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The map label for this gene is ung

Identifier: 54020108

GI number: 54020108

Start: 277729

End: 278394

Strand: Direct

Name: ung

Synonym: mhp251

Alternate gene names: 54020108

Gene position: 277729-278394 (Clockwise)

Preceding gene: 54020107

Following gene: 54020109

Centisome position: 31.11

GC content: 28.38

Gene sequence:

>666_bases
TTGAAAATGGAATCAAAACTAAGTTTTGAAAGCTTTTTTTATAATGAGTCTAAAAAAGCATATTTTCAAAAATTAATGGA
AAAACTCGATGAAGAATATGAAAAATATCAAGTTTTTCCAAATAAAAAAGATTTATTTCGCGCAATTGAATTAACAAATT
TTGCAACCCTAAAAATTGTTATTATTGGCCAGGATCCTTATCATAAAAAAGGTCAAGCTGATGGGCTTGCTTTTTCAACA
AGAACAAAAATTTTACCCCCATCACTTCGAAATTTATTTTTGGAGATAAAAAATGCCTACCCAAACTTTTCAAAACAAAA
CGGGAATCTTGAAAACTGGGCAAAACAAGGCGTTTTGTTACTTAATTGCGTTTTAACCGTGCGAAAATCCAGTCCCAATT
CACATAAAAATATTGGGTGGGAGGTTTTTAGTTCTAACTTAATCAACTTTATTGTAAAAAATAAAGTTGATATTGTTTTT
TTATTATTGGGTAAAAAAGCAAAATTAGCAGTTAAAAATATTAACCTTGAAAAGCAAAAAGTTTTTGCCTATTCACATCC
TTCGCCTTTTAGTTTCGCCAAATCGCTTAAAAATTCTATGGCTTTCCGCAAAATTAACGATTTTTTAAAAGAAAAAAAAC
GATTAGAAATTAATTGGGATTTATAA

Upstream 100 bases:

>100_bases
GATTTAAACCTTTTTGGTATGAGATGGTTTGAATAAACGCTAAAATTATAGCATTTTCTCTAAAAAAAGCAATAAAAAAA
TTTTTTTCTTGCTATAATTT

Downstream 100 bases:

>100_bases
AAAAAAAGTGTATAATTTTCTAAATTATATCATAAAAGAAAGGATTTTTTAAATGTCAATATTAGAAAAAATGAAAAAAT
ATTGCGACATTGATGGTATG

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MKMESKLSFESFFYNESKKAYFQKLMEKLDEEYEKYQVFPNKKDLFRAIELTNFATLKIVIIGQDPYHKKGQADGLAFST
RTKILPPSLRNLFLEIKNAYPNFSKQNGNLENWAKQGVLLLNCVLTVRKSSPNSHKNIGWEVFSSNLINFIVKNKVDIVF
LLLGKKAKLAVKNINLEKQKVFAYSHPSPFSFAKSLKNSMAFRKINDFLKEKKRLEINWDL

Sequences:

>Translated_221_residues
MKMESKLSFESFFYNESKKAYFQKLMEKLDEEYEKYQVFPNKKDLFRAIELTNFATLKIVIIGQDPYHKKGQADGLAFST
RTKILPPSLRNLFLEIKNAYPNFSKQNGNLENWAKQGVLLLNCVLTVRKSSPNSHKNIGWEVFSSNLINFIVKNKVDIVF
LLLGKKAKLAVKNINLEKQKVFAYSHPSPFSFAKSLKNSMAFRKINDFLKEKKRLEINWDL
>Mature_221_residues
MKMESKLSFESFFYNESKKAYFQKLMEKLDEEYEKYQVFPNKKDLFRAIELTNFATLKIVIIGQDPYHKKGQADGLAFST
RTKILPPSLRNLFLEIKNAYPNFSKQNGNLENWAKQGVLLLNCVLTVRKSSPNSHKNIGWEVFSSNLINFIVKNKVDIVF
LLLGKKAKLAVKNINLEKQKVFAYSHPSPFSFAKSLKNSMAFRKINDFLKEKKRLEINWDL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI6224979, Length=214, Percent_Identity=37.8504672897196, Blast_Score=157, Evalue=7e-39,
Organism=Homo sapiens, GI19718751, Length=214, Percent_Identity=37.8504672897196, Blast_Score=157, Evalue=8e-39,
Organism=Escherichia coli, GI1788934, Length=220, Percent_Identity=38.1818181818182, Blast_Score=173, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17556304, Length=216, Percent_Identity=38.8888888888889, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6323620, Length=213, Percent_Identity=40.3755868544601, Blast_Score=149, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 25757; Mature: 25757

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMESKLSFESFFYNESKKAYFQKLMEKLDEEYEKYQVFPNKKDLFRAIELTNFATLKIV
CCCCHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEEEE
IIGQDPYHKKGQADGLAFSTRTKILPPSLRNLFLEIKNAYPNFSKQNGNLENWAKQGVLL
EECCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHE
LNCVLTVRKSSPNSHKNIGWEVFSSNLINFIVKNKVDIVFLLLGKKAKLAVKNINLEKQK
EHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCHHE
VFAYSHPSPFSFAKSLKNSMAFRKINDFLKEKKRLEINWDL
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCC
>Mature Secondary Structure
MKMESKLSFESFFYNESKKAYFQKLMEKLDEEYEKYQVFPNKKDLFRAIELTNFATLKIV
CCCCHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCEEEEEEE
IIGQDPYHKKGQADGLAFSTRTKILPPSLRNLFLEIKNAYPNFSKQNGNLENWAKQGVLL
EECCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHE
LNCVLTVRKSSPNSHKNIGWEVFSSNLINFIVKNKVDIVFLLLGKKAKLAVKNINLEKQK
EHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCHHE
VFAYSHPSPFSFAKSLKNSMAFRKINDFLKEKKRLEINWDL
EEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA