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The map label for this gene is iolC

Identifier: 52787926

GI number: 52787926

Start: 4087547

End: 4088524

Strand: Reverse

Name: iolC

Synonym: BLi04249

Alternate gene names: 52787926

Gene position: 4088524-4087547 (Counterclockwise)

Preceding gene: 52787927

Following gene: 52787925

Centisome position: 96.82

GC content: 47.34

Gene sequence:

>978_bases
ATGAAGTATACGTTTAATGAAGAGAAAGAATTTGACATTGTAGCGATCGGCCGCGCATGCATCGATTTAAACGCAGTCGA
ATACAACAGGCCGATGGAGCAGACGATGACATTTTCAAAATATGTCGGCGGCTCCCCGGCTAATATTGCAATCGGCAGTT
CCAAATTAGGCTTGAAGACCGGATTTATCGGGAAGATTCCGGATGACCAGCACGGCAGATTCATCGAAACCTATATGAGA
AATACAGGTGTCGATACGTCACAAATGGCGGTTGATAAAGACGGACATAAAGCTGGGCTTGCTTTCACAGAAATTTTAAG
CCCTGAAGAATGCAGCATTTTAATGTACAGGGATGATGTTGCAGATCTTTACCTTGCCCCTTCTGAAGTGAACGAAGACT
ATATTGCCAAATCGAAGATGCTTCTTGTGTCAGGTACGGCGCTGGCTAAAAGCCCTTCCCGCGAAGCGGTGCTGAAAGCC
GTACAGCTGGCGAAAAAGCATCAAGTGAAAGTGGTCTTTGAGCTTGACTATCGTCCATATACGTGGACATCTGCGGAGGA
AACGGCCGTCTACTATACGCTTGTTGCCGAACAATCAGACATTGTCATCGGGACGCGTGATGAGTTTGATGTAATGGAAA
ATAAGAGCGGCGGCAGCAATGAAGAATCTGTTCAGCATTTATTTGCACATTCCGCAGATCTTGTCGTTATCAAGCACGGT
GTCGAAGGTTCATATGCATACAGCAAATCCGGGGACGTCTTCCGGGCGAAAGCGTACAAAACGAAGGTCTTGAAAACGTT
TGGAGCGGGCGATTCATACGCCTCCGCCTTCCTCTACGGACTCGTTTCAGGCAAAGATATTGAAACCGCGCTGAAATACG
GAAGCGCTTCCGCCTCGATTGTTGTTTCAAAGCACAGCTCATCTGAAGCGATGCCGACAGTCGCCGAGATTGAAGAGCTT
ATTGCGGCTCAGTCTTAA

Upstream 100 bases:

>100_bases
CGTGATGGCAGGGCCGACGCGTAAATGGAAGTTTCATAACGACCCTGACCATGAATGGATTTTGGAACGCTAACAATAAG
GCAAGGAGAGGCTGTTGAAG

Downstream 100 bases:

>100_bases
ATGAAGAATATGAATAAAGGTGGGATCGTTTGTGGGCAAGAAAATACGTTTAACCACAGCACAAGCGTTAATTAAGTTCT
TAAATCAGCAGTACATCCAT

Product: IolC

Products: NA

Alternate protein names: 2-deoxy-5-keto-D-gluconate kinase; DKG kinase

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MKYTFNEEKEFDIVAIGRACIDLNAVEYNRPMEQTMTFSKYVGGSPANIAIGSSKLGLKTGFIGKIPDDQHGRFIETYMR
NTGVDTSQMAVDKDGHKAGLAFTEILSPEECSILMYRDDVADLYLAPSEVNEDYIAKSKMLLVSGTALAKSPSREAVLKA
VQLAKKHQVKVVFELDYRPYTWTSAEETAVYYTLVAEQSDIVIGTRDEFDVMENKSGGSNEESVQHLFAHSADLVVIKHG
VEGSYAYSKSGDVFRAKAYKTKVLKTFGAGDSYASAFLYGLVSGKDIETALKYGSASASIVVSKHSSSEAMPTVAEIEEL
IAAQS

Sequences:

>Translated_325_residues
MKYTFNEEKEFDIVAIGRACIDLNAVEYNRPMEQTMTFSKYVGGSPANIAIGSSKLGLKTGFIGKIPDDQHGRFIETYMR
NTGVDTSQMAVDKDGHKAGLAFTEILSPEECSILMYRDDVADLYLAPSEVNEDYIAKSKMLLVSGTALAKSPSREAVLKA
VQLAKKHQVKVVFELDYRPYTWTSAEETAVYYTLVAEQSDIVIGTRDEFDVMENKSGGSNEESVQHLFAHSADLVVIKHG
VEGSYAYSKSGDVFRAKAYKTKVLKTFGAGDSYASAFLYGLVSGKDIETALKYGSASASIVVSKHSSSEAMPTVAEIEEL
IAAQS
>Mature_325_residues
MKYTFNEEKEFDIVAIGRACIDLNAVEYNRPMEQTMTFSKYVGGSPANIAIGSSKLGLKTGFIGKIPDDQHGRFIETYMR
NTGVDTSQMAVDKDGHKAGLAFTEILSPEECSILMYRDDVADLYLAPSEVNEDYIAKSKMLLVSGTALAKSPSREAVLKA
VQLAKKHQVKVVFELDYRPYTWTSAEETAVYYTLVAEQSDIVIGTRDEFDVMENKSGGSNEESVQHLFAHSADLVVIKHG
VEGSYAYSKSGDVFRAKAYKTKVLKTFGAGDSYASAFLYGLVSGKDIETALKYGSASASIVVSKHSSSEAMPTVAEIEEL
IAAQS

Specific function: Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D- gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5- dehydro-2-deoxy-D-gluconate (DKGP)

COG id: COG0524

COG function: function code G; Sugar kinases, ribokinase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carbohydrate kinase pfkB family

Homologues:

Organism=Escherichia coli, GI87082281, Length=267, Percent_Identity=30.3370786516854, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IOLC_BACLD (Q65D02)

Other databases:

- EMBL:   CP000002
- EMBL:   AE017333
- RefSeq:   YP_081321.1
- RefSeq:   YP_093755.1
- HSSP:   Q9TVW2
- ProteinModelPortal:   Q65D02
- SMR:   Q65D02
- STRING:   Q65D02
- EnsemblBacteria:   EBBACT00000057799
- EnsemblBacteria:   EBBACT00000061011
- GeneID:   3030836
- GeneID:   3100013
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi04249
- KEGG:   bli:BL00244
- NMPDR:   fig|279010.5.peg.4028
- eggNOG:   COG0524
- GeneTree:   EBGT00050000001879
- HOGENOM:   HBG466006
- OMA:   RPMFWSS
- ProtClustDB:   CLSK873289
- BioCyc:   BLIC279010-1:BLI04249-MONOMER
- BioCyc:   BLIC279010:BL00244-MONOMER
- HAMAP:   MF_01668
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR022841

Pfam domain/function: PF00294 PfkB

EC number: =2.7.1.92

Molecular weight: Translated: 35498; Mature: 35498

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00583 PFKB_KINASES_1; PS00584 PFKB_KINASES_2; PS00037 MYB_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYTFNEEKEFDIVAIGRACIDLNAVEYNRPMEQTMTFSKYVGGSPANIAIGSSKLGLKT
CCCCCCCCCCEEEEEECCCCEECCHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEC
GFIGKIPDDQHGRFIETYMRNTGVDTSQMAVDKDGHKAGLAFTEILSPEECSILMYRDDV
CCCCCCCCCCCCHHHHHHHHHCCCCHHHEEECCCCCCCCCCHHHHCCCCCCEEEEEECCC
ADLYLAPSEVNEDYIAKSKMLLVSGTALAKSPSREAVLKAVQLAKKHQVKVVFELDYRPY
CCEEECCCCCCHHHHHHCEEEEEECCHHCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCE
TWTSAEETAVYYTLVAEQSDIVIGTRDEFDVMENKSGGSNEESVQHLFAHSADLVVIKHG
EECCCCCCEEEEEEEECCCCEEEECCCCHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEC
VEGSYAYSKSGDVFRAKAYKTKVLKTFGAGDSYASAFLYGLVSGKDIETALKYGSASASI
CCCCEEECCCCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCEEE
VVSKHSSSEAMPTVAEIEELIAAQS
EEEECCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKYTFNEEKEFDIVAIGRACIDLNAVEYNRPMEQTMTFSKYVGGSPANIAIGSSKLGLKT
CCCCCCCCCCEEEEEECCCCEECCHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEC
GFIGKIPDDQHGRFIETYMRNTGVDTSQMAVDKDGHKAGLAFTEILSPEECSILMYRDDV
CCCCCCCCCCCCHHHHHHHHHCCCCHHHEEECCCCCCCCCCHHHHCCCCCCEEEEEECCC
ADLYLAPSEVNEDYIAKSKMLLVSGTALAKSPSREAVLKAVQLAKKHQVKVVFELDYRPY
CCEEECCCCCCHHHHHHCEEEEEECCHHCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCE
TWTSAEETAVYYTLVAEQSDIVIGTRDEFDVMENKSGGSNEESVQHLFAHSADLVVIKHG
EECCCCCCEEEEEEEECCCCEEEECCCCHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEEC
VEGSYAYSKSGDVFRAKAYKTKVLKTFGAGDSYASAFLYGLVSGKDIETALKYGSASASI
CCCCEEECCCCCEEEHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCEEE
VVSKHSSSEAMPTVAEIEELIAAQS
EEEECCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA