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The map label for this gene is pyrE [H]

Identifier: 58617617

GI number: 58617617

Start: 1421278

End: 1421889

Strand: Reverse

Name: pyrE [H]

Synonym: ERGA_CDS_08900

Alternate gene names: 58617617

Gene position: 1421889-1421278 (Counterclockwise)

Preceding gene: 58617618

Following gene: 58617616

Centisome position: 94.8

GC content: 31.37

Gene sequence:

>612_bases
GTGTTGTGTTGTATGGAAGTAGGTTTATTAAATAGTGATTCTATATATGATGAGTTCATTAAAATTGGTGTAATAATAAG
TGGTCACTTTATACTTTCTTCTGGTTTACATAGTGATACATATGTACAATGTGCTAGATTATTTGAAAATCCTGCTCTTG
CAGTAAAGTTTTGTTCTTTACTTGCAGAGAAAATTAATAAGGTTTTACCAAATATCGATATGATTGTTTCTCCGGCTATT
GGTGCTATTACTGTTGGGTATGAAATTGCTAGACAACTAGAAATTAGTAATGTGTTTTGTGAACGTGTTAATGGTATATT
TGTATTACGTCGTGGTTTTGAAATTAAAAAAAGTAGTCAAGTTTTGATTGTAGAAGATGTAATTACTACTGGCAAGACAT
CTATGGAAGTGGTAAATTGTGTTAAAAGTAATGGTGGAACTGTTGTTGCAGGTGCAGCGTTAGTTAAACGTAGTAAGGAT
GTAAGGCTTCCTTTTCCTATAATTAGCTTACTCGAGTTAAATGTAAAAAGTTATGTTGATGAAGATATTCCAGAATATTT
AAGAAGAATTCCTGTATCTACACCTGGAAGTAGAAAATATTTGAGTGAATAG

Upstream 100 bases:

>100_bases
AGTTTTATAAGTATGTAATTATACTTATTAGATAATTATATTAGTTGATTTTATTCAAAAGTACACATATTAATCAAATA
GAAGAAATAATGTTTTAAGG

Downstream 100 bases:

>100_bases
TTAGTGTTTGAGCGGTATAAAAAGCAGATTTTACTTTCAGAAGTAGGAGTAGTAGGTCAGGATAAGTTATGTAATAGTAG
TGTTCTAATAGTTGGATGTG

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MLCCMEVGLLNSDSIYDEFIKIGVIISGHFILSSGLHSDTYVQCARLFENPALAVKFCSLLAEKINKVLPNIDMIVSPAI
GAITVGYEIARQLEISNVFCERVNGIFVLRRGFEIKKSSQVLIVEDVITTGKTSMEVVNCVKSNGGTVVAGAALVKRSKD
VRLPFPIISLLELNVKSYVDEDIPEYLRRIPVSTPGSRKYLSE

Sequences:

>Translated_203_residues
MLCCMEVGLLNSDSIYDEFIKIGVIISGHFILSSGLHSDTYVQCARLFENPALAVKFCSLLAEKINKVLPNIDMIVSPAI
GAITVGYEIARQLEISNVFCERVNGIFVLRRGFEIKKSSQVLIVEDVITTGKTSMEVVNCVKSNGGTVVAGAALVKRSKD
VRLPFPIISLLELNVKSYVDEDIPEYLRRIPVSTPGSRKYLSE
>Mature_203_residues
MLCCMEVGLLNSDSIYDEFIKIGVIISGHFILSSGLHSDTYVQCARLFENPALAVKFCSLLAEKINKVLPNIDMIVSPAI
GAITVGYEIARQLEISNVFCERVNGIFVLRRGFEIKKSSQVLIVEDVITTGKTSMEVVNCVKSNGGTVVAGAALVKRSKD
VRLPFPIISLLELNVKSYVDEDIPEYLRRIPVSTPGSRKYLSE

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 22343; Mature: 22343

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLCCMEVGLLNSDSIYDEFIKIGVIISGHFILSSGLHSDTYVQCARLFENPALAVKFCSL
CEEEEEECCCCCCHHHHHHHHHHHHEECHHHEECCCCCHHHHHHHHHHCCCHHHHHHHHH
LAEKINKVLPNIDMIVSPAIGAITVGYEIARQLEISNVFCERVNGIFVLRRGFEIKKSSQ
HHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEECCCCC
VLIVEDVITTGKTSMEVVNCVKSNGGTVVAGAALVKRSKDVRLPFPIISLLELNVKSYVD
EEEEEEHHHCCCHHHHHHHHHHCCCCEEEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
EDIPEYLRRIPVSTPGSRKYLSE
HHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MLCCMEVGLLNSDSIYDEFIKIGVIISGHFILSSGLHSDTYVQCARLFENPALAVKFCSL
CEEEEEECCCCCCHHHHHHHHHHHHEECHHHEECCCCCHHHHHHHHHHCCCHHHHHHHHH
LAEKINKVLPNIDMIVSPAIGAITVGYEIARQLEISNVFCERVNGIFVLRRGFEIKKSSQ
HHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCEECCCCC
VLIVEDVITTGKTSMEVVNCVKSNGGTVVAGAALVKRSKDVRLPFPIISLLELNVKSYVD
EEEEEEHHHCCCHHHHHHHHHHCCCCEEEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHCC
EDIPEYLRRIPVSTPGSRKYLSE
HHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA