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The map label for this gene is rpoC [H]

Identifier: 54293315

GI number: 54293315

Start: 423306

End: 427511

Strand: Direct

Name: rpoC [H]

Synonym: lpl0363

Alternate gene names: 54293315

Gene position: 423306-427511 (Clockwise)

Preceding gene: 54293314

Following gene: 54293316

Centisome position: 12.65

GC content: 41.49

Gene sequence:

>4206_bases
ATGAGTGACTTACTTGGTATTCTTAAGCAACAAGGTCAAAGTGAAGAATTTGATGCAATAAAAATTGCACTGGCGTCACC
TGAATTAATTCGATCATGGTCCTACGGCGAAGTTAAAAAACCTGAAACAATCAACTACAGGACATTTAAGCCTGAAAGAG
ATGGTTTGTTTTGTGCTAAAACTTTTGGTCCGGTTAAAGATTATGAGTGTTTGTGTGGAAAGTACAAGCGACTAAAGCAT
CGTGGTGTTATTTGCGAGAAGTGTGGGGTTGAATTGGCTCTTGCCAAAGTGAGACGAGAAAGGATGGGGCATATCGAACT
CGCTAGCCCAGTCGCACACATATGGTTCTTAAAATCCTTACCATCAAGAATTGGTTTGCTCCTCGATATGACACTAAGAG
ATATCGAGAGAGTACTCTATTTTGAGGCTTTTGTCGTTGTTGATCCTGGAATGACAGAACTTGAAAGAGGGCAACTACTT
AATGACGAAGCCTATCTTGATGCGATGGAACAGTATGGAGATGAGTTTGACGCGCGTATGGGCGCAGAAGCAATTCGTGA
TTTATTGCGCCAAATTGATCTGGAAGATGAAATTAGAAATTTACGTGAAGAGCTTCCAACAACTAACTCTGAGACGAAGA
TTAAAAAAATCACCAAAAGACTCAAGTTATTAGAAGCTTTTTACGAGTCAGGAAATAAACCAGAATGGATGATCATGGAT
GTACTTCCAGTGCTTCCACCCGATTTGAGACCATTGGTTCCGCTAGATGGTGGACGTTTTGCTACTTCAGACTTGAATGA
TTTATACAGGCGCGTCATTAATAGGAATAACCGACTAAAACGCCTGCTGGATCTGAATGCGCCTGACATTATCGTTCGTA
ACGAAAAACGAATGCTGCAAGAATCCGTAGATGCTTTGCTTGATAACGGCAGAAGGGGTCGTGCCATCACTGGTACAAAT
AAGAGACCTCTTAAATCACTGGCTGATATGATTAAAGGAAAACAGGGTCGTTTCAGACAAAACCTCTTAGGTAAGCGTGT
CGACTACTCTGGGCGTTCAGTTATTGTAGTTGGACCAACTTTAAAATTGCACCAATGCGGATTGCCTAAAAAAATGGCGT
TGGAATTATTCAAGCCATTTATATTTTCCAAATTGGAATTTAGAGGTTTGGCAACTACTATCAAAGCAGCCAAGAAAATG
GTCGAAAGAGAGGAATCGGTTGTTTGGGATATATTAGATGATGTTATTAGGGAACATCCTATCCTTTTAAACCGTGCTCC
TACTTTGCATAGATTAGGTATTCAAGCATTTGAGCCTGTTTTAATTGAAGGTAAAGCGATCCAGCTCCATCCTTTGGTAT
GTACAGCATACAACGCTGACTTCGATGGAGACCAAATGGCTGTGCACGTGCCCTTGACACTGGAAGCGCAGCTGGAAGCT
CGTTCATTGATGATGTCTACAAACAATATATTATCTCCAGCCAGTGGTGAGCCGATTATTGTCCCCAGTCAGGACGTCGT
CCTTGGGTTATACTATTTAACAAGAGAAAAGGTTAATGCATTAGGCGAAGGAAAAATATATTCAAGTGCTCAGGAAGCGC
AAAATTTCTATGAAGCAGGTCATTTGGATATCCATGCAAAAATTAAAATTCGTATGCCTAAAGAAGATGGTGAAACTGGA
TATCATTTAGTTGAGACAACAGTCGGACGCGCTATTTTAGCTGAGATTTTGCCTAAAGGAATGCCATTTGACTATATAAA
CCGTACAATGACAAAAAAGGTTATCTCAAAAGTAATAGACAGCTGCTACCGCAAATTCGGCTTGAAAGAAACAGTCATTT
TTGCTGATCAGTTAATGTATACCGGGTTTAAATACGCCACACGATCTGGAGCATCCATAGGTATTGAAGACATGGAAATA
CCAGATGATAAGGCCAGTATTATTGAACACGCCGATAATGAAGTAAGAGAAATCGAATCTCAATTCAGATCGGGTTTGGT
AACGAATGGTGAACGATACAACAAGGTAATTGATATTTGGTCAAGAACTAATGAATTAGTTGCCAAATCAATGATGTCTA
AAATTGCAACAGAAGAAGTCGCTGATGCAAAGGGCAACAAAGTAAGACAAGAATCATTTAACCCAATTTTCATGATGGCT
GATTCTGGAGCTAGAGGTTCTGCTGCTCAGATACGACAGCTTGCCGGGATGCGAGGTTTGATGGCAGCTCCAGATGGCTC
AATTATTGAAACGCCTATCACTGCAAACTTCCGCGAAGGTTTGAATGTATTCCAGTACTTTATTTCTACACACGGAGCTC
GTAAGGGTTTGGCAGATACGGCGTTAAAGACAGCAAACTCAGGGTATCTGACACGACGATTGGTAGATGTTGCGCAGGAT
GTTGTTATTACCGAAGATGATTGTGGTACTGATACTGGTATTCTAATGCAACCACTGATTGAAGGTGGTGATATTGTTGA
GCCTTTGCATGAACGCGTCCTTGGGCGGGTGGTTGCTTCAGATGTCTATATTCCTACTCAAACTGAACCAGTAGTCAAGG
CTGGAACTTTACTGGATGAAGAATGGGTTGAAAAATTAGAGAAGCATGGGGTAGACCAGGTTATGGTCAGGTCACCAATC
ACTTGTCAAACGAGATTTGGTCTTTGCGCAAAATGCTATGGTAGAGATCTTGCTCGTGGGCATCTTGTCAACACAGGTGA
AGCAGTTGGTATTATCGCAGCACAATCAATCGGTGAGCCAGGAACACAGTTAACCATGCGTACCTTCCACATTGGAGGTG
CTGCATCAAGGGCAACAGCTGCGAATAATATTCAAATTAAAACGAAAGGGGTTATTCGGTTACATAATATAAAGACCGTA
ACTCATGAGAATAAAAACCTGGTGGCAGTTTCTCGCTCAGGTGAGGTAACTATTGTTGATGAGTTCGGACGAGAAAGGGA
GCGATATAAAGTTCCTTATGGTGCAGTAATTTCAGCACAGGATAATTCTCCTGTTGAAGCTGGTCAGGTTATTGCAACGT
GGGATCCTCATACGCATCCTGTTATTTCTGAAGTGTCAGGGCGTTTGAAGTTTGTTGATCTCATTGATGGTATTACAATG
AATAGGCAAACTGATGAATTAACCGGATTAAGTAATATTGTAATAATTGATGCCAAACAACGGAGTGCTGCAGGTCGAGA
TTTGCGTCCAATGGTAAAATTAGTTACAGATGAAGGGGATGACATATATCTTGCTGGAACCAATGTCCCGGCACAATATT
ATCTACCTGTCGATGCCATTGTAAACTTTGAAGATAGAAGTCTGGTGGGAATAGGAGATGTTATTGCCCGTATTCCGCAA
GAACGCTCTAAAACTCGTGATATTACCGGAGGTTTACCAAGAGTAGCGGACTTATTTGAAGCCAGAAAACCAAAGGATTC
TGCAGTAATGGCAGAAGTATCAGGATTGGTTAATTTTGGTAAAGAAACCAAAGGTAAGCGACGCTTGATTATCAACGTAT
CAGAAGATCAATGTCATGAAGAGCTTATTCCTAAATGGCGTCATATTTCAGTGTTTGAAGGCGAGCACGTAGAGCGTGGT
GAAATCATCGCAGAGGGTGCACTTAATCCTCATGATATATTGCGCTTGTTAGGTGTTGGAGCGCTGGCTAATTACATTGT
AAATGAGGTCCAGGACGTCTATCGTTTACAAGGTGTGAAAATTAATGATAAACACATTGAAGTAATTGTCAGACAAATGC
TACGTAAGAGAGTTATTACTTTCGCTGGTGACTCGAAATTCCTCGTAGGAGAGCAAGTAGAAGAGAGCGCTATGCTTCAG
GAAAATGATAAACTTCTGGCTGAAGGAAAGCAGATTGCGCGAGGTACTCCTATTTTACTAGGTATCACAAAAGCTTCATT
AGCTACAGAATCGTTTATATCAGCCGCTTCATTCCAAGAGACAACCAGAGTCTTGACTGAAGCAGCAGTAAGCGGAAAAG
TTGATGAATTGCGTGGTTTAAAAGAAAACGTGATGGTAGGTCGCCTAATTCCAGCAGGAACAGGTTATACTTATCATCAA
AGCCGAAAGGCAAAGAGAGCAAGGGTTGCAGCAGGCGGAGACAGTTCAGCAACACACACAGTTACTGCAAGTGATGTTGA
ACACGCGTTGAGTGAAGCATTAAACGCGGATAATCATGAACATTAA

Upstream 100 bases:

>100_bases
GAGCATGACTAACTCATCAGCGATACATACTGACTAACCATTTTTTGGAGGCATAGACTTGGCTACCCTAAGCAACGACC
CAATGAAAAAAGCACCAGTA

Downstream 100 bases:

>100_bases
TCAGGATTCAAAAATGGCAGATTTAAGCTTGACAAATCTGCCGTACCTATATAGAATCCGGCCTCCTTATGCATTCAAAA
TATTCACAAGTGACAGATCG

Product: DNA-directed RNA polymerase subunit beta'

Products: NA

Alternate protein names: RNAP subunit beta'; RNA polymerase subunit beta'; Transcriptase subunit beta' [H]

Number of amino acids: Translated: 1401; Mature: 1400

Protein sequence:

>1401_residues
MSDLLGILKQQGQSEEFDAIKIALASPELIRSWSYGEVKKPETINYRTFKPERDGLFCAKTFGPVKDYECLCGKYKRLKH
RGVICEKCGVELALAKVRRERMGHIELASPVAHIWFLKSLPSRIGLLLDMTLRDIERVLYFEAFVVVDPGMTELERGQLL
NDEAYLDAMEQYGDEFDARMGAEAIRDLLRQIDLEDEIRNLREELPTTNSETKIKKITKRLKLLEAFYESGNKPEWMIMD
VLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLNAPDIIVRNEKRMLQESVDALLDNGRRGRAITGTN
KRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVIVVGPTLKLHQCGLPKKMALELFKPFIFSKLEFRGLATTIKAAKKM
VEREESVVWDILDDVIREHPILLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCTAYNADFDGDQMAVHVPLTLEAQLEA
RSLMMSTNNILSPASGEPIIVPSQDVVLGLYYLTREKVNALGEGKIYSSAQEAQNFYEAGHLDIHAKIKIRMPKEDGETG
YHLVETTVGRAILAEILPKGMPFDYINRTMTKKVISKVIDSCYRKFGLKETVIFADQLMYTGFKYATRSGASIGIEDMEI
PDDKASIIEHADNEVREIESQFRSGLVTNGERYNKVIDIWSRTNELVAKSMMSKIATEEVADAKGNKVRQESFNPIFMMA
DSGARGSAAQIRQLAGMRGLMAAPDGSIIETPITANFREGLNVFQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQD
VVITEDDCGTDTGILMQPLIEGGDIVEPLHERVLGRVVASDVYIPTQTEPVVKAGTLLDEEWVEKLEKHGVDQVMVRSPI
TCQTRFGLCAKCYGRDLARGHLVNTGEAVGIIAAQSIGEPGTQLTMRTFHIGGAASRATAANNIQIKTKGVIRLHNIKTV
THENKNLVAVSRSGEVTIVDEFGRERERYKVPYGAVISAQDNSPVEAGQVIATWDPHTHPVISEVSGRLKFVDLIDGITM
NRQTDELTGLSNIVIIDAKQRSAAGRDLRPMVKLVTDEGDDIYLAGTNVPAQYYLPVDAIVNFEDRSLVGIGDVIARIPQ
ERSKTRDITGGLPRVADLFEARKPKDSAVMAEVSGLVNFGKETKGKRRLIINVSEDQCHEELIPKWRHISVFEGEHVERG
EIIAEGALNPHDILRLLGVGALANYIVNEVQDVYRLQGVKINDKHIEVIVRQMLRKRVITFAGDSKFLVGEQVEESAMLQ
ENDKLLAEGKQIARGTPILLGITKASLATESFISAASFQETTRVLTEAAVSGKVDELRGLKENVMVGRLIPAGTGYTYHQ
SRKAKRARVAAGGDSSATHTVTASDVEHALSEALNADNHEH

Sequences:

>Translated_1401_residues
MSDLLGILKQQGQSEEFDAIKIALASPELIRSWSYGEVKKPETINYRTFKPERDGLFCAKTFGPVKDYECLCGKYKRLKH
RGVICEKCGVELALAKVRRERMGHIELASPVAHIWFLKSLPSRIGLLLDMTLRDIERVLYFEAFVVVDPGMTELERGQLL
NDEAYLDAMEQYGDEFDARMGAEAIRDLLRQIDLEDEIRNLREELPTTNSETKIKKITKRLKLLEAFYESGNKPEWMIMD
VLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLNAPDIIVRNEKRMLQESVDALLDNGRRGRAITGTN
KRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVIVVGPTLKLHQCGLPKKMALELFKPFIFSKLEFRGLATTIKAAKKM
VEREESVVWDILDDVIREHPILLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCTAYNADFDGDQMAVHVPLTLEAQLEA
RSLMMSTNNILSPASGEPIIVPSQDVVLGLYYLTREKVNALGEGKIYSSAQEAQNFYEAGHLDIHAKIKIRMPKEDGETG
YHLVETTVGRAILAEILPKGMPFDYINRTMTKKVISKVIDSCYRKFGLKETVIFADQLMYTGFKYATRSGASIGIEDMEI
PDDKASIIEHADNEVREIESQFRSGLVTNGERYNKVIDIWSRTNELVAKSMMSKIATEEVADAKGNKVRQESFNPIFMMA
DSGARGSAAQIRQLAGMRGLMAAPDGSIIETPITANFREGLNVFQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQD
VVITEDDCGTDTGILMQPLIEGGDIVEPLHERVLGRVVASDVYIPTQTEPVVKAGTLLDEEWVEKLEKHGVDQVMVRSPI
TCQTRFGLCAKCYGRDLARGHLVNTGEAVGIIAAQSIGEPGTQLTMRTFHIGGAASRATAANNIQIKTKGVIRLHNIKTV
THENKNLVAVSRSGEVTIVDEFGRERERYKVPYGAVISAQDNSPVEAGQVIATWDPHTHPVISEVSGRLKFVDLIDGITM
NRQTDELTGLSNIVIIDAKQRSAAGRDLRPMVKLVTDEGDDIYLAGTNVPAQYYLPVDAIVNFEDRSLVGIGDVIARIPQ
ERSKTRDITGGLPRVADLFEARKPKDSAVMAEVSGLVNFGKETKGKRRLIINVSEDQCHEELIPKWRHISVFEGEHVERG
EIIAEGALNPHDILRLLGVGALANYIVNEVQDVYRLQGVKINDKHIEVIVRQMLRKRVITFAGDSKFLVGEQVEESAMLQ
ENDKLLAEGKQIARGTPILLGITKASLATESFISAASFQETTRVLTEAAVSGKVDELRGLKENVMVGRLIPAGTGYTYHQ
SRKAKRARVAAGGDSSATHTVTASDVEHALSEALNADNHEH
>Mature_1400_residues
SDLLGILKQQGQSEEFDAIKIALASPELIRSWSYGEVKKPETINYRTFKPERDGLFCAKTFGPVKDYECLCGKYKRLKHR
GVICEKCGVELALAKVRRERMGHIELASPVAHIWFLKSLPSRIGLLLDMTLRDIERVLYFEAFVVVDPGMTELERGQLLN
DEAYLDAMEQYGDEFDARMGAEAIRDLLRQIDLEDEIRNLREELPTTNSETKIKKITKRLKLLEAFYESGNKPEWMIMDV
LPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLNAPDIIVRNEKRMLQESVDALLDNGRRGRAITGTNK
RPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVIVVGPTLKLHQCGLPKKMALELFKPFIFSKLEFRGLATTIKAAKKMV
EREESVVWDILDDVIREHPILLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCTAYNADFDGDQMAVHVPLTLEAQLEAR
SLMMSTNNILSPASGEPIIVPSQDVVLGLYYLTREKVNALGEGKIYSSAQEAQNFYEAGHLDIHAKIKIRMPKEDGETGY
HLVETTVGRAILAEILPKGMPFDYINRTMTKKVISKVIDSCYRKFGLKETVIFADQLMYTGFKYATRSGASIGIEDMEIP
DDKASIIEHADNEVREIESQFRSGLVTNGERYNKVIDIWSRTNELVAKSMMSKIATEEVADAKGNKVRQESFNPIFMMAD
SGARGSAAQIRQLAGMRGLMAAPDGSIIETPITANFREGLNVFQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDV
VITEDDCGTDTGILMQPLIEGGDIVEPLHERVLGRVVASDVYIPTQTEPVVKAGTLLDEEWVEKLEKHGVDQVMVRSPIT
CQTRFGLCAKCYGRDLARGHLVNTGEAVGIIAAQSIGEPGTQLTMRTFHIGGAASRATAANNIQIKTKGVIRLHNIKTVT
HENKNLVAVSRSGEVTIVDEFGRERERYKVPYGAVISAQDNSPVEAGQVIATWDPHTHPVISEVSGRLKFVDLIDGITMN
RQTDELTGLSNIVIIDAKQRSAAGRDLRPMVKLVTDEGDDIYLAGTNVPAQYYLPVDAIVNFEDRSLVGIGDVIARIPQE
RSKTRDITGGLPRVADLFEARKPKDSAVMAEVSGLVNFGKETKGKRRLIINVSEDQCHEELIPKWRHISVFEGEHVERGE
IIAEGALNPHDILRLLGVGALANYIVNEVQDVYRLQGVKINDKHIEVIVRQMLRKRVITFAGDSKFLVGEQVEESAMLQE
NDKLLAEGKQIARGTPILLGITKASLATESFISAASFQETTRVLTEAAVSGKVDELRGLKENVMVGRLIPAGTGYTYHQS
RKAKRARVAAGGDSSATHTVTASDVEHALSEALNADNHEH

Specific function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates [H]

COG id: COG0086

COG function: function code K; DNA-directed RNA polymerase, beta' subunit/160 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNA polymerase beta' chain family [H]

Homologues:

Organism=Homo sapiens, GI39725938, Length=847, Percent_Identity=26.3282172373081, Blast_Score=186, Evalue=1e-46,
Organism=Homo sapiens, GI4505939, Length=848, Percent_Identity=24.4103773584906, Blast_Score=186, Evalue=2e-46,
Organism=Homo sapiens, GI103471997, Length=226, Percent_Identity=31.4159292035398, Blast_Score=90, Evalue=1e-17,
Organism=Escherichia coli, GI2367335, Length=1403, Percent_Identity=72.0598717034925, Blast_Score=2078, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25145495, Length=350, Percent_Identity=31.1428571428571, Blast_Score=151, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI71987878, Length=580, Percent_Identity=26.551724137931, Blast_Score=150, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6324690, Length=717, Percent_Identity=26.3598326359833, Blast_Score=194, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6320061, Length=550, Percent_Identity=26.7272727272727, Blast_Score=147, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324917, Length=458, Percent_Identity=25.764192139738, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI281360912, Length=1046, Percent_Identity=25.1434034416826, Blast_Score=196, Evalue=9e-50,
Organism=Drosophila melanogaster, GI17530899, Length=495, Percent_Identity=26.0606060606061, Blast_Score=159, Evalue=2e-38,
Organism=Drosophila melanogaster, GI17647875, Length=328, Percent_Identity=28.3536585365854, Blast_Score=105, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000722
- InterPro:   IPR006592
- InterPro:   IPR007080
- InterPro:   IPR007066
- InterPro:   IPR007083
- InterPro:   IPR007081
- InterPro:   IPR012754 [H]

Pfam domain/function: PF04997 RNA_pol_Rpb1_1; PF00623 RNA_pol_Rpb1_2; PF04983 RNA_pol_Rpb1_3; PF05000 RNA_pol_Rpb1_4; PF04998 RNA_pol_Rpb1_5 [H]

EC number: =2.7.7.6 [H]

Molecular weight: Translated: 155725; Mature: 155594

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLLGILKQQGQSEEFDAIKIALASPELIRSWSYGEVKKPETINYRTFKPERDGLFCAK
CHHHHHHHHHCCCCCCCCEEEEEECCHHHHHCCCCCCCCCCCCCCEEECCCCCCCEEEEC
TFGPVKDYECLCGKYKRLKHRGVICEKCGVELALAKVRRERMGHIELASPVAHIWFLKSL
CCCCCCHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHH
PSRIGLLLDMTLRDIERVLYFEAFVVVDPGMTELERGQLLNDEAYLDAMEQYGDEFDARM
HHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHCCCCCCHHHHHHHHHHHCCHHHHHH
GAEAIRDLLRQIDLEDEIRNLREELPTTNSETKIKKITKRLKLLEAFYESGNKPEWMIMD
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
VLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLNAPDIIVRNEKRMLQ
EHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCEEEECHHHHHH
ESVDALLDNGRRGRAITGTNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVIVVGPT
HHHHHHHHCCCCCCEECCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEEEECCC
LKLHQCGLPKKMALELFKPFIFSKLEFRGLATTIKAAKKMVEREESVVWDILDDVIREHP
EEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ILLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCTAYNADFDGDQMAVHVPLTLEAQLEA
EEECCCCCHHHHCHHHCCCEEEECCEEEEEEEEEEEECCCCCCCCEEEEEEEEEEHHHHH
RSLMMSTNNILSPASGEPIIVPSQDVVLGLYYLTREKVNALGEGKIYSSAQEAQNFYEAG
HHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCC
HLDIHAKIKIRMPKEDGETGYHLVETTVGRAILAEILPKGMPFDYINRTMTKKVISKVID
CEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SCYRKFGLKETVIFADQLMYTGFKYATRSGASIGIEDMEIPDDKASIIEHADNEVREIES
HHHHHHCCCHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHH
QFRSGLVTNGERYNKVIDIWSRTNELVAKSMMSKIATEEVADAKGNKVRQESFNPIFMMA
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEEE
DSGARGSAAQIRQLAGMRGLMAAPDGSIIETPITANFREGLNVFQYFISTHGARKGLADT
CCCCCCCHHHHHHHHCCCCEEECCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHH
ALKTANSGYLTRRLVDVAQDVVITEDDCGTDTGILMQPLIEGGDIVEPLHERVLGRVVAS
HHHHCCCCHHHHHHHHHHHCEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHC
DVYIPTQTEPVVKAGTLLDEEWVEKLEKHGVDQVMVRSPITCQTRFGLCAKCYGRDLARG
CEECCCCCCCHHHHCCCCCHHHHHHHHHCCCCEEHHCCCCCCHHHHCHHHHHHCCHHHCC
HLVNTGEAVGIIAAQSIGEPGTQLTMRTFHIGGAASRATAANNIQIKTKGVIRLHNIKTV
CCCCCCCEEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEECCEEEEEEEEEE
THENKNLVAVSRSGEVTIVDEFGRERERYKVPYGAVISAQDNSPVEAGQVIATWDPHTHP
EECCCCEEEEECCCCEEEEHHHCCCHHHEECCCCEEEECCCCCCCCCCCEEEECCCCCCH
VISEVSGRLKFVDLIDGITMNRQTDELTGLSNIVIIDAKQRSAAGRDLRPMVKLVTDEGD
HHHHHCCCEEEEHHHCCCCCCCCCHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCC
DIYLAGTNVPAQYYLPVDAIVNFEDRSLVGIGDVIARIPQERSKTRDITGGLPRVADLFE
EEEEEECCCCCEEEECHHHEEECCCCCEECHHHHHHHCCHHHHHCCCCCCCCHHHHHHHH
ARKPKDSAVMAEVSGLVNFGKETKGKRRLIINVSEDQCHEELIPKWRHISVFEGEHVERG
HCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHCCCCCEEEEECCCCCCCC
EIIAEGALNPHDILRLLGVGALANYIVNEVQDVYRLQGVKINDKHIEVIVRQMLRKRVIT
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHEE
FAGDSKFLVGEQVEESAMLQENDKLLAEGKQIARGTPILLGITKASLATESFISAASFQE
ECCCCCEEECCHHHHHHHHHCCCHHHHCCHHHHCCCCEEEEECHHHHHHHHHHHHHHHHH
TTRVLTEAAVSGKVDELRGLKENVMVGRLIPAGTGYTYHQSRKAKRARVAAGGDSSATHT
HHHHHHHHHHCCCHHHHHCCHHHCEEEEEEECCCCCCHHHHHHHHHHHEECCCCCCCEEE
VTASDVEHALSEALNADNHEH
EEHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SDLLGILKQQGQSEEFDAIKIALASPELIRSWSYGEVKKPETINYRTFKPERDGLFCAK
HHHHHHHHHCCCCCCCCEEEEEECCHHHHHCCCCCCCCCCCCCCEEECCCCCCCEEEEC
TFGPVKDYECLCGKYKRLKHRGVICEKCGVELALAKVRRERMGHIELASPVAHIWFLKSL
CCCCCCHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHH
PSRIGLLLDMTLRDIERVLYFEAFVVVDPGMTELERGQLLNDEAYLDAMEQYGDEFDARM
HHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHCCCCCCHHHHHHHHHHHCCHHHHHH
GAEAIRDLLRQIDLEDEIRNLREELPTTNSETKIKKITKRLKLLEAFYESGNKPEWMIMD
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEE
VLPVLPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLNAPDIIVRNEKRMLQ
EHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCEEEECHHHHHH
ESVDALLDNGRRGRAITGTNKRPLKSLADMIKGKQGRFRQNLLGKRVDYSGRSVIVVGPT
HHHHHHHHCCCCCCEECCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEEEECCC
LKLHQCGLPKKMALELFKPFIFSKLEFRGLATTIKAAKKMVEREESVVWDILDDVIREHP
EEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ILLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCTAYNADFDGDQMAVHVPLTLEAQLEA
EEECCCCCHHHHCHHHCCCEEEECCEEEEEEEEEEEECCCCCCCCEEEEEEEEEEHHHHH
RSLMMSTNNILSPASGEPIIVPSQDVVLGLYYLTREKVNALGEGKIYSSAQEAQNFYEAG
HHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCC
HLDIHAKIKIRMPKEDGETGYHLVETTVGRAILAEILPKGMPFDYINRTMTKKVISKVID
CEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SCYRKFGLKETVIFADQLMYTGFKYATRSGASIGIEDMEIPDDKASIIEHADNEVREIES
HHHHHHCCCHHHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHH
QFRSGLVTNGERYNKVIDIWSRTNELVAKSMMSKIATEEVADAKGNKVRQESFNPIFMMA
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEEE
DSGARGSAAQIRQLAGMRGLMAAPDGSIIETPITANFREGLNVFQYFISTHGARKGLADT
CCCCCCCHHHHHHHHCCCCEEECCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHH
ALKTANSGYLTRRLVDVAQDVVITEDDCGTDTGILMQPLIEGGDIVEPLHERVLGRVVAS
HHHHCCCCHHHHHHHHHHHCEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHC
DVYIPTQTEPVVKAGTLLDEEWVEKLEKHGVDQVMVRSPITCQTRFGLCAKCYGRDLARG
CEECCCCCCCHHHHCCCCCHHHHHHHHHCCCCEEHHCCCCCCHHHHCHHHHHHCCHHHCC
HLVNTGEAVGIIAAQSIGEPGTQLTMRTFHIGGAASRATAANNIQIKTKGVIRLHNIKTV
CCCCCCCEEEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEECCEEEEEEEEEE
THENKNLVAVSRSGEVTIVDEFGRERERYKVPYGAVISAQDNSPVEAGQVIATWDPHTHP
EECCCCEEEEECCCCEEEEHHHCCCHHHEECCCCEEEECCCCCCCCCCCEEEECCCCCCH
VISEVSGRLKFVDLIDGITMNRQTDELTGLSNIVIIDAKQRSAAGRDLRPMVKLVTDEGD
HHHHHCCCEEEEHHHCCCCCCCCCHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCC
DIYLAGTNVPAQYYLPVDAIVNFEDRSLVGIGDVIARIPQERSKTRDITGGLPRVADLFE
EEEEEECCCCCEEEECHHHEEECCCCCEECHHHHHHHCCHHHHHCCCCCCCCHHHHHHHH
ARKPKDSAVMAEVSGLVNFGKETKGKRRLIINVSEDQCHEELIPKWRHISVFEGEHVERG
HCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHCCCCCEEEEECCCCCCCC
EIIAEGALNPHDILRLLGVGALANYIVNEVQDVYRLQGVKINDKHIEVIVRQMLRKRVIT
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHEE
FAGDSKFLVGEQVEESAMLQENDKLLAEGKQIARGTPILLGITKASLATESFISAASFQE
ECCCCCEEECCHHHHHHHHHCCCHHHHCCHHHHCCCCEEEEECHHHHHHHHHHHHHHHHH
TTRVLTEAAVSGKVDELRGLKENVMVGRLIPAGTGYTYHQSRKAKRARVAAGGDSSATHT
HHHHHHHHHHCCCHHHHHCCHHHCEEEEEEECCCCCCHHHHHHHHHHHEECCCCCCCEEE
VTASDVEHALSEALNADNHEH
EEHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA