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The map label for this gene is parC

Identifier: 54020319

GI number: 54020319

Start: 41702

End: 44242

Strand: Reverse

Name: parC

Synonym: mhp034

Alternate gene names: 54020319

Gene position: 44242-41702 (Counterclockwise)

Preceding gene: 54020320

Following gene: 54020318

Centisome position: 4.96

GC content: 28.3

Gene sequence:

>2541_bases
ATGAATAAAAGTCTTGATTCAGTAATTAATTCCCGGTTAGAAAAAATTTTAGCAGAAAAATTTATCCGTTATTCAAAATA
TGTAATTCAACAACGGGCAATTCCAGATGTCAGAGACGGCCTAAAACCGGTTCAGAGGCGAATTCTTTATTCAATGTGAC
AGTTGGGGCTAAAAAATAGTAAAAATTACAAAAAATCTGCTAGAGTTGTCGGTGATGTAATCGGAAAATATCATCCTCAT
GGTGATTCTTCAATCTATGATGCTCTTGTCAGACTTGCCCAGGAATGAAAAATGAATTCTCCGCTTGTGGAAATGCACGG
AAATAAAGGGTCAATTGATGACGATCCACCTGCCGCGATGCGATATACAGAGGTTAGATTGGCTGAAATTAGTGAGCATT
TACTTGAATTAATTTCGAAAAATGTTGTAAGTTTTTGCCCTAATTTTGATGATAGTGAAAAAGAACCAACAATTTTACCT
GCAATTTTCCCAAATTTATTAATAAATGGGGCAATTGGAATTGCAAGTGGATTTGCAACTGAAATCCCCCCGCATAATTT
AGGCGAAGTGATCGATGCAACAATTTTGATGATTAAAAATCCAGGAATTACAATTGAAGAAATTTCTACTATAATTTTAG
GTCCTGATTTTCCAACAGGCGGAATTGTTTATGGAAAATCAGGTATTTTTGATGCCTTCAAAACTGGAAAAGGCAAAATA
AAAATAAGCTCTGATTATAAAATTTTCGAAAAAAATGGGCAAAATGTAATTGAAATTACCTCGATTCCTTTTGGAATTTC
AAAGTCAAGTTTAATCGAAGAAATTGATGACATTCGTTTTGATGCAAAAATTTATGGGATTAAAAATGTAATTGATCAAT
CCGATCAAAATGGAGTTTCCATTTTGATCGAACTCGAACAGGACGGAAATCCTGACCTAATTATTAATTATCTACTACAA
AAAACTCATCTACAAATACATTATTCTTATAATTCCGTTGCAATTTGTGATAATTCACCAAAACTTTTGTCAATCAAGGA
GATGATTTTTTACTATCTTGAGCATTTAAGAAAAATTAAGCTTGCCGAATTTAATTTTGAGCTTTACAAAAATAAAAAAA
GATTAGAAATTATTACTGGTTTTCTCAAAGTTGCCGATATTACTGACGAAGTTATTAAAGTTATTCGCGCATCTGATAAT
TCAAAAGTTGGGGTAGTTAGTGATTTAATTAAATTTTTTAACTTTAGCCAAACCCAAGCAGAGGCAATTGCATCAATGCG
TTTATACCGTCTTTCGAAAATTGAGCAGCAAATTTACCTTGAAGAATCAAAAAATTTAGAAAAAAACATTGCTAGGTTTA
AAAAACTTATTGAAAATAAAGATGAATTTGATAAAAATTTAATAAATATGTTAACTGATTTTAAAAAACATCACGGAAAA
CCGCGGAAAACTAAGATAATTGACTCTGATATTAAGATAAAAATTAACAAAGATGAATTAGTAAAAGATGAGTTTTTTTA
TTTTTGAATAACAAAATCGGGACTTTATAAAAAATTAGATATAAAAAATTCTCTCCCTGATGAAATAGAAAAAACTCAGC
TTCCAAATGGAGATTTTTTCATTTTTCAAGGTATAATTAACCAAAAACAAAAAGCAGTTTTTCTAACTAATAAAGGTGAA
ATAGCAATTTTAGCTGTGCATCAAATTCCTGAATTAAATCTGAAAAACTCACCTAATAATTTAAAAATAACTTTAGGAAT
CCCAAATAATCAACAAATTTTAAGTGTTTTTTTTGCTGATAGTTTTGAAAGTAGTCAATTTTTAATTTTTATTTCCAAAT
TCAGTTTTGCTAAAAGAATGAATTTGGACCAATTAATGAAAATTAAGCAAAAAAAATTACAAAATATTTTTCGATTCAAG
GAAGGTGATGAGCTAATTAGTGTTTTTTTAGAAGAAAAATTAAAAAATATTGTTCTAATTACCACACAAAACCGCGCTCT
AAAAATGAGTATATCAGAAATTCCAATTTATACTAGAAATTCCACAGGTATAAAAATTTTCAGACACCGAAAAAATGAAT
TTATCAGTGCCAGTCAAACTATTGAAAGCTCAGAATCACTTGCAGTTATTGACTTTAATTCACAGTTTGAAAAAATTAAT
ACTGAAAATTTGTTTTTTGGAAATAAAATTCTTACTCCAAAAAACTTTAAAACAAAGCTTGATTTTTCCCTGAGCCCAAA
AAGCATAATAATTTATAACGAAAATTTGCAAATTTTTGAATTTGGAGAAGGATTAAAAATTTTTAGTTTAAATGATTTTA
GAAAGCTAAAAACTAATCAAAAAAAAGATTATAAATTCTTTTTACCAAATATTCAATCGGGAAAAAACCACATAAAAAAC
AACAACTTTTTGCTAAAAAGCAATTCTAATGATCAAAATTCTATATCAAAAAATGACTCAACTTTAGAAGAAAAACTTCG
GAAAGTAAGTGAAATTGATATTGATTTAATTCTGAAAAAAATAGAAAAGGATGACAAATAA

Upstream 100 bases:

>100_bases
ATTTTAATGGGCGAAAGAGCTGATCTAAGAAAGAGCTGAATTGAAAAAAACGTTGATTTTTCCCTTGAAGACAAATTTAT
TGAAAATTTAAAGGAAACAT

Downstream 100 bases:

>100_bases
TGGATAAAAATTTTTATAAAAATTCATTAAATATTTTTAATTCTAATTTTTCAATGAAAGCAAATTTGTCAGAAAAAGAC
AAATTTTATGCTGATTTTTG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 846; Mature: 846

Protein sequence:

>846_residues
MNKSLDSVINSRLEKILAEKFIRYSKYVIQQRAIPDVRDGLKPVQRRILYSMWQLGLKNSKNYKKSARVVGDVIGKYHPH
GDSSIYDALVRLAQEWKMNSPLVEMHGNKGSIDDDPPAAMRYTEVRLAEISEHLLELISKNVVSFCPNFDDSEKEPTILP
AIFPNLLINGAIGIASGFATEIPPHNLGEVIDATILMIKNPGITIEEISTIILGPDFPTGGIVYGKSGIFDAFKTGKGKI
KISSDYKIFEKNGQNVIEITSIPFGISKSSLIEEIDDIRFDAKIYGIKNVIDQSDQNGVSILIELEQDGNPDLIINYLLQ
KTHLQIHYSYNSVAICDNSPKLLSIKEMIFYYLEHLRKIKLAEFNFELYKNKKRLEIITGFLKVADITDEVIKVIRASDN
SKVGVVSDLIKFFNFSQTQAEAIASMRLYRLSKIEQQIYLEESKNLEKNIARFKKLIENKDEFDKNLINMLTDFKKHHGK
PRKTKIIDSDIKIKINKDELVKDEFFYFWITKSGLYKKLDIKNSLPDEIEKTQLPNGDFFIFQGIINQKQKAVFLTNKGE
IAILAVHQIPELNLKNSPNNLKITLGIPNNQQILSVFFADSFESSQFLIFISKFSFAKRMNLDQLMKIKQKKLQNIFRFK
EGDELISVFLEEKLKNIVLITTQNRALKMSISEIPIYTRNSTGIKIFRHRKNEFISASQTIESSESLAVIDFNSQFEKIN
TENLFFGNKILTPKNFKTKLDFSLSPKSIIIYNENLQIFEFGEGLKIFSLNDFRKLKTNQKKDYKFFLPNIQSGKNHIKN
NNFLLKSNSNDQNSISKNDSTLEEKLRKVSEIDIDLILKKIEKDDK

Sequences:

>Translated_846_residues
MNKSLDSVINSRLEKILAEKFIRYSKYVIQQRAIPDVRDGLKPVQRRILYSM*QLGLKNSKNYKKSARVVGDVIGKYHPH
GDSSIYDALVRLAQE*KMNSPLVEMHGNKGSIDDDPPAAMRYTEVRLAEISEHLLELISKNVVSFCPNFDDSEKEPTILP
AIFPNLLINGAIGIASGFATEIPPHNLGEVIDATILMIKNPGITIEEISTIILGPDFPTGGIVYGKSGIFDAFKTGKGKI
KISSDYKIFEKNGQNVIEITSIPFGISKSSLIEEIDDIRFDAKIYGIKNVIDQSDQNGVSILIELEQDGNPDLIINYLLQ
KTHLQIHYSYNSVAICDNSPKLLSIKEMIFYYLEHLRKIKLAEFNFELYKNKKRLEIITGFLKVADITDEVIKVIRASDN
SKVGVVSDLIKFFNFSQTQAEAIASMRLYRLSKIEQQIYLEESKNLEKNIARFKKLIENKDEFDKNLINMLTDFKKHHGK
PRKTKIIDSDIKIKINKDELVKDEFFYF*ITKSGLYKKLDIKNSLPDEIEKTQLPNGDFFIFQGIINQKQKAVFLTNKGE
IAILAVHQIPELNLKNSPNNLKITLGIPNNQQILSVFFADSFESSQFLIFISKFSFAKRMNLDQLMKIKQKKLQNIFRFK
EGDELISVFLEEKLKNIVLITTQNRALKMSISEIPIYTRNSTGIKIFRHRKNEFISASQTIESSESLAVIDFNSQFEKIN
TENLFFGNKILTPKNFKTKLDFSLSPKSIIIYNENLQIFEFGEGLKIFSLNDFRKLKTNQKKDYKFFLPNIQSGKNHIKN
NNFLLKSNSNDQNSISKNDSTLEEKLRKVSEIDIDLILKKIEKDDK
>Mature_846_residues
MNKSLDSVINSRLEKILAEKFIRYSKYVIQQRAIPDVRDGLKPVQRRILYSM*QLGLKNSKNYKKSARVVGDVIGKYHPH
GDSSIYDALVRLAQE*KMNSPLVEMHGNKGSIDDDPPAAMRYTEVRLAEISEHLLELISKNVVSFCPNFDDSEKEPTILP
AIFPNLLINGAIGIASGFATEIPPHNLGEVIDATILMIKNPGITIEEISTIILGPDFPTGGIVYGKSGIFDAFKTGKGKI
KISSDYKIFEKNGQNVIEITSIPFGISKSSLIEEIDDIRFDAKIYGIKNVIDQSDQNGVSILIELEQDGNPDLIINYLLQ
KTHLQIHYSYNSVAICDNSPKLLSIKEMIFYYLEHLRKIKLAEFNFELYKNKKRLEIITGFLKVADITDEVIKVIRASDN
SKVGVVSDLIKFFNFSQTQAEAIASMRLYRLSKIEQQIYLEESKNLEKNIARFKKLIENKDEFDKNLINMLTDFKKHHGK
PRKTKIIDSDIKIKINKDELVKDEFFYF*ITKSGLYKKLDIKNSLPDEIEKTQLPNGDFFIFQGIINQKQKAVFLTNKGE
IAILAVHQIPELNLKNSPNNLKITLGIPNNQQILSVFFADSFESSQFLIFISKFSFAKRMNLDQLMKIKQKKLQNIFRFK
EGDELISVFLEEKLKNIVLITTQNRALKMSISEIPIYTRNSTGIKIFRHRKNEFISASQTIESSESLAVIDFNSQFEKIN
TENLFFGNKILTPKNFKTKLDFSLSPKSIIIYNENLQIFEFGEGLKIFSLNDFRKLKTNQKKDYKFFLPNIQSGKNHIKN
NNFLLKSNSNDQNSISKNDSTLEEKLRKVSEIDIDLILKKIEKDDK

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=180, Percent_Identity=30, Blast_Score=78, Evalue=4e-14,
Organism=Homo sapiens, GI19913406, Length=174, Percent_Identity=31.0344827586207, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1788562, Length=715, Percent_Identity=31.0489510489511, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1789396, Length=662, Percent_Identity=30.6646525679758, Blast_Score=298, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17535065, Length=173, Percent_Identity=31.2138728323699, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI212645845, Length=260, Percent_Identity=31.5384615384615, Blast_Score=76, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=247, Percent_Identity=27.5303643724696, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 96498; Mature: 96498

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKSLDSVINSRLEKILAEKFIRYSKYVIQQRAIPDVRDGLKPVQRRILYSMQLGLKNSK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
NYKKSARVVGDVIGKYHPHGDSSIYDALVRLAQEKMNSPLVEMHGNKGSIDDDPPAAMRY
CHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHH
TEVRLAEISEHLLELISKNVVSFCPNFDDSEKEPTILPAIFPNLLINGAIGIASGFATEI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHCCHHHCCCCCCCC
PPHNLGEVIDATILMIKNPGITIEEISTIILGPDFPTGGIVYGKSGIFDAFKTGKGKIKI
CCCCHHHHHCEEEEEEECCCCCHHHCCEEEECCCCCCCCEEECCCCCHHHHHCCCCEEEE
SSDYKIFEKNGQNVIEITSIPFGISKSSLIEEIDDIRFDAKIYGIKNVIDQSDQNGVSIL
CCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCEECEEEEEHHHHHCCCCCCCEEEE
IELEQDGNPDLIINYLLQKTHLQIHYSYNSVAICDNSPKLLSIKEMIFYYLEHLRKIKLA
EEECCCCCCCHHHHHHHHCEEEEEEEECCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHH
EFNFELYKNKKRLEIITGFLKVADITDEVIKVIRASDNSKVGVVSDLIKFFNFSQTQAEA
EECHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHH
IASMRLYRLSKIEQQIYLEESKNLEKNIARFKKLIENKDEFDKNLINMLTDFKKHHGKPR
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
KTKIIDSDIKIKINKDELVKDEFFYFITKSGLYKKLDIKNSLPDEIEKTQLPNGDFFIFQ
CEEEECCCEEEEECHHHHHHHHEEEEEECCCCEEEECCCCCCCCHHHHHCCCCCCEEEEE
GIINQKQKAVFLTNKGEIAILAVHQIPELNLKNSPNNLKITLGIPNNQQILSVFFADSFE
CCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCC
SSQFLIFISKFSFAKRMNLDQLMKIKQKKLQNIFRFKEGDELISVFLEEKLKNIVLITTQ
CCEEEEEEECHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEEEC
NRALKMSISEIPIYTRNSTGIKIFRHRKNEFISASQTIESSESLAVIDFNSQFEKINTEN
CCEEEEEHHHCCEEECCCCCEEEEEECCCHHHHHHHHHCCCCCEEEEECCCHHHHCCCCC
LFFGNKILTPKNFKTKLDFSLSPKSIIIYNENLQIFEFGEGLKIFSLNDFRKLKTNQKKD
EEECCEECCCCCCCEEEEECCCCCEEEEECCCEEEEEECCCEEEEECCHHHHHHCCCCCC
YKFFLPNIQSGKNHIKNNNFLLKSNSNDQNSISKNDSTLEEKLRKVSEIDIDLILKKIEK
EEEECCCCCCCHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHC
DDK
CCC
>Mature Secondary Structure
MNKSLDSVINSRLEKILAEKFIRYSKYVIQQRAIPDVRDGLKPVQRRILYSMQLGLKNSK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
NYKKSARVVGDVIGKYHPHGDSSIYDALVRLAQEKMNSPLVEMHGNKGSIDDDPPAAMRY
CHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHH
TEVRLAEISEHLLELISKNVVSFCPNFDDSEKEPTILPAIFPNLLINGAIGIASGFATEI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHCCHHHCCCCCCCC
PPHNLGEVIDATILMIKNPGITIEEISTIILGPDFPTGGIVYGKSGIFDAFKTGKGKIKI
CCCCHHHHHCEEEEEEECCCCCHHHCCEEEECCCCCCCCEEECCCCCHHHHHCCCCEEEE
SSDYKIFEKNGQNVIEITSIPFGISKSSLIEEIDDIRFDAKIYGIKNVIDQSDQNGVSIL
CCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCEECEEEEEHHHHHCCCCCCCEEEE
IELEQDGNPDLIINYLLQKTHLQIHYSYNSVAICDNSPKLLSIKEMIFYYLEHLRKIKLA
EEECCCCCCCHHHHHHHHCEEEEEEEECCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHH
EFNFELYKNKKRLEIITGFLKVADITDEVIKVIRASDNSKVGVVSDLIKFFNFSQTQAEA
EECHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHH
IASMRLYRLSKIEQQIYLEESKNLEKNIARFKKLIENKDEFDKNLINMLTDFKKHHGKPR
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
KTKIIDSDIKIKINKDELVKDEFFYFITKSGLYKKLDIKNSLPDEIEKTQLPNGDFFIFQ
CEEEECCCEEEEECHHHHHHHHEEEEEECCCCEEEECCCCCCCCHHHHHCCCCCCEEEEE
GIINQKQKAVFLTNKGEIAILAVHQIPELNLKNSPNNLKITLGIPNNQQILSVFFADSFE
CCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCC
SSQFLIFISKFSFAKRMNLDQLMKIKQKKLQNIFRFKEGDELISVFLEEKLKNIVLITTQ
CCEEEEEEECHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEEEC
NRALKMSISEIPIYTRNSTGIKIFRHRKNEFISASQTIESSESLAVIDFNSQFEKINTEN
CCEEEEEHHHCCEEECCCCCEEEEEECCCHHHHHHHHHCCCCCEEEEECCCHHHHCCCCC
LFFGNKILTPKNFKTKLDFSLSPKSIIIYNENLQIFEFGEGLKIFSLNDFRKLKTNQKKD
EEECCEECCCCCCCEEEEECCCCCEEEEECCCEEEEEECCCEEEEECCHHHHHHCCCCCC
YKFFLPNIQSGKNHIKNNNFLLKSNSNDQNSISKNDSTLEEKLRKVSEIDIDLILKKIEK
EEEECCCCCCCHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHC
DDK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8763932; 11463916; 8891124; 8913454 [H]