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The map label for this gene is csdA [H]

Identifier: 59711197

GI number: 59711197

Start: 647700

End: 648932

Strand: Reverse

Name: csdA [H]

Synonym: VF_0590

Alternate gene names: 59711197

Gene position: 648932-647700 (Counterclockwise)

Preceding gene: 59711201

Following gene: 59711196

Centisome position: 22.4

GC content: 39.01

Gene sequence:

>1233_bases
ATGAAGAAAATTCTTATGACTGCATTTAATGTTGAACTTGTTCGTTCTCAATTCCCAGCTCTATTACAAGAAGTAAATGA
GCAACCTATTGCGTATTTTGATAGTGCGGCAACCACACAAAAACCATTAGCTGTATTAAATGCAATTCAAGATTATTATC
AAAAAAGTAATGCCAATGTGCATCGCGGCAGTCATAGCCTAACTGCCTCTGCTACGCTTCAATTTGAACAAGCCAGAGAA
ACGGTTCAACACTTCATTAATGCGAAAAGCAGTAAAGAGATTATTTGGACTCGTGGTGCAACAGAAGCCATTAATTTAAT
CGCTCAAACTTATGCTCGTAATACATTACAAGTTAATGATGAAATTTTAGTGAGTGAATTAGAACACCACGCGAATATTG
TTCCTTGGCAAATTGTTGCAGAACAAACCGGGGCAAAAGTCATTAAAATCCCAATGAAATCAAATTGCACATTAGATATG
GATGCATTTGAATCATTGGTAACCCAAAACACCAAAATTGTAGCCGTAGCTCAAGTGACCAACGTAACTGGAACCCTAAA
CCCTATTGAAGAAATCATTAAGATTGCACACAACGTTGGGGCGATTGTTGTAGTTGATGGTGCTCAAGGTATTGTTCATC
ATACTATTGATGTTCAAGCAATGAATGCCGACTTCTATGTTTGCTCTGGTCATAAATTATTTGCACCTGCAGGGATCGGT
GCTCTATATGGTAAACAACACTTACTTGAGTCCATGCCTGTATGGCACGGGGGCGGTAAAATGGTTGAGAAAGTGTCGTT
TGAAAAAACCACATTTGCAGAACTTCCAGGAAAATTTGAAGCAGGTACACCTAATGTTGCCGGAGCGATTGCTTTTGCCA
CAGCAATTAACTGGGTTAAGCAATTTGCCCATGATGATCTAAATGCTCATATTAATGAACTTCGTCAAATAGCGATTGAT
GGAATCAAAGATATTGAGGATTTACGCTTTATTGGGTTACAAGATAACGCTAGCCTATTCTCTTTTGTTATTGATGGTGT
CCATCACCAAGATATAGCTACGCTATTAGATCAACAAGGCATCGCTGTACGCTCAGGTAATCACTGTGCTCACCCTATGC
TAGATGCTCTAGGGCTTACAGGTACTGTACGTGTTTCATTTGCCTTGTATAATACAAAACAAGATGTTCAACGTTTTATC
GACGCGCTAAACAAAGCCGCAGATATGCTATAA

Upstream 100 bases:

>100_bases
AAAAAAGATTAGTTAGCACCGTTTAATACGGTGCTTTTTTTTGCCTGTAATTTTGACTTACGCCCCATAAATCCGCATCA
TTCTCCTGTTTGCTAACCCA

Downstream 100 bases:

>100_bases
GCTCAAATTTAAGGTATTCATTTATGTCCACTTTCCCATCATCGCCTTTTGGTTTTGACATTACTCACTCGACAGTACTT
GATTTAATGAGTAACGCTAA

Product: cysteine sulfinate desulfinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MKKILMTAFNVELVRSQFPALLQEVNEQPIAYFDSAATTQKPLAVLNAIQDYYQKSNANVHRGSHSLTASATLQFEQARE
TVQHFINAKSSKEIIWTRGATEAINLIAQTYARNTLQVNDEILVSELEHHANIVPWQIVAEQTGAKVIKIPMKSNCTLDM
DAFESLVTQNTKIVAVAQVTNVTGTLNPIEEIIKIAHNVGAIVVVDGAQGIVHHTIDVQAMNADFYVCSGHKLFAPAGIG
ALYGKQHLLESMPVWHGGGKMVEKVSFEKTTFAELPGKFEAGTPNVAGAIAFATAINWVKQFAHDDLNAHINELRQIAID
GIKDIEDLRFIGLQDNASLFSFVIDGVHHQDIATLLDQQGIAVRSGNHCAHPMLDALGLTGTVRVSFALYNTKQDVQRFI
DALNKAADML

Sequences:

>Translated_410_residues
MKKILMTAFNVELVRSQFPALLQEVNEQPIAYFDSAATTQKPLAVLNAIQDYYQKSNANVHRGSHSLTASATLQFEQARE
TVQHFINAKSSKEIIWTRGATEAINLIAQTYARNTLQVNDEILVSELEHHANIVPWQIVAEQTGAKVIKIPMKSNCTLDM
DAFESLVTQNTKIVAVAQVTNVTGTLNPIEEIIKIAHNVGAIVVVDGAQGIVHHTIDVQAMNADFYVCSGHKLFAPAGIG
ALYGKQHLLESMPVWHGGGKMVEKVSFEKTTFAELPGKFEAGTPNVAGAIAFATAINWVKQFAHDDLNAHINELRQIAID
GIKDIEDLRFIGLQDNASLFSFVIDGVHHQDIATLLDQQGIAVRSGNHCAHPMLDALGLTGTVRVSFALYNTKQDVQRFI
DALNKAADML
>Mature_410_residues
MKKILMTAFNVELVRSQFPALLQEVNEQPIAYFDSAATTQKPLAVLNAIQDYYQKSNANVHRGSHSLTASATLQFEQARE
TVQHFINAKSSKEIIWTRGATEAINLIAQTYARNTLQVNDEILVSELEHHANIVPWQIVAEQTGAKVIKIPMKSNCTLDM
DAFESLVTQNTKIVAVAQVTNVTGTLNPIEEIIKIAHNVGAIVVVDGAQGIVHHTIDVQAMNADFYVCSGHKLFAPAGIG
ALYGKQHLLESMPVWHGGGKMVEKVSFEKTTFAELPGKFEAGTPNVAGAIAFATAINWVKQFAHDDLNAHINELRQIAID
GIKDIEDLRFIGLQDNASLFSFVIDGVHHQDIATLLDQQGIAVRSGNHCAHPMLDALGLTGTVRVSFALYNTKQDVQRFI
DALNKAADML

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=228, Percent_Identity=28.9473684210526, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI156713448, Length=428, Percent_Identity=24.0654205607477, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789175, Length=405, Percent_Identity=47.6543209876543, Blast_Score=386, Evalue=1e-108,
Organism=Escherichia coli, GI1787970, Length=403, Percent_Identity=41.9354838709677, Blast_Score=368, Evalue=1e-103,
Organism=Escherichia coli, GI48994898, Length=396, Percent_Identity=24.4949494949495, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25143064, Length=396, Percent_Identity=26.010101010101, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI193211090, Length=409, Percent_Identity=24.4498777506112, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319831, Length=395, Percent_Identity=26.5822784810127, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI20129463, Length=239, Percent_Identity=31.3807531380753, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR022471
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44897; Mature: 44897

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILMTAFNVELVRSQFPALLQEVNEQPIAYFDSAATTQKPLAVLNAIQDYYQKSNANV
CCCCEEHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCE
HRGSHSLTASATLQFEQARETVQHFINAKSSKEIIWTRGATEAINLIAQTYARNTLQVND
ECCCCCEEEHEEEEHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCEEECH
EILVSELEHHANIVPWQIVAEQTGAKVIKIPMKSNCTLDMDAFESLVTQNTKIVAVAQVT
HHHHHHHHHHCCCCCCEEEECCCCCEEEEEECCCCCEECHHHHHHHHHCCCEEEEEEEEE
NVTGTLNPIEEIIKIAHNVGAIVVVDGAQGIVHHTIDVQAMNADFYVCSGHKLFAPAGIG
CCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEEEEEECCCEEEECCCEEECCCCCH
ALYGKQHLLESMPVWHGGGKMVEKVSFEKTTFAELPGKFEAGTPNVAGAIAFATAINWVK
HHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
QFAHDDLNAHINELRQIAIDGIKDIEDLRFIGLQDNASLFSFVIDGVHHQDIATLLDQQG
HHHCCCHHHHHHHHHHHHHHCCCCHHHHEEEECCCCHHHHHHHHCCCCHHHHHHHHHCCC
IAVRSGNHCAHPMLDALGLTGTVRVSFALYNTKQDVQRFIDALNKAADML
CEEECCCCCCHHHHHHHCCCEEEEEEEEEECCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKILMTAFNVELVRSQFPALLQEVNEQPIAYFDSAATTQKPLAVLNAIQDYYQKSNANV
CCCCEEHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCE
HRGSHSLTASATLQFEQARETVQHFINAKSSKEIIWTRGATEAINLIAQTYARNTLQVND
ECCCCCEEEHEEEEHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCEEECH
EILVSELEHHANIVPWQIVAEQTGAKVIKIPMKSNCTLDMDAFESLVTQNTKIVAVAQVT
HHHHHHHHHHCCCCCCEEEECCCCCEEEEEECCCCCEECHHHHHHHHHCCCEEEEEEEEE
NVTGTLNPIEEIIKIAHNVGAIVVVDGAQGIVHHTIDVQAMNADFYVCSGHKLFAPAGIG
CCCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEEEEEECCCEEEECCCEEECCCCCH
ALYGKQHLLESMPVWHGGGKMVEKVSFEKTTFAELPGKFEAGTPNVAGAIAFATAINWVK
HHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHH
QFAHDDLNAHINELRQIAIDGIKDIEDLRFIGLQDNASLFSFVIDGVHHQDIATLLDQQG
HHHCCCHHHHHHHHHHHHHHCCCCHHHHEEEECCCCHHHHHHHHCCCCHHHHHHHHHCCC
IAVRSGNHCAHPMLDALGLTGTVRVSFALYNTKQDVQRFIDALNKAADML
CEEECCCCCCHHHHHHHCCCEEEEEEEEEECCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]