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The map label for this gene is fabF [H]

Identifier: 54293354

GI number: 54293354

Start: 450910

End: 452187

Strand: Direct

Name: fabF [H]

Synonym: lpl0403

Alternate gene names: 54293354

Gene position: 450910-452187 (Clockwise)

Preceding gene: 54293353

Following gene: 54293355

Centisome position: 13.48

GC content: 41.71

Gene sequence:

>1278_bases
ATGAGTCAAGCGAATAGAGTATTTATTACTGGCCGCAGCGCTCTAACTGCCTCTGGTGCAACTGCTGATGAAACTTGGAA
TGCAATCATTTCAGGCCAGTGTGGAATAGATGAAATTAATTTTTGGGAATTATCTGAATGGTCGCATCGTTTGGGCGGAG
AAATAAAAGATTTCCAACCTTCCAAGATGCTTCCTGATAGAAAATTAATAAAAGTTATTTCCCGTCAGGATATAATGGGA
GTCAATGCGGCAGTGCAAGCTGTTGAGCATAGTAAAATGATTGCTTACAGAGATAGCTTGGCGGATGCTGATTTATTTAA
TGAACAAACCGCTATTTATGTTGGGTCTCCAGGGAATAAATATTTTCAACAATATGACTTTATACCTTTGTTGGCTAAAA
CCCATGGAGATATGCGTAGCTTTGCAAATCAGTTGTTTGATGAAGTGCATCCTATGTGGTTATTGAGGATTTTACCTAAT
AATGTGCTTGCCTATACAGGTATTACCTATGGCTTTAAAGGTCCAAATCACAATGTAACAAATCATGCGGTAGGTGGTAC
ACAAGCCATTTTGGAAGCGTATCATGCCATACGTAGCGGGCAGGCAGAACGTGCGGTTGTGGTTGCCTATGATATAGGCA
CAGAACCTCAAGGCTTATTTTATTATGAAAAATTGGGTGTGGTAAGTAATCGTCATTTAAAACCTTTTGATAAAGAGCAT
GACGGCACTATTCTTGCTGAAGGTGCCGCAGCCCTTGTATTGGAAAGCGAAGCCAGTGTGAAGTCCAGGGCTGCGACTTG
TTATGGCGAGATAGTTGGTGGCTTATCCGCTTCTGAAGCAACAGGATTATTTTCTATTGAAGCAGATGGGCAACATTTGG
CTTCATTGATGGGGCAGACATTAAGCACATCAGGAATAAACTCTGAGGAAATTGGACTAATAGTAACCCATGGAAATGGA
AACAGTAAATCAGATGACAGTGAGGCCCTGGCTATTAAATCAGTATTCAAACAAGAAGAAGTTCCTGCGACTGCTTTTAA
ATGGTCCATGGGACATACTTTATGCGCCTCTGGGGTATTGGATGCGGTATTAACTACATATGCCCTTGAAACCAAATGCG
CGCCGGGGATCGCTAATTTTCAACAAATTGCCCCGACGTGTGAAGGCTTGTCAGTAAGTCGTGAGCATAGAGAGATAATA
TCTAATCCCTATGCCATGATGATCAACCGAGGGTTTGCCAGCATGAATGTATGTTTGGTGATCAAAGCCTGTGAATAA

Upstream 100 bases:

>100_bases
TGAAAAATCTTTAGGGGTAGTATTATCTAATTCGTTTGGTTTTGGCGGTTCTAATAGCTGTTTGTTATTTAAACATCCAG
AATTCGAGGAGGCAAAATAA

Downstream 100 bases:

>100_bases
TTTAGCTCAACAAATAGAAGCATTACCCATTACACTGGCGGGACGTTTTATTTATCGGTTTTTGCCATACAGGCGCCGGT
TGATTTTTTCCAATATTAGC

Product: hypothetical protein

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSQANRVFITGRSALTASGATADETWNAIISGQCGIDEINFWELSEWSHRLGGEIKDFQPSKMLPDRKLIKVISRQDIMG
VNAAVQAVEHSKMIAYRDSLADADLFNEQTAIYVGSPGNKYFQQYDFIPLLAKTHGDMRSFANQLFDEVHPMWLLRILPN
NVLAYTGITYGFKGPNHNVTNHAVGGTQAILEAYHAIRSGQAERAVVVAYDIGTEPQGLFYYEKLGVVSNRHLKPFDKEH
DGTILAEGAAALVLESEASVKSRAATCYGEIVGGLSASEATGLFSIEADGQHLASLMGQTLSTSGINSEEIGLIVTHGNG
NSKSDDSEALAIKSVFKQEEVPATAFKWSMGHTLCASGVLDAVLTTYALETKCAPGIANFQQIAPTCEGLSVSREHREII
SNPYAMMINRGFASMNVCLVIKACE

Sequences:

>Translated_425_residues
MSQANRVFITGRSALTASGATADETWNAIISGQCGIDEINFWELSEWSHRLGGEIKDFQPSKMLPDRKLIKVISRQDIMG
VNAAVQAVEHSKMIAYRDSLADADLFNEQTAIYVGSPGNKYFQQYDFIPLLAKTHGDMRSFANQLFDEVHPMWLLRILPN
NVLAYTGITYGFKGPNHNVTNHAVGGTQAILEAYHAIRSGQAERAVVVAYDIGTEPQGLFYYEKLGVVSNRHLKPFDKEH
DGTILAEGAAALVLESEASVKSRAATCYGEIVGGLSASEATGLFSIEADGQHLASLMGQTLSTSGINSEEIGLIVTHGNG
NSKSDDSEALAIKSVFKQEEVPATAFKWSMGHTLCASGVLDAVLTTYALETKCAPGIANFQQIAPTCEGLSVSREHREII
SNPYAMMINRGFASMNVCLVIKACE
>Mature_424_residues
SQANRVFITGRSALTASGATADETWNAIISGQCGIDEINFWELSEWSHRLGGEIKDFQPSKMLPDRKLIKVISRQDIMGV
NAAVQAVEHSKMIAYRDSLADADLFNEQTAIYVGSPGNKYFQQYDFIPLLAKTHGDMRSFANQLFDEVHPMWLLRILPNN
VLAYTGITYGFKGPNHNVTNHAVGGTQAILEAYHAIRSGQAERAVVVAYDIGTEPQGLFYYEKLGVVSNRHLKPFDKEHD
GTILAEGAAALVLESEASVKSRAATCYGEIVGGLSASEATGLFSIEADGQHLASLMGQTLSTSGINSEEIGLIVTHGNGN
SKSDDSEALAIKSVFKQEEVPATAFKWSMGHTLCASGVLDAVLTTYALETKCAPGIANFQQIAPTCEGLSVSREHREIIS
NPYAMMINRGFASMNVCLVIKACE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=393, Percent_Identity=26.2086513994911, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1787337, Length=426, Percent_Identity=26.5258215962441, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788663, Length=445, Percent_Identity=22.0224719101124, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71983541, Length=442, Percent_Identity=21.2669683257919, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71983535, Length=256, Percent_Identity=22.65625, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI212642053, Length=282, Percent_Identity=24.822695035461, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=454, Percent_Identity=22.9074889867841, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24644341, Length=397, Percent_Identity=26.7002518891688, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI221330659, Length=264, Percent_Identity=23.1060606060606, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19920632, Length=264, Percent_Identity=23.1060606060606, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24581345, Length=244, Percent_Identity=25.4098360655738, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 46063; Mature: 45931

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQANRVFITGRSALTASGATADETWNAIISGQCGIDEINFWELSEWSHRLGGEIKDFQP
CCCCCEEEEECCCEEEECCCCCCCCCHHEEECCCCCCCCCCEEHHHHHHHHCCCCCCCCC
SKMLPDRKLIKVISRQDIMGVNAAVQAVEHSKMIAYRDSLADADLFNEQTAIYVGSPGNK
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEEECCCHH
YFQQYDFIPLLAKTHGDMRSFANQLFDEVHPMWLLRILPNNVLAYTGITYGFKGPNHNVT
HHHHCCCCHHHHHCCCHHHHHHHHHHHHHCHHHEEHHCCCCEEEECCEEECCCCCCCCCC
NHAVGGTQAILEAYHAIRSGQAERAVVVAYDIGTEPQGLFYYEKLGVVSNRHLKPFDKEH
CCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEHHCCCCCCCCCCCCCCC
DGTILAEGAAALVLESEASVKSRAATCYGEIVGGLSASEATGLFSIEADGQHLASLMGQT
CCEEEECCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHH
LSTSGINSEEIGLIVTHGNGNSKSDDSEALAIKSVFKQEEVPATAFKWSMGHTLCASGVL
HHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHEEECCCHHHHHHHHH
DAVLTTYALETKCAPGIANFQQIAPTCEGLSVSREHREIISNPYAMMINRGFASMNVCLV
HHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCEEEEE
IKACE
EEECC
>Mature Secondary Structure 
SQANRVFITGRSALTASGATADETWNAIISGQCGIDEINFWELSEWSHRLGGEIKDFQP
CCCCEEEEECCCEEEECCCCCCCCCHHEEECCCCCCCCCCEEHHHHHHHHCCCCCCCCC
SKMLPDRKLIKVISRQDIMGVNAAVQAVEHSKMIAYRDSLADADLFNEQTAIYVGSPGNK
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEEECCCHH
YFQQYDFIPLLAKTHGDMRSFANQLFDEVHPMWLLRILPNNVLAYTGITYGFKGPNHNVT
HHHHCCCCHHHHHCCCHHHHHHHHHHHHHCHHHEEHHCCCCEEEECCEEECCCCCCCCCC
NHAVGGTQAILEAYHAIRSGQAERAVVVAYDIGTEPQGLFYYEKLGVVSNRHLKPFDKEH
CCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEHHCCCCCCCCCCCCCCC
DGTILAEGAAALVLESEASVKSRAATCYGEIVGGLSASEATGLFSIEADGQHLASLMGQT
CCEEEECCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHH
LSTSGINSEEIGLIVTHGNGNSKSDDSEALAIKSVFKQEEVPATAFKWSMGHTLCASGVL
HHCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHEEECCCHHHHHHHHH
DAVLTTYALETKCAPGIANFQQIAPTCEGLSVSREHREIISNPYAMMINRGFASMNVCLV
HHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEECCCCCCEEEEE
IKACE
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]