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The map label for this gene is proY [H]

Identifier: 62390043

GI number: 62390043

Start: 1209677

End: 1211083

Strand: Reverse

Name: proY [H]

Synonym: cg1305

Alternate gene names: 62390043

Gene position: 1211083-1209677 (Counterclockwise)

Preceding gene: 62390045

Following gene: 62390041

Centisome position: 36.89

GC content: 57.14

Gene sequence:

>1407_bases
ATGAATGCCTCCCCTGCCCCAACCCGATCTTTTAAAGGATTGCGGGCTCGACACATTCACTTCATCGCGCTGGGTTCCGC
GATCGGCACCGGCTTGTTCTACGGTTCCGCTGGCGCAATCCAAGCAGCTGGTCCATCTGTACTCTTGGTCTACCTTCTCG
GTGGCGCCGTCGTGTACTTCATGCTGCGCGCACTCGGCGAGATGGCTGTGCATCACCCAGTCCGTGGTTCCTTCGCGGTC
TACACCCGCGCACACCTTGGCGGATGGGCAGGCTACATCACCGGCTGGATGTTCGCGTTTGAGATGCTCATCGTCTGCCT
GGCTGACCTCACAGCCATCGGCATCTATATGAACTTCTGGTTCCCCGGCACCCCACAATGGACTTGGGTGGTAGCCACCC
TTCTTATTGTCGGTGGCGCAAACCTCGCATCAGTGCGTTGGTTCGGTGAGCTCGAGTTCATCTTCACCATCATTAAGGTC
ACCGCAGTTGTCGCCATGATCGTCGGCGGCGCAGCCATCCTCGCATTCGGTCTCGGCGCCAACGCTGAAGTTGCCGGCGT
ATCCAACCTCTGGGAGCACGGCGGATTCTTCCCCAACGGTGTTGAAGGCATGATCGCAGCCTTCATCCTTGTTCTCTTCG
CATTCGGTGGCACCGAAATCATCGGTGTTGCAGGCTCTGAAGCTGAAGATCCTGAGAAGTCCATCCCCAAGGCTGTTAAT
ACTGTCCCAGTACGCATCCTCCTCTTCTATGTGGGTGCCATCCTGGTGATCCTTGCCCTTAATCCTTGGCCTTCCATCAC
CGGCGAAGAATCCCCATTCGTCCAGATCTTCGACACCCTCGGCGTCAACTGGGCTGCTGGTCTCCTCAACGCCGTGGTCA
TCACCGCTGCACTGTCTGCCATCAACGCTGACCTCTTCGGCGCTGGCCGCGTTCTCACTGGTCTTGCGAAGGAAAACCTC
GCACCAAAGGCCATGGGCAAGATCGCCAAGAACGGCGTTCCAGTCATGACCACCACCATCATGATCATCGTCTTGATCGT
GGGAGTAATCCTCAACGCAGTGCTTCCCGAGCGCGTCTTCGAGATCGTCGCTTCCCTAGCAACCTTCGCCACAGTTTACG
TCTGGCTGATGATCCTGCTCGCACAGGTGGGATCCCGCCGAAACATGCCTGCCGACGAGGTCAAGTCCCTGAAGTTCCCT
GTCCCCTTCTACCCCTTCGGACAATACTTCGCGATCCTATTTATCGCCTTCACCTTCGGCATCATGGTCTGGTACGACAA
CTACCACCTGCCACTCGCCGTCGGCGTTGGATTCCTTGTCCTGATGACAATCCTTTACTACGCCACAGGCCGACCAAAGG
CGATCGCTCCGATCGATTATGAAGAGCTAGATCCGCGACGCGATTAA

Upstream 100 bases:

>100_bases
CAGTAAAAGTGCACCGACACTAAGAATCCTTATCCTTCAGAGTAAGGTGATCTGCGTCAAAAAATGTCCGCTATTCACCC
GAAACGAGGTCAGCATCTCG

Downstream 100 bases:

