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The map label for this gene is rmlCD [H]

Identifier: 62389231

GI number: 62389231

Start: 348950

End: 350311

Strand: Reverse

Name: rmlCD [H]

Synonym: cg0402

Alternate gene names: 62389231

Gene position: 350311-348950 (Counterclockwise)

Preceding gene: 62389232

Following gene: 62389230

Centisome position: 10.67

GC content: 59.1

Gene sequence:

>1362_bases
ATGGAATACGGTAAACAACTCACCTCCCACACCACCGACATCGAAGGCCTACTGGTTTTCGATTTCCCCGTCCACGGCGA
CAACCGCGGCTGGTTCAAGGAAAATTGGCAGCGCACCAAGATGACCAACCTGGGGCTGCCCGATTTTGGCCCCGTCCAAA
ACAACATGAGTTTCAACGCCACCGCCGGCACGACTCGCGGCATGCACGCTGAGCCGTGGGATAAATTTGTGTCCGTCGCG
GTGGGTTCCGTTTTCGGAGCTTGGGTGGATCTGCGCGCGGGCTCGAGCACGTACGGTAACGTCGTAACGCAAAAAATTAC
CCCTGACGTGGGAGTTTACGTCCCGCGTGGTGTGGCAAACGGCTTCCAGGCGCTCGAGGACGGCACGCTGTACACCTACC
TCGTCAACGATCATTGGTCCCCCGACGCGCATTACGCCAACGTCAACCTCAACATGATCGACTGGCCGCTGCCCATCACC
GAGATCTCCGAAAAAGATAAAAAACATCCAGCGCTTATCGACGCCACCCCCCTGCCCGCCCGCAAGGTTCTCGTGGTCGG
CGCCGGCGGACAACTGGGAACCGCGCTACGCGCGCAGTTCCCAGACGCGGAATTTGTCACGCGCCAAGAACTCGATATCA
CCTCAGATCTCACCGAGGCTCGCGCGTGGAAACAATACTCCACCATCATAAACGCCGCCGCCTACACTGCCGTTGACCAG
GCAGAACACGACCGCGCAGCAGCGTGGGACATCAACGCAGCGGCAGTGGCTAACCTCGCGACCATCGCGCGCGACAACAA
CCTCACCCTCGTGCACGTGTCCTCAGATTATGTCTTCGACGGTGCGGCCGAATCCTACGATGAAAACGCACCGTTTTCCC
CACTCGGCGTGTACGGCCAATCCAAAGCAGCCGGCGACATCGCAGCCACCACCGCACCGCGCCACTACATTGTGCGCACC
AGCTGGGTGATTGGCGATGGCAATAATTTTGTCCGCACCATGAAATCCCTCGACGAACGCGGCATCGCACCATCAGTAGT
TGATGATCAAATCGGCCGCCTATCCTTCACCGAAGACATCGCAGCCGGCATCGCGCACCTTTTGGAAGTGGGTGCAGCAT
ATGGCACCTACAACCTCACCAACACCGGCGAACCCGCAAGCTGGGCCGATGTTGCCCGCGCAGTATTTTCCGACCCCACC
AAAGTTACCGGCGTGAGCACCGCCGAGTACTTCGCCAACAAAGACGCAGCGCCCCGCCCACTGAACTCCGTTTTGGATCT
CGGCAAAATCGAAGCCACCGGATTTAGCGCACCGACCTGGCAGACCCGCCTCAACGACTACCTCAAGGAACTCTCAAAGT
GA

Upstream 100 bases:

>100_bases
AAGGCCTAGAGCAGACCATCGATTGGTACCGCGAAAACGAGGCCTGGTGGCGCCCTGCCAAGAACAACGTCGAAGCTACC
TACGCTAAGCAGGGACAATA

Downstream 100 bases:

>100_bases
AAGGCATCATCCTCGCAGGTGGCTCCGGCACCCGGCTCTACCCCATCACCAAGGGCATCTCCAAGCAACTGATGCCGATT
TACGACAAACCCATGGTCTA

Product: dTDP-4-dehydrorhamnose 3,5-epimerase, dTDP-dehydrorhamnose reductase

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MEYGKQLTSHTTDIEGLLVFDFPVHGDNRGWFKENWQRTKMTNLGLPDFGPVQNNMSFNATAGTTRGMHAEPWDKFVSVA
VGSVFGAWVDLRAGSSTYGNVVTQKITPDVGVYVPRGVANGFQALEDGTLYTYLVNDHWSPDAHYANVNLNMIDWPLPIT
EISEKDKKHPALIDATPLPARKVLVVGAGGQLGTALRAQFPDAEFVTRQELDITSDLTEARAWKQYSTIINAAAYTAVDQ
AEHDRAAAWDINAAAVANLATIARDNNLTLVHVSSDYVFDGAAESYDENAPFSPLGVYGQSKAAGDIAATTAPRHYIVRT
SWVIGDGNNFVRTMKSLDERGIAPSVVDDQIGRLSFTEDIAAGIAHLLEVGAAYGTYNLTNTGEPASWADVARAVFSDPT
KVTGVSTAEYFANKDAAPRPLNSVLDLGKIEATGFSAPTWQTRLNDYLKELSK

Sequences:

>Translated_453_residues
MEYGKQLTSHTTDIEGLLVFDFPVHGDNRGWFKENWQRTKMTNLGLPDFGPVQNNMSFNATAGTTRGMHAEPWDKFVSVA
VGSVFGAWVDLRAGSSTYGNVVTQKITPDVGVYVPRGVANGFQALEDGTLYTYLVNDHWSPDAHYANVNLNMIDWPLPIT
EISEKDKKHPALIDATPLPARKVLVVGAGGQLGTALRAQFPDAEFVTRQELDITSDLTEARAWKQYSTIINAAAYTAVDQ
AEHDRAAAWDINAAAVANLATIARDNNLTLVHVSSDYVFDGAAESYDENAPFSPLGVYGQSKAAGDIAATTAPRHYIVRT
SWVIGDGNNFVRTMKSLDERGIAPSVVDDQIGRLSFTEDIAAGIAHLLEVGAAYGTYNLTNTGEPASWADVARAVFSDPT
KVTGVSTAEYFANKDAAPRPLNSVLDLGKIEATGFSAPTWQTRLNDYLKELSK
>Mature_453_residues
MEYGKQLTSHTTDIEGLLVFDFPVHGDNRGWFKENWQRTKMTNLGLPDFGPVQNNMSFNATAGTTRGMHAEPWDKFVSVA
VGSVFGAWVDLRAGSSTYGNVVTQKITPDVGVYVPRGVANGFQALEDGTLYTYLVNDHWSPDAHYANVNLNMIDWPLPIT
EISEKDKKHPALIDATPLPARKVLVVGAGGQLGTALRAQFPDAEFVTRQELDITSDLTEARAWKQYSTIINAAAYTAVDQ
AEHDRAAAWDINAAAVANLATIARDNNLTLVHVSSDYVFDGAAESYDENAPFSPLGVYGQSKAAGDIAATTAPRHYIVRT
SWVIGDGNNFVRTMKSLDERGIAPSVVDDQIGRLSFTEDIAAGIAHLLEVGAAYGTYNLTNTGEPASWADVARAVFSDPT
KVTGVSTAEYFANKDAAPRPLNSVLDLGKIEATGFSAPTWQTRLNDYLKELSK

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788352, Length=292, Percent_Identity=32.1917808219178, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1788350, Length=155, Percent_Identity=30.9677419354839, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 49153; Mature: 49153

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYGKQLTSHTTDIEGLLVFDFPVHGDNRGWFKENWQRTKMTNLGLPDFGPVQNNMSFNA
CCCHHHHHCCCCCCCEEEEEEEEEECCCCCCHHHCCCHHHHCCCCCCCCCCCCCCCEEEC
TAGTTRGMHAEPWDKFVSVAVGSVFGAWVDLRAGSSTYGNVVTQKITPDVGVYVPRGVAN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEEECCCCCCEEECCCHHH
GFQALEDGTLYTYLVNDHWSPDAHYANVNLNMIDWPLPITEISEKDKKHPALIDATPLPA
HHHHHCCCEEEEEEECCCCCCCCEEEEEEEEEEECCCCHHHHHHCCCCCCCEEECCCCCC
RKVLVVGAGGQLGTALRAQFPDAEFVTRQELDITSDLTEARAWKQYSTIINAAAYTAVDQ
CEEEEEECCCCCCHHHHHCCCCHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEHDRAAAWDINAAAVANLATIARDNNLTLVHVSSDYVFDGAAESYDENAPFSPLGVYGQ
HCCCCCEEECCCHHHHHHHHHHEECCCEEEEEECCCEEECCCHHCCCCCCCCCCCCCCCC
SKAAGDIAATTAPRHYIVRTSWVIGDGNNFVRTMKSLDERGIAPSVVDDQIGRLSFTEDI
CCCCCCEEECCCCCEEEEEEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHCCCEEHHHHH
AAGIAHLLEVGAAYGTYNLTNTGEPASWADVARAVFSDPTKVTGVSTAEYFANKDAAPRP
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCC
LNSVLDLGKIEATGFSAPTWQTRLNDYLKELSK
HHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MEYGKQLTSHTTDIEGLLVFDFPVHGDNRGWFKENWQRTKMTNLGLPDFGPVQNNMSFNA
CCCHHHHHCCCCCCCEEEEEEEEEECCCCCCHHHCCCHHHHCCCCCCCCCCCCCCCEEEC
TAGTTRGMHAEPWDKFVSVAVGSVFGAWVDLRAGSSTYGNVVTQKITPDVGVYVPRGVAN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEEECCCCCCEEECCCHHH
GFQALEDGTLYTYLVNDHWSPDAHYANVNLNMIDWPLPITEISEKDKKHPALIDATPLPA
HHHHHCCCEEEEEEECCCCCCCCEEEEEEEEEEECCCCHHHHHHCCCCCCCEEECCCCCC
RKVLVVGAGGQLGTALRAQFPDAEFVTRQELDITSDLTEARAWKQYSTIINAAAYTAVDQ
CEEEEEECCCCCCHHHHHCCCCHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEHDRAAAWDINAAAVANLATIARDNNLTLVHVSSDYVFDGAAESYDENAPFSPLGVYGQ
HCCCCCEEECCCHHHHHHHHHHEECCCEEEEEECCCEEECCCHHCCCCCCCCCCCCCCCC
SKAAGDIAATTAPRHYIVRTSWVIGDGNNFVRTMKSLDERGIAPSVVDDQIGRLSFTEDI
CCCCCCEEECCCCCEEEEEEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHCCCEEHHHHH
AAGIAHLLEVGAAYGTYNLTNTGEPASWADVARAVFSDPTKVTGVSTAEYFANKDAAPRP
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCC
LNSVLDLGKIEATGFSAPTWQTRLNDYLKELSK
HHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA