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The map label for this gene is phoP [H]

Identifier: 52786788

GI number: 52786788

Start: 2944954

End: 2945676

Strand: Reverse

Name: phoP [H]

Synonym: BLi03059

Alternate gene names: 52786788

Gene position: 2945676-2944954 (Counterclockwise)

Preceding gene: 52786789

Following gene: 52786787

Centisome position: 69.76

GC content: 46.89

Gene sequence:

>723_bases
ATGAGCAAAAAGATATTAGTTGTAGATGATGAGGAATCGATTGTTACCCTTCTAAAATATAACCTTGAACGGTCGGGCTA
TCATGTGGTGACCGCCATGGACGGAGAGGCCGGCTTATTAAAGGCGATTGAAGAGAAGCCGGATCTGATCGTGCTCGATC
TGATGCTTCCTAAAATGGACGGCATTGAAGTATGCAAGGAACTCAGACAGAAGAAGCTGATGTATCCGATTTTGATGCTG
ACCGCAAAGGATGATGAATTTGATAAAGTGCTCGGTCTCGAGCTGGGTGCCGATGACTATATGACAAAGCCGTTCAGCCC
GAGAGAGGTGACGGCAAGGGTCAAAGCGATTTTAAGAAGAACACAGACGCTGTCCGTTCAGCCGGAGGAGACGGAAGAAC
CGGATGCAGGCGAGCTGATCATAGGCGAACTGAAAATACTGCCTGAACATTATGAGGTTTATTTTCAAAACGAACGCCTC
GAGCTGACGCCGAAGGAATTCGAACTTCTCTTATATTTGGGAAGGCATAAAGGGAGGGTGCTGACGAGAGACCTTCTCCT
CAACGCTGTCTGGAACTACGACTTCGCGGGCGATACGCGCATCGTCGATGTCCACATCAGCCACCTTCGCGATAAGATCG
AAAAAAATACAAAAAAACCGGAATACATTAAAACAATCAGAGGTCTTGGCTACAAAATGGAGGAGCCGAAACTGAATGAT
TAA

Upstream 100 bases:

>100_bases
GTCGAACGGATAGGCTTTCGTTAAAATAGGAGTGAAAACGTTTATTTAACAAAAGATAGAGAAAGAGATGTCGGGGAAAT
CTGAAGCCTGGAGGCATGTC

Downstream 100 bases:

>100_bases
ATTCCGGACCCGGCTTTTAGCTGCCCTGCTGACGCTTTTGATTCTCGTATTTGCTTCACTCGGTTTTCTGCTCGTTCACT
TGTTTCACTCCTCTTACGAT

Product: PhoP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MSKKILVVDDEESIVTLLKYNLERSGYHVVTAMDGEAGLLKAIEEKPDLIVLDLMLPKMDGIEVCKELRQKKLMYPILML
TAKDDEFDKVLGLELGADDYMTKPFSPREVTARVKAILRRTQTLSVQPEETEEPDAGELIIGELKILPEHYEVYFQNERL
ELTPKEFELLLYLGRHKGRVLTRDLLLNAVWNYDFAGDTRIVDVHISHLRDKIEKNTKKPEYIKTIRGLGYKMEEPKLND

Sequences:

>Translated_240_residues
MSKKILVVDDEESIVTLLKYNLERSGYHVVTAMDGEAGLLKAIEEKPDLIVLDLMLPKMDGIEVCKELRQKKLMYPILML
TAKDDEFDKVLGLELGADDYMTKPFSPREVTARVKAILRRTQTLSVQPEETEEPDAGELIIGELKILPEHYEVYFQNERL
ELTPKEFELLLYLGRHKGRVLTRDLLLNAVWNYDFAGDTRIVDVHISHLRDKIEKNTKKPEYIKTIRGLGYKMEEPKLND
>Mature_239_residues
SKKILVVDDEESIVTLLKYNLERSGYHVVTAMDGEAGLLKAIEEKPDLIVLDLMLPKMDGIEVCKELRQKKLMYPILMLT
AKDDEFDKVLGLELGADDYMTKPFSPREVTARVKAILRRTQTLSVQPEETEEPDAGELIIGELKILPEHYEVYFQNERLE
LTPKEFELLLYLGRHKGRVLTRDLLLNAVWNYDFAGDTRIVDVHISHLRDKIEKNTKKPEYIKTIRGLGYKMEEPKLND

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=235, Percent_Identity=40.4255319148936, Blast_Score=166, Evalue=1e-42,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=39.3013100436681, Blast_Score=160, Evalue=8e-41,
Organism=Escherichia coli, GI1788394, Length=235, Percent_Identity=40.4255319148936, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI2367329, Length=233, Percent_Identity=42.4892703862661, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1786784, Length=233, Percent_Identity=37.7682403433476, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1790860, Length=231, Percent_Identity=38.961038961039, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1786911, Length=230, Percent_Identity=36.5217391304348, Blast_Score=144, Evalue=3e-36,
Organism=Escherichia coli, GI87082012, Length=235, Percent_Identity=36.5957446808511, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI1790552, Length=233, Percent_Identity=38.6266094420601, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1789402, Length=233, Percent_Identity=36.480686695279, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=34.9344978165939, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=35.0649350649351, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1787375, Length=231, Percent_Identity=31.6017316017316, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=30.9012875536481, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1790299, Length=160, Percent_Identity=30, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788550, Length=117, Percent_Identity=31.6239316239316, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790437, Length=123, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787487, Length=104, Percent_Identity=30.7692307692308, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27746; Mature: 27614

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKILVVDDEESIVTLLKYNLERSGYHVVTAMDGEAGLLKAIEEKPDLIVLDLMLPKMD
CCCCEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHCCCCEEEEEEECCCCC
GIEVCKELRQKKLMYPILMLTAKDDEFDKVLGLELGADDYMTKPFSPREVTARVKAILRR
HHHHHHHHHHHHHHCEEEEEEECCCCHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
TQTLSVQPEETEEPDAGELIIGELKILPEHYEVYFQNERLELTPKEFELLLYLGRHKGRV
HHHCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEECCEEEECHHHEEEEEEECCCCCCC
LTRDLLLNAVWNYDFAGDTRIVDVHISHLRDKIEKNTKKPEYIKTIRGLGYKMEEPKLND
HHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SKKILVVDDEESIVTLLKYNLERSGYHVVTAMDGEAGLLKAIEEKPDLIVLDLMLPKMD
CCCEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHCCCCEEEEEEECCCCC
GIEVCKELRQKKLMYPILMLTAKDDEFDKVLGLELGADDYMTKPFSPREVTARVKAILRR
HHHHHHHHHHHHHHCEEEEEEECCCCHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
TQTLSVQPEETEEPDAGELIIGELKILPEHYEVYFQNERLELTPKEFELLLYLGRHKGRV
HHHCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEEECCEEEECHHHEEEEEEECCCCCCC
LTRDLLLNAVWNYDFAGDTRIVDVHISHLRDKIEKNTKKPEYIKTIRGLGYKMEEPKLND
HHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]