Click here to switch to the map view.

The map label for this gene is mutT1 [H]

Identifier: 62390200

GI number: 62390200

Start: 1384309

End: 1385319

Strand: Reverse

Name: mutT1 [H]

Synonym: cg1490

Alternate gene names: 62390200

Gene position: 1385319-1384309 (Counterclockwise)

Preceding gene: 62390204

Following gene: 62390197

Centisome position: 42.2

GC content: 56.97

Gene sequence:

>1011_bases
ATGGCAAATAAGAACAATAAGCCTCATGAGGTGGACAAAGACCAAGATTCAGCCATGCTGATCAACGGTCGCCTGCAACA
GATCCCGGCGCGTCCCACTGAGGAATTCACCCGCCCAACTCTTGCAGCAGGTGCAGTACTGTGGCGCGGCGACATCACCA
ACCCGGACAGCATCGAGGTCGCTGTCATCCACCGCCCGCACTATGATGACTGGTCCCTGGCCAAGGGCAAAGTCGATCCC
GGCGAGTCTATTCCGACAACCGCGGCCCGTGAAATCCTTGAAGAAACTGGCTACGACATCCGTCTGGGCAAGCTGATCGG
CAAGGTTACTTACCCTGTGCTCGACCGAACCAAAGTGGTCTACTACTGGACTGCCCAGGTTCTTGGTGGAGAGTTTGTCC
CCAACGATGAAGTTGATGAAATCCGTTGGCTGTCTGTTGATGAAGCATGCGAGTTGCTCAGCTACCAAGTAGATACCGAA
GTTCTGGCCAAGGCAGCAAAGCGTTTCCGCACTCCTTCCACCACTCGGGTGCTGTATGTTCGCCATGCTCATGCACATGG
TCGCCAAACCTGGGGTGGCGACGACAATAAGCGCCCATTGGACAAAAAGGGGCGTCGACAAGCAGAAATGCTCGTACCCA
TGTTGTTGCCCTTCAAACCCACCGCAATTTACTCGGCGGTGCCCGATCGCTGCCAAGCCACCGCGCTCCCCCTTGCCGAT
GAGCTCGGCCTCGACGTGTCCGTCAACCGACTGTTCGGCGACGACGCCTGGGAAACCGATCCCGAGGCCTGCAAGAAGCG
CTTCACCGACGTGGTCGCGCAAGGTGGCGTGCCGATGATCGTTGGGCAGGGCGACATCATTCCGGAAATGATCAAATGGT
TCTCCGAGAACGGCACCCTCCCTATCGATGAGAAGATCAAGGCGAAAAAGGGCAGCGTGTGGGTGTTGAGCTTTCACGAC
GGTGTGTTCACCGGCGCTGATTACCTGGCGAGTTCCCTGCCGGTTAAATAG

Upstream 100 bases:

>100_bases
AATAGATGGAAGTAGTTTTTCATTCACTTATGTGCGCGTTTTTAATCTGGTTTCTACCAAGAACTGTGTGCACCACAACG
CGGAAGGTGAATCGCACCCA

Downstream 100 bases:

>100_bases
GAGCGCGTTTAAGGCCTCCAGTTTGGCGAGTGGGTATGGGCTTGGGTTTGAGCCTGTTAGGGGCTTAGAACCCATTCTGG
AGGGGCACTTTTCATGCGTT

Product: NTP pyrophosphohydrolase including oxidative damage repair enzyme

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MANKNNKPHEVDKDQDSAMLINGRLQQIPARPTEEFTRPTLAAGAVLWRGDITNPDSIEVAVIHRPHYDDWSLAKGKVDP
GESIPTTAAREILEETGYDIRLGKLIGKVTYPVLDRTKVVYYWTAQVLGGEFVPNDEVDEIRWLSVDEACELLSYQVDTE
VLAKAAKRFRTPSTTRVLYVRHAHAHGRQTWGGDDNKRPLDKKGRRQAEMLVPMLLPFKPTAIYSAVPDRCQATALPLAD
ELGLDVSVNRLFGDDAWETDPEACKKRFTDVVAQGGVPMIVGQGDIIPEMIKWFSENGTLPIDEKIKAKKGSVWVLSFHD
GVFTGADYLASSLPVK

Sequences:

