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The map label for this gene is rmlA1 [H]

Identifier: 62389230

GI number: 62389230

Start: 348096

End: 348953

Strand: Reverse

Name: rmlA1 [H]

Synonym: cg0401

Alternate gene names: 62389230

Gene position: 348953-348096 (Counterclockwise)

Preceding gene: 62389231

Following gene: 62389229

Centisome position: 10.63

GC content: 54.55

Gene sequence:

>858_bases
GTGAAAGGCATCATCCTCGCAGGTGGCTCCGGCACCCGGCTCTACCCCATCACCAAGGGCATCTCCAAGCAACTGATGCC
GATTTACGACAAACCCATGGTCTACTACCCACTGACCACGCTCATTCAGGCCGGCATCAAAGACATCCTGATTATCACCA
CCCCTGAAGACAGCGCCTCCTTTGAACGCTTGCTTGGCGACGGCTCCTCCTGGGGCATCAACCTCACCTACGCCGTCCAA
CCCTCCCCCGACGGACTAGCCCAAGCATTCATCATCGGCGAGGAATTCATCGGTGACGACGACGTCGCGTTGGTGCTTGG
CGATAACATCTTCGACGGCGCACAACTTGGCCACGCACTAAAGCAGTGCTCCAACCCCGACGGTGGCATTGTCTTTGCTT
ATGAGGTCTCCGATCCTGAGCGTTATGGCGTGGTGGAATTTGATGCTGCTAATAAGGCGGTGTCTATTGAAGAAAAGCCC
ACCGCGCCAAAATCCAACTTTGCCGTGGTAGGACTATATTTCTACGACAATCGCGTGGTGGACATCGCCAAGTCAATCAA
GCCTTCCTCGCGTGGCGAACTGGAAATCACCTCCGTTAACGATGCCTACCTCCAGCAAGGTGCTTTAACTGTGCAGCGCC
TGGACCGTGGCGATGTCTGGTTAGATACCGGCACAATCGATTCCATGTCCGAGGCGTCTTCCTATGTTGAGGTCCTGCAA
AAACGTACCGGCAACATCATCGGATCCCCCGAAGTCGCTGCGTACCGCGAAGGTTTCATCACAGCTGAAGAACTCACAGT
GCTTGGTGAGGAACTGAAGAAATCAGGCTACGGAAACTACCTGCTGAGAGCTTTGTAA

Upstream 100 bases:

>100_bases
CACTGAACTCCGTTTTGGATCTCGGCAAAATCGAAGCCACCGGATTTAGCGCACCGACCTGGCAGACCCGCCTCAACGAC
TACCTCAAGGAACTCTCAAA

Downstream 100 bases:

>100_bases
TTTACGGTGTGGTTGTGGAGGGGTGCGTCGAGAAGCGCTCGTAGGCGCTTTTGATTTTTCGGTAGGCTAACTGGGGTGAG
TATCTCAGTAAAAGCACTAC

Product: TDP-glucose pyrophosphorylase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MKGIILAGGSGTRLYPITKGISKQLMPIYDKPMVYYPLTTLIQAGIKDILIITTPEDSASFERLLGDGSSWGINLTYAVQ
PSPDGLAQAFIIGEEFIGDDDVALVLGDNIFDGAQLGHALKQCSNPDGGIVFAYEVSDPERYGVVEFDAANKAVSIEEKP
TAPKSNFAVVGLYFYDNRVVDIAKSIKPSSRGELEITSVNDAYLQQGALTVQRLDRGDVWLDTGTIDSMSEASSYVEVLQ
KRTGNIIGSPEVAAYREGFITAEELTVLGEELKKSGYGNYLLRAL

Sequences:

>Translated_285_residues
MKGIILAGGSGTRLYPITKGISKQLMPIYDKPMVYYPLTTLIQAGIKDILIITTPEDSASFERLLGDGSSWGINLTYAVQ
PSPDGLAQAFIIGEEFIGDDDVALVLGDNIFDGAQLGHALKQCSNPDGGIVFAYEVSDPERYGVVEFDAANKAVSIEEKP
TAPKSNFAVVGLYFYDNRVVDIAKSIKPSSRGELEITSVNDAYLQQGALTVQRLDRGDVWLDTGTIDSMSEASSYVEVLQ
KRTGNIIGSPEVAAYREGFITAEELTVLGEELKKSGYGNYLLRAL
>Mature_285_residues
MKGIILAGGSGTRLYPITKGISKQLMPIYDKPMVYYPLTTLIQAGIKDILIITTPEDSASFERLLGDGSSWGINLTYAVQ
PSPDGLAQAFIIGEEFIGDDDVALVLGDNIFDGAQLGHALKQCSNPDGGIVFAYEVSDPERYGVVEFDAANKAVSIEEKP
TAPKSNFAVVGLYFYDNRVVDIAKSIKPSSRGELEITSVNDAYLQQGALTVQRLDRGDVWLDTGTIDSMSEASSYVEVLQ
KRTGNIIGSPEVAAYREGFITAEELTVLGEELKKSGYGNYLLRAL

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=283, Percent_Identity=62.1908127208481, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1790224, Length=286, Percent_Identity=60.4895104895105, Blast_Score=350, Evalue=6e-98,
Organism=Escherichia coli, GI1787488, Length=242, Percent_Identity=26.0330578512397, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788355, Length=236, Percent_Identity=25.4237288135593, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=192, Percent_Identity=25.5208333333333, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=263, Percent_Identity=29.277566539924, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355443, Length=248, Percent_Identity=22.9838709677419, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24644084, Length=248, Percent_Identity=22.9838709677419, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 30835; Mature: 30835

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPITKGISKQLMPIYDKPMVYYPLTTLIQAGIKDILIITTPEDSAS
CCCEEEECCCCCEEEEECCCCHHCCCCCCCCCEEEECHHHHHHCCCCEEEEEECCCCCHH
FERLLGDGSSWGINLTYAVQPSPDGLAQAFIIGEEFIGDDDVALVLGDNIFDGAQLGHAL
HHHHHCCCCCCCEEEEEEECCCCCCCEEEEEEHHHHCCCCCEEEEECCCCCCHHHHHHHH
KQCSNPDGGIVFAYEVSDPERYGVVEFDAANKAVSIEEKPTAPKSNFAVVGLYFYDNRVV
HHCCCCCCCEEEEEECCCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEECCCCE
DIAKSIKPSSRGELEITSVNDAYLQQGALTVQRLDRGDVWLDTGTIDSMSEASSYVEVLQ
EHHHHCCCCCCCCEEEEECCHHHHHCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHH
KRTGNIIGSPEVAAYREGFITAEELTVLGEELKKSGYGNYLLRAL
HHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure
MKGIILAGGSGTRLYPITKGISKQLMPIYDKPMVYYPLTTLIQAGIKDILIITTPEDSAS
CCCEEEECCCCCEEEEECCCCHHCCCCCCCCCEEEECHHHHHHCCCCEEEEEECCCCCHH
FERLLGDGSSWGINLTYAVQPSPDGLAQAFIIGEEFIGDDDVALVLGDNIFDGAQLGHAL
HHHHHCCCCCCCEEEEEEECCCCCCCEEEEEEHHHHCCCCCEEEEECCCCCCHHHHHHHH
KQCSNPDGGIVFAYEVSDPERYGVVEFDAANKAVSIEEKPTAPKSNFAVVGLYFYDNRVV
HHCCCCCCCEEEEEECCCCCCCCEEEECCCCCEEEECCCCCCCCCCEEEEEEEEECCCCE
DIAKSIKPSSRGELEITSVNDAYLQQGALTVQRLDRGDVWLDTGTIDSMSEASSYVEVLQ
EHHHHCCCCCCCCEEEEECCHHHHHCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHH
KRTGNIIGSPEVAAYREGFITAEELTVLGEELKKSGYGNYLLRAL
HHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]