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The map label for this gene is sahH [H]

Identifier: 54294919

GI number: 54294919

Start: 2238341

End: 2239666

Strand: Reverse

Name: sahH [H]

Synonym: lpl1998

Alternate gene names: 54294919

Gene position: 2239666-2238341 (Counterclockwise)

Preceding gene: 54294920

Following gene: 54294918

Centisome position: 66.94

GC content: 42.61

Gene sequence:

>1326_bases
ATGGAACTGGTAGAAGAAGGAGTACAGAAAATCAATACATTACAAGATTATAAAGTAGCAGATATTTCATTAGCGGACTG
GGGGCGAAAAGAAATAGCGATTGCTGAAACCGAAATGCCGGGTTTAATGGCTTTACGCGAGGAATTTTCTGCGAAAAAAC
CACTTCAAGGCGCTCGGATTGCAGGTTGTCTGCATATGACGATTCAAACCGCGGTATTGATTGAGACTCTGGTTGCATTG
GGTGCTGAAGTACGCTGGTCTTCCTGCAATATTTTTTCTACTCAGGATCATGCAGCTTCCGCTATTGCTGCAAAAGGAAT
CCCTGTTTTTGCCTGGAAGGGTGAAACAGAAGAAGAATATTGGTGGTGTGTTGAGCAAACTTTAAGTGGCCCCAATGGTT
GGACACCTAATTTATTATTAGATGATGGTGGGGATCTGACACAAATTGTTCACCAGAAACATCCCAAATTACTGACCGCA
ATTAAGGGGGTATCTGAGGAAACCACTACAGGTGTAGCCAGGCTGTACGAAATAGCGAAACATGGACAATTAAAAATTCC
AGCCATTAATGTTAATAATGCGGTGACCAAATCCAAATTTGATAATTTGTATGGATGTCGGGAATCCCTGCTTGATGGGT
TAAAACGTGCAACAGATGTTATGATAGCTGGTAAGGTTGCCTTGATTCTAGGCTATGGTGACGTAGGGAAAGGTTGCGCT
CAGGCCTTGCGCGGACAGGGAGCTACAGTACTTGTCGCAGAAATTGATCCTATTTGCGCACTTCAGGCAGCAATGGAAGG
CTACAGAGTAGTCACTCTGGATGATGTTGCTGAACAAGTGGATATCGTAGTTACAGCTACTGGCAATTACCATGTTGTAA
CTCACGATCACATGAAACGTATGCGCAATCAGGCGATATTGTGCAACATAGGCCATTTTGATTCCGAAATTGATATTCAA
AGCTTAAAACAGTATCAATGGGAAAATATCAAGCCGCAGGTTGATCATGTGATTTTTCCTGATGGAAAGCGGATTATTAT
CCTGGCTGAAGGGCGTTTAGTGAATTTGGGCTGCGCTACAGGCCATCCGAGCTTTGTCATGTCTGCTTCCTTTACCAATC
AAGTATTGGCGCAGATTGAGCTGTTCCAAAACTCTAGCCAATACCAGAATCAAGTATATGTACTTCCAAAAGTTTTGGAT
GAAAAAGTAGCCCGGTTGCATTTGGGGCGTATTGGTGCAAAATTAACTCAATTAAGTAATGAGCAGGCTGATTATATCGG
TGTCGATAAAAATGGACCTTACAAGCCGGATCATTATCGTTATTAA

Upstream 100 bases:

>100_bases
GGCAACTTATGGGCACTATGGCAGGGAAAGTTTTCCATGGGAGCGATTGGACAAAGTAGCTGAATTAAGCAAGGCATTAT
AATTTTTTAAGGATACTCTA

Downstream 100 bases:

