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The map label for this gene is pdhB [H]

Identifier: 54295417

GI number: 54295417

Start: 2853433

End: 2855670

Strand: Reverse

Name: pdhB [H]

Synonym: lpl2503

Alternate gene names: 54295417

Gene position: 2855670-2853433 (Counterclockwise)

Preceding gene: 54295425

Following gene: 54295416

Centisome position: 85.35

GC content: 42.67

Gene sequence:

>2238_bases
ATGTTAGATAGAGCAAGTTTAGTGGATGAACAATTTCTGAAAAGAGTGTTGCAAGGGGATTTCCCACAATTAAGAAGCAG
CATGAGCCCCGATACAGCAGAGTTGGACAAGAAAACTGCTATAGAATTTTTTGACTCACAAATTAAATCCCGGCTTCTTG
ATATTATTGCGAGACAATTAAAGGAAAAAGGCCTCTCTTTTTATACGATAGGAAGTAGTGGTCATGAAGGCAATGCGGTC
TTGGGTCAGGTTTTTAGAGCGAGTGATATGGCGTTTTTGCACTATCGCAGCGGTGCCTTTTTCTTGCAACGAGCAAAGCA
GTTACCTGGAATCGATGGAGTAAAGGATATTTTATTGTCATTAGTGGCTGCGGCAAGTGATCCTATCTCAGGGGGCAGGC
ATAAAGTCTTTGGCAGCGTCCCTTTAAATATCCCGCCGCAAACGTCGACTATCGCATCTCATTTACCAAAAGCTTTAGGT
GCTGCTTTATCAATTACCCGGGCGAGAGAGTTAGGATTGCCAAGTAAACTGACGCCTGACTCCGTGATACTTTGTTCCTT
TGGTGATGCTTCAACCAACCATGCAACGAGCCAAGCCACATTGAATGCTTGCTCTTGGATAACCCAGCAAAATTATCCGC
TACCGATTGTGTTCATTTGTGAAGATAATGGAATCGGTATTTCAGTACCTACTCCATCCAGTTGGATTAAGTCATCCGTC
TCCTCTCGTCCAGGAATCCATTACATTGAGTGTGATGGATTAAATATTGCTGATGTTTTTGCCAAAGCGCAGGAAGCGGA
CTATTTGGCAAGAGTAAAAAAACAACCCGTGTTCTTGCATATGCGTTGTGTCCGTTTGTTGGGCCATGCCGGTTCTGATA
TTGAATCGCAATACAACACTCAGGAAGAAATTGAGCAACGAGAAGCAAACGACCCTTTATTGCATACAGCAGGAATTTTG
TACAGAGAGGGTTGGATGAGTTTGCAGGCAATGGTTGAGCTTTATCAGGACAATCGGGCTTTAATTGAAGCAAAAGCCCT
GGAGGCAATCAGAGAACCCAGAATGAGTTCTGCTGAAGAAATAATGGCTTCAATTGTCCCACGAATTGATAAAAAGCAAA
AATACTCATTGCCAGATGATAATAGACGAGCGCAAGTATTTGCCGGAGCTTATAATCAACTCACCCTAAAGCGTAATTTA
TGCCAGCAGATCAATTTTGCTTTGACCGATCTGATGATGCAGTATCCTAATATGTTGATTTTTGGAGAAGACGTAGGAAA
GAAAGGTGGAGTTTATCGAGTTACAGCTGATTTGCAGGCTCGTTTTGGGCAACGCAGGGTTTTTGATACCCTTCTCGATG
AAACGACCATTATAGGTACTGCTATTGGTTTGGCACATAATGGCTTTATTCCTGTTCCGGAAATTCAGTTCTTAGCTTAT
CTGCATAATGCCGAAGATCAATTACGTGGAGAAGCATCCACTTTATCTTTTTTTTCAAGTGGCCAATATCAAAACCCTAT
GGTACTTCGAATCGCCTCTCTTGCTTATCAGAAGGGATTTGGCGGTCATTTTCATAACGATAATTCGATAGCCGTTTTAC
GCGATTTGCCAGGGGTTATAGTGGCTTGCCCCTCTAATGGCCCGGACGCAGCAAAAATGTTGAGAACATGTATGCGCCTT
GCCTATGAGGAAGGGCGGGTTGTCGTGTTTTTAGAACCCATCGCCCTCTACATGACCAAGGATTTGTATAGACCGGGAGA
TAATGGGTGGTTATTTGAATACCCGTCACCTGATGGAATGATTTCTCAAGGAGAGGTTGGAGTATATGGGGAGGGGGATA
CTGTTATTTTAACATATGCCAATGGATATTATTTATCTCGCCAGGCGGAAAAGGTCTTGCGTCAAGCACATAATATTTCT
GTTAAGATCATTGATTTGCGCTGGCTCAGCCCCTTGCCAAAAGACGCCATTTTAAAAGAAATTGCCAAAGCAAAACGTAT
TTTAATTGTTGATGAGGGTAGACAAAGCGGCTCAATTAGTGAAGGATTGATGACATTATTGATGGAAGAGGCTTCGCCAC
GGTTAAAAATAAAGCGGATTACGGGCAAAGATTGCTTCATACCATTAGGAACTGCTTGGCAGTATTTATTGCCAAGTCAG
GAAAGTATTATAGACGCGGTAATCGCATTACAGTCAGATAAAAGGGAGAAGGAAAGTGGACGACTTGTTGTTTCTTGA

Upstream 100 bases:

>100_bases
AAAGGATACCAGGCATGGATATAAGAGTAATCATTACACAAAATGTAATTGAAATAGCCTTATTCATCTGGTCATTGCGC
AATTTAAACAGGGTGTGGTG

Downstream 100 bases:

>100_bases
TGAACAATTACATGATGACGAGCGCATGATACGAGATAGTGTGTCTCGTTTTGTTAGCAATGACGTAATACCTTTAATGG
CTGAATCTTATGAACATGCC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 745; Mature: 745

Protein sequence:

>745_residues
MLDRASLVDEQFLKRVLQGDFPQLRSSMSPDTAELDKKTAIEFFDSQIKSRLLDIIARQLKEKGLSFYTIGSSGHEGNAV
LGQVFRASDMAFLHYRSGAFFLQRAKQLPGIDGVKDILLSLVAAASDPISGGRHKVFGSVPLNIPPQTSTIASHLPKALG
AALSITRARELGLPSKLTPDSVILCSFGDASTNHATSQATLNACSWITQQNYPLPIVFICEDNGIGISVPTPSSWIKSSV
SSRPGIHYIECDGLNIADVFAKAQEADYLARVKKQPVFLHMRCVRLLGHAGSDIESQYNTQEEIEQREANDPLLHTAGIL
YREGWMSLQAMVELYQDNRALIEAKALEAIREPRMSSAEEIMASIVPRIDKKQKYSLPDDNRRAQVFAGAYNQLTLKRNL
CQQINFALTDLMMQYPNMLIFGEDVGKKGGVYRVTADLQARFGQRRVFDTLLDETTIIGTAIGLAHNGFIPVPEIQFLAY
LHNAEDQLRGEASTLSFFSSGQYQNPMVLRIASLAYQKGFGGHFHNDNSIAVLRDLPGVIVACPSNGPDAAKMLRTCMRL
AYEEGRVVVFLEPIALYMTKDLYRPGDNGWLFEYPSPDGMISQGEVGVYGEGDTVILTYANGYYLSRQAEKVLRQAHNIS
VKIIDLRWLSPLPKDAILKEIAKAKRILIVDEGRQSGSISEGLMTLLMEEASPRLKIKRITGKDCFIPLGTAWQYLLPSQ
ESIIDAVIALQSDKREKESGRLVVS

Sequences:

>Translated_745_residues
MLDRASLVDEQFLKRVLQGDFPQLRSSMSPDTAELDKKTAIEFFDSQIKSRLLDIIARQLKEKGLSFYTIGSSGHEGNAV
LGQVFRASDMAFLHYRSGAFFLQRAKQLPGIDGVKDILLSLVAAASDPISGGRHKVFGSVPLNIPPQTSTIASHLPKALG
AALSITRARELGLPSKLTPDSVILCSFGDASTNHATSQATLNACSWITQQNYPLPIVFICEDNGIGISVPTPSSWIKSSV
SSRPGIHYIECDGLNIADVFAKAQEADYLARVKKQPVFLHMRCVRLLGHAGSDIESQYNTQEEIEQREANDPLLHTAGIL
YREGWMSLQAMVELYQDNRALIEAKALEAIREPRMSSAEEIMASIVPRIDKKQKYSLPDDNRRAQVFAGAYNQLTLKRNL
CQQINFALTDLMMQYPNMLIFGEDVGKKGGVYRVTADLQARFGQRRVFDTLLDETTIIGTAIGLAHNGFIPVPEIQFLAY
LHNAEDQLRGEASTLSFFSSGQYQNPMVLRIASLAYQKGFGGHFHNDNSIAVLRDLPGVIVACPSNGPDAAKMLRTCMRL
AYEEGRVVVFLEPIALYMTKDLYRPGDNGWLFEYPSPDGMISQGEVGVYGEGDTVILTYANGYYLSRQAEKVLRQAHNIS
VKIIDLRWLSPLPKDAILKEIAKAKRILIVDEGRQSGSISEGLMTLLMEEASPRLKIKRITGKDCFIPLGTAWQYLLPSQ
ESIIDAVIALQSDKREKESGRLVVS
>Mature_745_residues
MLDRASLVDEQFLKRVLQGDFPQLRSSMSPDTAELDKKTAIEFFDSQIKSRLLDIIARQLKEKGLSFYTIGSSGHEGNAV
LGQVFRASDMAFLHYRSGAFFLQRAKQLPGIDGVKDILLSLVAAASDPISGGRHKVFGSVPLNIPPQTSTIASHLPKALG
AALSITRARELGLPSKLTPDSVILCSFGDASTNHATSQATLNACSWITQQNYPLPIVFICEDNGIGISVPTPSSWIKSSV
SSRPGIHYIECDGLNIADVFAKAQEADYLARVKKQPVFLHMRCVRLLGHAGSDIESQYNTQEEIEQREANDPLLHTAGIL
YREGWMSLQAMVELYQDNRALIEAKALEAIREPRMSSAEEIMASIVPRIDKKQKYSLPDDNRRAQVFAGAYNQLTLKRNL
CQQINFALTDLMMQYPNMLIFGEDVGKKGGVYRVTADLQARFGQRRVFDTLLDETTIIGTAIGLAHNGFIPVPEIQFLAY
LHNAEDQLRGEASTLSFFSSGQYQNPMVLRIASLAYQKGFGGHFHNDNSIAVLRDLPGVIVACPSNGPDAAKMLRTCMRL
AYEEGRVVVFLEPIALYMTKDLYRPGDNGWLFEYPSPDGMISQGEVGVYGEGDTVILTYANGYYLSRQAEKVLRQAHNIS
VKIIDLRWLSPLPKDAILKEIAKAKRILIVDEGRQSGSISEGLMTLLMEEASPRLKIKRITGKDCFIPLGTAWQYLLPSQ
ESIIDAVIALQSDKREKESGRLVVS

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=320, Percent_Identity=31.5625, Blast_Score=133, Evalue=6e-31,
Organism=Homo sapiens, GI34101272, Length=320, Percent_Identity=31.5625, Blast_Score=133, Evalue=6e-31,
Organism=Homo sapiens, GI156564403, Length=336, Percent_Identity=23.5119047619048, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI258645172, Length=328, Percent_Identity=22.2560975609756, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI11386135, Length=329, Percent_Identity=22.1884498480243, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI291084858, Length=338, Percent_Identity=22.189349112426, Blast_Score=75, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17506935, Length=344, Percent_Identity=28.1976744186047, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17538422, Length=354, Percent_Identity=27.1186440677966, Blast_Score=107, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI86563355, Length=324, Percent_Identity=22.8395061728395, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI86563357, Length=324, Percent_Identity=22.8395061728395, Blast_Score=94, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319698, Length=335, Percent_Identity=27.7611940298507, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI160714832, Length=338, Percent_Identity=27.2189349112426, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI160714828, Length=338, Percent_Identity=27.2189349112426, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21358145, Length=356, Percent_Identity=24.7191011235955, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24650940, Length=356, Percent_Identity=24.7191011235955, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21355903, Length=322, Percent_Identity=21.4285714285714, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 82468; Mature: 82468

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDRASLVDEQFLKRVLQGDFPQLRSSMSPDTAELDKKTAIEFFDSQIKSRLLDIIARQL
CCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEKGLSFYTIGSSGHEGNAVLGQVFRASDMAFLHYRSGAFFLQRAKQLPGIDGVKDILLS
HHCCCEEEEECCCCCCCCHHHHHHHHHCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHH
LVAAASDPISGGRHKVFGSVPLNIPPQTSTIASHLPKALGAALSITRARELGLPSKLTPD
HHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SVILCSFGDASTNHATSQATLNACSWITQQNYPLPIVFICEDNGIGISVPTPSSWIKSSV
CEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEECCCCHHHHHHHH
SSRPGIHYIECDGLNIADVFAKAQEADYLARVKKQPVFLHMRCVRLLGHAGSDIESQYNT
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHCCC
QEEIEQREANDPLLHTAGILYREGWMSLQAMVELYQDNRALIEAKALEAIREPRMSSAEE
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHH
IMASIVPRIDKKQKYSLPDDNRRAQVFAGAYNQLTLKRNLCQQINFALTDLMMQYPNMLI
HHHHHHCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
FGEDVGKKGGVYRVTADLQARFGQRRVFDTLLDETTIIGTAIGLAHNGFIPVPEIQFLAY
EECCCCCCCCEEEEEEHHHHHHCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHH
LHNAEDQLRGEASTLSFFSSGQYQNPMVLRIASLAYQKGFGGHFHNDNSIAVLRDLPGVI
HHCCHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEE
VACPSNGPDAAKMLRTCMRLAYEEGRVVVFLEPIALYMTKDLYRPGDNGWLFEYPSPDGM
EECCCCCCHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCCCEEEECCCCCCC
ISQGEVGVYGEGDTVILTYANGYYLSRQAEKVLRQAHNISVKIIDLRWLSPLPKDAILKE
CCCCCEEEEECCCEEEEEECCCEEEHHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHHHH
IAKAKRILIVDEGRQSGSISEGLMTLLMEEASPRLKIKRITGKDCFIPLGTAWQYLLPSQ
HHHCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCHHHHHCCCH
ESIIDAVIALQSDKREKESGRLVVS
HHHHHHHHHHHCCCCHHHCCCEEEC
>Mature Secondary Structure
MLDRASLVDEQFLKRVLQGDFPQLRSSMSPDTAELDKKTAIEFFDSQIKSRLLDIIARQL
CCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEKGLSFYTIGSSGHEGNAVLGQVFRASDMAFLHYRSGAFFLQRAKQLPGIDGVKDILLS
HHCCCEEEEECCCCCCCCHHHHHHHHHCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHH
LVAAASDPISGGRHKVFGSVPLNIPPQTSTIASHLPKALGAALSITRARELGLPSKLTPD
HHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SVILCSFGDASTNHATSQATLNACSWITQQNYPLPIVFICEDNGIGISVPTPSSWIKSSV
CEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEECCCCHHHHHHHH
SSRPGIHYIECDGLNIADVFAKAQEADYLARVKKQPVFLHMRCVRLLGHAGSDIESQYNT
CCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHCCC
QEEIEQREANDPLLHTAGILYREGWMSLQAMVELYQDNRALIEAKALEAIREPRMSSAEE
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHH
IMASIVPRIDKKQKYSLPDDNRRAQVFAGAYNQLTLKRNLCQQINFALTDLMMQYPNMLI
HHHHHHCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
FGEDVGKKGGVYRVTADLQARFGQRRVFDTLLDETTIIGTAIGLAHNGFIPVPEIQFLAY
EECCCCCCCCEEEEEEHHHHHHCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHH
LHNAEDQLRGEASTLSFFSSGQYQNPMVLRIASLAYQKGFGGHFHNDNSIAVLRDLPGVI
HHCCHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEE
VACPSNGPDAAKMLRTCMRLAYEEGRVVVFLEPIALYMTKDLYRPGDNGWLFEYPSPDGM
EECCCCCCHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCCCEEEECCCCCCC
ISQGEVGVYGEGDTVILTYANGYYLSRQAEKVLRQAHNISVKIIDLRWLSPLPKDAILKE
CCCCCEEEEECCCEEEEEECCCEEEHHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHHHH
IAKAKRILIVDEGRQSGSISEGLMTLLMEEASPRLKIKRITGKDCFIPLGTAWQYLLPSQ
HHHCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCHHHHHCCCH
ESIIDAVIALQSDKREKESGRLVVS
HHHHHHHHHHHCCCCHHHCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1735725 [H]