Click here to switch to the map view.

The map label for this gene is yrkH [H]

Identifier: 55980806

GI number: 55980806

Start: 802182

End: 803618

Strand: Reverse

Name: yrkH [H]

Synonym: TTHA0837

Alternate gene names: 55980806

Gene position: 803618-802182 (Counterclockwise)

Preceding gene: 55980810

Following gene: 55980805

Centisome position: 43.44

GC content: 70.49

Gene sequence:

>1437_bases
ATGATCTTTCGCCAGATCCACGAGGAAGGCCTCGCGCAGATGAGCTACCTCCTGGGCTGCGCCGCCACCGGGGAGGCCCT
GGTGGTGGACCCCAGGCGGGACGTGGACGTGTACCTGGAGCTCGCCCAGTCCTTGGGCCTCCGCATCACCGCCATCGCCG
AGACCCACATCCACGCCGACTACCTCTCGGGGGCGAGGGAGCTCGCCCGGGCCACGGGGGCCACCCTGTACCTCTCCGAC
GAGGGGGACGAGAACTGGAAGTACAAGGGCCTCGAGGGCTTCCCCCACGTCCTCCTCAAGGACGGGGACGAGTTCAAGGT
GGGGAACATCCGCGTCCGGGCGGTCCACACCCCGGGCCACACCCCCGAGCACCTCTCCTTCCTGGTGGCGGACGGGGCGG
TGACGGACGAGCCCCTCCTCTTCCTCACGGGGGACTTCGTCTTCGTGGGGGACGTGGGCCGGCCGGACCTTTTGGAAGAG
GCGGCGGGGATCAAGGGCACGGCGGAGCCCGGGGCGAGGCGGATGTTTAGGAGCCTCAAGGAAAAGTTCCTCACCCTTCC
CGACCACGTCCAGGTCTGGCCCGGCCACGGGGCGGGCTCCGCCTGCGGCAAGGCGCTTGGGGCCCTCCCGGCCACCACCG
TGGGGTACGAACGCCGCCACGCCTGGTGGGCGGAGTACCTGGAGCGGGACGACGAGGAGGGGTTCGTGAAGGCCCTCCTC
CAGGGCCAGCCCGAGGCCCCCACCTACTTCAAGGAGATGAAGCGGCTGAACCGGGACGGGATGGCCATCCTGGGCGGCCT
TCCCCACCCGGGCCGCCTCACCCCGGCCCAGTTTGAGCGCTGGCTGAGGGAGGGGGCCATCCTCGTGGACACCCGGGACA
AGTTCGCCTTCGCCGGCGGGCACATCCCGGGGAGCATCAACATCCCCGCGGGGAAGAACTTCTCCACCTGGGCGGGCTGG
CTCCTCCCCTACGACCGCCCCCTCGTCCTCCTCGCCCGGCCCGAGGAGGTGGAGGCCCTCACCCGGGCCCTCGTCCGCAT
CGGCCTGGACGAGGTGGTGGGGTACATCCCGGGGCTGGAGGGCTACGCCCAGGGCGAGCTGGAAACCGTCCCCCAGGTCA
CCGCCAAGGAGGCCAAGGAGCTCTGGGAGAAGGGGAAGGCCTTCGTCCTGGACGTGCGCGGGCGGGACGAGTACCTCGCG
GGGCACATCCCCGGGGCCCAAAACATCCACGCGGGCCGCGTCCTCGCCCACCTGGACCGGCTCCCCAAGGACAGGCCCCT
CATCGTCCACTGCGTGGGCGGGGACCGCTCCAGCACCGCCATCAGCGCCCTACTGGCCCACGGTTTTAGAAACGCCCTGA
ACCTCACCGGGGGGATCAAGGCTTGGCGGGAGGCGGGCTTCCCCGTGGTGCAGGGCGAGGAACTGGTGCAGGCCTAA

Upstream 100 bases:

>100_bases
AAAGAGCGCACTTTCACGTTCCCGCGGCTTGACACCATTACCCCCCATGGGTATACTCTGCCCCGAGGAGGGACAAAGGT
CCCTCACCGGAGGTGAAGCC

Downstream 100 bases:

>100_bases
GCGAGCCCACCCCGGCCTGGGCCGGGGTGGGCCGCCCAGACCCCAAGGAGGTTTTCCATGTACGAGACCCAGGTGCAAGA
ACTTTCCCCCGAAGAGGCCA

Product: metallo-beta-lactamase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MIFRQIHEEGLAQMSYLLGCAATGEALVVDPRRDVDVYLELAQSLGLRITAIAETHIHADYLSGARELARATGATLYLSD
EGDENWKYKGLEGFPHVLLKDGDEFKVGNIRVRAVHTPGHTPEHLSFLVADGAVTDEPLLFLTGDFVFVGDVGRPDLLEE
AAGIKGTAEPGARRMFRSLKEKFLTLPDHVQVWPGHGAGSACGKALGALPATTVGYERRHAWWAEYLERDDEEGFVKALL
QGQPEAPTYFKEMKRLNRDGMAILGGLPHPGRLTPAQFERWLREGAILVDTRDKFAFAGGHIPGSINIPAGKNFSTWAGW
LLPYDRPLVLLARPEEVEALTRALVRIGLDEVVGYIPGLEGYAQGELETVPQVTAKEAKELWEKGKAFVLDVRGRDEYLA
GHIPGAQNIHAGRVLAHLDRLPKDRPLIVHCVGGDRSSTAISALLAHGFRNALNLTGGIKAWREAGFPVVQGEELVQA

Sequences:

>Translated_478_residues
MIFRQIHEEGLAQMSYLLGCAATGEALVVDPRRDVDVYLELAQSLGLRITAIAETHIHADYLSGARELARATGATLYLSD
EGDENWKYKGLEGFPHVLLKDGDEFKVGNIRVRAVHTPGHTPEHLSFLVADGAVTDEPLLFLTGDFVFVGDVGRPDLLEE
AAGIKGTAEPGARRMFRSLKEKFLTLPDHVQVWPGHGAGSACGKALGALPATTVGYERRHAWWAEYLERDDEEGFVKALL
QGQPEAPTYFKEMKRLNRDGMAILGGLPHPGRLTPAQFERWLREGAILVDTRDKFAFAGGHIPGSINIPAGKNFSTWAGW
LLPYDRPLVLLARPEEVEALTRALVRIGLDEVVGYIPGLEGYAQGELETVPQVTAKEAKELWEKGKAFVLDVRGRDEYLA
GHIPGAQNIHAGRVLAHLDRLPKDRPLIVHCVGGDRSSTAISALLAHGFRNALNLTGGIKAWREAGFPVVQGEELVQA
>Mature_478_residues
MIFRQIHEEGLAQMSYLLGCAATGEALVVDPRRDVDVYLELAQSLGLRITAIAETHIHADYLSGARELARATGATLYLSD
EGDENWKYKGLEGFPHVLLKDGDEFKVGNIRVRAVHTPGHTPEHLSFLVADGAVTDEPLLFLTGDFVFVGDVGRPDLLEE
AAGIKGTAEPGARRMFRSLKEKFLTLPDHVQVWPGHGAGSACGKALGALPATTVGYERRHAWWAEYLERDDEEGFVKALL
QGQPEAPTYFKEMKRLNRDGMAILGGLPHPGRLTPAQFERWLREGAILVDTRDKFAFAGGHIPGSINIPAGKNFSTWAGW
LLPYDRPLVLLARPEEVEALTRALVRIGLDEVVGYIPGLEGYAQGELETVPQVTAKEAKELWEKGKAFVLDVRGRDEYLA
GHIPGAQNIHAGRVLAHLDRLPKDRPLIVHCVGGDRSSTAISALLAHGFRNALNLTGGIKAWREAGFPVVQGEELVQA

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=204, Percent_Identity=26.4705882352941, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI21703352, Length=211, Percent_Identity=29.3838862559242, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI116642887, Length=211, Percent_Identity=29.3838862559242, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI46361987, Length=178, Percent_Identity=33.1460674157303, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI14150041, Length=185, Percent_Identity=32.972972972973, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1787158, Length=232, Percent_Identity=31.0344827586207, Blast_Score=99, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17538952, Length=199, Percent_Identity=28.1407035175879, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI221330176, Length=201, Percent_Identity=25.8706467661692, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR001763 [H]

Pfam domain/function: PF00753 Lactamase_B; PF00581 Rhodanese [H]

EC number: NA

Molecular weight: Translated: 52293; Mature: 52293

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00380 RHODANESE_1 ; PS50206 RHODANESE_3 ; PS00383 TYR_PHOSPHATASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFRQIHEEGLAQMSYLLGCAATGEALVVDPRRDVDVYLELAQSLGLRITAIAETHIHAD
CCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCEEEEEEHHHHHHH
YLSGARELARATGATLYLSDEGDENWKYKGLEGFPHVLLKDGDEFKVGNIRVRAVHTPGH
HHHHHHHHHHHCCCEEEEECCCCCCCEECCCCCCCEEEECCCCCEEECCEEEEEEECCCC
TPEHLSFLVADGAVTDEPLLFLTGDFVFVGDVGRPDLLEEAAGIKGTAEPGARRMFRSLK
CHHHHEEEEECCCCCCCCEEEEECCEEEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHH
EKFLTLPDHVQVWPGHGAGSACGKALGALPATTVGYERRHAWWAEYLERDDEEGFVKALL
HHHCCCCCCEEEECCCCCCHHHHHHHHCCCCHHCCCHHHHHHHHHHHHCCCCHHHHHHHH
QGQPEAPTYFKEMKRLNRDGMAILGGLPHPGRLTPAQFERWLREGAILVDTRDKFAFAGG
CCCCCCCHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHCCCEEEECCCCEEEECC
HIPGSINIPAGKNFSTWAGWLLPYDRPLVLLARPEEVEALTRALVRIGLDEVVGYIPGLE
CCCCEEECCCCCCCCCCEEEECCCCCCEEEEECCHHHHHHHHHHHHHCHHHHHHHCCCCC
GYAQGELETVPQVTAKEAKELWEKGKAFVLDVRGRDEYLAGHIPGAQNIHAGRVLAHLDR
CCCCCCHHHCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHH
LPKDRPLIVHCVGGDRSSTAISALLAHGFRNALNLTGGIKAWREAGFPVVQGEELVQA
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEECCHHHHCC
>Mature Secondary Structure
MIFRQIHEEGLAQMSYLLGCAATGEALVVDPRRDVDVYLELAQSLGLRITAIAETHIHAD
CCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCEEEEEEHHHHHHH
YLSGARELARATGATLYLSDEGDENWKYKGLEGFPHVLLKDGDEFKVGNIRVRAVHTPGH
HHHHHHHHHHHCCCEEEEECCCCCCCEECCCCCCCEEEECCCCCEEECCEEEEEEECCCC
TPEHLSFLVADGAVTDEPLLFLTGDFVFVGDVGRPDLLEEAAGIKGTAEPGARRMFRSLK
CHHHHEEEEECCCCCCCCEEEEECCEEEEECCCCCHHHHHHCCCCCCCCHHHHHHHHHHH
EKFLTLPDHVQVWPGHGAGSACGKALGALPATTVGYERRHAWWAEYLERDDEEGFVKALL
HHHCCCCCCEEEECCCCCCHHHHHHHHCCCCHHCCCHHHHHHHHHHHHCCCCHHHHHHHH
QGQPEAPTYFKEMKRLNRDGMAILGGLPHPGRLTPAQFERWLREGAILVDTRDKFAFAGG
CCCCCCCHHHHHHHHHCCCCCEEECCCCCCCCCCHHHHHHHHHCCCEEEECCCCEEEECC
HIPGSINIPAGKNFSTWAGWLLPYDRPLVLLARPEEVEALTRALVRIGLDEVVGYIPGLE
CCCCEEECCCCCCCCCCEEEECCCCCCEEEEECCHHHHHHHHHHHHHCHHHHHHHCCCCC
GYAQGELETVPQVTAKEAKELWEKGKAFVLDVRGRDEYLAGHIPGAQNIHAGRVLAHLDR
CCCCCCHHHCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCCCCHHHHHHHHHHH
LPKDRPLIVHCVGGDRSSTAISALLAHGFRNALNLTGGIKAWREAGFPVVQGEELVQA
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]