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The map label for this gene is moaA [H]

Identifier: 62390085

GI number: 62390085

Start: 1263153

End: 1264361

Strand: Reverse

Name: moaA [H]

Synonym: cg1352

Alternate gene names: 62390085

Gene position: 1264361-1263153 (Counterclockwise)

Preceding gene: 62390086

Following gene: 62390084

Centisome position: 38.52

GC content: 57.32

Gene sequence:

>1209_bases
GTGAAAAATAACTTCCCTATTTATTCCGGCTTTTACTGGCTTTATTCCGCAGCTCTTTCTAGGATGGGCAAGAAGATGAC
TACTCGCCTTTATCTTTCGCCAACGCCGCCCCGAAATGATCGGGAGGGGGCGTCGAAAAGCACTTCTGCGAGCATCAAAC
ATGATGCGTACCTGCCACCCGCAGACGGCAATCGCGTGCTTGTGGACAGATTCGGACGCATCGCGCGTGACCTGCGGGTG
TCACTGACCGACCGATGCAACCTCCGCTGCACCTATTGCATGCCCGCGGAGGGTTTAGAGTGGCTGCCCACCGAGCAGAC
GCTTAACGACGCCGAGGTGCTGCGACTCATCCGCATTGCGGTGGTTAAGCTGGGCATTCGTCAAATTCGATTCACCGGCG
GCGAGCCTTTACTGCGGAAAAATTTGGAAGACATCATCGCCGGCACCGCAGCCCTGCGCACCGACGAAGGCGAAAAAGTT
CACATCGCTCTCACCACCAACGGCCTTGGCCTAGACAAACGCATCGCAGGACTGAAAGAAGCTGGTCTTGACCGGGTCAA
TATTTCACTCGACACCATCGACGCCGAACGCTACGTCTCGCTAACCAGGCGTGATCGATTGTCCGGTGTGTTGGCGTCCA
TCGATGCCGCTGTTGCCGCTGGCCTTCACCCAGTGAAGATCAACGCCGTGGTCATGCCTGGGGTCAATGAAGTAGATATC
GTCCCCCTTGCGGAATACTGCATTTCCAAAGGCTCCCAACTGCGATTCATCGAACAAATGCCACTTGGCCCGCGCGAGCA
GTGGAAACGCGGCGATATGGTCACAGCCGAAGAAATCCTGGCGCGCCTGGAAGAAAAATTCACCTTATCCCCCGCCAAGG
AACCCCGAGGAGCTGCACCTGCTGCGCTGTGGAATGTGGTAGATAAATCCAACCCTGATATCACTGGACAAATCGGCATC
ATCGCCTCGGTGACGCACCCATTTTGCGGAGATTGCGATCGCTCCCGCCTCACCACCGACGGCACCATCCGAAACTGCCT
TTTCTCCCGCACTGAAACTCCCCTACGTGACGCGCTTCGCGACGGCGCCTCCGACGATGAGCTCGCGCAACTGTGGGCAG
GCGCCATGTGGGAGAAGAAACCCGGCCATGGCATCGACGATGAAGGCTTCCTCCAACCAGATCGCCCCATGTCTGCCATC
GGTGGCTAG

Upstream 100 bases:

>100_bases
GATGAGGTGGATAAAACCTCCGTCGGTAAATATGACAAGAAGGACCTCCGCAACCACCTGCGCAACGGCGATTTCGAAGT
AATTAAGCTTAAAGGGCCAG

Downstream 100 bases:

>100_bases
CCCATACCAGCCCCAACCAGACAGGCGTGACAAGATTCGAGAATTTCCACAGCTTTTGGCACGTGTGTCTGGTTTTTGGT
CCCGATAACCGGACAGGTGT

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MKNNFPIYSGFYWLYSAALSRMGKKMTTRLYLSPTPPRNDREGASKSTSASIKHDAYLPPADGNRVLVDRFGRIARDLRV
SLTDRCNLRCTYCMPAEGLEWLPTEQTLNDAEVLRLIRIAVVKLGIRQIRFTGGEPLLRKNLEDIIAGTAALRTDEGEKV
HIALTTNGLGLDKRIAGLKEAGLDRVNISLDTIDAERYVSLTRRDRLSGVLASIDAAVAAGLHPVKINAVVMPGVNEVDI
VPLAEYCISKGSQLRFIEQMPLGPREQWKRGDMVTAEEILARLEEKFTLSPAKEPRGAAPAALWNVVDKSNPDITGQIGI
IASVTHPFCGDCDRSRLTTDGTIRNCLFSRTETPLRDALRDGASDDELAQLWAGAMWEKKPGHGIDDEGFLQPDRPMSAI
GG

Sequences:

>Translated_402_residues
MKNNFPIYSGFYWLYSAALSRMGKKMTTRLYLSPTPPRNDREGASKSTSASIKHDAYLPPADGNRVLVDRFGRIARDLRV
SLTDRCNLRCTYCMPAEGLEWLPTEQTLNDAEVLRLIRIAVVKLGIRQIRFTGGEPLLRKNLEDIIAGTAALRTDEGEKV
HIALTTNGLGLDKRIAGLKEAGLDRVNISLDTIDAERYVSLTRRDRLSGVLASIDAAVAAGLHPVKINAVVMPGVNEVDI
VPLAEYCISKGSQLRFIEQMPLGPREQWKRGDMVTAEEILARLEEKFTLSPAKEPRGAAPAALWNVVDKSNPDITGQIGI
IASVTHPFCGDCDRSRLTTDGTIRNCLFSRTETPLRDALRDGASDDELAQLWAGAMWEKKPGHGIDDEGFLQPDRPMSAI
GG
>Mature_402_residues
MKNNFPIYSGFYWLYSAALSRMGKKMTTRLYLSPTPPRNDREGASKSTSASIKHDAYLPPADGNRVLVDRFGRIARDLRV
SLTDRCNLRCTYCMPAEGLEWLPTEQTLNDAEVLRLIRIAVVKLGIRQIRFTGGEPLLRKNLEDIIAGTAALRTDEGEKV
HIALTTNGLGLDKRIAGLKEAGLDRVNISLDTIDAERYVSLTRRDRLSGVLASIDAAVAAGLHPVKINAVVMPGVNEVDI
VPLAEYCISKGSQLRFIEQMPLGPREQWKRGDMVTAEEILARLEEKFTLSPAKEPRGAAPAALWNVVDKSNPDITGQIGI
IASVTHPFCGDCDRSRLTTDGTIRNCLFSRTETPLRDALRDGASDDELAQLWAGAMWEKKPGHGIDDEGFLQPDRPMSAI
GG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=337, Percent_Identity=39.1691394658754, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI22027536, Length=337, Percent_Identity=39.1691394658754, Blast_Score=222, Evalue=6e-58,
Organism=Escherichia coli, GI1786999, Length=338, Percent_Identity=33.7278106508876, Blast_Score=185, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI32566329, Length=370, Percent_Identity=35.1351351351351, Blast_Score=214, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17561210, Length=348, Percent_Identity=36.4942528735632, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI32566331, Length=357, Percent_Identity=34.453781512605, Blast_Score=207, Evalue=7e-54,
Organism=Drosophila melanogaster, GI28574488, Length=340, Percent_Identity=40.8823529411765, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI28574490, Length=322, Percent_Identity=41.304347826087, Blast_Score=219, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 44236; Mature: 44236

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNNFPIYSGFYWLYSAALSRMGKKMTTRLYLSPTPPRNDREGASKSTSASIKHDAYLPP
CCCCCCCHHHHHHHHHHHHHHHCHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
ADGNRVLVDRFGRIARDLRVSLTDRCNLRCTYCMPAEGLEWLPTEQTLNDAEVLRLIRIA
CCCCEEHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHH
VVKLGIRQIRFTGGEPLLRKNLEDIIAGTAALRTDEGEKVHIALTTNGLGLDKRIAGLKE
HHHHHHHHEEECCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEECCCCHHHHHHHHHH
AGLDRVNISLDTIDAERYVSLTRRDRLSGVLASIDAAVAAGLHPVKINAVVMPGVNEVDI
CCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCEEE
VPLAEYCISKGSQLRFIEQMPLGPREQWKRGDMVTAEEILARLEEKFTLSPAKEPRGAAP
EEHHHHHHCCCCCEEEHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCH
AALWNVVDKSNPDITGQIGIIASVTHPFCGDCDRSRLTTDGTIRNCLFSRTETPLRDALR
HHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHH
DGASDDELAQLWAGAMWEKKPGHGIDDEGFLQPDRPMSAIGG
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MKNNFPIYSGFYWLYSAALSRMGKKMTTRLYLSPTPPRNDREGASKSTSASIKHDAYLPP
CCCCCCCHHHHHHHHHHHHHHHCHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
ADGNRVLVDRFGRIARDLRVSLTDRCNLRCTYCMPAEGLEWLPTEQTLNDAEVLRLIRIA
CCCCEEHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHH
VVKLGIRQIRFTGGEPLLRKNLEDIIAGTAALRTDEGEKVHIALTTNGLGLDKRIAGLKE
HHHHHHHHEEECCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEECCCCHHHHHHHHHH
AGLDRVNISLDTIDAERYVSLTRRDRLSGVLASIDAAVAAGLHPVKINAVVMPGVNEVDI
CCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCEEE
VPLAEYCISKGSQLRFIEQMPLGPREQWKRGDMVTAEEILARLEEKFTLSPAKEPRGAAP
EEHHHHHHCCCCCEEEHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCH
AALWNVVDKSNPDITGQIGIIASVTHPFCGDCDRSRLTTDGTIRNCLFSRTETPLRDALR
HHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHH
DGASDDELAQLWAGAMWEKKPGHGIDDEGFLQPDRPMSAIGG
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA