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The map label for this gene is degU [H]

Identifier: 52787473

GI number: 52787473

Start: 3610664

End: 3611353

Strand: Reverse

Name: degU [H]

Synonym: BLi03793

Alternate gene names: 52787473

Gene position: 3611353-3610664 (Counterclockwise)

Preceding gene: 52787474

Following gene: 52787472

Centisome position: 85.52

GC content: 43.62

Gene sequence:

>690_bases
GTGACTAAAGTAAATATTGTAATTATTGACGATCATCAGTTATTCCGTGAAGGTGTCAAACGGATTTTGGATTTCGAACC
TACCTTTGAGGTAGTGGCCGAAGGAGACGACGGAGATGAAGCGGCTCGCATTGTCGAGCACTACCATCCTGATGTTGTTA
TCATGGATATTAATATGCCGAATGTGAACGGAGTAGAAGCGACAAAACAACTGGTCGACTTGTATCCGGAATCAAAGGTT
ATTATTTTATCCATCCATGATGACGAAAACTATGTTACACATGCATTAAAAACAGGAGCCCGGGGCTATCTGCTGAAAGA
AATGGATGCCGATACGCTGATCGAAGCCGTGAAAGTAGTAGCTGAAGGCGGATCTTATCTGCATCCTAAGGTTACACACA
ATCTTGTGAATGAATTCCGCCGTCTTGCAACAAGCGGTGTATCATCTCACGCTCAGCATGAGGTGTATCCGGAAATCCGG
AGACCTCTTCACATTCTCACAAGAAGGGAATGCGAGGTACTGCAGATGCTGGCGGATGGAAAAAGCAACCGCGGAATCGG
CGAATCATTATTTATCAGTGAAAAAACGGTTAAAAACCATGTCAGCAACATCCTTCAAAAAATGAATGTAAACGACAGAA
CGCAGGCTGTTGTTGTAGCCATTAAAAACGGCTGGGTAGAAATGAGATAA

Upstream 100 bases:

>100_bases
AGTTCCACTGTCTTTGTAAAGATAATTGTAAAATAGAGACAAAAGACATATTGACCATAAAAGCGGTGTGTTTAACAATG
AGAATGGGGAGGCGTAGCTT

Downstream 100 bases:

>100_bases
AGATGGACTTGCCATAAGGCAGGTCTTTTCTTTTGGCAGAAAATTAAACTTTATAATGAAAAAAGCTGCTTTTTCTTTTA
GAATAGAAAAGAGTATCTTT

Product: DegU

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARIVEHYHPDVVIMDINMPNVNGVEATKQLVDLYPESKV
IILSIHDDENYVTHALKTGARGYLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSSHAQHEVYPEIR
RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVVVAIKNGWVEMR

Sequences:

>Translated_229_residues
MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARIVEHYHPDVVIMDINMPNVNGVEATKQLVDLYPESKV
IILSIHDDENYVTHALKTGARGYLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSSHAQHEVYPEIR
RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVVVAIKNGWVEMR
>Mature_228_residues
TKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARIVEHYHPDVVIMDINMPNVNGVEATKQLVDLYPESKVI
ILSIHDDENYVTHALKTGARGYLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSSHAQHEVYPEIRR
PLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVVVAIKNGWVEMR

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=222, Percent_Identity=35.1351351351351, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1790102, Length=223, Percent_Identity=34.0807174887892, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1788222, Length=222, Percent_Identity=27.4774774774775, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787473, Length=222, Percent_Identity=33.7837837837838, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1788712, Length=220, Percent_Identity=28.6363636363636, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1786747, Length=210, Percent_Identity=25.7142857142857, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1789937, Length=216, Percent_Identity=23.6111111111111, Blast_Score=61, Evalue=5e-11,
Organism=Escherichia coli, GI1787277, Length=167, Percent_Identity=29.3413173652695, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 25843; Mature: 25712

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARIVEHYHPDVVIMDINMP
CCEEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEECCC
NVNGVEATKQLVDLYPESKVIILSIHDDENYVTHALKTGARGYLLKEMDADTLIEAVKVV
CCCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHCCCCCEEEHHCCHHHHHHHHHHH
AEGGSYLHPKVTHNLVNEFRRLATSGVSSHAQHEVYPEIRRPLHILTRRECEVLQMLADG
HCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVVVAIKNGWVEMR
CCCCCCCCHHEEHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEECC
>Mature Secondary Structure 
TKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARIVEHYHPDVVIMDINMP
CEEEEEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEECCC
NVNGVEATKQLVDLYPESKVIILSIHDDENYVTHALKTGARGYLLKEMDADTLIEAVKVV
CCCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHCCCCCEEEHHCCHHHHHHHHHHH
AEGGSYLHPKVTHNLVNEFRRLATSGVSSHAQHEVYPEIRRPLHILTRRECEVLQMLADG
HCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVVVAIKNGWVEMR
CCCCCCCCHHEEHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]