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The map label for this gene is hflK [H]

Identifier: 54293475

GI number: 54293475

Start: 570741

End: 571883

Strand: Direct

Name: hflK [H]

Synonym: lpl0524

Alternate gene names: 54293475

Gene position: 570741-571883 (Clockwise)

Preceding gene: 54293474

Following gene: 54293476

Centisome position: 17.06

GC content: 41.12

Gene sequence:

>1143_bases
ATGGGGTGGAATGAGCCAGAGAAGGGCAAAGATCCATGGTCGGGTAAAAATCAACCTCCGGATTTGGATGAAGCTCTTAA
ACGTATCCAGGATAAATTGAAGAAAACATTTTTTGGAGGCACGGGCAAATCAAATAATAATTCGTCAGGTGGTTCCAGTG
GCGGGTTGCTTGCTGTCACAGTTTTATTAATAGCTTTTATTCTTTGGGCTCTTTCTGGTATTTTTATTGTGGATCCCGCA
GAGCAAGCTGTGATACTCCGCTTTGGTAAATATGCAGAAACAGTTGGCCCTGGTCCTCATTGGATTCCTCGTTTTATCTC
ATCAAAGATTGTTATGAATGTGGATAGGATGCTAGATTACTCCTACTCCGCGCAAATGCTTACCAGTGATGAAAATTTAG
TATCGGTCTCTTTGGCTGTCCAGTACCGCATTAATGATTTGAGTGAATATTTATTTAATGTCGCAAATCCTGAGGAAAGC
TTACAACAGGCAACTTCCAGCGCTTTAAGGCAGGTTGTAGGCACGACAACCCTGGATCAGATAATAACTGAAGGTCGAGA
AGTTTGGGGAGGTAGAGTACAAGAAACTCTGACGAAAACTTTAGAAAGCTATAAGACCGGAATTTTAATCGTTAATGTGT
CACCCCAACCTGCCAGAGCTCCAGAAAGTGTTCAGGATGCTTTTGATGACGCGATTAAAGCTCAAGAGGATGAAAAACGT
TTCAAGGAACAGGCTTATGCTTATGCAGCAAAAGTGGTGCCGATTGCAGAAGGTAAAGCGAGTCGTATTCAACAGGAAGC
AGAAGCTTATTCGAAGCAAGTCGTCTTAAGAGCACAGGGAGAAGTAGCGGAATTTTTAGCCTTACTTCCTCAATACAATG
CAGCTCCTCAGGTTACGGCTAAGCGGATGTATCTTGAAGCTATGCAAAAAGTAATGAATAAGAGCAGTACTATTATTGTT
GACAGTAAAGCAGGAAATTTATTGTATCTACCTTTAGATAAACTACTTGGTAATCAATACGTTCCGCAATCTGAAAATCT
AAAAGCTATAAAAAATGGTACGAATGTCAGGAATGAGGAGGACAACTTGATTCTTTCTGGAAGAGATCTCACAAGACCAA
CTTATAGTCAAGGGAGAGATTGA

Upstream 100 bases:

>100_bases
TTTGCTTCATTTCAATATACAAGTCCTGAAGTATCTACTTGCTTAAACTTCATATACCCCATAAAATCCTAAATTCATTT
GAAATTGCTAGGAGTAGTAC

Downstream 100 bases:

>100_bases
GAATGAATGCATTTAAAACGACATTGGGTGTCTTAATCTTTTTGGTACTAGTGCTTTTGTTTACCAGTATGTTTACTGTC
ACACAAGGACAGCAGGGTAT

Product: protease subunit HflK

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MGWNEPEKGKDPWSGKNQPPDLDEALKRIQDKLKKTFFGGTGKSNNNSSGGSSGGLLAVTVLLIAFILWALSGIFIVDPA
EQAVILRFGKYAETVGPGPHWIPRFISSKIVMNVDRMLDYSYSAQMLTSDENLVSVSLAVQYRINDLSEYLFNVANPEES
LQQATSSALRQVVGTTTLDQIITEGREVWGGRVQETLTKTLESYKTGILIVNVSPQPARAPESVQDAFDDAIKAQEDEKR
FKEQAYAYAAKVVPIAEGKASRIQQEAEAYSKQVVLRAQGEVAEFLALLPQYNAAPQVTAKRMYLEAMQKVMNKSSTIIV
DSKAGNLLYLPLDKLLGNQYVPQSENLKAIKNGTNVRNEEDNLILSGRDLTRPTYSQGRD

Sequences:

>Translated_380_residues
MGWNEPEKGKDPWSGKNQPPDLDEALKRIQDKLKKTFFGGTGKSNNNSSGGSSGGLLAVTVLLIAFILWALSGIFIVDPA
EQAVILRFGKYAETVGPGPHWIPRFISSKIVMNVDRMLDYSYSAQMLTSDENLVSVSLAVQYRINDLSEYLFNVANPEES
LQQATSSALRQVVGTTTLDQIITEGREVWGGRVQETLTKTLESYKTGILIVNVSPQPARAPESVQDAFDDAIKAQEDEKR
FKEQAYAYAAKVVPIAEGKASRIQQEAEAYSKQVVLRAQGEVAEFLALLPQYNAAPQVTAKRMYLEAMQKVMNKSSTIIV
DSKAGNLLYLPLDKLLGNQYVPQSENLKAIKNGTNVRNEEDNLILSGRDLTRPTYSQGRD
>Mature_379_residues
GWNEPEKGKDPWSGKNQPPDLDEALKRIQDKLKKTFFGGTGKSNNNSSGGSSGGLLAVTVLLIAFILWALSGIFIVDPAE
QAVILRFGKYAETVGPGPHWIPRFISSKIVMNVDRMLDYSYSAQMLTSDENLVSVSLAVQYRINDLSEYLFNVANPEESL
QQATSSALRQVVGTTTLDQIITEGREVWGGRVQETLTKTLESYKTGILIVNVSPQPARAPESVQDAFDDAIKAQEDEKRF
KEQAYAYAAKVVPIAEGKASRIQQEAEAYSKQVVLRAQGEVAEFLALLPQYNAAPQVTAKRMYLEAMQKVMNKSSTIIVD
SKAGNLLYLPLDKLLGNQYVPQSENLKAIKNGTNVRNEEDNLILSGRDLTRPTYSQGRD

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=371, Percent_Identity=41.2398921832884, Blast_Score=260, Evalue=1e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 41955; Mature: 41824

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGWNEPEKGKDPWSGKNQPPDLDEALKRIQDKLKKTFFGGTGKSNNNSSGGSSGGLLAVT
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
VLLIAFILWALSGIFIVDPAEQAVILRFGKYAETVGPGPHWIPRFISSKIVMNVDRMLDY
HHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
SYSAQMLTSDENLVSVSLAVQYRINDLSEYLFNVANPEESLQQATSSALRQVVGTTTLDQ
CCCHHEEECCCCEEEEEEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHH
IITEGREVWGGRVQETLTKTLESYKTGILIVNVSPQPARAPESVQDAFDDAIKAQEDEKR
HHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCHHHHH
FKEQAYAYAAKVVPIAEGKASRIQQEAEAYSKQVVLRAQGEVAEFLALLPQYNAAPQVTA
HHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCCCCCHHHH
KRMYLEAMQKVMNKSSTIIVDSKAGNLLYLPLDKLLGNQYVPQSENLKAIKNGTNVRNEE
HHHHHHHHHHHHCCCCEEEEECCCCCEEEEEHHHHCCCCCCCCCCCCHHHHCCCCCCCCC
DNLILSGRDLTRPTYSQGRD
CCEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
GWNEPEKGKDPWSGKNQPPDLDEALKRIQDKLKKTFFGGTGKSNNNSSGGSSGGLLAVT
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
VLLIAFILWALSGIFIVDPAEQAVILRFGKYAETVGPGPHWIPRFISSKIVMNVDRMLDY
HHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
SYSAQMLTSDENLVSVSLAVQYRINDLSEYLFNVANPEESLQQATSSALRQVVGTTTLDQ
CCCHHEEECCCCEEEEEEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHH
IITEGREVWGGRVQETLTKTLESYKTGILIVNVSPQPARAPESVQDAFDDAIKAQEDEKR
HHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCHHHHH
FKEQAYAYAAKVVPIAEGKASRIQQEAEAYSKQVVLRAQGEVAEFLALLPQYNAAPQVTA
HHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHCCCCCCCHHHH
KRMYLEAMQKVMNKSSTIIVDSKAGNLLYLPLDKLLGNQYVPQSENLKAIKNGTNVRNEE
HHHHHHHHHHHHCCCCEEEEECCCCCEEEEEHHHHCCCCCCCCCCCCHHHHCCCCCCCCC
DNLILSGRDLTRPTYSQGRD
CCEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]