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The map label for this gene is ppiB [H]

Identifier: 54295565

GI number: 54295565

Start: 3023339

End: 3023833

Strand: Reverse

Name: ppiB [H]

Synonym: lpl2652

Alternate gene names: 54295565

Gene position: 3023833-3023339 (Counterclockwise)

Preceding gene: 54295566

Following gene: 54295563

Centisome position: 90.38

GC content: 38.79

Gene sequence:

>495_bases
ATGGTTTTAATTTCTACATCCATGGGTGATATTCATATCAAATTAGATACAGAAAATACCCCATTAACTGCAGAAAACTT
CCTAAATTATGTGCGTAAAGGTTTTTATAATGACACGATTTTTCATCGTGTTATCGATGGTTTTATGATTCAAGGCGGCG
GTTTGAATACAAATATGGAGCAAAAAACAACTGCCTCTCCAATTCAAAATGAAGCAAAAGGAGCGAAACCTAACAAACGT
GGAACCATCGCAATGGCGAGGACAATGGATCCCCATTCTGCAACAGCCCAATTTTTTATTAATGTTGCGGATAATGGTTT
TCTGAATTACAGTGGCGACCATCCTCAAGGTTACGGTTACTGCGTATTTGGGGAAGTAGTTGAAGGGATGGATGTGGTTG
ATGCTATTGCTAAAGTGAAAACAGGCCAACGAAATGGTCATGCAGATGTTCCTGTAGAAGAAATAAGCATCATTGAAGTT
AGGGAATTGGCTTAG

Upstream 100 bases:

>100_bases
TGGCAAGCATCCATAATGTTCATGTTTTGCATGATGTTTGTAATCACATGCGTCATTTGATAATAAATTCCTAAATTATT
TAATATTAAGAGGTGAAATA

Downstream 100 bases:

>100_bases
CGAGAAAATACATGGCTGAAATAGCATAGGTTTTCCATGCCAAAAGTATATTTTCTTTAATTTCATCCCCAGTATGGAAG
AGGGATCTTCCTTATACATG

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MVLISTSMGDIHIKLDTENTPLTAENFLNYVRKGFYNDTIFHRVIDGFMIQGGGLNTNMEQKTTASPIQNEAKGAKPNKR
GTIAMARTMDPHSATAQFFINVADNGFLNYSGDHPQGYGYCVFGEVVEGMDVVDAIAKVKTGQRNGHADVPVEEISIIEV
RELA

Sequences:

>Translated_164_residues
MVLISTSMGDIHIKLDTENTPLTAENFLNYVRKGFYNDTIFHRVIDGFMIQGGGLNTNMEQKTTASPIQNEAKGAKPNKR
GTIAMARTMDPHSATAQFFINVADNGFLNYSGDHPQGYGYCVFGEVVEGMDVVDAIAKVKTGQRNGHADVPVEEISIIEV
RELA
>Mature_164_residues
MVLISTSMGDIHIKLDTENTPLTAENFLNYVRKGFYNDTIFHRVIDGFMIQGGGLNTNMEQKTTASPIQNEAKGAKPNKR
GTIAMARTMDPHSATAQFFINVADNGFLNYSGDHPQGYGYCVFGEVVEGMDVVDAIAKVKTGQRNGHADVPVEEISIIEV
RELA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI24308049, Length=161, Percent_Identity=37.2670807453416, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI19557636, Length=166, Percent_Identity=32.5301204819277, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI7706339, Length=163, Percent_Identity=32.5153374233129, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI22547212, Length=162, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI7657473, Length=162, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI22547215, Length=162, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI310129267, Length=148, Percent_Identity=35.8108108108108, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310120620, Length=148, Percent_Identity=35.8108108108108, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI10863927, Length=162, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI310110104, Length=148, Percent_Identity=35.1351351351351, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI64276486, Length=130, Percent_Identity=32.3076923076923, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1786736, Length=160, Percent_Identity=61.25, Blast_Score=200, Evalue=5e-53,
Organism=Escherichia coli, GI1789763, Length=163, Percent_Identity=52.760736196319, Blast_Score=171, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17506311, Length=164, Percent_Identity=35.3658536585366, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=32.1917808219178, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=32.1917808219178, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539496, Length=165, Percent_Identity=32.1212121212121, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532641, Length=163, Percent_Identity=27.6073619631902, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320510, Length=164, Percent_Identity=35.9756097560976, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323562, Length=157, Percent_Identity=35.031847133758, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17986117, Length=164, Percent_Identity=33.5365853658537, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922912, Length=162, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19922376, Length=168, Percent_Identity=27.9761904761905, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24652460, Length=161, Percent_Identity=29.8136645962733, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17969; Mature: 17969

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLISTSMGDIHIKLDTENTPLTAENFLNYVRKGFYNDTIFHRVIDGFMIQGGGLNTNME
CEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCEEEECCCCCCCCC
QKTTASPIQNEAKGAKPNKRGTIAMARTMDPHSATAQFFINVADNGFLNYSGDHPQGYGY
CCCCCCCCHHHHCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCEEECCCCCCCCCEE
CVFGEVVEGMDVVDAIAKVKTGQRNGHADVPVEEISIIEVRELA
EEHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHEEEEEEEECC
>Mature Secondary Structure
MVLISTSMGDIHIKLDTENTPLTAENFLNYVRKGFYNDTIFHRVIDGFMIQGGGLNTNME
CEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCEEEECCCCCCCCC
QKTTASPIQNEAKGAKPNKRGTIAMARTMDPHSATAQFFINVADNGFLNYSGDHPQGYGY
CCCCCCCCHHHHCCCCCCCCCEEEEEEECCCCCCEEEEEEEECCCCEEECCCCCCCCCEE
CVFGEVVEGMDVVDAIAKVKTGQRNGHADVPVEEISIIEVRELA
EEHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]