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The map label for this gene is mvk [H]

Identifier: 54294938

GI number: 54294938

Start: 2262074

End: 2262955

Strand: Reverse

Name: mvk [H]

Synonym: lpl2017

Alternate gene names: 54294938

Gene position: 2262955-2262074 (Counterclockwise)

Preceding gene: 54294939

Following gene: 54294932

Centisome position: 67.64

GC content: 40.25

Gene sequence:

>882_bases
ATGATGTTTTATGATTTTGAAACCACCACTTTCGGCAAGTGGATTTTAGCAGGTGAACATGCGGTAGTAAGGGGGCATGA
AGCTTTAGTATTTCCTATTAAGGAAAGGCAATTAACTTTGAAATATAATCCTTCCTCACCGTCCTTGAGCGCAGAATTTC
AAGGTATTAATGGTTCTGATATGCATTTATTATTTTGGAGCGTATTAGAGCGTGGTATGCATTTGTTGGGACGTTCACTG
AATGAATTAGGCGGTCACTTTTATTTGGAAACCAATATTCCTGTTGGGGTTGGCATGGGCGCTTCGGCAGCGCTTTGTGT
TGCCATGAGTCGGTGGTACTGTGCGCAGCAAATGATACAAGATAATCAATGCAATGAATTTGCCAAACAATTAGAACATC
TGTTTCATGGTAAAAGTAGTGGCTTGGATGTAGCTGGTGTAGCATCAGATACTGGTGTATATTTTAAATCCGGGCTTTGT
ACTCCAGTAAAGCAAACCATTTATCCCTATTGGTATTTATCCTCCTGCAATCAAATCGGCATTACTTCTCATTGTATACA
GCAAGTTGAATATTTATGGAATAAAAATCCAGAACTTGCTCACCAAGTAGATAAGCAAATGGTAGAGGCTGTTCAGGAAG
CAAAAGCTGTTTTGGAAGAAGGGGGGAGTAATGCTTTAAACCGTTTGGCAAAAGCGATAAATAAAGCCGCAGATTGTTTT
TTACAATGGGGTTTGGTTAGTGAGAGCTTGCAACAACATATGAATCATTTGTTTGCTGATGGTGCAATTGCTGTTAAGCC
AACCGGTTCAGGTGGTGGAGGGTTTGTATTAAGCCTTTGGGATAAAATTCCCTCATCCCATATAGAGTTGATTCCGGTCT
AG

Upstream 100 bases:

>100_bases
GTAGTTACTATGGATGCTGGTCCTAATGTTCATTTGCTTTATAGATCAGATCAAACAGATCTCGCACGACAATTTAAATC
GGATCATTTGGTAGGAAACT

Downstream 100 bases:

>100_bases
GTCCTTTCAAGCCTAATCGACAAATTGATAATATACTTCATTTTGCTTAATCATGCCGAGTTCATATCGAGCTTGTTCTT
CAAGAGCCTGATCACCACTT

Product: hypothetical protein

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MMFYDFETTTFGKWILAGEHAVVRGHEALVFPIKERQLTLKYNPSSPSLSAEFQGINGSDMHLLFWSVLERGMHLLGRSL
NELGGHFYLETNIPVGVGMGASAALCVAMSRWYCAQQMIQDNQCNEFAKQLEHLFHGKSSGLDVAGVASDTGVYFKSGLC
TPVKQTIYPYWYLSSCNQIGITSHCIQQVEYLWNKNPELAHQVDKQMVEAVQEAKAVLEEGGSNALNRLAKAINKAADCF
LQWGLVSESLQQHMNHLFADGAIAVKPTGSGGGGFVLSLWDKIPSSHIELIPV

Sequences:

>Translated_293_residues
MMFYDFETTTFGKWILAGEHAVVRGHEALVFPIKERQLTLKYNPSSPSLSAEFQGINGSDMHLLFWSVLERGMHLLGRSL
NELGGHFYLETNIPVGVGMGASAALCVAMSRWYCAQQMIQDNQCNEFAKQLEHLFHGKSSGLDVAGVASDTGVYFKSGLC
TPVKQTIYPYWYLSSCNQIGITSHCIQQVEYLWNKNPELAHQVDKQMVEAVQEAKAVLEEGGSNALNRLAKAINKAADCF
LQWGLVSESLQQHMNHLFADGAIAVKPTGSGGGGFVLSLWDKIPSSHIELIPV
>Mature_293_residues
MMFYDFETTTFGKWILAGEHAVVRGHEALVFPIKERQLTLKYNPSSPSLSAEFQGINGSDMHLLFWSVLERGMHLLGRSL
NELGGHFYLETNIPVGVGMGASAALCVAMSRWYCAQQMIQDNQCNEFAKQLEHLFHGKSSGLDVAGVASDTGVYFKSGLC
TPVKQTIYPYWYLSSCNQIGITSHCIQQVEYLWNKNPELAHQVDKQMVEAVQEAKAVLEEGGSNALNRLAKAINKAADCF
LQWGLVSESLQQHMNHLFADGAIAVKPTGSGGGGFVLSLWDKIPSSHIELIPV

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 32311; Mature: 32311

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFYDFETTTFGKWILAGEHAVVRGHEALVFPIKERQLTLKYNPSSPSLSAEFQGINGSD
CEEEECCCCCCCCEEEECCCEEEECCCEEEEEEECCEEEEEECCCCCCCCEEECCCCCCC
MHLLFWSVLERGMHLLGRSLNELGGHFYLETNIPVGVGMGASAALCVAMSRWYCAQQMIQ
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEECCCCCHHHHHHHHHHHHHHHHHHC
DNQCNEFAKQLEHLFHGKSSGLDVAGVASDTGVYFKSGLCTPVKQTIYPYWYLSSCNQIG
CCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEECCCCCHHHHHHCCCCEECCCCCCC
ITSHCIQQVEYLWNKNPELAHQVDKQMVEAVQEAKAVLEEGGSNALNRLAKAINKAADCF
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LQWGLVSESLQQHMNHLFADGAIAVKPTGSGGGGFVLSLWDKIPSSHIELIPV
HHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEHHHHCCCCCEEEECC
>Mature Secondary Structure
MMFYDFETTTFGKWILAGEHAVVRGHEALVFPIKERQLTLKYNPSSPSLSAEFQGINGSD
CEEEECCCCCCCCEEEECCCEEEECCCEEEEEEECCEEEEEECCCCCCCCEEECCCCCCC
MHLLFWSVLERGMHLLGRSLNELGGHFYLETNIPVGVGMGASAALCVAMSRWYCAQQMIQ
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEECCCCCHHHHHHHHHHHHHHHHHHC
DNQCNEFAKQLEHLFHGKSSGLDVAGVASDTGVYFKSGLCTPVKQTIYPYWYLSSCNQIG
CCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEECCCCCHHHHHHCCCCEECCCCCCC
ITSHCIQQVEYLWNKNPELAHQVDKQMVEAVQEAKAVLEEGGSNALNRLAKAINKAADCF
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LQWGLVSESLQQHMNHLFADGAIAVKPTGSGGGGFVLSLWDKIPSSHIELIPV
HHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]