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The map label for this gene is adhC [H]

Identifier: 62389229

GI number: 62389229

Start: 346959

End: 348020

Strand: Reverse

Name: adhC [H]

Synonym: cg0400

Alternate gene names: 62389229

Gene position: 348020-346959 (Counterclockwise)

Preceding gene: 62389230

Following gene: 62389228

Centisome position: 10.6

GC content: 56.31

Gene sequence:

>1062_bases
GTGAGTATCTCAGTAAAAGCACTACAAAAGTCCGGCCCAGAAGCACCTTTCGAGGTCAAGATCATTGAACGCCGTGACCC
ACGCGCAGATGATGTGGTTATTGATATCAAAGCTGCGGGCATCTGCCACAGCGATATCCACACCATCCGCAACGAATGGG
GCGAGGCGCACTTCCCGCTCACCGTCGGCCACGAAATCGCAGGCGTTGTCTCTGCGGTTGGATCCGATGTAACCAAATGG
AAAGTCGGCGACCGCGTGGGCGTCGGCTGCCTCGTTAACTCCTGCGGCGAATGCGAACAGTGCGTCGCAGGATTTGAAAA
CAACTGCCTTCGCGGAAACGTCGGAACCTACAACTCTAACGACGTCGACGGCACCATCACCCAAGGCGGCTACGCTGAAA
AGGTAGTGGTCAACGAACGTTTCCTGTGCAGCATCCCAGAGGAACTTAACTTCGATGTCGCAGCACCACTGCTGTGCGCA
GGCATCACCACCTACTCCCCAATCGCTCGCTGGAACGTTAAAGAAGGCGACAAAGTAGCAGTCATGGGCCTCGGCGGACT
CGGACACATGGGTGTCCAGATCGCTGCAGCCAAGGGTGCTGAGGTTACCGTTCTGTCCCGTTCCCTGCGCAAGGCAGAAC
TTGCCAAGGAACTCGGCGCAGCTCGCACGCTTGCGACTTCTGATGAGGATTTCTTCACCGAACACGCCGGTGAATTCGAC
TTCATCCTCAACACCATTAGCGCATCCATCCCAGTCGACAAGTACCTGAGCCTTCTCAAGCCACACGGTGTCATGGCTGT
TGTCGGTCTGCCACCAGAGAAGCAGCCACTGAGCTTCGGTGCGCTCATCGGCGGCGGAAAAGTCCTCACCGGATCCAACA
TTGGCGGCATCCCTGAAACCCAGGAAATGCTCGACTTCTGTGCAAAACACGGCCTCGGTGCGATGATCGAAACTGTCGGC
GTCAACGATGTTGATGCAGCCTACGACCGTGTTGTTGCCGGCGACGTTCAGTTCCGCGTTGTCATTGATACTGCTTCGTT
TGCTGAGGTTGAGGCGGTTTAG

Upstream 100 bases:

>100_bases
AAACTACCTGCTGAGAGCTTTGTAATTTACGGTGTGGTTGTGGAGGGGTGCGTCGAGAAGCGCTCGTAGGCGCTTTTGAT
TTTTCGGTAGGCTAACTGGG

Downstream 100 bases:

>100_bases
GTTTACTGAAGTTCAGACTTTATCCCTGGCTTTGGAGAGTTACTTTTAAGCGGTGTCGGTTCCTCCGGCACCGCTTTTGG
GTTTCAATTATTCAATACAA

Product: alcohol dehydrogenase, class C

Products: aldehyde; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MSISVKALQKSGPEAPFEVKIIERRDPRADDVVIDIKAAGICHSDIHTIRNEWGEAHFPLTVGHEIAGVVSAVGSDVTKW
KVGDRVGVGCLVNSCGECEQCVAGFENNCLRGNVGTYNSNDVDGTITQGGYAEKVVVNERFLCSIPEELNFDVAAPLLCA
GITTYSPIARWNVKEGDKVAVMGLGGLGHMGVQIAAAKGAEVTVLSRSLRKAELAKELGAARTLATSDEDFFTEHAGEFD
FILNTISASIPVDKYLSLLKPHGVMAVVGLPPEKQPLSFGALIGGGKVLTGSNIGGIPETQEMLDFCAKHGLGAMIETVG
VNDVDAAYDRVVAGDVQFRVVIDTASFAEVEAV

Sequences:

>Translated_353_residues
MSISVKALQKSGPEAPFEVKIIERRDPRADDVVIDIKAAGICHSDIHTIRNEWGEAHFPLTVGHEIAGVVSAVGSDVTKW
KVGDRVGVGCLVNSCGECEQCVAGFENNCLRGNVGTYNSNDVDGTITQGGYAEKVVVNERFLCSIPEELNFDVAAPLLCA
GITTYSPIARWNVKEGDKVAVMGLGGLGHMGVQIAAAKGAEVTVLSRSLRKAELAKELGAARTLATSDEDFFTEHAGEFD
FILNTISASIPVDKYLSLLKPHGVMAVVGLPPEKQPLSFGALIGGGKVLTGSNIGGIPETQEMLDFCAKHGLGAMIETVG
VNDVDAAYDRVVAGDVQFRVVIDTASFAEVEAV
>Mature_352_residues
SISVKALQKSGPEAPFEVKIIERRDPRADDVVIDIKAAGICHSDIHTIRNEWGEAHFPLTVGHEIAGVVSAVGSDVTKWK
VGDRVGVGCLVNSCGECEQCVAGFENNCLRGNVGTYNSNDVDGTITQGGYAEKVVVNERFLCSIPEELNFDVAAPLLCAG
ITTYSPIARWNVKEGDKVAVMGLGGLGHMGVQIAAAKGAEVTVLSRSLRKAELAKELGAARTLATSDEDFFTEHAGEFDF
ILNTISASIPVDKYLSLLKPHGVMAVVGLPPEKQPLSFGALIGGGKVLTGSNIGGIPETQEMLDFCAKHGLGAMIETVGV
NDVDAAYDRVVAGDVQFRVVIDTASFAEVEAV

Specific function: Functions in the protection against aldehyde-stress [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=361, Percent_Identity=30.1939058171745, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI34577061, Length=337, Percent_Identity=29.673590504451, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4501929, Length=353, Percent_Identity=28.328611898017, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI4501939, Length=332, Percent_Identity=28.3132530120482, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI156523966, Length=332, Percent_Identity=28.3132530120482, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI71743840, Length=313, Percent_Identity=27.4760383386581, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI262073058, Length=313, Percent_Identity=27.4760383386581, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI71565154, Length=230, Percent_Identity=30.4347826086957, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI71565152, Length=234, Percent_Identity=28.6324786324786, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1786518, Length=352, Percent_Identity=46.3068181818182, Blast_Score=285, Evalue=2e-78,
Organism=Escherichia coli, GI87082401, Length=336, Percent_Identity=33.9285714285714, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI87081918, Length=323, Percent_Identity=27.8637770897833, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1788073, Length=283, Percent_Identity=29.3286219081272, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788407, Length=248, Percent_Identity=29.8387096774194, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1787863, Length=272, Percent_Identity=31.25, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790045, Length=346, Percent_Identity=25.7225433526012, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082125, Length=219, Percent_Identity=30.5936073059361, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788075, Length=298, Percent_Identity=30.2013422818792, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786552, Length=233, Percent_Identity=32.618025751073, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786825, Length=217, Percent_Identity=29.4930875576037, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=340, Percent_Identity=30.5882352941176, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17562584, Length=336, Percent_Identity=30.3571428571429, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17562582, Length=341, Percent_Identity=28.1524926686217, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI25146526, Length=366, Percent_Identity=26.5027322404372, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=368, Percent_Identity=26.3586956521739, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=260, Percent_Identity=28.0769230769231, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17562878, Length=207, Percent_Identity=30.4347826086957, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=333, Percent_Identity=26.7267267267267, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323980, Length=328, Percent_Identity=37.5, Blast_Score=181, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6319949, Length=326, Percent_Identity=34.9693251533742, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6323729, Length=338, Percent_Identity=30.4733727810651, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6319621, Length=351, Percent_Identity=30.1994301994302, Blast_Score=149, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6324486, Length=338, Percent_Identity=30.1775147928994, Blast_Score=149, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6323961, Length=338, Percent_Identity=30.1775147928994, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6319258, Length=227, Percent_Identity=34.8017621145374, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=330, Percent_Identity=26.969696969697, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=286, Percent_Identity=28.6713286713287, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=280, Percent_Identity=28.9285714285714, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319257, Length=214, Percent_Identity=30.8411214953271, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6323099, Length=227, Percent_Identity=28.1938325991189, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737895, Length=321, Percent_Identity=27.7258566978193, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17137530, Length=209, Percent_Identity=29.6650717703349, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17737897, Length=199, Percent_Identity=31.1557788944724, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.2

