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The map label for this gene is icd [H]

Identifier: 58617621

GI number: 58617621

Start: 1428412

End: 1429863

Strand: Reverse

Name: icd [H]

Synonym: ERGA_CDS_08940

Alternate gene names: 58617621

Gene position: 1429863-1428412 (Counterclockwise)

Preceding gene: 58617625

Following gene: 58617619

Centisome position: 95.33

GC content: 31.13

Gene sequence:

>1452_bases
ATGTCAATTCCAGTAACAGTTGCTTATGGAGATGGTATTGGTCCAGAAATTATGGAAGCTGTACTTTTAATCTTAAGTGA
AGCTAAATCAGGTTTGGTTATAGAGACTATAGAGCTGGGGCACAATTTATATAAAAAAGAATGGTCTTGTGGTATTGCTC
CTTCTTCTTGGGATTCTATCCATAGAACTAAGGTATTACTAAAATCTCCTACAATGACCCCACAGGGACAAGGACATAAA
AGCTTAAATGTTACATTGAGAAAGAAGTTGGGACTATATGCAAATGTTAGACCATGTATTTCTTATCATCCTGTAATAAA
AACAAAATATCCTAATTTGAATGTAGTAATAATTAGAGAAAACGAGGAAGATACTTATACTGGTATAGAACATAGATTAA
CTAGTGATACATATCAATGTTTAAAAGTAATAACAAGATCAGGTTCAGAAAGGATATGTAATTATGCTTTTCAATATGCG
ATAACTCATAATAGGAAAAAAGTTACATGTTTGGTAAAAGATAATATTATGAAGATGACAGATGGCATATTTCATAAGTC
TTTTTCAAAAATTGCAGAGGGTTATCCTAGTATTATATCTGATCATTATATTGTTGACATTGGTATGGCAAGAGTAGCCA
CTAATCCAGAAAATTTTGATGTTATAGTAACTACTAATTTATATGGTGATATAATTTCTGATATAGTTGCTGAACTATCT
GGATCAATTGGTCTTGCAGGAAGTGCCAATATAGGGGACAATTATGCAATGTTTGAGGCTGTACATGGATCAGCCCCAGA
TATAGCTGGTAAAAATATAGCTAATCCTTCTGGTTTATTGAGTGCTGCAATACAGATGCTAGTTTATTTGAAGAAGTTTA
ATGAAGCAGAATTAATTCATAATGCATTTCTTAAAACTTTAGAAGATGGAATTCACACAGCAGATATTTACCAAGATAAT
ATTAGTAAAGAAAAAGTTTCTACTATGGATTTTGCTAAAGCTGTGGTTGAGAATTTTGGGCAATCTCCTTGTAACATACA
AAAACCTGTATTAAGTATTATGAATAGTACAAGTGGTACAACAAGTGTGCCATATGTATATCAGCCATCTTATACCGATA
AAATTTTGGTTGGTGTGGATGTTACTATTGGTTGTGATGTTATAGATCTGAATCTTAATCAATTGATTGTTGATTTACGA
AATATAAAACATGATCAGTTAGAACTTGTATTAGTTCATAGTAAAGGATTGGAAATTTGGCCAGATGAATCTTCTACTGT
AAATCTTTCTTATGTTGATCAAATATGTTGTAGATTTTATATGAAATGTAAAAGTGAAATCATTCATGACCATGTGAATC
AATTGCTTTTGGAATTAGATAAAAAGAAAATAAATGTAGTGAAAATGGAAAAGCTCTATCTGTATGATGATCAACCTGGA
TTTTTTACGTAG

Upstream 100 bases:

>100_bases
AATTATTATATTTCTTGTTGTGTTTAATGTTATGTTAATTTATATAGTGATTTGTTAGTCTGATTGTATAAGACTTTGTA
ATAAATGAGGAAGTAGTAAA

Downstream 100 bases:

>100_bases
TACTATAAAATACTAAAGTGTTTGTATAGGATATTAGTAGAAAGAGTAGTTTTTATATTATATAAGAATTAATAGTTTTT
AATTTTGAAATAAGTTAAAG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MSIPVTVAYGDGIGPEIMEAVLLILSEAKSGLVIETIELGHNLYKKEWSCGIAPSSWDSIHRTKVLLKSPTMTPQGQGHK
SLNVTLRKKLGLYANVRPCISYHPVIKTKYPNLNVVIIRENEEDTYTGIEHRLTSDTYQCLKVITRSGSERICNYAFQYA
ITHNRKKVTCLVKDNIMKMTDGIFHKSFSKIAEGYPSIISDHYIVDIGMARVATNPENFDVIVTTNLYGDIISDIVAELS
GSIGLAGSANIGDNYAMFEAVHGSAPDIAGKNIANPSGLLSAAIQMLVYLKKFNEAELIHNAFLKTLEDGIHTADIYQDN
ISKEKVSTMDFAKAVVENFGQSPCNIQKPVLSIMNSTSGTTSVPYVYQPSYTDKILVGVDVTIGCDVIDLNLNQLIVDLR
NIKHDQLELVLVHSKGLEIWPDESSTVNLSYVDQICCRFYMKCKSEIIHDHVNQLLLELDKKKINVVKMEKLYLYDDQPG
FFT

Sequences:

>Translated_483_residues
MSIPVTVAYGDGIGPEIMEAVLLILSEAKSGLVIETIELGHNLYKKEWSCGIAPSSWDSIHRTKVLLKSPTMTPQGQGHK
SLNVTLRKKLGLYANVRPCISYHPVIKTKYPNLNVVIIRENEEDTYTGIEHRLTSDTYQCLKVITRSGSERICNYAFQYA
ITHNRKKVTCLVKDNIMKMTDGIFHKSFSKIAEGYPSIISDHYIVDIGMARVATNPENFDVIVTTNLYGDIISDIVAELS
GSIGLAGSANIGDNYAMFEAVHGSAPDIAGKNIANPSGLLSAAIQMLVYLKKFNEAELIHNAFLKTLEDGIHTADIYQDN
ISKEKVSTMDFAKAVVENFGQSPCNIQKPVLSIMNSTSGTTSVPYVYQPSYTDKILVGVDVTIGCDVIDLNLNQLIVDLR
NIKHDQLELVLVHSKGLEIWPDESSTVNLSYVDQICCRFYMKCKSEIIHDHVNQLLLELDKKKINVVKMEKLYLYDDQPG
FFT
>Mature_482_residues
SIPVTVAYGDGIGPEIMEAVLLILSEAKSGLVIETIELGHNLYKKEWSCGIAPSSWDSIHRTKVLLKSPTMTPQGQGHKS
LNVTLRKKLGLYANVRPCISYHPVIKTKYPNLNVVIIRENEEDTYTGIEHRLTSDTYQCLKVITRSGSERICNYAFQYAI
THNRKKVTCLVKDNIMKMTDGIFHKSFSKIAEGYPSIISDHYIVDIGMARVATNPENFDVIVTTNLYGDIISDIVAELSG
SIGLAGSANIGDNYAMFEAVHGSAPDIAGKNIANPSGLLSAAIQMLVYLKKFNEAELIHNAFLKTLEDGIHTADIYQDNI
SKEKVSTMDFAKAVVENFGQSPCNIQKPVLSIMNSTSGTTSVPYVYQPSYTDKILVGVDVTIGCDVIDLNLNQLIVDLRN
IKHDQLELVLVHSKGLEIWPDESSTVNLSYVDQICCRFYMKCKSEIIHDHVNQLLLELDKKKINVVKMEKLYLYDDQPGF
FT

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=310, Percent_Identity=42.9032258064516, Blast_Score=239, Evalue=5e-63,
Organism=Homo sapiens, GI4758582, Length=326, Percent_Identity=37.4233128834356, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI28178838, Length=308, Percent_Identity=37.987012987013, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI28178821, Length=307, Percent_Identity=36.8078175895765, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI28178816, Length=307, Percent_Identity=36.8078175895765, Blast_Score=172, Evalue=9e-43,
Organism=Homo sapiens, GI28178819, Length=166, Percent_Identity=40.3614457831325, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1787381, Length=389, Percent_Identity=31.3624678663239, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1788101, Length=333, Percent_Identity=32.7327327327327, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI87081683, Length=337, Percent_Identity=29.080118694362, Blast_Score=127, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71986051, Length=306, Percent_Identity=41.1764705882353, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI25144293, Length=343, Percent_Identity=39.067055393586, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17505779, Length=336, Percent_Identity=36.9047619047619, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17550882, Length=346, Percent_Identity=33.8150289017341, Blast_Score=172, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6324709, Length=352, Percent_Identity=40.0568181818182, Blast_Score=233, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6324291, Length=338, Percent_Identity=37.8698224852071, Blast_Score=193, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6322097, Length=337, Percent_Identity=32.9376854599407, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319830, Length=280, Percent_Identity=28.9285714285714, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24643270, Length=313, Percent_Identity=44.408945686901, Blast_Score=262, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24643268, Length=313, Percent_Identity=44.408945686901, Blast_Score=262, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24661184, Length=342, Percent_Identity=42.1052631578947, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI161078635, Length=328, Percent_Identity=36.5853658536585, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI161078637, Length=337, Percent_Identity=36.4985163204748, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI161078633, Length=337, Percent_Identity=36.4985163204748, Blast_Score=188, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24650122, Length=337, Percent_Identity=36.4985163204748, Blast_Score=188, Evalue=7e-48,
Organism=Drosophila melanogaster, GI161078639, Length=323, Percent_Identity=36.5325077399381, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI281362242, Length=343, Percent_Identity=34.402332361516, Blast_Score=172, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24648872, Length=343, Percent_Identity=34.402332361516, Blast_Score=172, Evalue=7e-43,
Organism=Drosophila melanogaster, GI20130355, Length=335, Percent_Identity=28.955223880597, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI45550436, Length=216, Percent_Identity=22.6851851851852, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR014273 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 53781; Mature: 53649

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPVTVAYGDGIGPEIMEAVLLILSEAKSGLVIETIELGHNLYKKEWSCGIAPSSWDSI
CCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEHHHCCHHHHHCCCCCCCCCCCHHH
HRTKVLLKSPTMTPQGQGHKSLNVTLRKKLGLYANVRPCISYHPVIKTKYPNLNVVIIRE
HHHEEEEECCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCEEEEEEEC
NEEDTYTGIEHRLTSDTYQCLKVITRSGSERICNYAFQYAITHNRKKVTCLVKDNIMKMT
CCCCCCCCHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHEEEECCCEEEEEEEECCHHHHH
DGIFHKSFSKIAEGYPSIISDHYIVDIGMARVATNPENFDVIVTTNLYGDIISDIVAELS
HHHHHHHHHHHHCCCHHHHCCCEEEEECHHHEECCCCCEEEEEEECHHHHHHHHHHHHHC
GSIGLAGSANIGDNYAMFEAVHGSAPDIAGKNIANPSGLLSAAIQMLVYLKKFNEAELIH
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHH
NAFLKTLEDGIHTADIYQDNISKEKVSTMDFAKAVVENFGQSPCNIQKPVLSIMNSTSGT
HHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCC
TSVPYVYQPSYTDKILVGVDVTIGCDVIDLNLNQLIVDLRNIKHDQLELVLVHSKGLEIW
CCCCEEECCCCCCEEEEEEEEEECCEEEECCHHHHHHHHHHCCCCCEEEEEEECCCCEEC
PDESSTVNLSYVDQICCRFYMKCKSEIIHDHVNQLLLELDKKKINVVKMEKLYLYDDQPG
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEEECCCC
FFT
CCC
>Mature Secondary Structure 
SIPVTVAYGDGIGPEIMEAVLLILSEAKSGLVIETIELGHNLYKKEWSCGIAPSSWDSI
CCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEHHHCCHHHHHCCCCCCCCCCCHHH
HRTKVLLKSPTMTPQGQGHKSLNVTLRKKLGLYANVRPCISYHPVIKTKYPNLNVVIIRE
HHHEEEEECCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCEEEEEEEC
NEEDTYTGIEHRLTSDTYQCLKVITRSGSERICNYAFQYAITHNRKKVTCLVKDNIMKMT
CCCCCCCCHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHEEEECCCEEEEEEEECCHHHHH
DGIFHKSFSKIAEGYPSIISDHYIVDIGMARVATNPENFDVIVTTNLYGDIISDIVAELS
HHHHHHHHHHHHCCCHHHHCCCEEEEECHHHEECCCCCEEEEEEECHHHHHHHHHHHHHC
GSIGLAGSANIGDNYAMFEAVHGSAPDIAGKNIANPSGLLSAAIQMLVYLKKFNEAELIH
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHH
NAFLKTLEDGIHTADIYQDNISKEKVSTMDFAKAVVENFGQSPCNIQKPVLSIMNSTSGT
HHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCC
TSVPYVYQPSYTDKILVGVDVTIGCDVIDLNLNQLIVDLRNIKHDQLELVLVHSKGLEIW
CCCCEEECCCCCCEEEEEEEEEECCEEEECCHHHHHHHHHHCCCCCEEEEEEECCCCEEC
PDESSTVNLSYVDQICCRFYMKCKSEIIHDHVNQLLLELDKKKINVVKMEKLYLYDDQPG
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEEECCCC
FFT
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA