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The map label for this gene is murC [H]

Identifier: 54295451

GI number: 54295451

Start: 2894078

End: 2895487

Strand: Reverse

Name: murC [H]

Synonym: lpl2537

Alternate gene names: 54295451

Gene position: 2895487-2894078 (Counterclockwise)

Preceding gene: 54295452

Following gene: 54295450

Centisome position: 86.54

GC content: 42.34

Gene sequence:

>1410_bases
TTGAATAACTCAGAGCAATTTTTATCTCCGCGCATGGGGCGTGTAGAGCAAATTCATTTTGTTGGTATTGGTGGTGCCGG
TATGTGTGGTATTGCCGAAGTATTGCATAACCAGGGCTACCGTATTACTGGTTCGGATCTCGGAGAAAGTGGCACGGTAC
AACGCTTAAGGTCATTAGGTATTCAAGTCTATATCGGTCACAGGCTGGAAAACATTAAAGGCGCTGATGTTGTAGTAAGG
TCTTCGGCTGTTGATTTTAATAATCCCGAAATTGTGGCTGCTCGCGAGTTAATGATTCCAGTTATTCCCAGAGCAGCTAT
GCTTGCTGAGCTAATGCGATTTAGGCATGGTATAGCAATTGCTGGCACTCATGGCAAAACGACAACAACGAGCTTGGTCA
GTAGTTTGCTTGCTGAAGGTGGTTTGGATCCCAGTTTTGTTATTGGCGGAAAGCTGAATAGTTGTGGTGCGAATGCTCAG
CTTGGAAAGTCAGCTTATTTTGTTGTAGAGGCTGATGAGAGCGACGCCTCGTTTTTGTTTTTGAAGCCTATGATGGCGGT
AGTGACTAATATTGATGCTGATCACATGGATACTTATGAAGGTGATTTTGAAAAATTAAGAACAACATTTTTGGAATTTT
TGCATCATTTGCCTTTTTATGGATTAGCAGTAGTTTGTTTGGAAGATGAAGAAATTTGCCGTATCCTCCCGGCTATTCAA
AGACCAACCTTAACTTATGGGTTTAAAGAAGAGGCTCATTATCGGGCAATTAATTGGACTCAAAAGGGCATGCTGAGTGA
GTTTGTGGTCGTTCGACCTGCACCACATAAACAACTGACTATACAATTCCAGTATCCAGGCCGTCACAATGTATTAAATG
CATTAGCTTCTATAGCAATTGCCACCGAGTTAGGAGTTGATGACGATTCCATTGTTCGTGGCTTACAAAAATTCCAAGGA
GTGGGACGCCGCTTTCAAATGCTTGGTGAAAAACAGTTCGAAAAAGGCGCGGCAATTATTGTGGATGATTATGGACATCA
TCCACAGGAAATTTTATCCACAATTGATGCTTTTAGACGTGTTTGGCCCGAGAGACGTTTGGTTCATGTCTTTCAACCCC
ATCGTTATACCAGAACACAGTCCTTGCATAGACAATTTGTCGATGCTTTAAGTTTATCGGATGAACTGTTATTGATGGAT
ATCTATGCAGCGGGAGAAACAGCTATTCCAGGCGTTACCAGTGAAAATCTGGCCAATGAAATACGATCCAGGGATAAACG
AGTGACCATAGTGAGCGAGCAATCGTTGAAAGCCACCTTAGATGAATTTATTAAAGATGGTGATGTTATTTTGATGCAGG
GAGCTGGAAGTATCGGCCAAATGGCAGTGAACCTGATGAAAAACATGTGA

Upstream 100 bases:

>100_bases
GGTAATTAATTGTATCGTTATTGCACTATTATTGCGCATAGATCATGAAAATCGTTGGCAGTCTCTTGGGTTGAGACCGC
TAACGGCTTAAGGGGGAATA

Downstream 100 bases:

>100_bases
GAACGAACATGAGCATAACGGGAATAGACAGCAGTCATGTAACAGAGTCTCAGGGCACTTTGCTTTTCAATGAGCCTTTG
GCCGAGTATACTACCTGGCG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MNNSEQFLSPRMGRVEQIHFVGIGGAGMCGIAEVLHNQGYRITGSDLGESGTVQRLRSLGIQVYIGHRLENIKGADVVVR
SSAVDFNNPEIVAARELMIPVIPRAAMLAELMRFRHGIAIAGTHGKTTTTSLVSSLLAEGGLDPSFVIGGKLNSCGANAQ
LGKSAYFVVEADESDASFLFLKPMMAVVTNIDADHMDTYEGDFEKLRTTFLEFLHHLPFYGLAVVCLEDEEICRILPAIQ
RPTLTYGFKEEAHYRAINWTQKGMLSEFVVVRPAPHKQLTIQFQYPGRHNVLNALASIAIATELGVDDDSIVRGLQKFQG
VGRRFQMLGEKQFEKGAAIIVDDYGHHPQEILSTIDAFRRVWPERRLVHVFQPHRYTRTQSLHRQFVDALSLSDELLLMD
IYAAGETAIPGVTSENLANEIRSRDKRVTIVSEQSLKATLDEFIKDGDVILMQGAGSIGQMAVNLMKNM

Sequences:

>Translated_469_residues
MNNSEQFLSPRMGRVEQIHFVGIGGAGMCGIAEVLHNQGYRITGSDLGESGTVQRLRSLGIQVYIGHRLENIKGADVVVR
SSAVDFNNPEIVAARELMIPVIPRAAMLAELMRFRHGIAIAGTHGKTTTTSLVSSLLAEGGLDPSFVIGGKLNSCGANAQ
LGKSAYFVVEADESDASFLFLKPMMAVVTNIDADHMDTYEGDFEKLRTTFLEFLHHLPFYGLAVVCLEDEEICRILPAIQ
RPTLTYGFKEEAHYRAINWTQKGMLSEFVVVRPAPHKQLTIQFQYPGRHNVLNALASIAIATELGVDDDSIVRGLQKFQG
VGRRFQMLGEKQFEKGAAIIVDDYGHHPQEILSTIDAFRRVWPERRLVHVFQPHRYTRTQSLHRQFVDALSLSDELLLMD
IYAAGETAIPGVTSENLANEIRSRDKRVTIVSEQSLKATLDEFIKDGDVILMQGAGSIGQMAVNLMKNM
>Mature_469_residues
MNNSEQFLSPRMGRVEQIHFVGIGGAGMCGIAEVLHNQGYRITGSDLGESGTVQRLRSLGIQVYIGHRLENIKGADVVVR
SSAVDFNNPEIVAARELMIPVIPRAAMLAELMRFRHGIAIAGTHGKTTTTSLVSSLLAEGGLDPSFVIGGKLNSCGANAQ
LGKSAYFVVEADESDASFLFLKPMMAVVTNIDADHMDTYEGDFEKLRTTFLEFLHHLPFYGLAVVCLEDEEICRILPAIQ
RPTLTYGFKEEAHYRAINWTQKGMLSEFVVVRPAPHKQLTIQFQYPGRHNVLNALASIAIATELGVDDDSIVRGLQKFQG
VGRRFQMLGEKQFEKGAAIIVDDYGHHPQEILSTIDAFRRVWPERRLVHVFQPHRYTRTQSLHRQFVDALSLSDELLLMD
IYAAGETAIPGVTSENLANEIRSRDKRVTIVSEQSLKATLDEFIKDGDVILMQGAGSIGQMAVNLMKNM

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=463, Percent_Identity=53.7796976241901, Blast_Score=445, Evalue=1e-126,
Organism=Escherichia coli, GI1790680, Length=395, Percent_Identity=28.6075949367089, Blast_Score=145, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 51955; Mature: 51955

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNSEQFLSPRMGRVEQIHFVGIGGAGMCGIAEVLHNQGYRITGSDLGESGTVQRLRSLG
CCCCHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCC
IQVYIGHRLENIKGADVVVRSSAVDFNNPEIVAARELMIPVIPRAAMLAELMRFRHGIAI
EEEEECCHHCCCCCCCEEEEECCCCCCCCCEEEEHHHHHHCCCHHHHHHHHHHHHCCEEE
AGTHGKTTTTSLVSSLLAEGGLDPSFVIGGKLNSCGANAQLGKSAYFVVEADESDASFLF
EECCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCEEH
LKPMMAVVTNIDADHMDTYEGDFEKLRTTFLEFLHHLPFYGLAVVCLEDEEICRILPAIQ
HHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHC
RPTLTYGFKEEAHYRAINWTQKGMLSEFVVVRPAPHKQLTIQFQYPGRHNVLNALASIAI
CCCEEECCCCCCCEEEECCHHHCCHHCEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHH
ATELGVDDDSIVRGLQKFQGVGRRFQMLGEKQFEKGAAIIVDDYGHHPQEILSTIDAFRR
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHH
VWPERRLVHVFQPHRYTRTQSLHRQFVDALSLSDELLLMDIYAAGETAIPGVTSENLANE
HCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHH
IRSRDKRVTIVSEQSLKATLDEFIKDGDVILMQGAGSIGQMAVNLMKNM
HHCCCCEEEEEECHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNNSEQFLSPRMGRVEQIHFVGIGGAGMCGIAEVLHNQGYRITGSDLGESGTVQRLRSLG
CCCCHHHHCCCCCCEEEEEEEEECCCCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCC
IQVYIGHRLENIKGADVVVRSSAVDFNNPEIVAARELMIPVIPRAAMLAELMRFRHGIAI
EEEEECCHHCCCCCCCEEEEECCCCCCCCCEEEEHHHHHHCCCHHHHHHHHHHHHCCEEE
AGTHGKTTTTSLVSSLLAEGGLDPSFVIGGKLNSCGANAQLGKSAYFVVEADESDASFLF
EECCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCEEH
LKPMMAVVTNIDADHMDTYEGDFEKLRTTFLEFLHHLPFYGLAVVCLEDEEICRILPAIQ
HHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHC
RPTLTYGFKEEAHYRAINWTQKGMLSEFVVVRPAPHKQLTIQFQYPGRHNVLNALASIAI
CCCEEECCCCCCCEEEECCHHHCCHHCEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHH
ATELGVDDDSIVRGLQKFQGVGRRFQMLGEKQFEKGAAIIVDDYGHHPQEILSTIDAFRR
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHH
VWPERRLVHVFQPHRYTRTQSLHRQFVDALSLSDELLLMDIYAAGETAIPGVTSENLANE
HCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHH
IRSRDKRVTIVSEQSLKATLDEFIKDGDVILMQGAGSIGQMAVNLMKNM
HHCCCCEEEEEECHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA