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The map label for this gene is iscS [H]

Identifier: 62389956

GI number: 62389956

Start: 1117298

End: 1118374

Strand: Reverse

Name: iscS [H]

Synonym: cg1214

Alternate gene names: 62389956

Gene position: 1118374-1117298 (Counterclockwise)

Preceding gene: 62389957

Following gene: 62389953

Centisome position: 34.07

GC content: 54.69

Gene sequence:

>1077_bases
ATGCTCTACCTTGATAATGCAGCCACCACCAGTGTGCGCAATGAAGCACTTGAGGCCATGTGGCCTTATCTCACCGGAGC
GTTTGGCAATCCGTCAAGTCCCCATGAGGTGGGAAGACTCGCCTCTGCGGGGCTGGAGGATGCTCGAACTCGGGTGGCCC
GCATTATCGGAGGACGCCCCACACAGGTGACGTTTACGTCGGGTGGATCAGAAGCCAACAACCTCGCTATCAAAGGAGCG
TGCTTAGCTAATCCTCGTGGCCGGCACCTCATCACCACCCCGATCGAGCATGACAGTGTCCTAGAAACTGCTGCTTATCT
TGAAAGGTTTCATGATTTCGAGATCACCTACCTATCCCCCGATCACACTGGGCTGATCTCCCCGGAGGGTCTCCGCAAAG
CAGTCAGGCCGGACACCACATTGATCAGCATTGGTTATGCCAACAATGAGGTGGGAACCATTCAGCCGATAGCTGAGTTG
GCGGCGGTAAGCAGTACGCCTTTTCACACCGATGCAGTGCAAGCTGCACATTTAACCTTTGACTTGGGAGTTGACGCGTT
AAGTTTGTCGGGTCATAAATTCGGTGCGCCTAAAGGGATTGGAGTGTTATGGTCAAAGCTTCCCCTGGAGCCGGTAATCC
ATGGCGGCGGCCAGGAAAAAGGGCGGCGTAGTGGCACGGAAAACGTTGCGGGGGCTATCGCCTTTGCCACTGCCTTGGAA
TTGGCCAGGGCGGAATCCTATCCAGATCTTGGCGAATTCATCGAGGAAGTTCTCACTATCCCGGGAGCACACCTGACTGG
ACATCCTAGGATGCGCATTGATGGACACGCATCTTTTCTCTTCGACAGCATAGGATCTGAAACTGTTCTTCTGGAATTGG
AACGCCAAGGCATTGTGTGCTCCCCTGGTTCTGCCTGTGGTTCCGGAGAGGTATCCCATGTGTTGCTGGCGTTGGGGCTT
GAGGAGGATCAAGCACGAACGGCTGTGCGCTGTACTTTTAGTACAACACACAGCCGTGAAGATGCGCTCGTGGCAGCCTC
TGCTCTTAAATCCGCGGTCGCCTTAATCAGAGGGTGA

Upstream 100 bases:

>100_bases
ACACCGCGGGAAAGATTGCATCAACCGGTGTCGACGTCATTTCCGTTGGAGCGCTTACCCATTCTGTGCATGCACTTGAC
CTAGGACTCGATATTTTCTA

Downstream 100 bases:

>100_bases
CGCTAGTCAGAGGTTTACGGGCTCTTCCTGTTTTAGAGTGCATTGATCTTATGGACCAACTGCCCTGAATGGATAAGGCA
CCGCAGAATGTAGTGGTTCA

Product: cysteine sulfinate desulfinase/cysteine desulfurase

Products: NA

Alternate protein names: NifS protein homolog [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MLYLDNAATTSVRNEALEAMWPYLTGAFGNPSSPHEVGRLASAGLEDARTRVARIIGGRPTQVTFTSGGSEANNLAIKGA
CLANPRGRHLITTPIEHDSVLETAAYLERFHDFEITYLSPDHTGLISPEGLRKAVRPDTTLISIGYANNEVGTIQPIAEL
AAVSSTPFHTDAVQAAHLTFDLGVDALSLSGHKFGAPKGIGVLWSKLPLEPVIHGGGQEKGRRSGTENVAGAIAFATALE
LARAESYPDLGEFIEEVLTIPGAHLTGHPRMRIDGHASFLFDSIGSETVLLELERQGIVCSPGSACGSGEVSHVLLALGL
EEDQARTAVRCTFSTTHSREDALVAASALKSAVALIRG

Sequences:

>Translated_358_residues
MLYLDNAATTSVRNEALEAMWPYLTGAFGNPSSPHEVGRLASAGLEDARTRVARIIGGRPTQVTFTSGGSEANNLAIKGA
CLANPRGRHLITTPIEHDSVLETAAYLERFHDFEITYLSPDHTGLISPEGLRKAVRPDTTLISIGYANNEVGTIQPIAEL
AAVSSTPFHTDAVQAAHLTFDLGVDALSLSGHKFGAPKGIGVLWSKLPLEPVIHGGGQEKGRRSGTENVAGAIAFATALE
LARAESYPDLGEFIEEVLTIPGAHLTGHPRMRIDGHASFLFDSIGSETVLLELERQGIVCSPGSACGSGEVSHVLLALGL
EEDQARTAVRCTFSTTHSREDALVAASALKSAVALIRG
>Mature_358_residues
MLYLDNAATTSVRNEALEAMWPYLTGAFGNPSSPHEVGRLASAGLEDARTRVARIIGGRPTQVTFTSGGSEANNLAIKGA
CLANPRGRHLITTPIEHDSVLETAAYLERFHDFEITYLSPDHTGLISPEGLRKAVRPDTTLISIGYANNEVGTIQPIAEL
AAVSSTPFHTDAVQAAHLTFDLGVDALSLSGHKFGAPKGIGVLWSKLPLEPVIHGGGQEKGRRSGTENVAGAIAFATALE
LARAESYPDLGEFIEEVLTIPGAHLTGHPRMRIDGHASFLFDSIGSETVLLELERQGIVCSPGSACGSGEVSHVLLALGL
EEDQARTAVRCTFSTTHSREDALVAASALKSAVALIRG

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=352, Percent_Identity=38.3522727272727, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI156713448, Length=413, Percent_Identity=31.4769975786925, Blast_Score=159, Evalue=5e-39,
Organism=Escherichia coli, GI48994898, Length=380, Percent_Identity=34.4736842105263, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1789175, Length=396, Percent_Identity=26.010101010101, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787970, Length=304, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25143064, Length=353, Percent_Identity=36.8271954674221, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17533177, Length=304, Percent_Identity=31.9078947368421, Blast_Score=115, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6319831, Length=378, Percent_Identity=35.7142857142857, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI20129463, Length=352, Percent_Identity=37.5, Blast_Score=199, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 37788; Mature: 37788

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYLDNAATTSVRNEALEAMWPYLTGAFGNPSSPHEVGRLASAGLEDARTRVARIIGGRP
CEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCC
TQVTFTSGGSEANNLAIKGACLANPRGRHLITTPIEHDSVLETAAYLERFHDFEITYLSP
CEEEEECCCCCCCCEEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEECC
DHTGLISPEGLRKAVRPDTTLISIGYANNEVGTIQPIAELAAVSSTPFHTDAVQAAHLTF
CCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHHEEEEE
DLGVDALSLSGHKFGAPKGIGVLWSKLPLEPVIHGGGQEKGRRSGTENVAGAIAFATALE
ECCCCEEEECCCCCCCCCCCHHHHHHCCCCHHCCCCCCCHHCCCCCHHHHHHHHHHHHHH
LARAESYPDLGEFIEEVLTIPGAHLTGHPRMRIDGHASFLFDSIGSETVLLELERQGIVC
HHHHCCCCCHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHCCCCEEEEEEECCCEEE
SPGSACGSGEVSHVLLALGLEEDQARTAVRCTFSTTHSREDALVAASALKSAVALIRG
CCCCCCCCCCHHEEEEEECCCCHHCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLYLDNAATTSVRNEALEAMWPYLTGAFGNPSSPHEVGRLASAGLEDARTRVARIIGGRP
CEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCC
TQVTFTSGGSEANNLAIKGACLANPRGRHLITTPIEHDSVLETAAYLERFHDFEITYLSP
CEEEEECCCCCCCCEEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEECC
DHTGLISPEGLRKAVRPDTTLISIGYANNEVGTIQPIAELAAVSSTPFHTDAVQAAHLTF
CCCCCCCCHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHHEEEEE
DLGVDALSLSGHKFGAPKGIGVLWSKLPLEPVIHGGGQEKGRRSGTENVAGAIAFATALE
ECCCCEEEECCCCCCCCCCCHHHHHHCCCCHHCCCCCCCHHCCCCCHHHHHHHHHHHHHH
LARAESYPDLGEFIEEVLTIPGAHLTGHPRMRIDGHASFLFDSIGSETVLLELERQGIVC
HHHHCCCCCHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHCCCCEEEEEEECCCEEE
SPGSACGSGEVSHVLLALGLEEDQARTAVRCTFSTTHSREDALVAASALKSAVALIRG
CCCCCCCCCCHHEEEEEECCCCHHCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10930739 [H]