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The map label for this gene is degS [H]

Identifier: 52787474

GI number: 52787474

Start: 3611435

End: 3612643

Strand: Reverse

Name: degS [H]

Synonym: BLi03794

Alternate gene names: 52787474

Gene position: 3612643-3611435 (Counterclockwise)

Preceding gene: 52787477

Following gene: 52787473

Centisome position: 85.55

GC content: 43.59

Gene sequence:

>1209_bases
ATGAAATTTATGATAAAACTAAATGACAATGCTGTTACGGAGGGAAAATGGGTGAGCGTTTCCAAAATGGACTCCAAAGT
TTTAGATTCAATCATTATGAAGATGTTAAAAACGGTTGACGGGAGCAAGGATGAAGTCTTTCAAATCGGAGAGCAGTCCC
GCCAGCAATACGAAGGCTTGGTAGAAGAGCTGAAACAGATTAAACAGCAGGTCAACGAAGTCATCGATCTTGGAGACAGG
CTGGAAGTGCATGCCCGCCATGCGCGGAACCGCTTGTCAGAGGTCAGCAGAAACTTTCATAAATTCAGTGAAGAAGAGAT
TCGCGAAGCTTATGAAAAAGCCCACAAACTGCAGGTTGAACTGACAATGATCCAGCAGCGGGAAAAGCAGCTGAGAGAGA
AGCGTGATGATCTGGAACGGCGCCTTTTGGGGCTTCAGGAAATCATCGAGCGTTCAGAAGGGCTTGTCAGTCAGATTACC
GTCGTCTTAAACTACTTAAATCAGGATCTGCGCCAGGTCGGCGTTCTCCTTGAAGATGCGCAGGCCAAGCAGGATTTCGG
ACTGCGGATTATCGAAGCCCAGGAGGAAGAAAGAAAAAGGGTCTCAAGGGAAATTCACGACGGTCCTGCGCAAATGCTGG
CCAACGTTATGATGAGATCTGAACTGATCGAACGCATCTTCAGAGACAAAGGAACAGAAGAAGGCTTTCAGGAAATTAAA
AACCTCCGGCAAAACGTCAGAAATGCTCTTTATGAAGTCAGAAGAATCATTTATGATTTAAGGCCGATGGCTTTAGACGA
TTTGGGATTGATACCGACGCTCAGAAAATACTTGAACACGATCGAAGATTATCATGGAAAAGCAAAGATTCATTTCCAAT
GCATCGGAGAATCCGAAGAAAGAAGAATAGCACCGCGGTTTGAGGTTGCACTATTCCGGCTTGCACAGGAAGCGGTGACA
AACGCCTTAAAACACTCCGAATCAACTGAAATTCATGTTAAAGTAGAAGTGACAAAAGATTTTGTGACGCTGATTATCAA
AGACAATGGAAACGGCTTTGACTTAAAAGAAGTAAAAGGCAAGAAGAACAAATCTTTCGGTCTGCTAGGTATGAAAGAAA
GAGTCGATTTGCTCGAAGGCTCAATGACAATCGATTCGAAAATAGGTCTTGGGACATTTATATTGATTAAAGTTCCACTG
TCTTTGTAA

Upstream 100 bases:

>100_bases
TGGCGCGTATTTTGTTATGATTAAATAGAAATGGATCGGTAACCATAAAAAAACCAGAATACGCATTCTTTCATTATAAT
TCGACACGAATTTCAGTTCA

Downstream 100 bases:

>100_bases
AGATAATTGTAAAATAGAGACAAAAGACATATTGACCATAAAAGCGGTGTGTTTAACAATGAGAATGGGGAGGCGTAGCT
TGTGACTAAAGTAAATATTG

Product: DegS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MKFMIKLNDNAVTEGKWVSVSKMDSKVLDSIIMKMLKTVDGSKDEVFQIGEQSRQQYEGLVEELKQIKQQVNEVIDLGDR
LEVHARHARNRLSEVSRNFHKFSEEEIREAYEKAHKLQVELTMIQQREKQLREKRDDLERRLLGLQEIIERSEGLVSQIT
VVLNYLNQDLRQVGVLLEDAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDKGTEEGFQEIK
NLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLNTIEDYHGKAKIHFQCIGESEERRIAPRFEVALFRLAQEAVT
NALKHSESTEIHVKVEVTKDFVTLIIKDNGNGFDLKEVKGKKNKSFGLLGMKERVDLLEGSMTIDSKIGLGTFILIKVPL
SL

Sequences:

>Translated_402_residues
MKFMIKLNDNAVTEGKWVSVSKMDSKVLDSIIMKMLKTVDGSKDEVFQIGEQSRQQYEGLVEELKQIKQQVNEVIDLGDR
LEVHARHARNRLSEVSRNFHKFSEEEIREAYEKAHKLQVELTMIQQREKQLREKRDDLERRLLGLQEIIERSEGLVSQIT
VVLNYLNQDLRQVGVLLEDAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDKGTEEGFQEIK
NLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLNTIEDYHGKAKIHFQCIGESEERRIAPRFEVALFRLAQEAVT
NALKHSESTEIHVKVEVTKDFVTLIIKDNGNGFDLKEVKGKKNKSFGLLGMKERVDLLEGSMTIDSKIGLGTFILIKVPL
SL
>Mature_402_residues
MKFMIKLNDNAVTEGKWVSVSKMDSKVLDSIIMKMLKTVDGSKDEVFQIGEQSRQQYEGLVEELKQIKQQVNEVIDLGDR
LEVHARHARNRLSEVSRNFHKFSEEEIREAYEKAHKLQVELTMIQQREKQLREKRDDLERRLLGLQEIIERSEGLVSQIT
VVLNYLNQDLRQVGVLLEDAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDKGTEEGFQEIK
NLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLNTIEDYHGKAKIHFQCIGESEERRIAPRFEVALFRLAQEAVT
NALKHSESTEIHVKVEVTKDFVTLIIKDNGNGFDLKEVKGKKNKSFGLLGMKERVDLLEGSMTIDSKIGLGTFILIKVPL
SL

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788812, Length=246, Percent_Identity=28.4552845528455, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787474, Length=201, Percent_Identity=25.3731343283582, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082311, Length=203, Percent_Identity=29.5566502463054, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 46613; Mature: 46613

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFMIKLNDNAVTEGKWVSVSKMDSKVLDSIIMKMLKTVDGSKDEVFQIGEQSRQQYEGL
CEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VEELKQIKQQVNEVIDLGDRLEVHARHARNRLSEVSRNFHKFSEEEIREAYEKAHKLQVE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LTMIQQREKQLREKRDDLERRLLGLQEIIERSEGLVSQITVVLNYLNQDLRQVGVLLEDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDKGTEEGFQEIK
HHHHHCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
NLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLNTIEDYHGKAKIHFQCIGESEE
HHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
RRIAPRFEVALFRLAQEAVTNALKHSESTEIHVKVEVTKDFVTLIIKDNGNGFDLKEVKG
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCEEEEEEEECCCCCCHHHHCC
KKNKSFGLLGMKERVDLLEGSMTIDSKIGLGTFILIKVPLSL
CCCCCCCCCCHHHHHHHHHCCCEECCCCCCCEEEEEEECCCC
>Mature Secondary Structure
MKFMIKLNDNAVTEGKWVSVSKMDSKVLDSIIMKMLKTVDGSKDEVFQIGEQSRQQYEGL
CEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
VEELKQIKQQVNEVIDLGDRLEVHARHARNRLSEVSRNFHKFSEEEIREAYEKAHKLQVE
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LTMIQQREKQLREKRDDLERRLLGLQEIIERSEGLVSQITVVLNYLNQDLRQVGVLLEDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDKGTEEGFQEIK
HHHHHCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
NLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLNTIEDYHGKAKIHFQCIGESEE
HHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCC
RRIAPRFEVALFRLAQEAVTNALKHSESTEIHVKVEVTKDFVTLIIKDNGNGFDLKEVKG
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCEEEEEEEECCCCCCHHHHCC
KKNKSFGLLGMKERVDLLEGSMTIDSKIGLGTFILIKVPLSL
CCCCCCCCCCHHHHHHHHHCCCEECCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]