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The map label for this gene is toxR [H]

Identifier: 59711398

GI number: 59711398

Start: 864530

End: 865411

Strand: Reverse

Name: toxR [H]

Synonym: VF_0791

Alternate gene names: 59711398

Gene position: 865411-864530 (Counterclockwise)

Preceding gene: 59711409

Following gene: 59711397

Centisome position: 29.87

GC content: 37.07

Gene sequence:

>882_bases
ATGAATACAGAAAATAACAAAATTATTATTGGCGACCGGTTTCTCTTCGATCCAAACGACAATAGTCTTATTGATACTCT
AAATGATGATGAGATTATTCGCTTGGGTGGTAATGAAAGTCGAGTTTTAAGCCTGCTGATTCAAGAACCAGGGAAGGTTG
TTAGCCGTCACGAATTACATGAGTATGTTTGGAGAGATCAAGGCTTTGAAGTTGATGATTCAAGTTTAACTCAAGCTATC
TCTACATTAAGGAAGATGCTCCAAGACCCAACCAAGTTACCTGTTTATGTCAAAACAGTACCAAAACGTGGTTATCAATT
TATTTCAACAGCTGTTGCTCAAGTCGATCCTGACCAGCAAACAGAAGTTGAAACTGAACACAATTTAGAGAATACTCCGT
CAATCGATTCTCTAAATACCGCTTCAGTGCATCAAGATGATGCTCAAGAAGCACAAGCTGTGGCACCGCAACAAAACGCA
ACAATAAATCAGCCATCTACGACTAATTCAGCACCACAAGCACATCTATCTCTTTTAGGCACAATAATGCTTATTATTGC
TTTTGTTTTGCCTATTATTGCTTATGTCAATCATACGCCAAAATCAGATGCTTTTGTTCAAGTTGCTAATTATGATAATA
CGCCTGTTTTTGTTCCGGTTAACCACCCTAGTATCGAACAGTGGAAACCTCTTATTGAGCAATGTACAAATTTTTATAAT
TCAAAGCACACTGATTCATTAAAACCAATTGAAGTTATTGCCACTAGCGGTCAACCAAATCAAATTACATTAAATTATAT
ACATAGCGAAGAACACAGTGATCAAAGCATCAGTGTACGCTTGCTAATTGATCAAAAAGGGGTGGATAAGGTATGTGGAT
AA

Upstream 100 bases:

>100_bases
GATCAAAAATGATTAATGATAAATTTTGACATAATATAGACATTCTAAAAGTGATACTCTTTATCATATCTAAGAACTGC
CACTACTGAGTTAATAACCG

Downstream 100 bases:

>100_bases
ACAAAGAGCAGTTACCTCTATTCAAACGTTTATTACCCTTAATCCTGCTAACTATCTCAATAATAGGTAGTGCATGGTTT
TATTGGAAAAGCGACAGTAA

Product: transcriptional activator ToxR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MNTENNKIIIGDRFLFDPNDNSLIDTLNDDEIIRLGGNESRVLSLLIQEPGKVVSRHELHEYVWRDQGFEVDDSSLTQAI
STLRKMLQDPTKLPVYVKTVPKRGYQFISTAVAQVDPDQQTEVETEHNLENTPSIDSLNTASVHQDDAQEAQAVAPQQNA
TINQPSTTNSAPQAHLSLLGTIMLIIAFVLPIIAYVNHTPKSDAFVQVANYDNTPVFVPVNHPSIEQWKPLIEQCTNFYN
SKHTDSLKPIEVIATSGQPNQITLNYIHSEEHSDQSISVRLLIDQKGVDKVCG

Sequences:

>Translated_293_residues
MNTENNKIIIGDRFLFDPNDNSLIDTLNDDEIIRLGGNESRVLSLLIQEPGKVVSRHELHEYVWRDQGFEVDDSSLTQAI
STLRKMLQDPTKLPVYVKTVPKRGYQFISTAVAQVDPDQQTEVETEHNLENTPSIDSLNTASVHQDDAQEAQAVAPQQNA
TINQPSTTNSAPQAHLSLLGTIMLIIAFVLPIIAYVNHTPKSDAFVQVANYDNTPVFVPVNHPSIEQWKPLIEQCTNFYN
SKHTDSLKPIEVIATSGQPNQITLNYIHSEEHSDQSISVRLLIDQKGVDKVCG
>Mature_293_residues
MNTENNKIIIGDRFLFDPNDNSLIDTLNDDEIIRLGGNESRVLSLLIQEPGKVVSRHELHEYVWRDQGFEVDDSSLTQAI
STLRKMLQDPTKLPVYVKTVPKRGYQFISTAVAQVDPDQQTEVETEHNLENTPSIDSLNTASVHQDDAQEAQAVAPQQNA
TINQPSTTNSAPQAHLSLLGTIMLIIAFVLPIIAYVNHTPKSDAFVQVANYDNTPVFVPVNHPSIEQWKPLIEQCTNFYN
SKHTDSLKPIEVIATSGQPNQITLNYIHSEEHSDQSISVRLLIDQKGVDKVCG

Specific function: This transcription activator controls cholera toxin, pilus colonization factor and outer membrane protein expression in V.cholerae. It binds to the 5'-TTTTGAT-3' tandemly repeated DNA sequence in the cholera toxin promoter region. ToxS interacts with the

COG id: COG3710

COG function: function code K; DNA-binding winged-HTH domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 32689; Mature: 32689

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTENNKIIIGDRFLFDPNDNSLIDTLNDDEIIRLGGNESRVLSLLIQEPGKVVSRHELH
CCCCCCEEEECCEEEECCCCCCEEECCCCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHH
EYVWRDQGFEVDDSSLTQAISTLRKMLQDPTKLPVYVKTVPKRGYQFISTAVAQVDPDQQ
HHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCC
TEVETEHNLENTPSIDSLNTASVHQDDAQEAQAVAPQQNATINQPSTTNSAPQAHLSLLG
CCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
TIMLIIAFVLPIIAYVNHTPKSDAFVQVANYDNTPVFVPVNHPSIEQWKPLIEQCTNFYN
HHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHC
SKHTDSLKPIEVIATSGQPNQITLNYIHSEEHSDQSISVRLLIDQKGVDKVCG
CCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCEEEEEEEECCCCHHHCC
>Mature Secondary Structure
MNTENNKIIIGDRFLFDPNDNSLIDTLNDDEIIRLGGNESRVLSLLIQEPGKVVSRHELH
CCCCCCEEEECCEEEECCCCCCEEECCCCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHH
EYVWRDQGFEVDDSSLTQAISTLRKMLQDPTKLPVYVKTVPKRGYQFISTAVAQVDPDQQ
HHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCC
TEVETEHNLENTPSIDSLNTASVHQDDAQEAQAVAPQQNATINQPSTTNSAPQAHLSLLG
CCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
TIMLIIAFVLPIIAYVNHTPKSDAFVQVANYDNTPVFVPVNHPSIEQWKPLIEQCTNFYN
HHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHC
SKHTDSLKPIEVIATSGQPNQITLNYIHSEEHSDQSISVRLLIDQKGVDKVCG
CCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCEEEEEEEECCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3802195; 10952301; 2124707; 1898871; 1400230 [H]