>100_bases
ACTATTTTTATTCAAGATTTAGTTAAGCCAACTAAATCTTGAATTTTTTTCACATTATTGGATCTTATACTCTAATCTAG
ATTAGAATTAATTCACTTCT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MELVEEGVQKINTLQDYKVADISLADWGRKEIAIAETEMPGLMALREEFSAKKPLQGARIAGCLHMTIQTAVLIETLVAL
GAEVRWSSCNIFSTQDHAASAIAAKGIPVFAWKGETEEEYWWCVEQTLSGPNGWTPNLLLDDGGDLTQIVHQKHPKLLTA
IKGVSEETTTGVARLYEIAKHGQLKIPAINVNNAVTKSKFDNLYGCRESLLDGLKRATDVMIAGKVALILGYGDVGKGCA
QALRGQGATVLVAEIDPICALQAAMEGYRVVTLDDVAEQVDIVVTATGNYHVVTHDHMKRMRNQAILCNIGHFDSEIDIQ
SLKQYQWENIKPQVDHVIFPDGKRIIILAEGRLVNLGCATGHPSFVMSASFTNQVLAQIELFQNSSQYQNQVYVLPKVLD
EKVARLHLGRIGAKLTQLSNEQADYIGVDKNGPYKPDHYRY

Sequences:

>Translated_441_residues
MELVEEGVQKINTLQDYKVADISLADWGRKEIAIAETEMPGLMALREEFSAKKPLQGARIAGCLHMTIQTAVLIETLVAL
GAEVRWSSCNIFSTQDHAASAIAAKGIPVFAWKGETEEEYWWCVEQTLSGPNGWTPNLLLDDGGDLTQIVHQKHPKLLTA
IKGVSEETTTGVARLYEIAKHGQLKIPAINVNNAVTKSKFDNLYGCRESLLDGLKRATDVMIAGKVALILGYGDVGKGCA
QALRGQGATVLVAEIDPICALQAAMEGYRVVTLDDVAEQVDIVVTATGNYHVVTHDHMKRMRNQAILCNIGHFDSEIDIQ
SLKQYQWENIKPQVDHVIFPDGKRIIILAEGRLVNLGCATGHPSFVMSASFTNQVLAQIELFQNSSQYQNQVYVLPKVLD
EKVARLHLGRIGAKLTQLSNEQADYIGVDKNGPYKPDHYRY
>Mature_441_residues
MELVEEGVQKINTLQDYKVADISLADWGRKEIAIAETEMPGLMALREEFSAKKPLQGARIAGCLHMTIQTAVLIETLVAL
GAEVRWSSCNIFSTQDHAASAIAAKGIPVFAWKGETEEEYWWCVEQTLSGPNGWTPNLLLDDGGDLTQIVHQKHPKLLTA
IKGVSEETTTGVARLYEIAKHGQLKIPAINVNNAVTKSKFDNLYGCRESLLDGLKRATDVMIAGKVALILGYGDVGKGCA
QALRGQGATVLVAEIDPICALQAAMEGYRVVTLDDVAEQVDIVVTATGNYHVVTHDHMKRMRNQAILCNIGHFDSEIDIQ
SLKQYQWENIKPQVDHVIFPDGKRIIILAEGRLVNLGCATGHPSFVMSASFTNQVLAQIELFQNSSQYQNQVYVLPKVLD
EKVARLHLGRIGAKLTQLSNEQADYIGVDKNGPYKPDHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=427, Percent_Identity=66.5105386416862, Blast_Score=586, Evalue=1e-167,
Organism=Homo sapiens, GI239937451, Length=405, Percent_Identity=66.1728395061728, Blast_Score=555, Evalue=1e-158,
Organism=Homo sapiens, GI298286489, Length=429, Percent_Identity=56.4102564102564, Blast_Score=533, Evalue=1e-151,
Organism=Homo sapiens, GI24308043, Length=429, Percent_Identity=56.4102564102564, Blast_Score=533, Evalue=1e-151,
Organism=Homo sapiens, GI195539337, Length=429, Percent_Identity=56.4102564102564, Blast_Score=533, Evalue=1e-151,
Organism=Homo sapiens, GI195539349, Length=429, Percent_Identity=56.4102564102564, Blast_Score=532, Evalue=1e-151,
Organism=Homo sapiens, GI21361647, Length=429, Percent_Identity=55.2447552447552, Blast_Score=511, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17506425, Length=430, Percent_Identity=65.1162790697674, Blast_Score=583, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6320882, Length=444, Percent_Identity=63.963963963964, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24642172, Length=427, Percent_Identity=66.7447306791569, Blast_Score=589, Evalue=1e-168,
Organism=Drosophila melanogaster, GI24656245, Length=418, Percent_Identity=56.4593301435407, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI45553387, Length=428, Percent_Identity=56.7757009345794, Blast_Score=513, Evalue=1e-146,
Organism=Drosophila melanogaster, GI45553385, Length=427, Percent_Identity=56.6744730679157, Blast_Score=511, Evalue=1e-145,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 48592; Mature: 48592

