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The map label for this gene is hmgA [H]

Identifier: 54294184

GI number: 54294184

Start: 1391232

End: 1392482

Strand: Reverse

Name: hmgA [H]

Synonym: lpl1248

Alternate gene names: 54294184

Gene position: 1392482-1391232 (Counterclockwise)

Preceding gene: 54294189

Following gene: 54294179

Centisome position: 41.62

GC content: 39.97

Gene sequence:

>1251_bases
GTGTATTTGCAAGGATTTGGTAATTATCACCACAGCGAGGCTGTTAAAGGAGCATTACCCCCAAATCAAAACTCACCTCA
ACACTGTAGCTTAGGACTTTACGCAGAGCAATTGAGTGGAACCTCGTTCACCCGTCCCCGACATAATAATCTTCGAAGTT
GGCTATATAGAATACTTCCTACTGTTACCCAGGGCACGTATTACCCCTATGAGTTTAATATTATGCAACCTTTAGTTGAT
GAGTTGTCACCCAATGCCATGCGTTGGTCACCTCTTTATAACAGCTCTCAAATTAAATGTGATTTTGTTGAAGGACTATT
TCATATTGCCGGTAGCCCGTTAGTTAATGCCTATACTTATTATTGCAACCACTCCATGAGCGATAAATATTTCGCCAATA
ATGATGGTGAGTTATTATTTGTTCCCTATACAGGCGAGATTCATCTGCATACTGAATTTGGCAAATTAATGCTCTCTTCT
GGATCGATCGCAGTGATACCTCGTGGCGTTAAATTTAAAGTGGAAGTAATCAGCAAGGAGGCAAAAGGTTATCTTTGTGA
AAATAGCGGAAATCCCTTAACCTTACCTCAGTTAGGCCCCATTGGAGCCAATGGTTTGGCAAACCCAAGACATTTTCAAT
ATCCAGTAGCCGCATTTGAAAACTCTGTAGGCGAGCATACTATAATCTGTAAAAACCAGAAAAAATTATGGTTTACTGTA
TGCAACCACTCTCCTTTAAATGTCGTCGCCTGGCATGGCAATTATGCACCATATTGTTATGATCTCAGTTTGTTCAATAC
AATTAACACAGTCAGTTTTGATCATCCTGATCCTTCCATATTCACTGTATTAACTTCAGAAAGCGAAATACCCGGTGTTT
CTAACTTGGACTTTGTTATTTTCCCACCTCGCTGGATGGTTGCCGAACATACTTTTAGACCGCCTTATTTTCATAGAAAC
TACATGAATGAACTGATGGGACTTGTCTATGGTGAATATGACGCCAAGAAGGAAGGATTCATACCGGGCGGTATCAGCAT
CCATAATTGCATGACTCCACACGGACCTGATTATGAATCTTATGAAATTGCAGCGTCGCAGGATCTAAAACCAAATTATA
TCAACTCCCTGGCCTTTATGTTTGAAACCAAAGACTACTGGCAAGTAACTGAGCAAGCTTATCGACATCCCAGCAGACAA
ATAGATTATCTTAATTGTTGGCAAGGCTTTAAAATAGAGTTTAGTCAATAA

Upstream 100 bases:

>100_bases
TAACACCAAAAAGAATGACTAAAGCCATCGATGCTCTCGACAATTTGAACTTTTTTGGACTATGCTAGCACCATAAAAAA
ATCTTGAAGGAGATTGAACT

Downstream 100 bases:

>100_bases
ATTGACTGCTTTTTAAGATGTAAAATTGACGGTAAATAATTAATTTAGTTTCAGTTGGGTCAAATTTGACCCAACTTGTA
TGTAATTAATTAACTAGTTA

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MYLQGFGNYHHSEAVKGALPPNQNSPQHCSLGLYAEQLSGTSFTRPRHNNLRSWLYRILPTVTQGTYYPYEFNIMQPLVD
ELSPNAMRWSPLYNSSQIKCDFVEGLFHIAGSPLVNAYTYYCNHSMSDKYFANNDGELLFVPYTGEIHLHTEFGKLMLSS
GSIAVIPRGVKFKVEVISKEAKGYLCENSGNPLTLPQLGPIGANGLANPRHFQYPVAAFENSVGEHTIICKNQKKLWFTV
CNHSPLNVVAWHGNYAPYCYDLSLFNTINTVSFDHPDPSIFTVLTSESEIPGVSNLDFVIFPPRWMVAEHTFRPPYFHRN
YMNELMGLVYGEYDAKKEGFIPGGISIHNCMTPHGPDYESYEIAASQDLKPNYINSLAFMFETKDYWQVTEQAYRHPSRQ
IDYLNCWQGFKIEFSQ

Sequences:

