Click here to switch to the map view.

The map label for this gene is rmlB1 [H]

Identifier: 62389232

GI number: 62389232

Start: 350311

End: 351330

Strand: Reverse

Name: rmlB1 [H]

Synonym: cg0403

Alternate gene names: 62389232

Gene position: 351330-350311 (Counterclockwise)

Preceding gene: 62389233

Following gene: 62389231

Centisome position: 10.7

GC content: 54.22

Gene sequence:

>1020_bases
ATGACTTCTTTGCTTGTGACCGGAGGTGCCGGATTTATCGGCGCCAACTTCGTCCGCCAAACCGTAGAGCAGCACCCTGA
ATACACCCACATCACGGTGCTGGATAAACTCACCTACGCAGGAAACGCCGACAATCTCAAAGGCCTCCCCGACAGCAAAG
TAACCCTCATCGAAGGCGATATCTGCGATGCTGAATTAGTCGACTCCCTGGTCAAAGACCACGACATCACAGTCCACTTC
GCAGCAGAATCCCACAACGACAACTCCCTCAACGACCCCTCCCCGTTTGTTCACACTAACCTCATCGGCACCTTTGTCCT
GCTAGAAGCAGTCCGCAAGCACAACAAACGCTTCCACCACATCTCCACCGATGAAGTCTTCGGCGATCTAGAGCTGGATG
ATCCAAACCGCTTCACTGAAACCACCGCCTACAAGCCATCGTCTCCATATTCTGCAACCAAGGCAGGGTCTGATCACTTG
GTACACGCATGGATCCGCTCCTTCGGAATCCAGGCAACCATGTCTAACTGCTCCAACAATTACGGTCCCTACCAGCACAT
TGAAAAGTTCATCCCCCGCCAGATCACCAATATTCTGGCCGGCCTGACACCAAAACTTTATGGAACCGGCGAGCAGGTCC
GCGACTGGATCCACGTCGATGATCACAATGACGCCGTCCACCTGATCCTGAGTAAGGGCAAGATCGGCGAAACCTACATC
ATCGGCGCCGACAACGATCATGTGAATAACAAGCAGGTCATCGAGCTTATTTGTGAACTCATGGGCCTCGACAAAAACGC
ATACGAGCACGTCGCAGACCGCCCCGGCCACGATATGCGTTACGCCATGGATTCCACCAAGCTGCGCACCGAGCTCGGCT
GGGCACCTAAATACACCGACGTTGATTCCGGCATGCGCAAAGGCCTAGAGCAGACCATCGATTGGTACCGCGAAAACGAG
GCCTGGTGGCGCCCTGCCAAGAACAACGTCGAAGCTACCTACGCTAAGCAGGGACAATAA

Upstream 100 bases:

>100_bases
CCTAATGAACAGCCGGAGCACCCTGGTCGTTTGCAGAATAGGCGCATCGACAACAGCTACTAACTCTGCCAGCTCGCCCG
GACGAACTAAGGTAGACGGC

Downstream 100 bases:

>100_bases
TGGAATACGGTAAACAACTCACCTCCCACACCACCGACATCGAAGGCCTACTGGTTTTCGATTTCCCCGTCCACGGCGAC
AACCGCGGCTGGTTCAAGGA

Product: dTDP-glucose 4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MTSLLVTGGAGFIGANFVRQTVEQHPEYTHITVLDKLTYAGNADNLKGLPDSKVTLIEGDICDAELVDSLVKDHDITVHF
AAESHNDNSLNDPSPFVHTNLIGTFVLLEAVRKHNKRFHHISTDEVFGDLELDDPNRFTETTAYKPSSPYSATKAGSDHL
VHAWIRSFGIQATMSNCSNNYGPYQHIEKFIPRQITNILAGLTPKLYGTGEQVRDWIHVDDHNDAVHLILSKGKIGETYI
IGADNDHVNNKQVIELICELMGLDKNAYEHVADRPGHDMRYAMDSTKLRTELGWAPKYTDVDSGMRKGLEQTIDWYRENE
AWWRPAKNNVEATYAKQGQ

Sequences:

>Translated_339_residues
MTSLLVTGGAGFIGANFVRQTVEQHPEYTHITVLDKLTYAGNADNLKGLPDSKVTLIEGDICDAELVDSLVKDHDITVHF
AAESHNDNSLNDPSPFVHTNLIGTFVLLEAVRKHNKRFHHISTDEVFGDLELDDPNRFTETTAYKPSSPYSATKAGSDHL
VHAWIRSFGIQATMSNCSNNYGPYQHIEKFIPRQITNILAGLTPKLYGTGEQVRDWIHVDDHNDAVHLILSKGKIGETYI
IGADNDHVNNKQVIELICELMGLDKNAYEHVADRPGHDMRYAMDSTKLRTELGWAPKYTDVDSGMRKGLEQTIDWYRENE
AWWRPAKNNVEATYAKQGQ
>Mature_338_residues
TSLLVTGGAGFIGANFVRQTVEQHPEYTHITVLDKLTYAGNADNLKGLPDSKVTLIEGDICDAELVDSLVKDHDITVHFA
AESHNDNSLNDPSPFVHTNLIGTFVLLEAVRKHNKRFHHISTDEVFGDLELDDPNRFTETTAYKPSSPYSATKAGSDHLV
HAWIRSFGIQATMSNCSNNYGPYQHIEKFIPRQITNILAGLTPKLYGTGEQVRDWIHVDDHNDAVHLILSKGKIGETYII
GADNDHVNNKQVIELICELMGLDKNAYEHVADRPGHDMRYAMDSTKLRTELGWAPKYTDVDSGMRKGLEQTIDWYRENEA
WWRPAKNNVEATYAKQGQ

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=341, Percent_Identity=35.4838709677419, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI42516563, Length=320, Percent_Identity=23.125, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI48994969, Length=352, Percent_Identity=46.875, Blast_Score=313, Evalue=9e-87,
Organism=Escherichia coli, GI1788353, Length=361, Percent_Identity=45.4293628808864, Blast_Score=294, Evalue=5e-81,
Organism=Escherichia coli, GI1788366, Length=283, Percent_Identity=26.8551236749117, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786974, Length=323, Percent_Identity=26.9349845201238, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17568069, Length=328, Percent_Identity=31.4024390243902, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI115532424, Length=321, Percent_Identity=30.5295950155763, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17539532, Length=328, Percent_Identity=23.4756097560976, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319493, Length=330, Percent_Identity=25.1515151515152, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356223, Length=321, Percent_Identity=25.2336448598131, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19923002, Length=354, Percent_Identity=26.8361581920904, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24158427, Length=281, Percent_Identity=24.9110320284698, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 38101; Mature: 37970

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLLVTGGAGFIGANFVRQTVEQHPEYTHITVLDKLTYAGNADNLKGLPDSKVTLIEGD
CCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEEHHHCCCCCCCCCCCCCCCEEEEECC
ICDAELVDSLVKDHDITVHFAAESHNDNSLNDPSPFVHTNLIGTFVLLEAVRKHNKRFHH
CCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
ISTDEVFGDLELDDPNRFTETTAYKPSSPYSATKAGSDHLVHAWIRSFGIQATMSNCSNN
CCHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCC
YGPYQHIEKFIPRQITNILAGLTPKLYGTGEQVRDWIHVDDHNDAVHLILSKGKIGETYI
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEEEECCCCCEEEEEEECCCCCCEEE
IGADNDHVNNKQVIELICELMGLDKNAYEHVADRPGHDMRYAMDSTKLRTELGWAPKYTD
EECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
VDSGMRKGLEQTIDWYRENEAWWRPAKNNVEATYAKQGQ
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCC
>Mature Secondary Structure 
TSLLVTGGAGFIGANFVRQTVEQHPEYTHITVLDKLTYAGNADNLKGLPDSKVTLIEGD
CEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEEHHHCCCCCCCCCCCCCCCEEEEECC
ICDAELVDSLVKDHDITVHFAAESHNDNSLNDPSPFVHTNLIGTFVLLEAVRKHNKRFHH
CCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
ISTDEVFGDLELDDPNRFTETTAYKPSSPYSATKAGSDHLVHAWIRSFGIQATMSNCSNN
CCHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCC
YGPYQHIEKFIPRQITNILAGLTPKLYGTGEQVRDWIHVDDHNDAVHLILSKGKIGETYI
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEEEECCCCCEEEEEEECCCCCCEEE
IGADNDHVNNKQVIELICELMGLDKNAYEHVADRPGHDMRYAMDSTKLRTELGWAPKYTD
EECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
VDSGMRKGLEQTIDWYRENEAWWRPAKNNVEATYAKQGQ
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186; 11796113 [H]