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELVEEGVQKINTLQDYKVADISLADWGRKEIAIAETEMPGLMALREEFSAKKPLQGARI
CCHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCHH
AGCLHMTIQTAVLIETLVALGAEVRWSSCNIFSTQDHAASAIAAKGIPVFAWKGETEEEY
HHHHHHHHHHHHHHHHHHHCCCCEEECCCCEECCCCHHHHHHHHCCCEEEEECCCCCCHH
WWCVEQTLSGPNGWTPNLLLDDGGDLTQIVHQKHPKLLTAIKGVSEETTTGVARLYEIAK
HHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHH
HGQLKIPAINVNNAVTKSKFDNLYGCRESLLDGLKRATDVMIAGKVALILGYGDVGKGCA
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECEEEEEEECCCCCHHHH
QALRGQGATVLVAEIDPICALQAAMEGYRVVTLDDVAEQVDIVVTATGNYHVVTHDHMKR
HHHCCCCCEEEEEECCCHHHHHHHHCCCEEEEHHHHHCCEEEEEEECCCEEEEEHHHHHH
MRNQAILCNIGHFDSEIDIQSLKQYQWENIKPQVDHVIFPDGKRIIILAEGRLVNLGCAT
HCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCEEECCCCCEEEEEECCEEEEEEECC
GHPSFVMSASFTNQVLAQIELFQNSSQYQNQVYVLPKVLDEKVARLHLGRIGAKLTQLSN
CCCCEEEECHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
EQADYIGVDKNGPYKPDHYRY
CCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MELVEEGVQKINTLQDYKVADISLADWGRKEIAIAETEMPGLMALREEFSAKKPLQGARI
CCHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCHH
AGCLHMTIQTAVLIETLVALGAEVRWSSCNIFSTQDHAASAIAAKGIPVFAWKGETEEEY
HHHHHHHHHHHHHHHHHHHCCCCEEECCCCEECCCCHHHHHHHHCCCEEEEECCCCCCHH
WWCVEQTLSGPNGWTPNLLLDDGGDLTQIVHQKHPKLLTAIKGVSEETTTGVARLYEIAK
HHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHH
HGQLKIPAINVNNAVTKSKFDNLYGCRESLLDGLKRATDVMIAGKVALILGYGDVGKGCA
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECEEEEEEECCCCCHHHH
QALRGQGATVLVAEIDPICALQAAMEGYRVVTLDDVAEQVDIVVTATGNYHVVTHDHMKR
HHHCCCCCEEEEEECCCHHHHHHHHCCCEEEEHHHHHCCEEEEEEECCCEEEEEHHHHHH
MRNQAILCNIGHFDSEIDIQSLKQYQWENIKPQVDHVIFPDGKRIIILAEGRLVNLGCAT
HCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCEEECCCCCEEEEEECCEEEEEEECC
GHPSFVMSASFTNQVLAQIELFQNSSQYQNQVYVLPKVLDEKVARLHLGRIGAKLTQLSN
CCCCEEEECHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
EQADYIGVDKNGPYKPDHYRY
CCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA