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The map label for this gene is macA [H]

Identifier: 54293172

GI number: 54293172

Start: 245723

End: 246901

Strand: Direct

Name: macA [H]

Synonym: lpl0218

Alternate gene names: 54293172

Gene position: 245723-246901 (Clockwise)

Preceding gene: 54293171

Following gene: 54293178

Centisome position: 7.34

GC content: 40.12

Gene sequence:

>1179_bases
ATGAAGATTATGAACCTGAATTTGAAAAAACTAATAGGGTATTTTCTGATAATAGTGATATTTTTCAGTGTTGTTCTCTG
GTTTCTTTCTCATCAAGGTATTTCAGTTGAAAGGGCAAAAGTGAAATATGATCACTTCATTCAGTATATTGAAGACGATG
CAAAAACACGTGCTATAAAAATATACAGTATTGTGTCTCCAGTGTCAGGAGAATTGTTACGCATTAATTTGACGGAAGGT
GATAAGGTAAAAAAAGATGACGTAATTGCCACTATTAAGTCCAAAATCCCTGCTTTGCTGGACATTCGAGCAAAGCAAGA
ATTAGAGCATGAGTTGGGCACTGCTGAGGCCTTGTATGAACAGGCAAAGGCAGAGTCAATTCGTGCTGAAGCAGCACTGG
AGACGGCCCACTCAGATTTCAAAAGAAAAGAGCCACTGGCAAAAAAAGGGTTCGTTTCGGAAACAGAATTGGAGCATGCT
CAATTGGAATATCAATTAAGACAGAAAGAACATAATGCCGCATTGCGTAAGTTACATGCTGCAGAGCATTACATTTTAAA
AGTTAAAGCATCCCTTTCGGCATCAGAGGGCAGTGAAGCGATTCAGCAAGACAAGATTGAGATTCGTTCACCTGTAACGG
GCTCTATTTTGAGAGTGATTGAAAAAAGCTCAACTACTGTTGAGTCTGGCACAAAAATTATGGATATTGCCGATGTGGTC
GGTCTTGAAGTCGTAGCTGACATATTAAGCGATGATGCTGCAAAAATTCCTCCGTATGCAAGGGTCATTATAAAACGATG
GGGAGGCCCTTATCCTTTGGAGGGGCGCGTACGAATTGTTGAGCCAAGCGGTTATACTAAAGTATCAGCGCTTGGAGTTG
AGGAACAACGAGTCAATGTCATCATTGATATCACGACCCCATATGAATTATGGAAAAATCTTGGTGATGGATATCGGGTA
GATGTTGAAATCATTCTTTTTGAATCGAACCATGCTCTTGTAGTGCCTATGAGCGCTTTATTTCGAGACGGAGAAGATTG
GGCTGTTTTTGTCGTGAAAGGGCACAGAGCTTATAAGAAGAAGTTAACTATAAAATACCATAACCCGGATTACGCGGTAA
TAGAGAGTGGTTTAGAGTTAGGAGATGAAGTCACTTTATCCCAGTTCTTTAATTCATGA

Upstream 100 bases:

>100_bases
CGATTATGGTGATATTTTTTTCTAGTTTAATTAGTTTTTATATTATTCAGCGTAAAGCAAGCCATCTGAATTTAACAGCT
GTATTAAAGGTAGCAGACTG

Downstream 100 bases:

>100_bases
TGGGGTCTTAATTAAGTAATGAGGTCATTTTCAAACTGAAAATATGGCATAAAGGAATTGTTTAAAAGTAGATGTCATTG
GATTGAGCGTCACTGGTTTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKIMNLNLKKLIGYFLIIVIFFSVVLWFLSHQGISVERAKVKYDHFIQYIEDDAKTRAIKIYSIVSPVSGELLRINLTEG
DKVKKDDVIATIKSKIPALLDIRAKQELEHELGTAEALYEQAKAESIRAEAALETAHSDFKRKEPLAKKGFVSETELEHA
QLEYQLRQKEHNAALRKLHAAEHYILKVKASLSASEGSEAIQQDKIEIRSPVTGSILRVIEKSSTTVESGTKIMDIADVV
GLEVVADILSDDAAKIPPYARVIIKRWGGPYPLEGRVRIVEPSGYTKVSALGVEEQRVNVIIDITTPYELWKNLGDGYRV
DVEIILFESNHALVVPMSALFRDGEDWAVFVVKGHRAYKKKLTIKYHNPDYAVIESGLELGDEVTLSQFFNS

Sequences:

>Translated_392_residues
MKIMNLNLKKLIGYFLIIVIFFSVVLWFLSHQGISVERAKVKYDHFIQYIEDDAKTRAIKIYSIVSPVSGELLRINLTEG
DKVKKDDVIATIKSKIPALLDIRAKQELEHELGTAEALYEQAKAESIRAEAALETAHSDFKRKEPLAKKGFVSETELEHA
QLEYQLRQKEHNAALRKLHAAEHYILKVKASLSASEGSEAIQQDKIEIRSPVTGSILRVIEKSSTTVESGTKIMDIADVV
GLEVVADILSDDAAKIPPYARVIIKRWGGPYPLEGRVRIVEPSGYTKVSALGVEEQRVNVIIDITTPYELWKNLGDGYRV
DVEIILFESNHALVVPMSALFRDGEDWAVFVVKGHRAYKKKLTIKYHNPDYAVIESGLELGDEVTLSQFFNS
>Mature_392_residues
MKIMNLNLKKLIGYFLIIVIFFSVVLWFLSHQGISVERAKVKYDHFIQYIEDDAKTRAIKIYSIVSPVSGELLRINLTEG
DKVKKDDVIATIKSKIPALLDIRAKQELEHELGTAEALYEQAKAESIRAEAALETAHSDFKRKEPLAKKGFVSETELEHA
QLEYQLRQKEHNAALRKLHAAEHYILKVKASLSASEGSEAIQQDKIEIRSPVTGSILRVIEKSSTTVESGTKIMDIADVV
GLEVVADILSDDAAKIPPYARVIIKRWGGPYPLEGRVRIVEPSGYTKVSALGVEEQRVNVIIDITTPYELWKNLGDGYRV
DVEIILFESNHALVVPMSALFRDGEDWAVFVVKGHRAYKKKLTIKYHNPDYAVIESGLELGDEVTLSQFFNS

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=384, Percent_Identity=23.6979166666667, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 44073; Mature: 44073

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIMNLNLKKLIGYFLIIVIFFSVVLWFLSHQGISVERAKVKYDHFIQYIEDDAKTRAIK
CEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCHHEEEE
IYSIVSPVSGELLRINLTEGDKVKKDDVIATIKSKIPALLDIRAKQELEHELGTAEALYE
EEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCHHEEHHHHHHHHHHHCHHHHHHH
QAKAESIRAEAALETAHSDFKRKEPLAKKGFVSETELEHAQLEYQLRQKEHNAALRKLHA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEHYILKVKASLSASEGSEAIQQDKIEIRSPVTGSILRVIEKSSTTVESGTKIMDIADVV
CCEEEEEEEECCCCCCCHHHHHHCCHHCCCCCHHHHHHHHHCCCCCHHCCCCHHHHHHHH
GLEVVADILSDDAAKIPPYARVIIKRWGGPYPLEGRVRIVEPSGYTKVSALGVEEQRVNV
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEECCCCCEEEE
IIDITTPYELWKNLGDGYRVDVEIILFESNHALVVPMSALFRDGEDWAVFVVKGHRAYKK
EEEECCHHHHHHHCCCCEEEEEEEEEEECCCEEEEEHHHHHCCCCCEEEEEEECCCCEEE
KLTIKYHNPDYAVIESGLELGDEVTLSQFFNS
EEEEEEECCCHHHHHHHHHCCCCHHHHHHHCC
>Mature Secondary Structure
MKIMNLNLKKLIGYFLIIVIFFSVVLWFLSHQGISVERAKVKYDHFIQYIEDDAKTRAIK
CEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCHHEEEE
IYSIVSPVSGELLRINLTEGDKVKKDDVIATIKSKIPALLDIRAKQELEHELGTAEALYE
EEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCHHEEHHHHHHHHHHHCHHHHHHH
QAKAESIRAEAALETAHSDFKRKEPLAKKGFVSETELEHAQLEYQLRQKEHNAALRKLHA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEHYILKVKASLSASEGSEAIQQDKIEIRSPVTGSILRVIEKSSTTVESGTKIMDIADVV
CCEEEEEEEECCCCCCCHHHHHHCCHHCCCCCHHHHHHHHHCCCCCHHCCCCHHHHHHHH
GLEVVADILSDDAAKIPPYARVIIKRWGGPYPLEGRVRIVEPSGYTKVSALGVEEQRVNV
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEECCCCCEEEE
IIDITTPYELWKNLGDGYRVDVEIILFESNHALVVPMSALFRDGEDWAVFVVKGHRAYKK
EEEECCHHHHHHHCCCCEEEEEEEEEEECCCEEEEEHHHHHCCCCCEEEEEEECCCCEEE
KLTIKYHNPDYAVIESGLELGDEVTLSQFFNS
EEEEEEECCCHHHHHHHHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]