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The map label for this gene is nagA2 [H]

Identifier: 59711272

GI number: 59711272

Start: 728699

End: 729859

Strand: Reverse

Name: nagA2 [H]

Synonym: VF_0665

Alternate gene names: 59711272

Gene position: 729859-728699 (Counterclockwise)

Preceding gene: 59711277

Following gene: 59711270

Centisome position: 25.19

GC content: 37.12

Gene sequence:

>1161_bases
ATGAACAGTACAAATGCTCAAAATAATCAGTATATGATTACCAATGTTGATGTATTTAATGGTCAAAAAATAGAAGAAAA
ACAGGCTATTATTATCAATAACGATTCAATTTCATCCATAATTTCAATGAAAGAAGCTGACTCTTTAACTCTAGATCGCA
TTGATGGAGAGGGTGCATTAGCAACCGCAGGTTTTATTGATATTCAACTTAATGGTTGTGGTGGTGTGTTACTCAATACT
GATATAGCGCTTTCAACATTAGAAACGATGAATAAAACCAACGTAAAATACGGAACAACTCAATACTTACCAACCTTAAT
TACCAGTACTGAACTCGACCTTCATAATACATTGTCAATGATGACCAATTTTGAGAATGCAGAACAGGAAGGTGTATTAG
GACTTCACCTTGAAGGACCTTTCATCAGTATTGAGAAAAAAGGCGCTCACCAAGCACAATACATTCGTGAACTAGATTTA
AATACCGCTCAGCTGCTTGCACAACATCGTGACCAAATAAAAGTCATTACACTTGCTCCAGAACACATCAAACAAGACGT
TCTAGATTGCTTAACAGCAGCTGGGATTACGGTTTCAATTGGACATACCAACGCCACTTATGATCAAGTAAACGCCCGTA
CTGGTTTCACTATGGCTACGCATTTATATAATGCAATGACACCTCTTGGTTCAAGAGAACCAGGTGTGGTTGGTTATATT
TTCGATAAAAAACCTCATGCAGGTATTATTGTAGATGGCATTCATGCTTCTTACCCATCAGTTAAAATTGCTCACGAACA
ACTAAAAGAAAAACTCTTTTTGGTTACCGATGCAGTCACTCCTGCGGGAACGGATTTAACAGAGTTTGATATGGCAGGAA
CGCCTGCTTATGTGACCGATGGAAAATGTCACTATAAAGATGGCACCATTGCAGGCGCAGCCATTACTATGATTGATGGG
GTACGTAACTTAATTAGTCATGTGGGTTTATCAAAAGAAGAAGCCTTAAGAATGGCAAGCTTATACCCAGCCCAAGCGTT
GAAAATAGACAATGAATACGGTCAATTAAAAGAAAACTACAAAGCAAACATTACTCTTATTGACAGTAATAATGACATTA
CAACAACGATTCAAATGGGTAAATTGGTTTATCAGAAATAA

Upstream 100 bases:

>100_bases
ATTTTAATTGATTGCATTTCGACATTACTGTATTTTTGACTGTATAAAATTCGGAGTGTAACTCCAATAGGAATGAATAT
TTGATGGATAAGGCAGAAAA

Downstream 100 bases:

>100_bases
AAAATAGGCCGTGAATATGTGTATATTCACGGCCTTATAATTTTATACAGTCAAAGAATTACGATTGGTTAGAAAGCGCT
TCTGTAGTCTTGAGTTTATT

Product: N-acetylglucosamine-6-phosphate deacetylase

Products: NA

Alternate protein names: GlcNAc 6-P deacetylase [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MNSTNAQNNQYMITNVDVFNGQKIEEKQAIIINNDSISSIISMKEADSLTLDRIDGEGALATAGFIDIQLNGCGGVLLNT
DIALSTLETMNKTNVKYGTTQYLPTLITSTELDLHNTLSMMTNFENAEQEGVLGLHLEGPFISIEKKGAHQAQYIRELDL
NTAQLLAQHRDQIKVITLAPEHIKQDVLDCLTAAGITVSIGHTNATYDQVNARTGFTMATHLYNAMTPLGSREPGVVGYI
FDKKPHAGIIVDGIHASYPSVKIAHEQLKEKLFLVTDAVTPAGTDLTEFDMAGTPAYVTDGKCHYKDGTIAGAAITMIDG
VRNLISHVGLSKEEALRMASLYPAQALKIDNEYGQLKENYKANITLIDSNNDITTTIQMGKLVYQK

Sequences:

>Translated_386_residues
MNSTNAQNNQYMITNVDVFNGQKIEEKQAIIINNDSISSIISMKEADSLTLDRIDGEGALATAGFIDIQLNGCGGVLLNT
DIALSTLETMNKTNVKYGTTQYLPTLITSTELDLHNTLSMMTNFENAEQEGVLGLHLEGPFISIEKKGAHQAQYIRELDL
NTAQLLAQHRDQIKVITLAPEHIKQDVLDCLTAAGITVSIGHTNATYDQVNARTGFTMATHLYNAMTPLGSREPGVVGYI
FDKKPHAGIIVDGIHASYPSVKIAHEQLKEKLFLVTDAVTPAGTDLTEFDMAGTPAYVTDGKCHYKDGTIAGAAITMIDG
VRNLISHVGLSKEEALRMASLYPAQALKIDNEYGQLKENYKANITLIDSNNDITTTIQMGKLVYQK
>Mature_386_residues
MNSTNAQNNQYMITNVDVFNGQKIEEKQAIIINNDSISSIISMKEADSLTLDRIDGEGALATAGFIDIQLNGCGGVLLNT
DIALSTLETMNKTNVKYGTTQYLPTLITSTELDLHNTLSMMTNFENAEQEGVLGLHLEGPFISIEKKGAHQAQYIRELDL
NTAQLLAQHRDQIKVITLAPEHIKQDVLDCLTAAGITVSIGHTNATYDQVNARTGFTMATHLYNAMTPLGSREPGVVGYI
FDKKPHAGIIVDGIHASYPSVKIAHEQLKEKLFLVTDAVTPAGTDLTEFDMAGTPAYVTDGKCHYKDGTIAGAAITMIDG
VRNLISHVGLSKEEALRMASLYPAQALKIDNEYGQLKENYKANITLIDSNNDITTTIQMGKLVYQK

Specific function: N-acetylglucosamine utilization. [C]

COG id: COG1820

COG function: function code G; N-acetylglucosamine-6-phosphate deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nagA family [H]

Homologues:

Organism=Homo sapiens, GI21361513, Length=421, Percent_Identity=31.353919239905, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI224922791, Length=419, Percent_Identity=30.7875894988067, Blast_Score=170, Evalue=2e-42,
Organism=Escherichia coli, GI1786892, Length=379, Percent_Identity=40.1055408970976, Blast_Score=284, Evalue=8e-78,
Organism=Caenorhabditis elegans, GI17553768, Length=354, Percent_Identity=33.8983050847458, Blast_Score=154, Evalue=5e-38,
Organism=Drosophila melanogaster, GI19920392, Length=349, Percent_Identity=35.243553008596, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI281361140, Length=363, Percent_Identity=33.8842975206612, Blast_Score=170, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR003764
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.1.25 [H]

Molecular weight: Translated: 42065; Mature: 42065

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSTNAQNNQYMITNVDVFNGQKIEEKQAIIINNDSISSIISMKEADSLTLDRIDGEGAL
CCCCCCCCCEEEEEEEEECCCCEECCCCEEEEECCCHHHHHHHHCCCCEEEEEECCCCCE
ATAGFIDIQLNGCGGVLLNTDIALSTLETMNKTNVKYGTTQYLPTLITSTELDLHNTLSM
EEEEEEEEEECCCCCEEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHH
MTNFENAEQEGVLGLHLEGPFISIEKKGAHQAQYIRELDLNTAQLLAQHRDQIKVITLAP
HHCCCCCCCCCEEEEEECCCEEEEECCCCHHHHHHHHHCCCHHHHHHHCCCCEEEEEECH
EHIKQDVLDCLTAAGITVSIGHTNATYDQVNARTGFTMATHLYNAMTPLGSREPGVVGYI
HHHHHHHHHHHHHCCCEEEECCCCCCHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEE
FDKKPHAGIIVDGIHASYPSVKIAHEQLKEKLFLVTDAVTPAGTDLTEFDMAGTPAYVTD
ECCCCCCCEEEECCCCCCCCEEHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCEEEC
GKCHYKDGTIAGAAITMIDGVRNLISHVGLSKEEALRMASLYPAQALKIDNEYGQLKENY
CEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEECCHHHHHCCCC
KANITLIDSNNDITTTIQMGKLVYQK
EEEEEEEECCCCEEEEEEECCHHHCC
>Mature Secondary Structure
MNSTNAQNNQYMITNVDVFNGQKIEEKQAIIINNDSISSIISMKEADSLTLDRIDGEGAL
CCCCCCCCCEEEEEEEEECCCCEECCCCEEEEECCCHHHHHHHHCCCCEEEEEECCCCCE
ATAGFIDIQLNGCGGVLLNTDIALSTLETMNKTNVKYGTTQYLPTLITSTELDLHNTLSM
EEEEEEEEEECCCCCEEEECCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHH
MTNFENAEQEGVLGLHLEGPFISIEKKGAHQAQYIRELDLNTAQLLAQHRDQIKVITLAP
HHCCCCCCCCCEEEEEECCCEEEEECCCCHHHHHHHHHCCCHHHHHHHCCCCEEEEEECH
EHIKQDVLDCLTAAGITVSIGHTNATYDQVNARTGFTMATHLYNAMTPLGSREPGVVGYI
HHHHHHHHHHHHHCCCEEEECCCCCCHHHCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEE
FDKKPHAGIIVDGIHASYPSVKIAHEQLKEKLFLVTDAVTPAGTDLTEFDMAGTPAYVTD
ECCCCCCCEEEECCCCCCCCEEHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCCCCEEEC
GKCHYKDGTIAGAAITMIDGVRNLISHVGLSKEEALRMASLYPAQALKIDNEYGQLKENY
CEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEECCHHHHHCCCC
KANITLIDSNNDITTTIQMGKLVYQK
EEEEEEEECCCCEEEEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9301118; 10952301 [H]