Molecular weight: Translated: 37285; Mature: 37154

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISVKALQKSGPEAPFEVKIIERRDPRADDVVIDIKAAGICHSDIHTIRNEWGEAHFPL
CCCCHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCE
TVGHEIAGVVSAVGSDVTKWKVGDRVGVGCLVNSCGECEQCVAGFENNCLRGNVGTYNSN
EECHHHHHHHHHHCCCCEEEECCCCCCHHHHHHCCCCHHHHHHCCCCCCEECCCCCCCCC
DVDGTITQGGYAEKVVVNERFLCSIPEELNFDVAAPLLCAGITTYSPIARWNVKEGDKVA
CCCCEEECCCCEEEEEECCCEEECCCHHCCCCHHHHHHHHCCCCCCCHHCCCCCCCCEEE
VMGLGGLGHMGVQIAAAKGAEVTVLSRSLRKAELAKELGAARTLATSDEDFFTEHAGEFD
EEECCCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHCCCCHH
FILNTISASIPVDKYLSLLKPHGVMAVVGLPPEKQPLSFGALIGGGKVLTGSNIGGIPET
HHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEECCCEEEECCCCCCCCCH
QEMLDFCAKHGLGAMIETVGVNDVDAAYDRVVAGDVQFRVVIDTASFAEVEAV
HHHHHHHHHCCCCCEEHCCCCCCHHHHHHHEEECCEEEEEEEECCCCCEEECC
>Mature Secondary Structure 
SISVKALQKSGPEAPFEVKIIERRDPRADDVVIDIKAAGICHSDIHTIRNEWGEAHFPL
CCCHHHHHHCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCE
TVGHEIAGVVSAVGSDVTKWKVGDRVGVGCLVNSCGECEQCVAGFENNCLRGNVGTYNSN
EECHHHHHHHHHHCCCCEEEECCCCCCHHHHHHCCCCHHHHHHCCCCCCEECCCCCCCCC
DVDGTITQGGYAEKVVVNERFLCSIPEELNFDVAAPLLCAGITTYSPIARWNVKEGDKVA
CCCCEEECCCCEEEEEECCCEEECCCHHCCCCHHHHHHHHCCCCCCCHHCCCCCCCCEEE
VMGLGGLGHMGVQIAAAKGAEVTVLSRSLRKAELAKELGAARTLATSDEDFFTEHAGEFD
EEECCCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHCCCCHH
FILNTISASIPVDKYLSLLKPHGVMAVVGLPPEKQPLSFGALIGGGKVLTGSNIGGIPET
HHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEECCCEEEECCCCCCCCCH
QEMLDFCAKHGLGAMIETVGVNDVDAAYDRVVAGDVQFRVVIDTASFAEVEAV
HHHHHHHHHCCCCCEEHCCCCCCHHHHHHHEEECCEEEEEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NADP+

Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]