLGARAGDIFGRKKVLYIGLALFAASS
LAIALSPNAAVLIGARVVQGAGAAIIAPATLALITEFFPEGPARLRATSAYGAVAGIGVAAGLVIGGVFADLLSWRIGFF
INVPIAAVLAYIVHKAIPATFSRPGSLDIFGAITSTAGIAAVLYAIVRSADYSWTDPFVLISLVLGIAVFIWFLRHESSA
KEPLLPLGLFKNRRRNTILASRFLLVGSVMSFFFFATQLFQDTMGMNALQAGLAFMPLSLLQFASAAMVPRLSRAGVSDS
MLTVIGFAIMVIGMAGLAFVPNTMIALILPIVLVGFGQGFAFGPMTALAVQGAPKDQSGAVSGLVNSLHQIGGTFGLGVF
SSLAVAVIGHDATSEMISDRAHFGFLLSTVTLTLATIFAVTLLKRHETRKSSERPTQLVDEKAVTS

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=407, Percent_Identity=27.7641277641278, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788710, Length=405, Percent_Identity=25.4320987654321, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1790195, Length=472, Percent_Identity=24.7881355932203, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789042, Length=416, Percent_Identity=24.2788461538462, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788392, Length=423, Percent_Identity=26.4775413711584, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324954, Length=447, Percent_Identity=24.3847874720358, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323520, Length=400, Percent_Identity=25.5, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6322958, Length=476, Percent_Identity=25.8403361344538, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6325455, Length=159, Percent_Identity=35.8490566037736, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319770, Length=387, Percent_Identity=24.2894056847545, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323935, Length=444, Percent_Identity=23.8738738738739, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48822; Mature: 48822

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILSIVLLGYFMILLDTSIVITGLPAIGSELGIDPVHLSWVQSSYTLVFGALLLLGARAG
CHHHHHHHHHHHHHHHHHHHEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
DIFGRKKVLYIGLALFAASSLAIALSPNAAVLIGARVVQGAGAAIIAPATLALITEFFPE
HHHCCCHHHHHHHHHHHHCCEEEEECCCCEEEEHHHHHHCCCCCHHHHHHHHHHHHHCCC
GPARLRATSAYGAVAGIGVAAGLVIGGVFADLLSWRIGFFINVPIAAVLAYIVHKAIPAT
CCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
FSRPGSLDIFGAITSTAGIAAVLYAIVRSADYSWTDPFVLISLVLGIAVFIWFLRHESSA
CCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
KEPLLPLGLFKNRRRNTILASRFLLVGSVMSFFFFATQLFQDTMGMNALQAGLAFMPLSL
CCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
LQFASAAMVPRLSRAGVSDSMLTVIGFAIMVIGMAGLAFVPNTMIALILPIVLVGFGQGF
HHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AFGPMTALAVQGAPKDQSGAVSGLVNSLHQIGGTFGLGVFSSLAVAVIGHDATSEMISDR
CCCCHHHHEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
AHFGFLLSTVTLTLATIFAVTLLKRHETRKSSERPTQLVDEKAVTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MILSIVLLGYFMILLDTSIVITGLPAIGSELGIDPVHLSWVQSSYTLVFGALLLLGARAG
CHHHHHHHHHHHHHHHHHHHEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
DIFGRKKVLYIGLALFAASSLAIALSPNAAVLIGARVVQGAGAAIIAPATLALITEFFPE
HHHCCCHHHHHHHHHHHHCCEEEEECCCCEEEEHHHHHHCCCCCHHHHHHHHHHHHHCCC
GPARLRATSAYGAVAGIGVAAGLVIGGVFADLLSWRIGFFINVPIAAVLAYIVHKAIPAT
CCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
FSRPGSLDIFGAITSTAGIAAVLYAIVRSADYSWTDPFVLISLVLGIAVFIWFLRHESSA
CCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
KEPLLPLGLFKNRRRNTILASRFLLVGSVMSFFFFATQLFQDTMGMNALQAGLAFMPLSL
CCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
LQFASAAMVPRLSRAGVSDSMLTVIGFAIMVIGMAGLAFVPNTMIALILPIVLVGFGQGF
HHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AFGPMTALAVQGAPKDQSGAVSGLVNSLHQIGGTFGLGVFSSLAVAVIGHDATSEMISDR
CCCCHHHHEECCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
AHFGFLLSTVTLTLATIFAVTLLKRHETRKSSERPTQLVDEKAVTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]