>Translated_336_residues
MANKNNKPHEVDKDQDSAMLINGRLQQIPARPTEEFTRPTLAAGAVLWRGDITNPDSIEVAVIHRPHYDDWSLAKGKVDP
GESIPTTAAREILEETGYDIRLGKLIGKVTYPVLDRTKVVYYWTAQVLGGEFVPNDEVDEIRWLSVDEACELLSYQVDTE
VLAKAAKRFRTPSTTRVLYVRHAHAHGRQTWGGDDNKRPLDKKGRRQAEMLVPMLLPFKPTAIYSAVPDRCQATALPLAD
ELGLDVSVNRLFGDDAWETDPEACKKRFTDVVAQGGVPMIVGQGDIIPEMIKWFSENGTLPIDEKIKAKKGSVWVLSFHD
GVFTGADYLASSLPVK
>Mature_335_residues
ANKNNKPHEVDKDQDSAMLINGRLQQIPARPTEEFTRPTLAAGAVLWRGDITNPDSIEVAVIHRPHYDDWSLAKGKVDPG
ESIPTTAAREILEETGYDIRLGKLIGKVTYPVLDRTKVVYYWTAQVLGGEFVPNDEVDEIRWLSVDEACELLSYQVDTEV
LAKAAKRFRTPSTTRVLYVRHAHAHGRQTWGGDDNKRPLDKKGRRQAEMLVPMLLPFKPTAIYSAVPDRCQATALPLADE
LGLDVSVNRLFGDDAWETDPEACKKRFTDVVAQGGVPMIVGQGDIIPEMIKWFSENGTLPIDEKIKAKKGSVWVLSFHDG
VFTGADYLASSLPVK

Specific function: May be involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine, 8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo- dGTP is inserted opposite dA and dC residues of template DNA with almost equa

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013078
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX; PF00300 PGAM [H]

EC number: NA

Molecular weight: Translated: 37420; Mature: 37289

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANKNNKPHEVDKDQDSAMLINGRLQQIPARPTEEFTRPTLAAGAVLWRGDITNPDSIEV
CCCCCCCCCCCCCCCCCEEEECCHHHHCCCCCHHHHCCCHHHHCEEEEECCCCCCCCEEE
AVIHRPHYDDWSLAKGKVDPGESIPTTAAREILEETGYDIRLGKLIGKVTYPVLDRTKVV
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHCHHCCCEEE
YYWTAQVLGGEFVPNDEVDEIRWLSVDEACELLSYQVDTEVLAKAAKRFRTPSTTRVLYV
EEEEEEHHCCCCCCCCCCCCEEEECHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEE
RHAHAHGRQTWGGDDNKRPLDKKGRRQAEMLVPMLLPFKPTAIYSAVPDRCQATALPLAD
EECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHCCCCCHH
ELGLDVSVNRLFGDDAWETDPEACKKRFTDVVAQGGVPMIVGQGDIIPEMIKWFSENGTL
HHCCCEEEHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCC
PIDEKIKAKKGSVWVLSFHDGVFTGADYLASSLPVK
CCCHHHHCCCCCEEEEEECCCCHHCHHHHHHCCCCC
>Mature Secondary Structure 
ANKNNKPHEVDKDQDSAMLINGRLQQIPARPTEEFTRPTLAAGAVLWRGDITNPDSIEV
CCCCCCCCCCCCCCCCEEEECCHHHHCCCCCHHHHCCCHHHHCEEEEECCCCCCCCEEE
AVIHRPHYDDWSLAKGKVDPGESIPTTAAREILEETGYDIRLGKLIGKVTYPVLDRTKVV
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHCHHCCCEEE
YYWTAQVLGGEFVPNDEVDEIRWLSVDEACELLSYQVDTEVLAKAAKRFRTPSTTRVLYV
EEEEEEHHCCCCCCCCCCCCEEEECHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEEE
RHAHAHGRQTWGGDDNKRPLDKKGRRQAEMLVPMLLPFKPTAIYSAVPDRCQATALPLAD
EECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHCCCCCHH
ELGLDVSVNRLFGDDAWETDPEACKKRFTDVVAQGGVPMIVGQGDIIPEMIKWFSENGTL
HHCCCEEEHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCC
PIDEKIKAKKGSVWVLSFHDGVFTGADYLASSLPVK
CCCHHHHCCCCCEEEEEECCCCHHCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]