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The map label for this gene is serS [H]

Identifier: 54293502

GI number: 54293502

Start: 599320

End: 600600

Strand: Direct

Name: serS [H]

Synonym: lpl0551

Alternate gene names: 54293502

Gene position: 599320-600600 (Clockwise)

Preceding gene: 54293501

Following gene: 54293503

Centisome position: 17.91

GC content: 40.28

Gene sequence:

>1281_bases
ATGTTAGATAATCAATTACTTAGAGAGAATCCTCAATATGTAGCAACCCAATTGCTGAAGCGAGGATTTCAATTTGATGC
GGTCACTTTCAGTCAGTTGGAAGAAAAGCGTAAGGCTTTGCAAGTAAGTACGCAATCATTACAGAACGAACGAAATTTGC
GTTCGAAAGCCATCGGTGAAGCAAAATCTCGCGGTGAAAACATAGAACCTATGCGCGAAGAAGTGAATAAACTTGGCGCT
AAACTGGAGCAACAAAAGACTGAACTGGATGAGATTCTTAAGCAAATTGAGGTAATTAGCCTATCATTACCTAATATTCC
TCATGAATCAGTACCTGTTGGTAAAGATGAATTGGATAATCAGGAAATCAGAAAATGGGGCGACGTACCTGCTTTTTCTT
TCCCTGTAAAGTCACATGATGAATTGGGTGAAGCACTAGGGCAAATGGATTTTGCGCTTGCAGCTAAAATTACGGGCAGT
CGTTTTGTCGTCATGAAAGGGCATCTGGCCCGATTACATCGGGCTTTAATTCAATTCATGCTGGATATACATATTCAGCA
ACATGGTTACCAGGAAATATATGTACCTTATATTGTTAATGCGGATAGCTTATTAGGGACTGGACAGTTACCAAAGTTTG
AGGCTGATTTATTTAAATTAACAGGAGATAATGGGTACTACTTGACGTCTACTTCAGAAATTCCAGTGACCAATACAGTA
AGGGAAATGATATTGTCTGCTGAGCAATTACCTATTCGTTATGTTTGCCATTCCCCATGTTTTCGTAGTGAGGCAGGTTC
TTACGGTAAAGACACAAAGGGAATGATTAGACAGCATCAATTTGAGAAAGTTGAACTGGTCTGGATTACCAAACCGGAAG
ATTCTTATAATGCTCTAGAGCAACTTACTCAGCATGCTGAAGTTATTTTACAGCGTTTGAAATTGCCTTACCGAGTGGTC
GCTTTGTGTACCGGGGATATAGGCGCCGGTTCAGCCAAAACCTATGATCTTGAGGTTTGGTTGCCTAGCCAGAATACTTA
TCGAGAAATATCCTCTTGTTCCAATATGGAGGCATTTCAGGCACGCCGAATGAAAGCGCGTTTCCGCAATCCGGATACTA
ATGAGATTCAATTAGTCCACACTCTAAATGGATCAGGTTTAGCTGTTGGAAGAACTTTAGTTGCCATTATGGAGAATTAT
CAAGATGAGCATGGAAACATTCATATACCGGATGCTTTGAAGCCTTATTTAGGTGGTATTGATATCATCTCTGTGAAATA
G

Upstream 100 bases:

>100_bases
TGTTGGCTCATTGTCCATGGTCTTTGTTGGAACATTAGTTGCTAAATATGTATTATTAGGACATCAGGGCTCCAATTAAT
AATTTTTAGAGTGTTGGCTT

Downstream 100 bases:

>100_bases
GTTTGCTCATAATGATGGATATTTTTTCTTAAAAGTTAGCCTTCAACAGGAAAGAGCGATAGATAGGCTATATTGAGCCA
AATCAATTGCTCTTAAGTAT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLDNQLLRENPQYVATQLLKRGFQFDAVTFSQLEEKRKALQVSTQSLQNERNLRSKAIGEAKSRGENIEPMREEVNKLGA
KLEQQKTELDEILKQIEVISLSLPNIPHESVPVGKDELDNQEIRKWGDVPAFSFPVKSHDELGEALGQMDFALAAKITGS
RFVVMKGHLARLHRALIQFMLDIHIQQHGYQEIYVPYIVNADSLLGTGQLPKFEADLFKLTGDNGYYLTSTSEIPVTNTV
REMILSAEQLPIRYVCHSPCFRSEAGSYGKDTKGMIRQHQFEKVELVWITKPEDSYNALEQLTQHAEVILQRLKLPYRVV
ALCTGDIGAGSAKTYDLEVWLPSQNTYREISSCSNMEAFQARRMKARFRNPDTNEIQLVHTLNGSGLAVGRTLVAIMENY
QDEHGNIHIPDALKPYLGGIDIISVK

Sequences:

>Translated_426_residues
MLDNQLLRENPQYVATQLLKRGFQFDAVTFSQLEEKRKALQVSTQSLQNERNLRSKAIGEAKSRGENIEPMREEVNKLGA
KLEQQKTELDEILKQIEVISLSLPNIPHESVPVGKDELDNQEIRKWGDVPAFSFPVKSHDELGEALGQMDFALAAKITGS
RFVVMKGHLARLHRALIQFMLDIHIQQHGYQEIYVPYIVNADSLLGTGQLPKFEADLFKLTGDNGYYLTSTSEIPVTNTV
REMILSAEQLPIRYVCHSPCFRSEAGSYGKDTKGMIRQHQFEKVELVWITKPEDSYNALEQLTQHAEVILQRLKLPYRVV
ALCTGDIGAGSAKTYDLEVWLPSQNTYREISSCSNMEAFQARRMKARFRNPDTNEIQLVHTLNGSGLAVGRTLVAIMENY
QDEHGNIHIPDALKPYLGGIDIISVK
>Mature_426_residues
MLDNQLLRENPQYVATQLLKRGFQFDAVTFSQLEEKRKALQVSTQSLQNERNLRSKAIGEAKSRGENIEPMREEVNKLGA
KLEQQKTELDEILKQIEVISLSLPNIPHESVPVGKDELDNQEIRKWGDVPAFSFPVKSHDELGEALGQMDFALAAKITGS
RFVVMKGHLARLHRALIQFMLDIHIQQHGYQEIYVPYIVNADSLLGTGQLPKFEADLFKLTGDNGYYLTSTSEIPVTNTV
REMILSAEQLPIRYVCHSPCFRSEAGSYGKDTKGMIRQHQFEKVELVWITKPEDSYNALEQLTQHAEVILQRLKLPYRVV
ALCTGDIGAGSAKTYDLEVWLPSQNTYREISSCSNMEAFQARRMKARFRNPDTNEIQLVHTLNGSGLAVGRTLVAIMENY
QDEHGNIHIPDALKPYLGGIDIISVK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=328, Percent_Identity=37.1951219512195, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI8923421, Length=396, Percent_Identity=29.5454545454545, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI225579074, Length=333, Percent_Identity=31.2312312312312, Blast_Score=175, Evalue=6e-44,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=58.8372093023256, Blast_Score=535, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17539260, Length=427, Percent_Identity=31.3817330210773, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17542084, Length=344, Percent_Identity=29.3604651162791, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=359, Percent_Identity=36.4902506963788, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6321799, Length=352, Percent_Identity=32.6704545454545, Blast_Score=186, Evalue=6e-48,
Organism=Drosophila melanogaster, GI24581334, Length=416, Percent_Identity=32.6923076923077, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17737985, Length=290, Percent_Identity=33.7931034482759, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48182; Mature: 48182

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDNQLLRENPQYVATQLLKRGFQFDAVTFSQLEEKRKALQVSTQSLQNERNLRSKAIGE
CCCCHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKSRGENIEPMREEVNKLGAKLEQQKTELDEILKQIEVISLSLPNIPHESVPVGKDELDN
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHCCH
QEIRKWGDVPAFSFPVKSHDELGEALGQMDFALAAKITGSRFVVMKGHLARLHRALIQFM
HHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHEEECCCEEEEECCHHHHHHHHHHHHH
LDIHIQQHGYQEIYVPYIVNADSLLGTGQLPKFEADLFKLTGDNGYYLTSTSEIPVTNTV
HHHHHHHCCCCEEEEEEEECCCHHCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCHHHH
REMILSAEQLPIRYVCHSPCFRSEAGSYGKDTKGMIRQHQFEKVELVWITKPEDSYNALE
HHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEEECCCCHHHHHH
QLTQHAEVILQRLKLPYRVVALCTGDIGAGSAKTYDLEVWLPSQNTYREISSCSNMEAFQ
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHHCCCHHHHH
ARRMKARFRNPDTNEIQLVHTLNGSGLAVGRTLVAIMENYQDEHGNIHIPDALKPYLGGI
HHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHCCE
DIISVK
EEEEEC
>Mature Secondary Structure
MLDNQLLRENPQYVATQLLKRGFQFDAVTFSQLEEKRKALQVSTQSLQNERNLRSKAIGE
CCCCHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKSRGENIEPMREEVNKLGAKLEQQKTELDEILKQIEVISLSLPNIPHESVPVGKDELDN
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHCCH
QEIRKWGDVPAFSFPVKSHDELGEALGQMDFALAAKITGSRFVVMKGHLARLHRALIQFM
HHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHEEECCCEEEEECCHHHHHHHHHHHHH
LDIHIQQHGYQEIYVPYIVNADSLLGTGQLPKFEADLFKLTGDNGYYLTSTSEIPVTNTV
HHHHHHHCCCCEEEEEEEECCCHHCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCHHHH
REMILSAEQLPIRYVCHSPCFRSEAGSYGKDTKGMIRQHQFEKVELVWITKPEDSYNALE
HHHHHHHHCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEEECCCCHHHHHH
QLTQHAEVILQRLKLPYRVVALCTGDIGAGSAKTYDLEVWLPSQNTYREISSCSNMEAFQ
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHHCCCHHHHH
ARRMKARFRNPDTNEIQLVHTLNGSGLAVGRTLVAIMENYQDEHGNIHIPDALKPYLGGI
HHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHCCE
DIISVK
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA