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The map label for this gene is hflC [H]

Identifier: 54293476

GI number: 54293476

Start: 571886

End: 572800

Strand: Direct

Name: hflC [H]

Synonym: lpl0525

Alternate gene names: 54293476

Gene position: 571886-572800 (Clockwise)

Preceding gene: 54293475

Following gene: 54293477

Centisome position: 17.09

GC content: 37.92

Gene sequence:

>915_bases
ATGAATGCATTTAAAACGACATTGGGTGTCTTAATCTTTTTGGTACTAGTGCTTTTGTTTACCAGTATGTTTACTGTCAC
ACAAGGACAGCAGGGTATTATTTTACGTTTAGGACGTTTGGTAAAAGACCCTCAAACTGACGCAGTGAAAGTATTAAATC
CTGGGCTCCACTTTAAAACCCCTTTTATCGAAAGTGTGCGAATTTTCGATACACGCATCCAAACCATGGATATCAAATCA
ACCCGTATTGTGACCAAAGAGAAAAAAGATGTCATGGTTGACTATTATGTGAAATGGCGAATTTCAGATTTAGCCCAGTA
TTTTAAATCAACAGGTGGAAATGAATTTAAAGCTGAAACGTTGCTAGAACAACAGTTAAATACCTTGCTCAGAGCCCAAT
TTGGTAAGCGTACCATATCCGATGCTGTTTCAGGAGGGCGTGATGATGTTATGGAAATACTCCGTAATGCTGCTGAGAAG
CAAGCTGGTGAATTAGGTATTAAAGTGGTTGATGTTCGTATTAAAGGTATTGAGTTGCCTTCAAATACCAGTAATGCTAT
CTATCAACGCATGAGAGCCGACATGCAAAAAATTGCAAACAGACATAGAGCTGACGGACAAGCTGCCGCAGAACAGATCC
AAGCGAAAGCTGATGCTGATGTTACGGTTTTATTGGCTAAAACTAAAAGTAATGCTCAGCGAATTAGAGCAGTTGGTGAA
GCGGAAGCAGCAGCTATCTATTCCAAAGCATACACTCAAAATCAGGATTTTTTTGCTTTATACAAAAGCTTGTTAGCCTA
TGAAGCCAGTTTTCATAGTAAAAAAGATATTTTAATATTGGATCAAAGCAGTTCATTTTTTGATTATTTCAAACAAGCTA
TGCCAAAAAATGATGGTACAGCGGCTAAAAAGTAA

Upstream 100 bases:

>100_bases
CTATAAAAAATGGTACGAATGTCAGGAATGAGGAGGACAACTTGATTCTTTCTGGAAGAGATCTCACAAGACCAACTTAT
AGTCAAGGGAGAGATTGAGA

Downstream 100 bases:

>100_bases
TTATAATGTGAAATTTTGCTGTAATCAGGTTCGATATTTATTAGCATCATCCATCTAATATAAATGCAGTTGGGTTTCTC
GTAAAATGCAACTGCATTTT

Product: membrane protease subunit HflC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MNAFKTTLGVLIFLVLVLLFTSMFTVTQGQQGIILRLGRLVKDPQTDAVKVLNPGLHFKTPFIESVRIFDTRIQTMDIKS
TRIVTKEKKDVMVDYYVKWRISDLAQYFKSTGGNEFKAETLLEQQLNTLLRAQFGKRTISDAVSGGRDDVMEILRNAAEK
QAGELGIKVVDVRIKGIELPSNTSNAIYQRMRADMQKIANRHRADGQAAAEQIQAKADADVTVLLAKTKSNAQRIRAVGE
AEAAAIYSKAYTQNQDFFALYKSLLAYEASFHSKKDILILDQSSSFFDYFKQAMPKNDGTAAKK

Sequences:

>Translated_304_residues
MNAFKTTLGVLIFLVLVLLFTSMFTVTQGQQGIILRLGRLVKDPQTDAVKVLNPGLHFKTPFIESVRIFDTRIQTMDIKS
TRIVTKEKKDVMVDYYVKWRISDLAQYFKSTGGNEFKAETLLEQQLNTLLRAQFGKRTISDAVSGGRDDVMEILRNAAEK
QAGELGIKVVDVRIKGIELPSNTSNAIYQRMRADMQKIANRHRADGQAAAEQIQAKADADVTVLLAKTKSNAQRIRAVGE
AEAAAIYSKAYTQNQDFFALYKSLLAYEASFHSKKDILILDQSSSFFDYFKQAMPKNDGTAAKK
>Mature_304_residues
MNAFKTTLGVLIFLVLVLLFTSMFTVTQGQQGIILRLGRLVKDPQTDAVKVLNPGLHFKTPFIESVRIFDTRIQTMDIKS
TRIVTKEKKDVMVDYYVKWRISDLAQYFKSTGGNEFKAETLLEQQLNTLLRAQFGKRTISDAVSGGRDDVMEILRNAAEK
QAGELGIKVVDVRIKGIELPSNTSNAIYQRMRADMQKIANRHRADGQAAAEQIQAKADADVTVLLAKTKSNAQRIRAVGE
AEAAAIYSKAYTQNQDFFALYKSLLAYEASFHSKKDILILDQSSSFFDYFKQAMPKNDGTAAKK

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=312, Percent_Identity=39.7435897435897, Blast_Score=235, Evalue=3e-63,
Organism=Escherichia coli, GI1786697, Length=292, Percent_Identity=24.3150684931507, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71989948, Length=202, Percent_Identity=27.7227722772277, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193209764, Length=179, Percent_Identity=29.608938547486, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17569493, Length=179, Percent_Identity=29.608938547486, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71989955, Length=176, Percent_Identity=28.4090909090909, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17569499, Length=184, Percent_Identity=29.8913043478261, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 34064; Mature: 34064

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAFKTTLGVLIFLVLVLLFTSMFTVTQGQQGIILRLGRLVKDPQTDAVKVLNPGLHFKT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHCCCCCCCCC
PFIESVRIFDTRIQTMDIKSTRIVTKEKKDVMVDYYVKWRISDLAQYFKSTGGNEFKAET
CHHHHHHHHHHHHHEEECCHHEEEECCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHH
LLEQQLNTLLRAQFGKRTISDAVSGGRDDVMEILRNAAEKQAGELGIKVVDVRIKGIELP
HHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEECC
SNTSNAIYQRMRADMQKIANRHRADGQAAAEQIQAKADADVTVLLAKTKSNAQRIRAVGE
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHH
AEAAAIYSKAYTQNQDFFALYKSLLAYEASFHSKKDILILDQSSSFFDYFKQAMPKNDGT
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCC
AAKK
CCCC
>Mature Secondary Structure
MNAFKTTLGVLIFLVLVLLFTSMFTVTQGQQGIILRLGRLVKDPQTDAVKVLNPGLHFKT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHCCCCCCCCC
PFIESVRIFDTRIQTMDIKSTRIVTKEKKDVMVDYYVKWRISDLAQYFKSTGGNEFKAET
CHHHHHHHHHHHHHEEECCHHEEEECCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHH
LLEQQLNTLLRAQFGKRTISDAVSGGRDDVMEILRNAAEKQAGELGIKVVDVRIKGIELP
HHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEECC
SNTSNAIYQRMRADMQKIANRHRADGQAAAEQIQAKADADVTVLLAKTKSNAQRIRAVGE
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHH
AEAAAIYSKAYTQNQDFFALYKSLLAYEASFHSKKDILILDQSSSFFDYFKQAMPKNDGT
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCCC
AAKK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]