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The map label for this gene is gcdH [H]

Identifier: 54295416

GI number: 54295416

Start: 2852298

End: 2853455

Strand: Reverse

Name: gcdH [H]

Synonym: lpl2502

Alternate gene names: 54295416

Gene position: 2853455-2852298 (Counterclockwise)

Preceding gene: 54295417

Following gene: 54295415

Centisome position: 85.29

GC content: 42.66

Gene sequence:

>1158_bases
GTGGACGACTTGTTGTTTCTTGATGAACAATTACATGATGACGAGCGCATGATACGAGATAGTGTGTCTCGTTTTGTTAG
CAATGACGTAATACCTTTAATGGCTGAATCTTATGAACATGCCCATTTTCCAAAAGAGTTGATAAAAAAATCTGCTGATC
TGGGTTTGTTGGGCTTAACTTTACCTGCGGAATATGGGGGTGCAGAAGCTTCTTATGTTGCCTATGGTTTAGTTTGTCAG
GAATTGGAGCGAGGTGATAGCGGTTTGCGCAGCTTTGTTTCTGTGCAAAGTTCTTTGTGTATGTATCCTATTTTTAAATT
TGGCAGTGAAGAGCAAAAAAAACGCTACCTGCCAGAGATGGCTGCGGGGAATATTATAGGTTGCTTTGGATTAACTGAGC
CAGACTCAGGATCTGACCCGGCCAGCATGCGTACTCATGCCAAAAAAATTGAAGGTGGCTGGATTTTGAATGGTGCTAAA
ATGTGGATCACCAATGCCCCTATCGCAGACATCGCAATAGTGTGGGCAAAAACAGAGGCGGGAATTCGTGGTTTTATTGT
CGATACAAAATCTGAAGGCATGAGTTGTCCTGAAATTAAGTTAAAGATGTCTTTACGAGCCTCCATTACCGGGGAGCTGG
TCTTTGATAATGTTTTTGTTCCAGACGAGAATTTATTGCCGAAAAGTGAAAAAGGGCTTGGAGCTGCGTTAAGTTGCTTG
AGTCAGGCGCGTTATGGTATCGCATGGGGAGCAATGGGCGCTGCCATGGCTTGCTTTGATATCGCTCGGGATTATTTGCT
GGAACGCAAGCAGTTTGCCAAACCTTTGGCCTCGTTTCAGTTGATTCAAAAAGATTTGGCTGATATGTATACAGAAATTA
TTAAAGCACAATGTCTTAATTTGCAGATTGGGCGTTTAAAGGATCAGCATCGTGAGACACCGACTATGATTTCTCTGGCT
AAGGGTAATGCGTGCCGTGAAGCATTGAAAATTGCGAGAAAATGTAGGAATCTAATGGGCGGGAATGGAATTAGTCTTGA
GTATCATGTCATTCGGCATATGCTGAATCTGGAGTCGGTCTTTACTTATGAAGGCACCGATAATGTGCATACTTTGGTCT
TGGGAAGACATATAACGGGAATTAATGCTTTTGGTTAA

Upstream 100 bases:

>100_bases
TTCATACCATTAGGAACTGCTTGGCAGTATTTATTGCCAAGTCAGGAAAGTATTATAGACGCGGTAATCGCATTACAGTC
AGATAAAAGGGAGAAGGAAA

Downstream 100 bases:

>100_bases
GGATTTTTCTGCTTTTATCGAGTTAGTTCTGAATACCACAAGATAACTATTCTTAATCAGTAATGATTACGGTTCAAGTT
CCTTTTTCTTATGGAAAGAG

Product: hypothetical protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MDDLLFLDEQLHDDERMIRDSVSRFVSNDVIPLMAESYEHAHFPKELIKKSADLGLLGLTLPAEYGGAEASYVAYGLVCQ
ELERGDSGLRSFVSVQSSLCMYPIFKFGSEEQKKRYLPEMAAGNIIGCFGLTEPDSGSDPASMRTHAKKIEGGWILNGAK
MWITNAPIADIAIVWAKTEAGIRGFIVDTKSEGMSCPEIKLKMSLRASITGELVFDNVFVPDENLLPKSEKGLGAALSCL
SQARYGIAWGAMGAAMACFDIARDYLLERKQFAKPLASFQLIQKDLADMYTEIIKAQCLNLQIGRLKDQHRETPTMISLA
KGNACREALKIARKCRNLMGGNGISLEYHVIRHMLNLESVFTYEGTDNVHTLVLGRHITGINAFG

Sequences:

>Translated_385_residues
MDDLLFLDEQLHDDERMIRDSVSRFVSNDVIPLMAESYEHAHFPKELIKKSADLGLLGLTLPAEYGGAEASYVAYGLVCQ
ELERGDSGLRSFVSVQSSLCMYPIFKFGSEEQKKRYLPEMAAGNIIGCFGLTEPDSGSDPASMRTHAKKIEGGWILNGAK
MWITNAPIADIAIVWAKTEAGIRGFIVDTKSEGMSCPEIKLKMSLRASITGELVFDNVFVPDENLLPKSEKGLGAALSCL
SQARYGIAWGAMGAAMACFDIARDYLLERKQFAKPLASFQLIQKDLADMYTEIIKAQCLNLQIGRLKDQHRETPTMISLA
KGNACREALKIARKCRNLMGGNGISLEYHVIRHMLNLESVFTYEGTDNVHTLVLGRHITGINAFG
>Mature_385_residues
MDDLLFLDEQLHDDERMIRDSVSRFVSNDVIPLMAESYEHAHFPKELIKKSADLGLLGLTLPAEYGGAEASYVAYGLVCQ
ELERGDSGLRSFVSVQSSLCMYPIFKFGSEEQKKRYLPEMAAGNIIGCFGLTEPDSGSDPASMRTHAKKIEGGWILNGAK
MWITNAPIADIAIVWAKTEAGIRGFIVDTKSEGMSCPEIKLKMSLRASITGELVFDNVFVPDENLLPKSEKGLGAALSCL
SQARYGIAWGAMGAAMACFDIARDYLLERKQFAKPLASFQLIQKDLADMYTEIIKAQCLNLQIGRLKDQHRETPTMISLA
KGNACREALKIARKCRNLMGGNGISLEYHVIRHMLNLESVFTYEGTDNVHTLVLGRHITGINAFG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=386, Percent_Identity=53.1088082901554, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI7669494, Length=366, Percent_Identity=52.4590163934426, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI4557233, Length=379, Percent_Identity=32.9815303430079, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=33.8666666666667, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=31.4666666666667, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI226958414, Length=339, Percent_Identity=32.7433628318584, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI187960098, Length=378, Percent_Identity=30.952380952381, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI4557231, Length=378, Percent_Identity=30.952380952381, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI4501857, Length=375, Percent_Identity=31.2, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI7656849, Length=374, Percent_Identity=29.144385026738, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI76496475, Length=405, Percent_Identity=29.3827160493827, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI4557235, Length=405, Percent_Identity=29.3827160493827, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI21361497, Length=360, Percent_Identity=30, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI38505218, Length=343, Percent_Identity=26.8221574344023, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI48976061, Length=403, Percent_Identity=23.5732009925558, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI211971008, Length=403, Percent_Identity=23.5732009925558, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1786223, Length=377, Percent_Identity=24.9336870026525, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI87081958, Length=384, Percent_Identity=26.3020833333333, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI87081702, Length=276, Percent_Identity=26.8115942028986, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17534353, Length=387, Percent_Identity=48.062015503876, Blast_Score=376, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17508101, Length=367, Percent_Identity=34.3324250681199, Blast_Score=207, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI17538396, Length=393, Percent_Identity=31.8066157760814, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17569725, Length=378, Percent_Identity=31.7460317460317, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=30.0268096514745, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=30.7894736842105, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17534899, Length=377, Percent_Identity=31.5649867374005, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71982178, Length=280, Percent_Identity=35.7142857142857, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71990804, Length=261, Percent_Identity=34.8659003831418, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71985184, Length=367, Percent_Identity=29.4277929155313, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17533517, Length=381, Percent_Identity=25.7217847769029, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71985192, Length=283, Percent_Identity=31.095406360424, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=33.7662337662338, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17551932, Length=351, Percent_Identity=25.3561253561254, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17505929, Length=352, Percent_Identity=25, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17562446, Length=381, Percent_Identity=26.7716535433071, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=28.2157676348548, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19920834, Length=387, Percent_Identity=54.0051679586563, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24666513, Length=374, Percent_Identity=34.7593582887701, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI21356377, Length=373, Percent_Identity=33.2439678284182, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI24660351, Length=384, Percent_Identity=32.5520833333333, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI21355753, Length=378, Percent_Identity=31.7460317460317, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24646207, Length=373, Percent_Identity=30.0268096514745, Blast_Score=177, Evalue=9e-45,
Organism=Drosophila melanogaster, GI281363737, Length=350, Percent_Identity=30.5714285714286, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42499; Mature: 42499

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00072 ACYL_COA_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDLLFLDEQLHDDERMIRDSVSRFVSNDVIPLMAESYEHAHFPKELIKKSADLGLLGLT
CCCCCHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHCCCCCCEEEEE
LPAEYGGAEASYVAYGLVCQELERGDSGLRSFVSVQSSLCMYPIFKFGSEEQKKRYLPEM
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHH
AAGNIIGCFGLTEPDSGSDPASMRTHAKKIEGGWILNGAKMWITNAPIADIAIVWAKTEA
HCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEECCCEEEEECCCHHHEEEEEEECCC
GIRGFIVDTKSEGMSCPEIKLKMSLRASITGELVFDNVFVPDENLLPKSEKGLGAALSCL
CCEEEEEECCCCCCCCCCEEEEEEEECCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHH
SQARYGIAWGAMGAAMACFDIARDYLLERKQFAKPLASFQLIQKDLADMYTEIIKAQCLN
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LQIGRLKDQHRETPTMISLAKGNACREALKIARKCRNLMGGNGISLEYHVIRHMLNLESV
CHHHHCCHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHE
FTYEGTDNVHTLVLGRHITGINAFG
EEECCCCCEEEEEEECEECCCCCCC
>Mature Secondary Structure
MDDLLFLDEQLHDDERMIRDSVSRFVSNDVIPLMAESYEHAHFPKELIKKSADLGLLGLT
CCCCCHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHCCCCCCEEEEE
LPAEYGGAEASYVAYGLVCQELERGDSGLRSFVSVQSSLCMYPIFKFGSEEQKKRYLPEM
CCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHH
AAGNIIGCFGLTEPDSGSDPASMRTHAKKIEGGWILNGAKMWITNAPIADIAIVWAKTEA
HCCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEECCCEEEEECCCHHHEEEEEEECCC
GIRGFIVDTKSEGMSCPEIKLKMSLRASITGELVFDNVFVPDENLLPKSEKGLGAALSCL
CCEEEEEECCCCCCCCCCEEEEEEEECCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHH
SQARYGIAWGAMGAAMACFDIARDYLLERKQFAKPLASFQLIQKDLADMYTEIIKAQCLN
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LQIGRLKDQHRETPTMISLAKGNACREALKIARKCRNLMGGNGISLEYHVIRHMLNLESV
CHHHHCCHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHE
FTYEGTDNVHTLVLGRHITGINAFG
EEECCCCCEEEEEEECEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]