>100_bases
TCTAGACTCGCACGAAAAAGGCAGCATCTTTTCCAATATGGAGGAGATGCTGCCTTTTAAGAATCTATTAGTGATTTAAA
TATGCCTTACAAGAAGCTGG

Product: amino acid permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MNASPAPTRSFKGLRARHIHFIALGSAIGTGLFYGSAGAIQAAGPSVLLVYLLGGAVVYFMLRALGEMAVHHPVRGSFAV
YTRAHLGGWAGYITGWMFAFEMLIVCLADLTAIGIYMNFWFPGTPQWTWVVATLLIVGGANLASVRWFGELEFIFTIIKV
TAVVAMIVGGAAILAFGLGANAEVAGVSNLWEHGGFFPNGVEGMIAAFILVLFAFGGTEIIGVAGSEAEDPEKSIPKAVN
TVPVRILLFYVGAILVILALNPWPSITGEESPFVQIFDTLGVNWAAGLLNAVVITAALSAINADLFGAGRVLTGLAKENL
APKAMGKIAKNGVPVMTTTIMIIVLIVGVILNAVLPERVFEIVASLATFATVYVWLMILLAQVGSRRNMPADEVKSLKFP
VPFYPFGQYFAILFIAFTFGIMVWYDNYHLPLAVGVGFLVLMTILYYATGRPKAIAPIDYEELDPRRD

Sequences:

>Translated_468_residues
MNASPAPTRSFKGLRARHIHFIALGSAIGTGLFYGSAGAIQAAGPSVLLVYLLGGAVVYFMLRALGEMAVHHPVRGSFAV
YTRAHLGGWAGYITGWMFAFEMLIVCLADLTAIGIYMNFWFPGTPQWTWVVATLLIVGGANLASVRWFGELEFIFTIIKV
TAVVAMIVGGAAILAFGLGANAEVAGVSNLWEHGGFFPNGVEGMIAAFILVLFAFGGTEIIGVAGSEAEDPEKSIPKAVN
TVPVRILLFYVGAILVILALNPWPSITGEESPFVQIFDTLGVNWAAGLLNAVVITAALSAINADLFGAGRVLTGLAKENL
APKAMGKIAKNGVPVMTTTIMIIVLIVGVILNAVLPERVFEIVASLATFATVYVWLMILLAQVGSRRNMPADEVKSLKFP
VPFYPFGQYFAILFIAFTFGIMVWYDNYHLPLAVGVGFLVLMTILYYATGRPKAIAPIDYEELDPRRD
>Mature_468_residues
MNASPAPTRSFKGLRARHIHFIALGSAIGTGLFYGSAGAIQAAGPSVLLVYLLGGAVVYFMLRALGEMAVHHPVRGSFAV
YTRAHLGGWAGYITGWMFAFEMLIVCLADLTAIGIYMNFWFPGTPQWTWVVATLLIVGGANLASVRWFGELEFIFTIIKV
TAVVAMIVGGAAILAFGLGANAEVAGVSNLWEHGGFFPNGVEGMIAAFILVLFAFGGTEIIGVAGSEAEDPEKSIPKAVN
TVPVRILLFYVGAILVILALNPWPSITGEESPFVQIFDTLGVNWAAGLLNAVVITAALSAINADLFGAGRVLTGLAKENL
APKAMGKIAKNGVPVMTTTIMIIVLIVGVILNAVLPERVFEIVASLATFATVYVWLMILLAQVGSRRNMPADEVKSLKFP
VPFYPFGQYFAILFIAFTFGIMVWYDNYHLPLAVGVGFLVLMTILYYATGRPKAIAPIDYEELDPRRD

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=313, Percent_Identity=25.2396166134185, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786602, Length=433, Percent_Identity=50.8083140877598, Blast_Score=423, Evalue=1e-120,
Organism=Escherichia coli, GI1786302, Length=412, Percent_Identity=43.6893203883495, Blast_Score=340, Evalue=8e-95,
Organism=Escherichia coli, GI1786789, Length=429, Percent_Identity=41.7249417249417, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI48994972, Length=453, Percent_Identity=40.3973509933775, Blast_Score=318, Evalue=4e-88,
Organism=Escherichia coli, GI1790653, Length=456, Percent_Identity=36.4035087719298, Blast_Score=311, Evalue=5e-86,
Organism=Escherichia coli, GI87081915, Length=400, Percent_Identity=39.5, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI87081708, Length=399, Percent_Identity=36.0902255639098, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1789017, Length=425, Percent_Identity=33.6470588235294, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1788480, Length=426, Percent_Identity=37.3239436619718, Blast_Score=234, Evalue=9e-63,
Organism=Escherichia coli, GI87081869, Length=241, Percent_Identity=25.3112033195021, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=427, Percent_Identity=22.0140515222482, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=430, Percent_Identity=31.1627906976744, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6324061, Length=433, Percent_Identity=30.2540415704388, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6324990, Length=444, Percent_Identity=28.3783783783784, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6322892, Length=425, Percent_Identity=28.7058823529412, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6324924, Length=454, Percent_Identity=28.1938325991189, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6324059, Length=442, Percent_Identity=28.9592760180996, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6320251, Length=430, Percent_Identity=25.8139534883721, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320717, Length=393, Percent_Identity=25.9541984732824, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6319824, Length=394, Percent_Identity=26.9035532994924, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6324553, Length=394, Percent_Identity=28.6802030456853, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319543, Length=445, Percent_Identity=25.1685393258427, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319542, Length=394, Percent_Identity=24.3654822335025, Blast_Score=139, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6321629, Length=404, Percent_Identity=23.7623762376238, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6321053, Length=435, Percent_Identity=25.2873563218391, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6322967, Length=393, Percent_Identity=26.7175572519084, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319608, Length=437, Percent_Identity=25.1716247139588, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6324981, Length=394, Percent_Identity=25.8883248730964, Blast_Score=110, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6320364, Length=493, Percent_Identity=21.501014198783, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221512776, Length=408, Percent_Identity=22.7941176470588, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24667468, Length=410, Percent_Identity=26.3414634146341, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24666159, Length=408, Percent_Identity=22.7941176470588, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI161077963, Length=358, Percent_Identity=25.1396648044693, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50188; Mature: 50188

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNASPAPTRSFKGLRARHIHFIALGSAIGTGLFYGSAGAIQAAGPSVLLVYLLGGAVVYF
CCCCCCCCHHHCCCHHHHEEEEEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
MLRALGEMAVHHPVRGSFAVYTRAHLGGWAGYITGWMFAFEMLIVCLADLTAIGIYMNFW
HHHHHHHHHHCCCCCCCEEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
FPGTPQWTWVVATLLIVGGANLASVRWFGELEFIFTIIKVTAVVAMIVGGAAILAFGLGA
CCCCCCHHHHHHHHHHHCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NAEVAGVSNLWEHGGFFPNGVEGMIAAFILVLFAFGGTEIIGVAGSEAEDPEKSIPKAVN
CCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHCCHHHH
TVPVRILLFYVGAILVILALNPWPSITGEESPFVQIFDTLGVNWAAGLLNAVVITAALSA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHH
INADLFGAGRVLTGLAKENLAPKAMGKIAKNGVPVMTTTIMIIVLIVGVILNAVLPERVF
HHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EIVASLATFATVYVWLMILLAQVGSRRNMPADEVKSLKFPVPFYPFGQYFAILFIAFTFG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
IMVWYDNYHLPLAVGVGFLVLMTILYYATGRPKAIAPIDYEELDPRRD
HHHEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHCCCCCC
>Mature Secondary Structure
MNASPAPTRSFKGLRARHIHFIALGSAIGTGLFYGSAGAIQAAGPSVLLVYLLGGAVVYF
CCCCCCCCHHHCCCHHHHEEEEEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
MLRALGEMAVHHPVRGSFAVYTRAHLGGWAGYITGWMFAFEMLIVCLADLTAIGIYMNFW
HHHHHHHHHHCCCCCCCEEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
FPGTPQWTWVVATLLIVGGANLASVRWFGELEFIFTIIKVTAVVAMIVGGAAILAFGLGA
CCCCCCHHHHHHHHHHHCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NAEVAGVSNLWEHGGFFPNGVEGMIAAFILVLFAFGGTEIIGVAGSEAEDPEKSIPKAVN
CCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHCCHHHH
TVPVRILLFYVGAILVILALNPWPSITGEESPFVQIFDTLGVNWAAGLLNAVVITAALSA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHH
INADLFGAGRVLTGLAKENLAPKAMGKIAKNGVPVMTTTIMIIVLIVGVILNAVLPERVF
HHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EIVASLATFATVYVWLMILLAQVGSRRNMPADEVKSLKFPVPFYPFGQYFAILFIAFTFG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
IMVWYDNYHLPLAVGVGFLVLMTILYYATGRPKAIAPIDYEELDPRRD
HHHEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]