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The map label for this gene is ndk

Identifier: 58617625

GI number: 58617625

Start: 1437213

End: 1437644

Strand: Reverse

Name: ndk

Synonym: ERGA_CDS_08980

Alternate gene names: 58617625

Gene position: 1437644-1437213 (Counterclockwise)

Preceding gene: 58617641

Following gene: 58617621

Centisome position: 95.85

GC content: 29.86

Gene sequence:

>432_bases
GTGCTAGAAAGAACTTTATCTATACTGAAACCAGATGTTGTAAAACGTAATATTGCTGGTCAAGTTAATTCATATATAGA
AAATTCAGGACTTAAAATAATTATACAAAAAATGTGCTTACTAACACGTTATCAAGCTGAAAAATTTTATGAAATACATA
AGTCACAAGTTTTTTTTGTACCTTTAATTAATTTTATGATATCTGGTCCAGTAGTGGTTCAGGTTCTAGAAGGAGAGAAT
GCTATAAGCTTATATAGGGAAGTTATGGGTGCTACTGATCCTAAAAAAGCAAATTCTGGAACTATTAGGGGAGATTTTGC
TGAAAATATAGATGCAAATTGTGTCCATGGTTCAGATAGTTTAGAAAATGCAATTAGGGAAATAAGGTTTTTCTTTAGTG
AATATGAGTTATTGTCTTTATATGAGTGTTAA

Upstream 100 bases:

>100_bases
AAATTCTGAATCATTATTCACCTTCTCTAGGGATTTTGACTTAACTTGATGTATGTTTTATACTATTTTAAATAGTTAGT
TTTTATGAGGAGATTTATTT

Downstream 100 bases:

>100_bases
TTTACATTTAACAATTGTTAATCTATATCTTATTGGATATTAGGTTGATGTCACTTAGTATTTTAGGAATGCAGTTAGTA
GTATATGATTATTATGCTAT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 143; Mature: 143

Protein sequence:

>143_residues
MLERTLSILKPDVVKRNIAGQVNSYIENSGLKIIIQKMCLLTRYQAEKFYEIHKSQVFFVPLINFMISGPVVVQVLEGEN
AISLYREVMGATDPKKANSGTIRGDFAENIDANCVHGSDSLENAIREIRFFFSEYELLSLYEC

Sequences:

>Translated_143_residues
MLERTLSILKPDVVKRNIAGQVNSYIENSGLKIIIQKMCLLTRYQAEKFYEIHKSQVFFVPLINFMISGPVVVQVLEGEN
AISLYREVMGATDPKKANSGTIRGDFAENIDANCVHGSDSLENAIREIRFFFSEYELLSLYEC
>Mature_143_residues
MLERTLSILKPDVVKRNIAGQVNSYIENSGLKIIIQKMCLLTRYQAEKFYEIHKSQVFFVPLINFMISGPVVVQVLEGEN
AISLYREVMGATDPKKANSGTIRGDFAENIDANCVHGSDSLENAIREIRFFFSEYELLSLYEC

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI4826862, Length=140, Percent_Identity=40, Blast_Score=108, Evalue=1e-24,
Organism=Homo sapiens, GI66392203, Length=142, Percent_Identity=36.6197183098592, Blast_Score=105, Evalue=9e-24,
Organism=Homo sapiens, GI66392227, Length=142, Percent_Identity=36.6197183098592, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI66392205, Length=142, Percent_Identity=36.6197183098592, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI4505409, Length=142, Percent_Identity=36.6197183098592, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI66392192, Length=142, Percent_Identity=36.6197183098592, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=38.2352941176471, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI38045913, Length=141, Percent_Identity=36.8794326241135, Blast_Score=103, Evalue=6e-23,
Organism=Homo sapiens, GI4557797, Length=141, Percent_Identity=36.8794326241135, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI37574614, Length=138, Percent_Identity=34.7826086956522, Blast_Score=86, Evalue=8e-18,
Organism=Homo sapiens, GI7019465, Length=138, Percent_Identity=34.7826086956522, Blast_Score=86, Evalue=8e-18,
Organism=Homo sapiens, GI5031951, Length=145, Percent_Identity=33.7931034482759, Blast_Score=84, Evalue=4e-17,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=32.3529411764706, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=29.6296296296296, Blast_Score=70, Evalue=4e-13,
Organism=Homo sapiens, GI148839372, Length=143, Percent_Identity=29.3706293706294, Blast_Score=63, Evalue=8e-11,
Organism=Escherichia coli, GI1788866, Length=136, Percent_Identity=48.5294117647059, Blast_Score=143, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=37.7777777777778, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322783, Length=138, Percent_Identity=37.6811594202899, Blast_Score=107, Evalue=5e-25,
Organism=Drosophila melanogaster, GI45549037, Length=138, Percent_Identity=39.8550724637681, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI18860097, Length=138, Percent_Identity=32.6086956521739, Blast_Score=80, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_EHRRG (Q5FGN1)

Other databases:

- EMBL:   CR925677
- RefSeq:   YP_196824.1
- ProteinModelPortal:   Q5FGN1
- SMR:   Q5FGN1
- STRING:   Q5FGN1
- GeneID:   3268512
- GenomeReviews:   CR925677_GR
- KEGG:   erg:ERGA_CDS_08980
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- BioCyc:   ERUM302409:ERGA_CDS_08980-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16245; Mature: 16245

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 116-116 BINDING 10-10 BINDING 58-58 BINDING 86-86 BINDING 92-92 BINDING 103-103 BINDING 113-113

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERTLSILKPDVVKRNIAGQVNSYIENSGLKIIIQKMCLLTRYQAEKFYEIHKSQVFFV
CCCHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
PLINFMISGPVVVQVLEGENAISLYREVMGATDPKKANSGTIRGDFAENIDANCVHGSDS
HHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCEECCCHH
LENAIREIRFFFSEYELLSLYEC
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLERTLSILKPDVVKRNIAGQVNSYIENSGLKIIIQKMCLLTRYQAEKFYEIHKSQVFFV
CCCHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
PLINFMISGPVVVQVLEGENAISLYREVMGATDPKKANSGTIRGDFAENIDANCVHGSDS
HHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCEECCCHH
LENAIREIRFFFSEYELLSLYEC
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA