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The map label for this gene is htrB [C]

Identifier: 54293355

GI number: 54293355

Start: 452180

End: 453025

Strand: Direct

Name: htrB [C]

Synonym: lpl0404

Alternate gene names: 54293355

Gene position: 452180-453025 (Clockwise)

Preceding gene: 54293354

Following gene: 54293361

Centisome position: 13.52

GC content: 40.54

Gene sequence:

>846_bases
GTGAATAATTTAGCTCAACAAATAGAAGCATTACCCATTACACTGGCGGGACGTTTTATTTATCGGTTTTTGCCATACAG
GCGCCGGTTGATTTTTTCCAATATTAGCCAGGTTTATAATGATCAACTGAATGAATCTCAAAAAAAGCGCTTGGCAAAAG
CGTATTACTCACATCTTGCAAAATCTTTAAAAGAAGCGCTGCAATTAAGATTCATGAGTGAAAAAAAATTACGAGCTCAG
GTTGAAGTAATCGGCCATGAAAAAATGTTGGCTGTTGTGGCACAGAAAAAAGGAGTGTTAGTCGTTACCGGTCACTTTGG
AAATTGGGAGTTTGCGCCCTTGGGAGGGGTATTAAACTTCAAGGAATTCAAAGGCCAATTTCATTTCATCAGGCGGACCT
TGCGATTTAAGTTCATAGAACGCATTATGTTCAAAAATTACTATCAAGCTGGCCTAAATGTTATTCCTAAAAAAAATTCT
CTGGAGCAGGTTTGTGTTGCGTTAGAACAAAATCATGCCGTAATCTTCGTATTGGATCAGCATGCATCCCTGGTGAACAG
AGACGGGATAGCGGTAGAGTTTTTTGGAAAAAAAGCGGGCACCTACAGAAGCCTTGCGACGATATCTCGCCATACAGGAA
TTCCAGTTATACCTGCAGCCAGCTACAGATTACCTAATGGAAAGCATGTTTTGGAGTTTCATGATCCCATTCCTTGGAAA
GATTATGACACTACGCAAGAATCTTTATACCGAAATACCTTGGCCTATAATCAGGCTTTGGAGAGGATTATTCTGGCACA
TCCGGAGCAGTGGAATTGGATGCACAAACGCTGGAAACTTTCTTAA

Upstream 100 bases:

>100_bases
TCAGTAAGTCGTGAGCATAGAGAGATAATATCTAATCCCTATGCCATGATGATCAACCGAGGGTTTGCCAGCATGAATGT
ATGTTTGGTGATCAAAGCCT

Downstream 100 bases:

>100_bases
ATGAATGGATTGTCTTCGTTTTCTTATTTATTCTTTGTCCCAGAATGTTTTCTCCAGGCTCCTACTTAATCACAAATGAC
TTTTTATGGGGCAAGTTATG

Product: hypothetical protein

Products: KDO2-(lauroyl)-lipid IVA [C]

Alternate protein names: Lipid A Biosynthesis Lauroyl Acyltransferase; Acyltransferase; Lauroyl/Myristoyl Acyltransferase; Bacterial Lipid A Biosynthesis Acyltransferase; Lipid A Biosynthesis Lauroyl/Myristoyl Acyltransferase; Bacterial Lipid A Biosynthesis Acyltransferase Superfamily; Acyltransferase HtrB Family; Acyltransferase HtrB/MsbB Family; Lipid A Biosynthesis-Lipid IVA Acyltransferase; Lipid A Lauroyl Acyltransferase; Lipid A Biosynthesis Lauroyl Acyltransferase Subfamily

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MNNLAQQIEALPITLAGRFIYRFLPYRRRLIFSNISQVYNDQLNESQKKRLAKAYYSHLAKSLKEALQLRFMSEKKLRAQ
VEVIGHEKMLAVVAQKKGVLVVTGHFGNWEFAPLGGVLNFKEFKGQFHFIRRTLRFKFIERIMFKNYYQAGLNVIPKKNS
LEQVCVALEQNHAVIFVLDQHASLVNRDGIAVEFFGKKAGTYRSLATISRHTGIPVIPAASYRLPNGKHVLEFHDPIPWK
DYDTTQESLYRNTLAYNQALERIILAHPEQWNWMHKRWKLS

Sequences:

>Translated_281_residues
MNNLAQQIEALPITLAGRFIYRFLPYRRRLIFSNISQVYNDQLNESQKKRLAKAYYSHLAKSLKEALQLRFMSEKKLRAQ
VEVIGHEKMLAVVAQKKGVLVVTGHFGNWEFAPLGGVLNFKEFKGQFHFIRRTLRFKFIERIMFKNYYQAGLNVIPKKNS
LEQVCVALEQNHAVIFVLDQHASLVNRDGIAVEFFGKKAGTYRSLATISRHTGIPVIPAASYRLPNGKHVLEFHDPIPWK
DYDTTQESLYRNTLAYNQALERIILAHPEQWNWMHKRWKLS
>Mature_281_residues
MNNLAQQIEALPITLAGRFIYRFLPYRRRLIFSNISQVYNDQLNESQKKRLAKAYYSHLAKSLKEALQLRFMSEKKLRAQ
VEVIGHEKMLAVVAQKKGVLVVTGHFGNWEFAPLGGVLNFKEFKGQFHFIRRTLRFKFIERIMFKNYYQAGLNVIPKKNS
LEQVCVALEQNHAVIFVLDQHASLVNRDGIAVEFFGKKAGTYRSLATISRHTGIPVIPAASYRLPNGKHVLEFHDPIPWK
DYDTTQESLYRNTLAYNQALERIILAHPEQWNWMHKRWKLS

Specific function: Acylates The Intermediate (Kdo)2-Lipid IVa To Form (Kdo)2-(Lauroyl)-Lipid IVa. Has 10 Fold Selectivity For Lauroyl- Acp Over Myristoyl-Acp. [C]

COG id: COG1560

COG function: function code M; Lauroyl/myristoyl acyltransferase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787292, Length=270, Percent_Identity=23.3333333333333, Blast_Score=71, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.3.1.- [C]

Molecular weight: Translated: 32760; Mature: 32760

Theoretical pI: Translated: 10.55; Mature: 10.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLAQQIEALPITLAGRFIYRFLPYRRRLIFSNISQVYNDQLNESQKKRLAKAYYSHLA
CCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KSLKEALQLRFMSEKKLRAQVEVIGHEKMLAVVAQKKGVLVVTGHFGNWEFAPLGGVLNF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCCCCCCH
KEFKGQFHFIRRTLRFKFIERIMFKNYYQAGLNVIPKKNSLEQVCVALEQNHAVIFVLDQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHHCCCEEEEEECC
HASLVNRDGIAVEFFGKKAGTYRSLATISRHTGIPVIPAASYRLPNGKHVLEFHDPIPWK
CCHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEECCCCEECCCCCEEEEECCCCCCC
DYDTTQESLYRNTLAYNQALERIILAHPEQWNWMHKRWKLS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCC
>Mature Secondary Structure
MNNLAQQIEALPITLAGRFIYRFLPYRRRLIFSNISQVYNDQLNESQKKRLAKAYYSHLA
CCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KSLKEALQLRFMSEKKLRAQVEVIGHEKMLAVVAQKKGVLVVTGHFGNWEFAPLGGVLNF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEECCCCCCCH
KEFKGQFHFIRRTLRFKFIERIMFKNYYQAGLNVIPKKNSLEQVCVALEQNHAVIFVLDQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCCHHHHHHHHHCCCEEEEEECC
HASLVNRDGIAVEFFGKKAGTYRSLATISRHTGIPVIPAASYRLPNGKHVLEFHDPIPWK
CCHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEECCCCEECCCCCEEEEECCCCCCC
DYDTTQESLYRNTLAYNQALERIILAHPEQWNWMHKRWKLS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: KDO2-lipid IVA; lauroyl-ACP [C]

Specific reaction: KDO2-lipid IVA + lauroyl-ACP = KDO2-(lauroyl)-lipid IVA + [acyl carrier protein] [C]

General reaction: Acyltransferases [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA