Click here to switch to the map view.

The map label for this gene is nanA [H]

Identifier: 59711270

GI number: 59711270

Start: 726576

End: 727469

Strand: Reverse

Name: nanA [H]

Synonym: VF_0663

Alternate gene names: 59711270

Gene position: 727469-726576 (Counterclockwise)

Preceding gene: 59711272

Following gene: 59711269

Centisome position: 25.11

GC content: 41.05

Gene sequence:

>894_bases
ATGAAAAAGTTAACCGGTTTAATTGCTGCTCCACATACTCCATTTGATTCTTCAAACAACGTAAACTTTGAAGAGATTGA
TAAAATCGCCAAGCATTTAATCAAAGATGGCGTAAAAGGCATTTATGTATGTGGGACTACAGGAGAAGGCATTCACTGTA
GTGTTGAAGAACGTAAAGCCATCGCTGAGCGTTGGGTAAGTGCTTCTAATAACCAATTAGATATCATTGTACATACAGGC
GCATTAAGCATTATTGATACGTTAGAACTTACACGCCATGCAGATACTCTCGATATTCTAGCAACATCAGCAATTGGCCC
ATGTTTCTTCAAACCTGGTAGCGTAGCTGACCTAGTTGAATACTGTGCAACCATTGCAGCTGCCGCACCATCAAAAGGCT
TCTACTACTACCACTCAGGCATGTCTGGTGTGAATTTAAATATGGAAGAGTTTTTAATCCAAGCCGATAAGCACATTCCT
AATTTATCTGGTCTTAAATTTAACAGTGGTGATTTGTACGAATACCAACGTTGCCTTCGTGCTTGTGATGGTAAATTTGA
TATTCCATTTGGTGTTGATGAGCACCTACCTGGCGCACTTGCTGTTGGCGCAAAAAGTGCGGTAGGTAGTACTTATAACT
ATGCTGCTCCACATTTTAATTCCATTATCGAAGCGTTTAATCGTGGCGATCAAGAAGCGGTATTCAATAAGATGACAAAT
GTTATTGAGCTTATCCGTGTATTAGTAGATTTCGGCGGTGTAGCGGCTGGTAAGGTTGCAATGGAGCTTCACGACATCAA
TGCTGGCGATCCTCGCTTACCTTTAATGCCGTTAACTGCAGAGCAGAAAGTAACCGTAGCAACTCGAATGAGAAACGCTG
GTTTCATACAATAA

Upstream 100 bases:

>100_bases
ATGTTGCTAAATGAAACTTTACTCCATAAGATTAGTTTAACTCCAATATTGATATTTAAATGAAGAATAACTTCATTAAA
AATAAACTAACGAGGCTTAA

Downstream 100 bases:

>100_bases
AATACAGACTTATCTTTGCTCTAAAGCTGAAAAACTTCCCCCTAGGTTTTTCAGCTTTTTTTGATCTATGTTTTCCCTTT
TTCAACGTGTAAACTCACTA

Product: N-acetylneuraminate lyase

Products: NA

Alternate protein names: DHDPS 2 [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MKKLTGLIAAPHTPFDSSNNVNFEEIDKIAKHLIKDGVKGIYVCGTTGEGIHCSVEERKAIAERWVSASNNQLDIIVHTG
ALSIIDTLELTRHADTLDILATSAIGPCFFKPGSVADLVEYCATIAAAAPSKGFYYYHSGMSGVNLNMEEFLIQADKHIP
NLSGLKFNSGDLYEYQRCLRACDGKFDIPFGVDEHLPGALAVGAKSAVGSTYNYAAPHFNSIIEAFNRGDQEAVFNKMTN
VIELIRVLVDFGGVAAGKVAMELHDINAGDPRLPLMPLTAEQKVTVATRMRNAGFIQ

Sequences:

>Translated_297_residues
MKKLTGLIAAPHTPFDSSNNVNFEEIDKIAKHLIKDGVKGIYVCGTTGEGIHCSVEERKAIAERWVSASNNQLDIIVHTG
ALSIIDTLELTRHADTLDILATSAIGPCFFKPGSVADLVEYCATIAAAAPSKGFYYYHSGMSGVNLNMEEFLIQADKHIP
NLSGLKFNSGDLYEYQRCLRACDGKFDIPFGVDEHLPGALAVGAKSAVGSTYNYAAPHFNSIIEAFNRGDQEAVFNKMTN
VIELIRVLVDFGGVAAGKVAMELHDINAGDPRLPLMPLTAEQKVTVATRMRNAGFIQ
>Mature_297_residues
MKKLTGLIAAPHTPFDSSNNVNFEEIDKIAKHLIKDGVKGIYVCGTTGEGIHCSVEERKAIAERWVSASNNQLDIIVHTG
ALSIIDTLELTRHADTLDILATSAIGPCFFKPGSVADLVEYCATIAAAAPSKGFYYYHSGMSGVNLNMEEFLIQADKHIP
NLSGLKFNSGDLYEYQRCLRACDGKFDIPFGVDEHLPGALAVGAKSAVGSTYNYAAPHFNSIIEAFNRGDQEAVFNKMTN
VIELIRVLVDFGGVAAGKVAMELHDINAGDPRLPLMPLTAEQKVTVATRMRNAGFIQ

Specific function: Important in N-acetylneuraminate lyase reaction [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI13540533, Length=301, Percent_Identity=38.8704318936877, Blast_Score=204, Evalue=1e-52,
Organism=Escherichia coli, GI1789620, Length=264, Percent_Identity=28.030303030303, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786463, Length=230, Percent_Identity=25.2173913043478, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87082415, Length=242, Percent_Identity=24.7933884297521, Blast_Score=75, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32149; Mature: 32149

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00665 DHDPS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLTGLIAAPHTPFDSSNNVNFEEIDKIAKHLIKDGVKGIYVCGTTGEGIHCSVEERKA
CCCHHCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEECHHHHHH
IAERWVSASNNQLDIIVHTGALSIIDTLELTRHADTLDILATSAIGPCFFKPGSVADLVE
HHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHH
YCATIAAAAPSKGFYYYHSGMSGVNLNMEEFLIQADKHIPNLSGLKFNSGDLYEYQRCLR
HHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHH
ACDGKFDIPFGVDEHLPGALAVGAKSAVGSTYNYAAPHFNSIIEAFNRGDQEAVFNKMTN
HCCCCCCCCCCCCCCCCCHHHHCCHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHH
VIELIRVLVDFGGVAAGKVAMELHDINAGDPRLPLMPLTAEQKVTVATRMRNAGFIQ
HHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKKLTGLIAAPHTPFDSSNNVNFEEIDKIAKHLIKDGVKGIYVCGTTGEGIHCSVEERKA
CCCHHCEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEECHHHHHH
IAERWVSASNNQLDIIVHTGALSIIDTLELTRHADTLDILATSAIGPCFFKPGSVADLVE
HHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHH
YCATIAAAAPSKGFYYYHSGMSGVNLNMEEFLIQADKHIPNLSGLKFNSGDLYEYQRCLR
HHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHH
ACDGKFDIPFGVDEHLPGALAVGAKSAVGSTYNYAAPHFNSIIEAFNRGDQEAVFNKMTN
HCCCCCCCCCCCCCCCCCHHHHCCHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHH
VIELIRVLVDFGGVAAGKVAMELHDINAGDPRLPLMPLTAEQKVTVATRMRNAGFIQ
HHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]