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The map label for this gene is moaE [H]

Identifier: 62389107

GI number: 62389107

Start: 226310

End: 226768

Strand: Reverse

Name: moaE [H]

Synonym: cg0258

Alternate gene names: 62389107

Gene position: 226768-226310 (Counterclockwise)

Preceding gene: 62389108

Following gene: 62389106

Centisome position: 6.91

GC content: 67.54

Gene sequence:

>459_bases
ATGAACACTGACCCCGCTTACGTCGCCGAACAAACCGGCAAACTCATCGACGCTTTCCTCACCACCGACCCCCTCGAACC
GCTGCTCGACGCCGCCAAAAACGGCGTCTGCACAGAGGCGATGGGCGCGCTGGTCACCTTCGAAGGCATCGTCCGCGACC
ACGACGGCGGCGCCCGCGTGACCTCCCTGACCTACACCGCGCATCCCACCGCGCCGCAGGTCCTTTCTGCTGTCGCGGAC
TCCATCGTTGAAAAACACCCGCGCACCCGCCTCTGGACCGCGCACCGCACCGGCGCCTTGAAAATCGGTGACGCCGCCTT
CCTCGTCGTCGCCGCCTCCGCCCACCGCGCCGACGCCTTCGCCGCCTGCTCCGACCTCGCCGACGCCGTCAAAGCCCAGG
TCCCGATCTGGAAAGAGCAAACGCGCCTCGACGGCTCCACCGATTGGGTCGGCCTGTGA

Upstream 100 bases:

>100_bases
TTCATCATGGCGCTGCCCGGCTCCACGGGTGCGGCGCGCGATGCCACCGCTGTCCTCGACCCACTCATTGATCACATCAC
TGGAACTCTGCAAGGCCACC

Downstream 100 bases:

>100_bases
AAAACCTCGACATCGCCCGCTACCGCCGCCAAATTATGCTCGGCGAAATCGGCCAGCAAAAACAACAATCGCTTTTCGAC
GCTAAGGTCTCCGTCATCGG

Product: molybdopterin synthase, large subunit

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E 2; Molybdopterin-converting factor large subunit 2; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MNTDPAYVAEQTGKLIDAFLTTDPLEPLLDAAKNGVCTEAMGALVTFEGIVRDHDGGARVTSLTYTAHPTAPQVLSAVAD
SIVEKHPRTRLWTAHRTGALKIGDAAFLVVAASAHRADAFAACSDLADAVKAQVPIWKEQTRLDGSTDWVGL

Sequences:

>Translated_152_residues
MNTDPAYVAEQTGKLIDAFLTTDPLEPLLDAAKNGVCTEAMGALVTFEGIVRDHDGGARVTSLTYTAHPTAPQVLSAVAD
SIVEKHPRTRLWTAHRTGALKIGDAAFLVVAASAHRADAFAACSDLADAVKAQVPIWKEQTRLDGSTDWVGL
>Mature_152_residues
MNTDPAYVAEQTGKLIDAFLTTDPLEPLLDAAKNGVCTEAMGALVTFEGIVRDHDGGARVTSLTYTAHPTAPQVLSAVAD
SIVEKHPRTRLWTAHRTGALKIGDAAFLVVAASAHRADAFAACSDLADAVKAQVPIWKEQTRLDGSTDWVGL

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=145, Percent_Identity=31.7241379310345, Blast_Score=73, Evalue=8e-14,
Organism=Escherichia coli, GI1787003, Length=110, Percent_Identity=36.3636363636364, Blast_Score=68, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 16096; Mature: 16096

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTDPAYVAEQTGKLIDAFLTTDPLEPLLDAAKNGVCTEAMGALVTFEGIVRDHDGGARV
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHEEECCCCCEE
TSLTYTAHPTAPQVLSAVADSIVEKHPRTRLWTAHRTGALKIGDAAFLVVAASAHRADAF
EEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCEEEEEECCCCCHHHH
AACSDLADAVKAQVPIWKEQTRLDGSTDWVGL
HHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNTDPAYVAEQTGKLIDAFLTTDPLEPLLDAAKNGVCTEAMGALVTFEGIVRDHDGGARV
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHEEECCCCCEE
TSLTYTAHPTAPQVLSAVADSIVEKHPRTRLWTAHRTGALKIGDAAFLVVAASAHRADAF
EEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCEEEEEECCCCCHHHH
AACSDLADAVKAQVPIWKEQTRLDGSTDWVGL
HHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]