>Translated_416_residues
MYLQGFGNYHHSEAVKGALPPNQNSPQHCSLGLYAEQLSGTSFTRPRHNNLRSWLYRILPTVTQGTYYPYEFNIMQPLVD
ELSPNAMRWSPLYNSSQIKCDFVEGLFHIAGSPLVNAYTYYCNHSMSDKYFANNDGELLFVPYTGEIHLHTEFGKLMLSS
GSIAVIPRGVKFKVEVISKEAKGYLCENSGNPLTLPQLGPIGANGLANPRHFQYPVAAFENSVGEHTIICKNQKKLWFTV
CNHSPLNVVAWHGNYAPYCYDLSLFNTINTVSFDHPDPSIFTVLTSESEIPGVSNLDFVIFPPRWMVAEHTFRPPYFHRN
YMNELMGLVYGEYDAKKEGFIPGGISIHNCMTPHGPDYESYEIAASQDLKPNYINSLAFMFETKDYWQVTEQAYRHPSRQ
IDYLNCWQGFKIEFSQ
>Mature_416_residues
MYLQGFGNYHHSEAVKGALPPNQNSPQHCSLGLYAEQLSGTSFTRPRHNNLRSWLYRILPTVTQGTYYPYEFNIMQPLVD
ELSPNAMRWSPLYNSSQIKCDFVEGLFHIAGSPLVNAYTYYCNHSMSDKYFANNDGELLFVPYTGEIHLHTEFGKLMLSS
GSIAVIPRGVKFKVEVISKEAKGYLCENSGNPLTLPQLGPIGANGLANPRHFQYPVAAFENSVGEHTIICKNQKKLWFTV
CNHSPLNVVAWHGNYAPYCYDLSLFNTINTVSFDHPDPSIFTVLTSESEIPGVSNLDFVIFPPRWMVAEHTFRPPYFHRN
YMNELMGLVYGEYDAKKEGFIPGGISIHNCMTPHGPDYESYEIAASQDLKPNYINSLAFMFETKDYWQVTEQAYRHPSRQ
IDYLNCWQGFKIEFSQ

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=432, Percent_Identity=47.9166666666667, Blast_Score=381, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17507969, Length=430, Percent_Identity=48.3720930232558, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24583650, Length=431, Percent_Identity=46.4037122969838, Blast_Score=360, Evalue=1e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 47451; Mature: 47451

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLQGFGNYHHSEAVKGALPPNQNSPQHCSLGLYAEQLSGTSFTRPRHNNLRSWLYRILP
CEECCCCCCCHHHHHCCCCCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCHHHHHHHHHHH
TVTQGTYYPYEFNIMQPLVDELSPNAMRWSPLYNSSQIKCDFVEGLFHIAGSPLVNAYTY
HHHCCEECCEEECHHHHHHHHCCCCCEEECCCCCCCCEEEHHHHHHHHHCCCCHHEEEEE
YCNHSMSDKYFANNDGELLFVPYTGEIHLHTEFGKLMLSSGSIAVIPRGVKFKVEVISKE
EECCCCCCCEEECCCCCEEEEEECCEEEEEECCCEEEECCCCEEEEECCCEEEEEEEECC
AKGYLCENSGNPLTLPQLGPIGANGLANPRHFQYPVAAFENSVGEHTIICKNQKKLWFTV
CCCEEEECCCCEEECCCCCCCCCCCCCCCCEEECCHHHHHCCCCCEEEEEECCCEEEEEE
CNHSPLNVVAWHGNYAPYCYDLSLFNTINTVSFDHPDPSIFTVLTSESEIPGVSNLDFVI
ECCCCCEEEEECCCCCCEEEEEEHHCCCCEEEECCCCCCEEEEEECCCCCCCCCCCCEEE
FPPRWMVAEHTFRPPYFHRNYMNELMGLVYGEYDAKKEGFIPGGISIHNCMTPHGPDYES
ECCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCC
YEIAASQDLKPNYINSLAFMFETKDYWQVTEQAYRHPSRQIDYLNCWQGFKIEFSQ
EEEEECCCCCCHHHHHEEEEEECCHHHHHHHHHHCCCCCCCCCEECCCCCEEEECC
>Mature Secondary Structure
MYLQGFGNYHHSEAVKGALPPNQNSPQHCSLGLYAEQLSGTSFTRPRHNNLRSWLYRILP
CEECCCCCCCHHHHHCCCCCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCHHHHHHHHHHH
TVTQGTYYPYEFNIMQPLVDELSPNAMRWSPLYNSSQIKCDFVEGLFHIAGSPLVNAYTY
HHHCCEECCEEECHHHHHHHHCCCCCEEECCCCCCCCEEEHHHHHHHHHCCCCHHEEEEE
YCNHSMSDKYFANNDGELLFVPYTGEIHLHTEFGKLMLSSGSIAVIPRGVKFKVEVISKE
EECCCCCCCEEECCCCCEEEEEECCEEEEEECCCEEEECCCCEEEEECCCEEEEEEEECC
AKGYLCENSGNPLTLPQLGPIGANGLANPRHFQYPVAAFENSVGEHTIICKNQKKLWFTV
CCCEEEECCCCEEECCCCCCCCCCCCCCCCEEECCHHHHHCCCCCEEEEEECCCEEEEEE
CNHSPLNVVAWHGNYAPYCYDLSLFNTINTVSFDHPDPSIFTVLTSESEIPGVSNLDFVI
ECCCCCEEEEECCCCCCEEEEEEHHCCCCEEEECCCCCCEEEEEECCCCCCCCCCCCEEE
FPPRWMVAEHTFRPPYFHRNYMNELMGLVYGEYDAKKEGFIPGGISIHNCMTPHGPDYES
ECCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCCCC
YEIAASQDLKPNYINSLAFMFETKDYWQVTEQAYRHPSRQIDYLNCWQGFKIEFSQ
EEEEECCCCCCHHHHHEEEEEECCHHHHHHHHHHCCCCCCCCCEECCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA