Click here to switch to the map view.

The map label for this gene is mutH [H]

Identifier: 59711062

GI number: 59711062

Start: 485652

End: 486320

Strand: Reverse

Name: mutH [H]

Synonym: VF_0455

Alternate gene names: 59711062

Gene position: 486320-485652 (Counterclockwise)

Preceding gene: 59711068

Following gene: 59711054

Centisome position: 16.78

GC content: 40.81

Gene sequence:

>669_bases
ATGAGCTTACCACCACCAAATACTATTGATGAATTATTACAACGAGCAGAAAGTATTGCAGGCTATACGCTATCTGAATT
GGCAGAGCAGGCCGGCATCCCTGTGCCTGAAAATTTAAAGCGAGATAAAGGCTGGGTTGGTCAATTATTAGAATGGCATT
TAGGAGCTTCAGCTGGCAGTAAACCTTTACCTGATTTCATCGATCTTAGTGTAGAACTAAAAACCATTCCAATCAGCTAT
ACAGGTAAACCATTAGAAACGACTTTTGTTTGTGTCGCTCCATTAACAGGCGTACACAGCTTACAATGGGAAGAGTCTCA
TGTTCGTCATAAACTGGCTCACGTATTATGGATCCCTGTAGAAGGCGAGCGAGAGATCCCTGTCGGTGATCGTCATGTCG
GATATCCAGTTTTATGGCAACCTTCTTTGGAAGAAGAACGACAGTTAAAACAAGATTGGGAAGAGTTAATGGATTTAATT
GTGCTCGGTAAGGTTGAGTCAATTACAGCAAAACATGGCGAAGTTCTTCAATTAAGACCTAAAGCAGCAAACAGCCAAGC
GCTAACTGAGGCATATGGTGAAAATGGACAACCTATAAAAACGCTACCCCGCGGTTTTTATTTAAAAACTCAATTTACTC
ATTCTATACTGACTTCATTCTTCAACTAA

Upstream 100 bases:

>100_bases
ATATACACTATTGTGGATAACTTACTAAGATCCAAATTAGGTCAAAAAATAATGTTGATAATATGATAATCTATTCATTC
AATCATGTTGAAGAGTCTTT

Downstream 100 bases:

>100_bases
AAAAATAGGCCTACCTAATTCAAGGTAAGCCTATTCTTCAATAAGGATTCGATTAGCTATAGCTTCTCGGCTCAGAAATC
AAATTATGTTTATTTAATAA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: Methyl-directed mismatch repair protein [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MSLPPPNTIDELLQRAESIAGYTLSELAEQAGIPVPENLKRDKGWVGQLLEWHLGASAGSKPLPDFIDLSVELKTIPISY
TGKPLETTFVCVAPLTGVHSLQWEESHVRHKLAHVLWIPVEGEREIPVGDRHVGYPVLWQPSLEEERQLKQDWEELMDLI
VLGKVESITAKHGEVLQLRPKAANSQALTEAYGENGQPIKTLPRGFYLKTQFTHSILTSFFN

Sequences:

>Translated_222_residues
MSLPPPNTIDELLQRAESIAGYTLSELAEQAGIPVPENLKRDKGWVGQLLEWHLGASAGSKPLPDFIDLSVELKTIPISY
TGKPLETTFVCVAPLTGVHSLQWEESHVRHKLAHVLWIPVEGEREIPVGDRHVGYPVLWQPSLEEERQLKQDWEELMDLI
VLGKVESITAKHGEVLQLRPKAANSQALTEAYGENGQPIKTLPRGFYLKTQFTHSILTSFFN
>Mature_221_residues
SLPPPNTIDELLQRAESIAGYTLSELAEQAGIPVPENLKRDKGWVGQLLEWHLGASAGSKPLPDFIDLSVELKTIPISYT
GKPLETTFVCVAPLTGVHSLQWEESHVRHKLAHVLWIPVEGEREIPVGDRHVGYPVLWQPSLEEERQLKQDWEELMDLIV
LGKVESITAKHGEVLQLRPKAANSQALTEAYGENGQPIKTLPRGFYLKTQFTHSILTSFFN

Specific function: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair [H]

COG id: COG3066

COG function: function code L; DNA mismatch repair protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mutH family [H]

Homologues:

Organism=Escherichia coli, GI1789196, Length=219, Percent_Identity=65.7534246575342, Blast_Score=295, Evalue=1e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004230
- InterPro:   IPR011337
- InterPro:   IPR011335 [H]

Pfam domain/function: PF02976 MutH [H]

EC number: NA

Molecular weight: Translated: 24859; Mature: 24727

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPPPNTIDELLQRAESIAGYTLSELAEQAGIPVPENLKRDKGWVGQLLEWHLGASAGS
CCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHCCCCCCHHHHHHHHHHCCCCCC
KPLPDFIDLSVELKTIPISYTGKPLETTFVCVAPLTGVHSLQWEESHVRHKLAHVLWIPV
CCCCHHHCCEEEEEEEEEEECCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHEEEEEC
EGEREIPVGDRHVGYPVLWQPSLEEERQLKQDWEELMDLIVLGKVESITAKHGEVLQLRP
CCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEECC
KAANSQALTEAYGENGQPIKTLPRGFYLKTQFTHSILTSFFN
CCCCHHHHHHHHCCCCCCHHHCCCCEEEEHHHHHHHHHHHCC
>Mature Secondary Structure 
SLPPPNTIDELLQRAESIAGYTLSELAEQAGIPVPENLKRDKGWVGQLLEWHLGASAGS
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHCCCCCCHHHHHHHHHHCCCCCC
KPLPDFIDLSVELKTIPISYTGKPLETTFVCVAPLTGVHSLQWEESHVRHKLAHVLWIPV
CCCCHHHCCEEEEEEEEEEECCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHEEEEEC
EGEREIPVGDRHVGYPVLWQPSLEEERQLKQDWEELMDLIVLGKVESITAKHGEVLQLRP
CCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEECC
KAANSQALTEAYGENGQPIKTLPRGFYLKTQFTHSILTSFFN
CCCCHHHHHHHHCCCCCCHHHCCCCEEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA