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The map label for this gene is moeZ [H]

Identifier: 62389106

GI number: 62389106

Start: 225240

End: 226313

Strand: Reverse

Name: moeZ [H]

Synonym: cg0257

Alternate gene names: 62389106

Gene position: 226313-225240 (Counterclockwise)

Preceding gene: 62389107

Following gene: 62389104

Centisome position: 6.89

GC content: 60.24

Gene sequence:

>1074_bases
GTGAAAAACCTCGACATCGCCCGCTACCGCCGCCAAATTATGCTCGGCGAAATCGGCCAGCAAAAACAACAATCGCTTTT
CGACGCTAAGGTCTCCGTCATCGGCGCAGGCGGCCTCGGGTCACCCGCCCTGCTCTACCTTGCTGGCGCTGGCGTCGGCC
ACATCCACATCATTGACGATGACCTCGTCGACCTCTCCAACCTCCACCGCCAGGTCATTCACACCACCGCTGGCGTTGGA
ACACCCAAGGCCGAGTCCGCGCGCGAAGCAATGCTGGCACTGAACCCTTCCGTTAAAGTGACGGTTTCTGTCAGGCGACT
GGACTGGTCAAATGCACTTTCTGAGCTGGCAGATTCCGATGTGATTTTGGATGGCTCCGATAACTTCGACACCCGACACC
TCGCATCCTGGGCCGCCGCAAAACTTGGCATCCCCCACGTCTGGGCATCCATCCTGGGTTTCGACGCCCAACTCTCCGTC
TTCCACGCCGGCCACGGCCCCATCTACGAAGACCTCTTCCCCACCCCGCCACCACCCGGATCCGTCCCATCATGTTCCCA
AGCAGGCGTTTTGGGTCCAGTTGTCGGCGTAATGGGCTCCGCGATGGCCATGGAAGCCCTGAAAATCATCACCGGCGTGG
GCACACCCTTGATCGGAAAACTCGGCTACTACTCCTCCCTCGACGGCACCTGGGAATACATCCCCGTCGTCGGTTCGCCG
GAGGTGCTGGAACGGGTGCTTGGGTCTGCTGGTGTTTCGGGGATTTCTGGCGGTTTTGGTGAGGTGCTCGATGTTCCTCG
AGTTTCCGCGCTGGTTGACGGCGTTTCGCTCATCGACGTCCGCGAACCCTCCGAATTCTCCGCCTACTCCATCCCCGGCG
CGCACAACACCCCACTGTCCGCCATCCGCGAAGGCGCCATCCCACCCTCCGTTTCCGCAGGTAAAGAGGTTATCGTCTAC
TGCGCAGCTGGTGTCCGCTCCGCACAAGCCATCGCAATTTTAGAATCCGCAGGCTACACCGGAATGAGCAGCCTCGACGG
CGGAATCGAAGGCTGGCTAGATTCCCTAGGGTAA

Upstream 100 bases:

>100_bases
CCTTCGCCGCCTGCTCCGACCTCGCCGACGCCGTCAAAGCCCAGGTCCCGATCTGGAAAGAGCAAACGCGCCTCGACGGC
TCCACCGATTGGGTCGGCCT

Downstream 100 bases:

>100_bases
AACCAAGGCGTTGTGCCACCTAAACACCGGCCCAACGCCTTGCGTTTTCACCCTCCTCCGCGGATGCTTCCGTTTGAACT
CCGCCACCTGTTTCACCAAC

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: Sulfur carrier protein CysO adenylyltransferase; Sulfur carrier protein CysO sulfurtransferase [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MKNLDIARYRRQIMLGEIGQQKQQSLFDAKVSVIGAGGLGSPALLYLAGAGVGHIHIIDDDLVDLSNLHRQVIHTTAGVG
TPKAESAREAMLALNPSVKVTVSVRRLDWSNALSELADSDVILDGSDNFDTRHLASWAAAKLGIPHVWASILGFDAQLSV
FHAGHGPIYEDLFPTPPPPGSVPSCSQAGVLGPVVGVMGSAMAMEALKIITGVGTPLIGKLGYYSSLDGTWEYIPVVGSP
EVLERVLGSAGVSGISGGFGEVLDVPRVSALVDGVSLIDVREPSEFSAYSIPGAHNTPLSAIREGAIPPSVSAGKEVIVY
CAAGVRSAQAIAILESAGYTGMSSLDGGIEGWLDSLG

Sequences:

>Translated_357_residues
MKNLDIARYRRQIMLGEIGQQKQQSLFDAKVSVIGAGGLGSPALLYLAGAGVGHIHIIDDDLVDLSNLHRQVIHTTAGVG
TPKAESAREAMLALNPSVKVTVSVRRLDWSNALSELADSDVILDGSDNFDTRHLASWAAAKLGIPHVWASILGFDAQLSV
FHAGHGPIYEDLFPTPPPPGSVPSCSQAGVLGPVVGVMGSAMAMEALKIITGVGTPLIGKLGYYSSLDGTWEYIPVVGSP
EVLERVLGSAGVSGISGGFGEVLDVPRVSALVDGVSLIDVREPSEFSAYSIPGAHNTPLSAIREGAIPPSVSAGKEVIVY
CAAGVRSAQAIAILESAGYTGMSSLDGGIEGWLDSLG
>Mature_357_residues
MKNLDIARYRRQIMLGEIGQQKQQSLFDAKVSVIGAGGLGSPALLYLAGAGVGHIHIIDDDLVDLSNLHRQVIHTTAGVG
TPKAESAREAMLALNPSVKVTVSVRRLDWSNALSELADSDVILDGSDNFDTRHLASWAAAKLGIPHVWASILGFDAQLSV
FHAGHGPIYEDLFPTPPPPGSVPSCSQAGVLGPVVGVMGSAMAMEALKIITGVGTPLIGKLGYYSSLDGTWEYIPVVGSP
EVLERVLGSAGVSGISGGFGEVLDVPRVSALVDGVSLIDVREPSEFSAYSIPGAHNTPLSAIREGAIPPSVSAGKEVIVY
CAAGVRSAQAIAILESAGYTGMSSLDGGIEGWLDSLG

Specific function: Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps:first, ATP-dependent activation of CysO as acyl- adenylate (CysO-COOAMP), followed by sulfur transfer to give CysO- thioca

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=394, Percent_Identity=33.756345177665, Blast_Score=152, Evalue=4e-37,
Organism=Escherichia coli, GI1787048, Length=241, Percent_Identity=35.2697095435685, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI87082356, Length=235, Percent_Identity=40.8510638297872, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17540406, Length=378, Percent_Identity=32.8042328042328, Blast_Score=183, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI193203301, Length=168, Percent_Identity=27.3809523809524, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321903, Length=396, Percent_Identity=34.5959595959596, Blast_Score=199, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6320598, Length=178, Percent_Identity=27.5280898876405, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24582879, Length=383, Percent_Identity=34.4647519582245, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24660640, Length=168, Percent_Identity=32.7380952380952, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573937, Length=188, Percent_Identity=29.7872340425532, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR001763
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00581 Rhodanese; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 36984; Mature: 36984

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS50206 RHODANESE_3 ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLDIARYRRQIMLGEIGQQKQQSLFDAKVSVIGAGGLGSPALLYLAGAGVGHIHIIDD
CCCCCHHHHHHHHHHHHHCHHHHHHHHHHHEEEEECCCCCCCEEEEEECCCCCEEEEECC
DLVDLSNLHRQVIHTTAGVGTPKAESAREAMLALNPSVKVTVSVRRLDWSNALSELADSD
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEECCCEEEEEEEEECCHHHHHHHHCCCC
VILDGSDNFDTRHLASWAAAKLGIPHVWASILGFDAQLSVFHAGHGPIYEDLFPTPPPPG
EEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCCCHHHCCCCCCCCC
SVPSCSQAGVLGPVVGVMGSAMAMEALKIITGVGTPLIGKLGYYSSLDGTWEYIPVVGSP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEEEEECCCH
EVLERVLGSAGVSGISGGFGEVLDVPRVSALVDGVSLIDVREPSEFSAYSIPGAHNTPLS
HHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHCCCEEEECCCCCCCCEEECCCCCCCCHH
AIREGAIPPSVSAGKEVIVYCAAGVRSAQAIAILESAGYTGMSSLDGGIEGWLDSLG
HHHHCCCCCCCCCCCEEEEEEECCCCCHHEEEEEHHCCCCCCHHCCCHHHHHHHHCC
>Mature Secondary Structure
MKNLDIARYRRQIMLGEIGQQKQQSLFDAKVSVIGAGGLGSPALLYLAGAGVGHIHIIDD
CCCCCHHHHHHHHHHHHHCHHHHHHHHHHHEEEEECCCCCCCEEEEEECCCCCEEEEECC
DLVDLSNLHRQVIHTTAGVGTPKAESAREAMLALNPSVKVTVSVRRLDWSNALSELADSD
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHEECCCEEEEEEEEECCHHHHHHHHCCCC
VILDGSDNFDTRHLASWAAAKLGIPHVWASILGFDAQLSVFHAGHGPIYEDLFPTPPPPG
EEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCCCHHHCCCCCCCCC
SVPSCSQAGVLGPVVGVMGSAMAMEALKIITGVGTPLIGKLGYYSSLDGTWEYIPVVGSP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEEEEECCCH
EVLERVLGSAGVSGISGGFGEVLDVPRVSALVDGVSLIDVREPSEFSAYSIPGAHNTPLS
HHHHHHHHHCCCCCCCCCHHHHHCCCHHHHHHCCCEEEECCCCCCCCEEECCCCCCCCHH
AIREGAIPPSVSAGKEVIVYCAAGVRSAQAIAILESAGYTGMSSLDGGIEGWLDSLG
HHHHCCCCCCCCCCCEEEEEEECCCCCHHEEEEEHHCCCCCCHHCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]