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The map label for this gene is ywrD [H]

Identifier: 52787529

GI number: 52787529

Start: 3677986

End: 3679569

Strand: Reverse

Name: ywrD [H]

Synonym: BLi03850

Alternate gene names: 52787529

Gene position: 3679569-3677986 (Counterclockwise)

Preceding gene: 52787533

Following gene: 52787527

Centisome position: 87.14

GC content: 52.08

Gene sequence:

>1584_bases
ATGGAGAAGCTGAAGATCGGTTCGAAACAAATGGTTGTCAGTCCTCATTATCTCGCTTCGCTTGCAGGCAGCATCATCAT
GGAGAAGGGGGGGAACGCGTTTGACGCCGCTGTTGCAGTAAGCGCGTGCCTAGCTGTTGTCTATCCGCATATGACAGGAC
TCGGAGGGGATGCCTTTTGGCTGATGTATCACAATGGAAGCGGGGAGATCAAAGGGTACAATGGCAGCGGGCGGTCGGGG
CGGAAAGCGGACCGGGATCAGTATAAAGGAGAGCGCGCCATTCCGGTCAGGGGCCCAAGGAGTGCGATTACCGTGCCGGG
GATGGTGGACAGCTGGGCCGAAATACTGGCTGCGTACGGCCGTCTATCGCTTCGAGAGGTGCTGAAGCCGGCGATTATGT
ATGCAGAAAAGGGGTTCCCGGTCTCGCCTGATCAATGTCAAAACACGGTGAAAAACGCTGAATGGCTTTCCTGTATGCCG
ATCACTGCAGATATTTATCTTCCGGGAGGAAAACCGCCCTCTCCAGGTGAGCGTTTTGTGCAGAAAGAGCTCGCGCGCAC
TTTGACGTTGATCGCTGAGAAAGGAAGAGACACCTTTTATAAAGGGGAAATTGCCCAAGCTTTAGCAGCCTATCTCCAAA
ACAACGGGGGCATCTTGAACCTTGAAGATTTCGGGCTGCATCGAGGGGAATGGGTGTCTCCGCTTTCCTCCACATACAGA
GGATATGCCATCTATCAAATGCCTCCGAATTCACAAGGATTTACCGGTCTTATGACATTGAACATTTTGGAAAACTACGA
CTTTGGCATGATCGAGCACGGTTCTTTCGAGTATTATCATCTGCTTATCGAAGCATTGAAATTAAGTTTTTCCGACTGCA
ACAAAGTATTGACTGACCCGGAATTCTCACAGATTCCGCTTGGACGCCTACTGGACAAAGAGTATGCCCGGGAGCTGGCC
GCAAAAATCGGACTGCCGGCGCTTCAGGCGGAGAGCCGGCCGCTCGGCAGCGATACATCTTATGCAGCAGCAGTAGATGA
AGACGGGAATGCTGTTTCGTTTATTCAAAGTTTGTATTTCGAATTCGGCTCAGGTGTGACAGCTGGAGATACCGGCGTCA
TTTTGCAGAACAGAGGGGCGTTTTTCTCGCTTGATCCCGACCATGTCAATACGCTGGAGCCGGGAAAAAGAACTTTTCAT
ACGCTGATGCCCGCCATGGCGTTTAGAGGCGGCAAGCCGAAATTCCTTTACGGAACGCAAGGGCAAGGGGGAGAAGGACA
GCCGCAGACGCAGACGGCTCTTATTACGAGAATGGTAGATTACGGGATGGATCCGCAAACAGCTGTTCATGAACCGAGAT
GGGTATGGGGCAGAACATGGGGAGAGCGGGTGGAAGGTGTAAGAATAGAAAGCAGAGTGGCGCCTGAAGTGATTGCAAAA
CTGCGAAAGCATGGGCATCATGTAACCGTTGTCGGTGAATTTGACGGGGTGATGGGTCATGCCGGAATCATTGAGATTGA
CGATCAAGGCTTCCTGAGAGGGGGGAGCGATCCGAGAAGCGATGGGGCAGCAATCGGCATTTAA

Upstream 100 bases:

>100_bases
AAAAAAGGGCGTTAGTTTTTCTTCCCTGAAAGTAGCGCCTCTTTTAACGGGCCACTATACTTCAAAGGACAAATGAATGC
TTGAAAGGAAGGAATGAGCT

Downstream 100 bases:

>100_bases
CTGCGTTTTCAAAACTTGCAAACGTCTATATGAGGAAAAAACCCCGTGAACAAGGAGGATTTGTCCACGGGGTTTTTTCT
ATACGGCTATGAGTGTTGAT

Product: YwrD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MEKLKIGSKQMVVSPHYLASLAGSIIMEKGGNAFDAAVAVSACLAVVYPHMTGLGGDAFWLMYHNGSGEIKGYNGSGRSG
RKADRDQYKGERAIPVRGPRSAITVPGMVDSWAEILAAYGRLSLREVLKPAIMYAEKGFPVSPDQCQNTVKNAEWLSCMP
ITADIYLPGGKPPSPGERFVQKELARTLTLIAEKGRDTFYKGEIAQALAAYLQNNGGILNLEDFGLHRGEWVSPLSSTYR
GYAIYQMPPNSQGFTGLMTLNILENYDFGMIEHGSFEYYHLLIEALKLSFSDCNKVLTDPEFSQIPLGRLLDKEYARELA
AKIGLPALQAESRPLGSDTSYAAAVDEDGNAVSFIQSLYFEFGSGVTAGDTGVILQNRGAFFSLDPDHVNTLEPGKRTFH
TLMPAMAFRGGKPKFLYGTQGQGGEGQPQTQTALITRMVDYGMDPQTAVHEPRWVWGRTWGERVEGVRIESRVAPEVIAK
LRKHGHHVTVVGEFDGVMGHAGIIEIDDQGFLRGGSDPRSDGAAIGI

Sequences:

>Translated_527_residues
MEKLKIGSKQMVVSPHYLASLAGSIIMEKGGNAFDAAVAVSACLAVVYPHMTGLGGDAFWLMYHNGSGEIKGYNGSGRSG
RKADRDQYKGERAIPVRGPRSAITVPGMVDSWAEILAAYGRLSLREVLKPAIMYAEKGFPVSPDQCQNTVKNAEWLSCMP
ITADIYLPGGKPPSPGERFVQKELARTLTLIAEKGRDTFYKGEIAQALAAYLQNNGGILNLEDFGLHRGEWVSPLSSTYR
GYAIYQMPPNSQGFTGLMTLNILENYDFGMIEHGSFEYYHLLIEALKLSFSDCNKVLTDPEFSQIPLGRLLDKEYARELA
AKIGLPALQAESRPLGSDTSYAAAVDEDGNAVSFIQSLYFEFGSGVTAGDTGVILQNRGAFFSLDPDHVNTLEPGKRTFH
TLMPAMAFRGGKPKFLYGTQGQGGEGQPQTQTALITRMVDYGMDPQTAVHEPRWVWGRTWGERVEGVRIESRVAPEVIAK
LRKHGHHVTVVGEFDGVMGHAGIIEIDDQGFLRGGSDPRSDGAAIGI
>Mature_527_residues
MEKLKIGSKQMVVSPHYLASLAGSIIMEKGGNAFDAAVAVSACLAVVYPHMTGLGGDAFWLMYHNGSGEIKGYNGSGRSG
RKADRDQYKGERAIPVRGPRSAITVPGMVDSWAEILAAYGRLSLREVLKPAIMYAEKGFPVSPDQCQNTVKNAEWLSCMP
ITADIYLPGGKPPSPGERFVQKELARTLTLIAEKGRDTFYKGEIAQALAAYLQNNGGILNLEDFGLHRGEWVSPLSSTYR
GYAIYQMPPNSQGFTGLMTLNILENYDFGMIEHGSFEYYHLLIEALKLSFSDCNKVLTDPEFSQIPLGRLLDKEYARELA
AKIGLPALQAESRPLGSDTSYAAAVDEDGNAVSFIQSLYFEFGSGVTAGDTGVILQNRGAFFSLDPDHVNTLEPGKRTFH
TLMPAMAFRGGKPKFLYGTQGQGGEGQPQTQTALITRMVDYGMDPQTAVHEPRWVWGRTWGERVEGVRIESRVAPEVIAK
LRKHGHHVTVVGEFDGVMGHAGIIEIDDQGFLRGGSDPRSDGAAIGI

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=498, Percent_Identity=25.3012048192771, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI73915090, Length=498, Percent_Identity=25.3012048192771, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI73915096, Length=498, Percent_Identity=25.3012048192771, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI73915094, Length=498, Percent_Identity=25.3012048192771, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI113429324, Length=502, Percent_Identity=24.9003984063745, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI113429326, Length=507, Percent_Identity=25.0493096646943, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI153266885, Length=475, Percent_Identity=25.8947368421053, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI153266901, Length=379, Percent_Identity=27.1767810026385, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI109148539, Length=528, Percent_Identity=25.9469696969697, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI153266907, Length=472, Percent_Identity=25, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1789856, Length=537, Percent_Identity=31.8435754189944, Blast_Score=248, Evalue=8e-67,
Organism=Caenorhabditis elegans, GI193208247, Length=554, Percent_Identity=24.5487364620939, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI193208245, Length=554, Percent_Identity=24.5487364620939, Blast_Score=125, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17506189, Length=433, Percent_Identity=25.635103926097, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI72000294, Length=489, Percent_Identity=25.1533742331288, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI212646519, Length=489, Percent_Identity=25.1533742331288, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17542894, Length=470, Percent_Identity=26.5957446808511, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI161077878, Length=486, Percent_Identity=26.3374485596708, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161077880, Length=486, Percent_Identity=26.3374485596708, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24642670, Length=486, Percent_Identity=26.3374485596708, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24642666, Length=486, Percent_Identity=26.3374485596708, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI45551474, Length=486, Percent_Identity=26.3374485596708, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI18859893, Length=439, Percent_Identity=24.6013667425968, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI161077496, Length=455, Percent_Identity=23.0769230769231, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI18859741, Length=404, Percent_Identity=24.7524752475248, Blast_Score=93, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 57394; Mature: 57394

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLKIGSKQMVVSPHYLASLAGSIIMEKGGNAFDAAVAVSACLAVVYPHMTGLGGDAFW
CCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEE
LMYHNGSGEIKGYNGSGRSGRKADRDQYKGERAIPVRGPRSAITVPGMVDSWAEILAAYG
EEEECCCCCEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHC
RLSLREVLKPAIMYAEKGFPVSPDQCQNTVKNAEWLSCMPITADIYLPGGKPPSPGERFV
CHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCHHHHHH
QKELARTLTLIAEKGRDTFYKGEIAQALAAYLQNNGGILNLEDFGLHRGEWVSPLSSTYR
HHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCEEEEHHCCCCCCCCCCHHHHCCC
GYAIYQMPPNSQGFTGLMTLNILENYDFGMIEHGSFEYYHLLIEALKLSFSDCNKVLTDP
CEEEEECCCCCCCCEEEEEEEECCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCC
EFSQIPLGRLLDKEYARELAAKIGLPALQAESRPLGSDTSYAAAVDEDGNAVSFIQSLYF
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHH
EFGSGVTAGDTGVILQNRGAFFSLDPDHVNTLEPGKRTFHTLMPAMAFRGGKPKFLYGTQ
HHCCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCC
GQGGEGQPQTQTALITRMVDYGMDPQTAVHEPRWVWGRTWGERVEGVRIESRVAPEVIAK
CCCCCCCCHHHHHHHHHHHHCCCCCCHHCCCCCEEECCCHHHHCCCEEEHHHCCHHHHHH
LRKHGHHVTVVGEFDGVMGHAGIIEIDDQGFLRGGSDPRSDGAAIGI
HHHCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEKLKIGSKQMVVSPHYLASLAGSIIMEKGGNAFDAAVAVSACLAVVYPHMTGLGGDAFW
CCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEE
LMYHNGSGEIKGYNGSGRSGRKADRDQYKGERAIPVRGPRSAITVPGMVDSWAEILAAYG
EEEECCCCCEEECCCCCCCCCCCCHHHHCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHC
RLSLREVLKPAIMYAEKGFPVSPDQCQNTVKNAEWLSCMPITADIYLPGGKPPSPGERFV
CHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCHHHHHH
QKELARTLTLIAEKGRDTFYKGEIAQALAAYLQNNGGILNLEDFGLHRGEWVSPLSSTYR
HHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCEEEEHHCCCCCCCCCCHHHHCCC
GYAIYQMPPNSQGFTGLMTLNILENYDFGMIEHGSFEYYHLLIEALKLSFSDCNKVLTDP
CEEEEECCCCCCCCEEEEEEEECCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCC
EFSQIPLGRLLDKEYARELAAKIGLPALQAESRPLGSDTSYAAAVDEDGNAVSFIQSLYF
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHH
EFGSGVTAGDTGVILQNRGAFFSLDPDHVNTLEPGKRTFHTLMPAMAFRGGKPKFLYGTQ
HHCCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCC
GQGGEGQPQTQTALITRMVDYGMDPQTAVHEPRWVWGRTWGERVEGVRIESRVAPEVIAK
CCCCCCCCHHHHHHHHHHHHCCCCCCHHCCCCCEEECCCHHHHCCCEEEHHHCCHHHHHH
LRKHGHHVTVVGEFDGVMGHAGIIEIDDQGFLRGGSDPRSDGAAIGI
HHHCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]