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The map label for this gene is cyoE [H]

Identifier: 54293406

GI number: 54293406

Start: 498677

End: 499561

Strand: Direct

Name: cyoE [H]

Synonym: lpl0455

Alternate gene names: 54293406

Gene position: 498677-499561 (Clockwise)

Preceding gene: 54293405

Following gene: 54293407

Centisome position: 14.91

GC content: 40.79

Gene sequence:

>885_bases
ATGCGTACTGAATACGCAGATCGACTTCCTGTGGATTGGCGTGATTATGTGGAATTGTGTAAGCCACGCGTCGTGTTGCT
CATGCTTCTAACTGTCATTGTAGGAATGTATTTAGCTGCTCCTGGCTGGGTAAGCTTGCGGTTAATCGCTTTTACTTTAC
TTGGTATAGGACTGTGCGCTGGCAGCGCTGCTGCAATCAATCATTTGGTAGACAGGCATATTGATTCGATTATGGCCAGA
ACAAAAAAGAGACCAGTCGCTTATGGACGTGTGTCAGTAAAGCAAGCCTTATGGTTCGCGGTCATTATCGGGCTAATGGG
ATTAAGTCTTCTTATCCTGTTTGTGAACCAATTAACAGCATTACTTACCTTTATAACACTGATTGGTTATGCTGGTGTTT
ACACAGGGTATTTAAAACGAGCTACTTCGCAGAATATTGTTATCGGCGGCCTGGCCGGAGCTGCGCCCCCCTTATTGGGT
TGGACTGCGGTTACTGACCAACTGGATCCTCAGGCCTTGTTATTAGTATTGATTATATTTACATGGACACCGCCTCATTT
TTGGGCTTTGGCAATTTATCGATATAAAGAATATCAAGATGCCGAAATTCCTATGTTACCTGTGACACACGGTATTCAAT
TCACTAAATTAAATATTTATCTCTATACGGTTTTATTGCTGGTAGTCAGTCTTTTGCCTTTTGTTGTAAGTATGAGCGGC
TGGATTTATTTGCTAGGTGCTTTGATTTTGGGCATAAGGTTTTTGGTTTGGGCACATAAATTGTATTTCACTGATAAACC
AGTTGTTGCTATGCAAACATTCCGATTTTCTATTCTGTACCTAATGCTGTTGTTTGTCTTTTTATTAGTAGATCACTATT
TTTAA

Upstream 100 bases:

>100_bases
TTACCGATCAAGGTTGCGGTCGCTCATAATGGTGTAGCCGCATTATTATTAGCGGTGGCATTTTGTTCTTTGCATTTTAC
ACAAGATAGGGAGGTTAGCC

Downstream 100 bases:

>100_bases
GGGGTTAGAATGAACATAAAGATAAAAGGGGGCGCTGTAACAATCACTGTATTGGCCCTGGTCAGTTTATTGGCTGGTAT
TTATATCTCTCAGAATTTTC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MRTEYADRLPVDWRDYVELCKPRVVLLMLLTVIVGMYLAAPGWVSLRLIAFTLLGIGLCAGSAAAINHLVDRHIDSIMAR
TKKRPVAYGRVSVKQALWFAVIIGLMGLSLLILFVNQLTALLTFITLIGYAGVYTGYLKRATSQNIVIGGLAGAAPPLLG
WTAVTDQLDPQALLLVLIIFTWTPPHFWALAIYRYKEYQDAEIPMLPVTHGIQFTKLNIYLYTVLLLVVSLLPFVVSMSG
WIYLLGALILGIRFLVWAHKLYFTDKPVVAMQTFRFSILYLMLLFVFLLVDHYF

Sequences:

>Translated_294_residues
MRTEYADRLPVDWRDYVELCKPRVVLLMLLTVIVGMYLAAPGWVSLRLIAFTLLGIGLCAGSAAAINHLVDRHIDSIMAR
TKKRPVAYGRVSVKQALWFAVIIGLMGLSLLILFVNQLTALLTFITLIGYAGVYTGYLKRATSQNIVIGGLAGAAPPLLG
WTAVTDQLDPQALLLVLIIFTWTPPHFWALAIYRYKEYQDAEIPMLPVTHGIQFTKLNIYLYTVLLLVVSLLPFVVSMSG
WIYLLGALILGIRFLVWAHKLYFTDKPVVAMQTFRFSILYLMLLFVFLLVDHYF
>Mature_294_residues
MRTEYADRLPVDWRDYVELCKPRVVLLMLLTVIVGMYLAAPGWVSLRLIAFTLLGIGLCAGSAAAINHLVDRHIDSIMAR
TKKRPVAYGRVSVKQALWFAVIIGLMGLSLLILFVNQLTALLTFITLIGYAGVYTGYLKRATSQNIVIGGLAGAAPPLLG
WTAVTDQLDPQALLLVLIIFTWTPPHFWALAIYRYKEYQDAEIPMLPVTHGIQFTKLNIYLYTVLLLVVSLLPFVVSMSG
WIYLLGALILGIRFLVWAHKLYFTDKPVVAMQTFRFSILYLMLLFVFLLVDHYF

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=251, Percent_Identity=33.4661354581673, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1786631, Length=280, Percent_Identity=36.0714285714286, Blast_Score=171, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI71998235, Length=196, Percent_Identity=36.2244897959184, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325085, Length=271, Percent_Identity=29.520295202952, Blast_Score=119, Evalue=5e-28,
Organism=Drosophila melanogaster, GI19921064, Length=283, Percent_Identity=32.1554770318021, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 33130; Mature: 33130

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTEYADRLPVDWRDYVELCKPRVVLLMLLTVIVGMYLAAPGWVSLRLIAFTLLGIGLCA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
GSAAAINHLVDRHIDSIMARTKKRPVAYGRVSVKQALWFAVIIGLMGLSLLILFVNQLTA
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLTFITLIGYAGVYTGYLKRATSQNIVIGGLAGAAPPLLGWTAVTDQLDPQALLLVLIIF
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHH
TWTPPHFWALAIYRYKEYQDAEIPMLPVTHGIQFTKLNIYLYTVLLLVVSLLPFVVSMSG
HCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
WIYLLGALILGIRFLVWAHKLYFTDKPVVAMQTFRFSILYLMLLFVFLLVDHYF
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRTEYADRLPVDWRDYVELCKPRVVLLMLLTVIVGMYLAAPGWVSLRLIAFTLLGIGLCA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
GSAAAINHLVDRHIDSIMARTKKRPVAYGRVSVKQALWFAVIIGLMGLSLLILFVNQLTA
CHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLTFITLIGYAGVYTGYLKRATSQNIVIGGLAGAAPPLLGWTAVTDQLDPQALLLVLIIF
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHH
TWTPPHFWALAIYRYKEYQDAEIPMLPVTHGIQFTKLNIYLYTVLLLVVSLLPFVVSMSG
HCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
WIYLLGALILGIRFLVWAHKLYFTDKPVVAMQTFRFSILYLMLLFVFLLVDHYF
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA