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The map label for this gene is lip3

Identifier: 54020107

GI number: 54020107

Start: 275939

End: 276763

Strand: Direct

Name: lip3

Synonym: mhp248

Alternate gene names: NA

Gene position: 275939-276763 (Clockwise)

Preceding gene: 54020106

Following gene: 54020108

Centisome position: 30.91

GC content: 26.3

Gene sequence:

>825_bases
ATGATAAATTCACAAAGTAATAACATTTTAGATAATTGAAATTACCCTTTTGTAATTAACAGGAATCCCTTTAGCAAAAT
TCATATTGTTTTTTGTCATGGTTTTAATTCAAATCATAACGTATTTTCAAGCACAATTGACTCAATAAGTAAAAAAATCC
CACTAAATTATTATAGTTTTACTCTCCCTGGAAATAATTTAACACCAGCTAGCGAAGACCAACTTTATTTAGAATATTAT
GCGGATTTAACAGTTAGTTTTATTAAAAAATTAAATTTAAAGGAGGTTATTTTAGTCGGACATTCGATGGGAGCAGCAAT
TGCAGCATTAATTTATAAAAGAATCCCTAAAATGATAGTAAAAATTGTTTTTATTGCACCAATGAATAAGGCAAACTTAC
CCCTAAAAGATTTTTTTTATGAAAAATTTTTTCCAAAAACACCAGAAGAAATGCTTGAATTTATGCCAATTTATGAATAT
GACAAAGAAAAATATAAAGATCCTAAATATTTAAAATGGGCAAAAAGTCTCTATAATTACGAGTATTTTAATAATTTTAA
TATTGTTTCATTAGCACAAAATCTGCTAAAAAACAATATGATGGACCAAATTGAGCAAGCCCTAAAATCAATAAAAATCC
CAACACTTTTAGTTTTAGGTCAAAGAGATGGAATTGTATTACAGCAAGAGACAAAAACATATTTTGAGTCACTAATTCCA
AAGGTTCAAACAGAGATAATTCCTAAAACAGGGCATTTAATTTATAGCGAAAATCCTGAATATTTTAATCAAATTTTTAG
TGACTTTATAAAAAAAACACTATAA

Upstream 100 bases:

>100_bases
AGTTTTTTCTAATTTTTTTTGGAAAAATTTAATGCTAAAAAAATTAGAATAATATTATATAATTAAAATAAAAAAAATTA
AGAAAAAACAAGGAAATACA

Downstream 100 bases:

>100_bases
AAACAAGTGTTTTTTTTATAAAGCAGCTTCTAAGTTTTTAAATTTTTGAAAATTAAAAACTTGGTTTTAAAAACCAAATT
TTCTTATTTTAAAATAATTT

Product: lipase-esterase

Products: diacylglycerol; carboxylate

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MINSQSNNILDNWNYPFVINRNPFSKIHIVFCHGFNSNHNVFSSTIDSISKKIPLNYYSFTLPGNNLTPASEDQLYLEYY
ADLTVSFIKKLNLKEVILVGHSMGAAIAALIYKRIPKMIVKIVFIAPMNKANLPLKDFFYEKFFPKTPEEMLEFMPIYEY
DKEKYKDPKYLKWAKSLYNYEYFNNFNIVSLAQNLLKNNMMDQIEQALKSIKIPTLLVLGQRDGIVLQQETKTYFESLIP
KVQTEIIPKTGHLIYSENPEYFNQIFSDFIKKTL

Sequences:

>Translated_274_residues
MINSQSNNILDN*NYPFVINRNPFSKIHIVFCHGFNSNHNVFSSTIDSISKKIPLNYYSFTLPGNNLTPASEDQLYLEYY
ADLTVSFIKKLNLKEVILVGHSMGAAIAALIYKRIPKMIVKIVFIAPMNKANLPLKDFFYEKFFPKTPEEMLEFMPIYEY
DKEKYKDPKYLKWAKSLYNYEYFNNFNIVSLAQNLLKNNMMDQIEQALKSIKIPTLLVLGQRDGIVLQQETKTYFESLIP
KVQTEIIPKTGHLIYSENPEYFNQIFSDFIKKTL
>Mature_274_residues
MINSQSNNILDN*NYPFVINRNPFSKIHIVFCHGFNSNHNVFSSTIDSISKKIPLNYYSFTLPGNNLTPASEDQLYLEYY
ADLTVSFIKKLNLKEVILVGHSMGAAIAALIYKRIPKMIVKIVFIAPMNKANLPLKDFFYEKFFPKTPEEMLEFMPIYEY
DKEKYKDPKYLKWAKSLYNYEYFNNFNIVSLAQNLLKNNMMDQIEQALKSIKIPTLLVLGQRDGIVLQQETKTYFESLIP
KVQTEIIPKTGHLIYSENPEYFNQIFSDFIKKTL

Specific function: Unknown

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lipase/esterase LIP3/BchO family [H]

Homologues:

Organism=Homo sapiens, GI189027141, Length=275, Percent_Identity=24, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: 3.1.1.3

Molecular weight: Translated: 31866; Mature: 31866

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINSQSNNILDNNYPFVINRNPFSKIHIVFCHGFNSNHNVFSSTIDSISKKIPLNYYSFT
CCCCCCCCCCCCCCCEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEE
LPGNNLTPASEDQLYLEYYADLTVSFIKKLNLKEVILVGHSMGAAIAALIYKRIPKMIVK
ECCCCCCCCCCCCEEHHHHHHHHHHHHHHCCHHHEEEECCCHHHHHHHHHHHHHHHHHHH
IVFIAPMNKANLPLKDFFYEKFFPKTPEEMLEFMPIYEYDKEKYKDPKYLKWAKSLYNYE
HHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCHHHCCHHHCCCCHHHHHHHHHHCHH
YFNNFNIVSLAQNLLKNNMMDQIEQALKSIKIPTLLVLGQRDGIVLQQETKTYFESLIPK
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEHHHHHHHHHHHHH
VQTEIIPKTGHLIYSENPEYFNQIFSDFIKKTL
HHHHHCCCCCCEEECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MINSQSNNILDNNYPFVINRNPFSKIHIVFCHGFNSNHNVFSSTIDSISKKIPLNYYSFT
CCCCCCCCCCCCCCCEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEE
LPGNNLTPASEDQLYLEYYADLTVSFIKKLNLKEVILVGHSMGAAIAALIYKRIPKMIVK
ECCCCCCCCCCCCEEHHHHHHHHHHHHHHCCHHHEEEECCCHHHHHHHHHHHHHHHHHHH
IVFIAPMNKANLPLKDFFYEKFFPKTPEEMLEFMPIYEYDKEKYKDPKYLKWAKSLYNYE
HHHCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCHHHCCHHHCCCCHHHHHHHHHHCHH
YFNNFNIVSLAQNLLKNNMMDQIEQALKSIKIPTLLVLGQRDGIVLQQETKTYFESLIPK
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEHHHHHHHHHHHHH
VQTEIIPKTGHLIYSENPEYFNQIFSDFIKKTL
HHHHHCCCCCCEEECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: triacylglycerol; H2O

Specific reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7569993 [H]