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The map label for this gene is gltP [H]

Identifier: 59711254

GI number: 59711254

Start: 706769

End: 708046

Strand: Reverse

Name: gltP [H]

Synonym: VF_0647

Alternate gene names: 59711254

Gene position: 708046-706769 (Counterclockwise)

Preceding gene: 59711255

Following gene: 59711252

Centisome position: 24.44

GC content: 40.3

Gene sequence:

>1278_bases
ATGTGGAACAAACTTCGTCATTCTTTGCCTCTGCAATTACTACTAGCAGCATTACTTGCTTGGTTTATTACACTATTTAT
TTCTCCAACAACTGACGTAACCCAAGCGGCTTGGTACCAAGTAATCATGTTAGGAAAAATTACCTATATTGGTTTACTCA
AAATGGTGGTCGGTTTAGTGGTAATGCTTTCTTTACTTCAAGGTATTACAAGCATTGGCTCTATCACCCGCTTAAAACAA
GTAGGTCGAAATACGTTATTGTTTTACAGTTTCACCACATTATTAGCGATATCTCTTGGTTTAGGTGCATCATTATTGAT
GCCTGCATGGCAACCTCTTACAGAGTTTGCTCCTGTTGGTGACAATGTTCAGCTCATTAGTGAAGAAGCCGCTGGTGGCG
CAGCCATTGCAAGTAAGTTATTAAATATGGCTTTAGTAAATCCTGTTGCAGCATTAACCAATGGGAACTTACTCGCTATC
GTTATGTTTTCATTTATGTTGGGACTGGCTTTACTTTCATCACTACCAGAAAAGCATCCTGTTTTTGATGTGCTCAGCGG
TTTAAATAAAAGCATTAATACACTAGTAGGTTGGATTATTCGCCTAGCTCCATTAGCTGTGTTTGCCATTGTTTTTGATT
TTACTGTCCGAGGTGGCGAGTCTTTATTTCAACAATTAGCTCTGTTTGCTTTACTGGTCTTTGTTCTTACTTTAATTCAT
GGCGCAATTGTTTTACCAACAATAGCTAAAATAGCGACAGGCATTAAATACACGACCTTATTTAAAGCGATCTCAGCTCC
AATGGCGATGGCATTTGCTACCTCTTCTAGCTCTGCAACTCTGCCTCTAGCAATGCAAAGCGCACAAGAAAAACTAGGGG
TATCTCAAAGTACAAGCAGTATGGTGCTACCACTTGGTGCGGTAATGAATATGGATGGAACAGCGCTATTTGAAGGTGTT
GCTGCTATATTCCTAGCTCAACTTTTTGGGGTCGATTTAACAACCTCAGGGTTAGTCATGATCTTTATTATGGCAATGGT
ATCATCTGTTGGCGCTCCTGGTATGCCATCAGGATCTATGTCGGGTATGCAACTGGTTCTGTTAGCTGCTGGGATCCCTC
TAGAAGCCATTGCGATCTTATTAATTATTGAACGTCCACTTGATACTTTCCGAACAGCGGTTAACGTTGAGGGAGATATG
ATTGCGGCTTTGGTTATTGATAAGTGGCAAAAAGAATCAGCTAACAAAGAAGTGTTCACACAAAATATCCCTGCATAA

Upstream 100 bases:

>100_bases
TTAACGGACTTTATTTTTTATACTGCATGCGTTTATTAAAGGAGCCATCTTTTAATAAACGTATAAAGCAACATTTTTCA
AAGTAACTGGAATAATCATT

Downstream 100 bases:

>100_bases
TGTCATGCAATAAAAAGCCCTCAATCTGCGAGGGCTTTTTTGTATCTCAAGTTTGTAGCTTAAATAAAAAATTACAATGT
CAGTAAATAATTTACCAGTT

Product: proton/sodium-glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MWNKLRHSLPLQLLLAALLAWFITLFISPTTDVTQAAWYQVIMLGKITYIGLLKMVVGLVVMLSLLQGITSIGSITRLKQ
VGRNTLLFYSFTTLLAISLGLGASLLMPAWQPLTEFAPVGDNVQLISEEAAGGAAIASKLLNMALVNPVAALTNGNLLAI
VMFSFMLGLALLSSLPEKHPVFDVLSGLNKSINTLVGWIIRLAPLAVFAIVFDFTVRGGESLFQQLALFALLVFVLTLIH
GAIVLPTIAKIATGIKYTTLFKAISAPMAMAFATSSSSATLPLAMQSAQEKLGVSQSTSSMVLPLGAVMNMDGTALFEGV
AAIFLAQLFGVDLTTSGLVMIFIMAMVSSVGAPGMPSGSMSGMQLVLLAAGIPLEAIAILLIIERPLDTFRTAVNVEGDM
IAALVIDKWQKESANKEVFTQNIPA

Sequences:

>Translated_425_residues
MWNKLRHSLPLQLLLAALLAWFITLFISPTTDVTQAAWYQVIMLGKITYIGLLKMVVGLVVMLSLLQGITSIGSITRLKQ
VGRNTLLFYSFTTLLAISLGLGASLLMPAWQPLTEFAPVGDNVQLISEEAAGGAAIASKLLNMALVNPVAALTNGNLLAI
VMFSFMLGLALLSSLPEKHPVFDVLSGLNKSINTLVGWIIRLAPLAVFAIVFDFTVRGGESLFQQLALFALLVFVLTLIH
GAIVLPTIAKIATGIKYTTLFKAISAPMAMAFATSSSSATLPLAMQSAQEKLGVSQSTSSMVLPLGAVMNMDGTALFEGV
AAIFLAQLFGVDLTTSGLVMIFIMAMVSSVGAPGMPSGSMSGMQLVLLAAGIPLEAIAILLIIERPLDTFRTAVNVEGDM
IAALVIDKWQKESANKEVFTQNIPA
>Mature_425_residues
MWNKLRHSLPLQLLLAALLAWFITLFISPTTDVTQAAWYQVIMLGKITYIGLLKMVVGLVVMLSLLQGITSIGSITRLKQ
VGRNTLLFYSFTTLLAISLGLGASLLMPAWQPLTEFAPVGDNVQLISEEAAGGAAIASKLLNMALVNPVAALTNGNLLAI
VMFSFMLGLALLSSLPEKHPVFDVLSGLNKSINTLVGWIIRLAPLAVFAIVFDFTVRGGESLFQQLALFALLVFVLTLIH
GAIVLPTIAKIATGIKYTTLFKAISAPMAMAFATSSSSATLPLAMQSAQEKLGVSQSTSSMVLPLGAVMNMDGTALFEGV
AAIFLAQLFGVDLTTSGLVMIFIMAMVSSVGAPGMPSGSMSGMQLVLLAAGIPLEAIAILLIIERPLDTFRTAVNVEGDM
IAALVIDKWQKESANKEVFTQNIPA

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI223468566, Length=277, Percent_Identity=35.3790613718412, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI223468564, Length=268, Percent_Identity=35.4477611940299, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI5032093, Length=277, Percent_Identity=35.3790613718412, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI21314632, Length=331, Percent_Identity=31.4199395770393, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4827012, Length=284, Percent_Identity=36.2676056338028, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI169790839, Length=280, Percent_Identity=33.5714285714286, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI66773030, Length=260, Percent_Identity=32.3076923076923, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI194239697, Length=273, Percent_Identity=31.1355311355311, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI40254478, Length=258, Percent_Identity=34.1085271317829, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI301601644, Length=154, Percent_Identity=37.6623376623377, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI262359914, Length=202, Percent_Identity=34.1584158415842, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1790514, Length=424, Percent_Identity=31.3679245283019, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1789947, Length=380, Percent_Identity=26.5789473684211, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1788024, Length=392, Percent_Identity=25, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1789473, Length=264, Percent_Identity=26.8939393939394, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71996953, Length=273, Percent_Identity=32.6007326007326, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71983106, Length=258, Percent_Identity=32.1705426356589, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71983099, Length=258, Percent_Identity=32.1705426356589, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17537407, Length=266, Percent_Identity=31.9548872180451, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI193206654, Length=292, Percent_Identity=29.7945205479452, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI193206505, Length=283, Percent_Identity=31.8021201413428, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17541374, Length=190, Percent_Identity=36.3157894736842, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24583025, Length=267, Percent_Identity=29.5880149812734, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17137668, Length=267, Percent_Identity=29.5880149812734, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24583023, Length=267, Percent_Identity=29.5880149812734, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI281360481, Length=290, Percent_Identity=26.2068965517241, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281360483, Length=290, Percent_Identity=26.2068965517241, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17137666, Length=290, Percent_Identity=26.2068965517241, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45072; Mature: 45072

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWNKLRHSLPLQLLLAALLAWFITLFISPTTDVTQAAWYQVIMLGKITYIGLLKMVVGLV
CCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMLSLLQGITSIGSITRLKQVGRNTLLFYSFTTLLAISLGLGASLLMPAWQPLTEFAPVG
HHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHCCCC
DNVQLISEEAAGGAAIASKLLNMALVNPVAALTNGNLLAIVMFSFMLGLALLSSLPEKHP
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCC
VFDVLSGLNKSINTLVGWIIRLAPLAVFAIVFDFTVRGGESLFQQLALFALLVFVLTLIH
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GAIVLPTIAKIATGIKYTTLFKAISAPMAMAFATSSSSATLPLAMQSAQEKLGVSQSTSS
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCC
MVLPLGAVMNMDGTALFEGVAAIFLAQLFGVDLTTSGLVMIFIMAMVSSVGAPGMPSGSM
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
SGMQLVLLAAGIPLEAIAILLIIERPLDTFRTAVNVEGDMIAALVIDKWQKESANKEVFT
CHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHH
QNIPA
CCCCC
>Mature Secondary Structure
MWNKLRHSLPLQLLLAALLAWFITLFISPTTDVTQAAWYQVIMLGKITYIGLLKMVVGLV
CCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMLSLLQGITSIGSITRLKQVGRNTLLFYSFTTLLAISLGLGASLLMPAWQPLTEFAPVG
HHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHCCCC
DNVQLISEEAAGGAAIASKLLNMALVNPVAALTNGNLLAIVMFSFMLGLALLSSLPEKHP
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCC
VFDVLSGLNKSINTLVGWIIRLAPLAVFAIVFDFTVRGGESLFQQLALFALLVFVLTLIH
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GAIVLPTIAKIATGIKYTTLFKAISAPMAMAFATSSSSATLPLAMQSAQEKLGVSQSTSS
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCC
MVLPLGAVMNMDGTALFEGVAAIFLAQLFGVDLTTSGLVMIFIMAMVSSVGAPGMPSGSM
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
SGMQLVLLAAGIPLEAIAILLIIERPLDTFRTAVNVEGDMIAALVIDKWQKESANKEVFT
CHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHH
QNIPA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]