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The map label for this gene is uvrC

Identifier: 52786728

GI number: 52786728

Start: 2878295

End: 2880067

Strand: Reverse

Name: uvrC

Synonym: BLi02997

Alternate gene names: 52786728

Gene position: 2880067-2878295 (Counterclockwise)

Preceding gene: 52786729

Following gene: 52786727

Centisome position: 68.21

GC content: 47.32

Gene sequence:

>1773_bases
ATGAACAAAAAAATCAAAGAAAAGCTGGCCCTTCTTCCGGATCAGCCTGGCTGCTACTTGATGAAAGACAGGCAGGATAC
CGTCATCTACGTCGGGAAAGCGAAAATCTTAAAAAACAGGGTCCGCTCCTATTTCAGCGGGTCCCATGATGCCAAAACAC
AGCGTCTTGTCAGTGAAATTGAAGACTTCGAATACATTGTCACATCCTCGAACATCGAAGCGCTCATTCTTGAAATGAAT
TTAATCAAAAAGTACGACCCGAAATATAACGTGATGCTTAAAGATGATAAAAGCTACCCGTTCATTAAAATCACGAACGA
GCGGCATCCGAAGCTGGTTGTCACAAGGAAGGTCAAAAAAGACAAAGGCCGCTATTTCGGGCCGTACCCCAATGTCCAGG
CTGCGAGGGAAACAAAAAAGCTGCTGGACCGCCTCTATCCGCTCAGAAAGTGCGCCAAGCTGCCTGACCGCGTCTGTTTG
TACTATCATCTCGGACAATGTCTGGCGCCATGCGTATATGATGTGTCTGAGGAGACAAACAGACAGCTCACAGAAGAAAT
TACCCGCTTTTTAAAAGGCGGCTACAATGAAGTGAAGAAAGAGCTTGAAGCAAAAATGCTCGAAGCCTCGGAAAACCTGC
AGTTTGAACGGGCGAAAGAATTCCGCGATCAAATTGCCCATATCGAGTCAACGATGGAAAAACAGAAAATGATGCTGAAT
GACATGGTTGACCGCGATGTATTTGCCTATTCGTATGACAAGGGCTGGATGTGCGTCCAGGTCTTCTTCATCAGGCAGGG
CAAATTGATTGAAAGAGATGTCAGCATGTTTCCTTTATACAGGGAAGCAGACGAGGAATTTCTGACATTCATCGGGCAAT
TTTACTCCAAAAACAACCATTTTCTTCCGAAGGAAATTTTGGTGCCTGACAGCGTCGACAAGGACATGATTGAGGAGCTT
TTGGACGTGAACGTGCGCCAGCCGAAAAGAGGAGCGAAAAAAGACCTGCTGCTCCTTGCCCATAAAAATGCAAAGCTCGC
TTTGAAGGAGAAGTTTTCGCTCATTGAACGGGATGAAGAGCGGACGATCGGCGCGATTGAAAAGCTCGGAAAAGCGCTGG
ACATCTACACGCCATACAGAATTGAAGCGTTTGATAACTCAAATATTCAAGGAACGGACCCTGTTTCGGCCATGGTTGTA
TTTCTCGATGGAAAACCGCATAAAAAAGAGTACCGCAAATATAAGATCAAGACGGTTGAAGGTCCTGACGACTACGGATC
AATGCGCGAAGTCATCAGAAGAAGATATACAAGGGTGCTGAAAGAGAATCTGCCGCTGCCTGATTTAATTTTGATCGACG
GCGGAAAGGGGCAGGTGTCTGCCGCCCTTGACGTTCTGGAAAATGAACTGGGTCTCGATGTCCCTGTTGCCGGTCTGGTG
AAAGACGATAAGCACAGAACATCCAACCTTTTGATCGGCGATCCCCTTGAGATCGTCCAGCTTGAGCGGAACAGCCAGGA
ATTTTACCTGCTTCAGCGCATTCAGGACGAAGTGCACAGGTTTGCGATCAGCTTCCACAGGCAGCTCAGGGGAAAAAGCG
CATTTCAATCGGTGCTGGACGGCATACCGGGCGTCGGCGAACAGCGGAAAAAACTGCTGTTAAAACATTTCGGTTCCGTT
AAGAAAATGAAGGAAGCGAGCGCCGAAGATATCCGCAAGCTCGGCATACCTCTGAAAACGGCGCAGCTGATCGAAGAGGC
ATTGAAAAAATAA

Upstream 100 bases:

>100_bases
TTTCTTACAAGTCATCTTCTTTCTCCATTTGTGGCGAACGTACGGTCGGTCATGGTAAACTTAAATGAAGGAAAAACGCC
GAAATAAGGAAGGATTTTTG

Downstream 100 bases:

>100_bases
TGTTGAACTTTTAAAAAGAATCTGATAGAATTTGTACTAATTTCATAATAAGATCGTGTGATATGGTGAAGATAGAGGTG
CGAACTTCAAGAGTAGGCTT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MNKKIKEKLALLPDQPGCYLMKDRQDTVIYVGKAKILKNRVRSYFSGSHDAKTQRLVSEIEDFEYIVTSSNIEALILEMN
LIKKYDPKYNVMLKDDKSYPFIKITNERHPKLVVTRKVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCAKLPDRVCL
YYHLGQCLAPCVYDVSEETNRQLTEEITRFLKGGYNEVKKELEAKMLEASENLQFERAKEFRDQIAHIESTMEKQKMMLN
DMVDRDVFAYSYDKGWMCVQVFFIRQGKLIERDVSMFPLYREADEEFLTFIGQFYSKNNHFLPKEILVPDSVDKDMIEEL
LDVNVRQPKRGAKKDLLLLAHKNAKLALKEKFSLIERDEERTIGAIEKLGKALDIYTPYRIEAFDNSNIQGTDPVSAMVV
FLDGKPHKKEYRKYKIKTVEGPDDYGSMREVIRRRYTRVLKENLPLPDLILIDGGKGQVSAALDVLENELGLDVPVAGLV
KDDKHRTSNLLIGDPLEIVQLERNSQEFYLLQRIQDEVHRFAISFHRQLRGKSAFQSVLDGIPGVGEQRKKLLLKHFGSV
KKMKEASAEDIRKLGIPLKTAQLIEEALKK

Sequences:

>Translated_590_residues
MNKKIKEKLALLPDQPGCYLMKDRQDTVIYVGKAKILKNRVRSYFSGSHDAKTQRLVSEIEDFEYIVTSSNIEALILEMN
LIKKYDPKYNVMLKDDKSYPFIKITNERHPKLVVTRKVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCAKLPDRVCL
YYHLGQCLAPCVYDVSEETNRQLTEEITRFLKGGYNEVKKELEAKMLEASENLQFERAKEFRDQIAHIESTMEKQKMMLN
DMVDRDVFAYSYDKGWMCVQVFFIRQGKLIERDVSMFPLYREADEEFLTFIGQFYSKNNHFLPKEILVPDSVDKDMIEEL
LDVNVRQPKRGAKKDLLLLAHKNAKLALKEKFSLIERDEERTIGAIEKLGKALDIYTPYRIEAFDNSNIQGTDPVSAMVV
FLDGKPHKKEYRKYKIKTVEGPDDYGSMREVIRRRYTRVLKENLPLPDLILIDGGKGQVSAALDVLENELGLDVPVAGLV
KDDKHRTSNLLIGDPLEIVQLERNSQEFYLLQRIQDEVHRFAISFHRQLRGKSAFQSVLDGIPGVGEQRKKLLLKHFGSV
KKMKEASAEDIRKLGIPLKTAQLIEEALKK
>Mature_590_residues
MNKKIKEKLALLPDQPGCYLMKDRQDTVIYVGKAKILKNRVRSYFSGSHDAKTQRLVSEIEDFEYIVTSSNIEALILEMN
LIKKYDPKYNVMLKDDKSYPFIKITNERHPKLVVTRKVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCAKLPDRVCL
YYHLGQCLAPCVYDVSEETNRQLTEEITRFLKGGYNEVKKELEAKMLEASENLQFERAKEFRDQIAHIESTMEKQKMMLN
DMVDRDVFAYSYDKGWMCVQVFFIRQGKLIERDVSMFPLYREADEEFLTFIGQFYSKNNHFLPKEILVPDSVDKDMIEEL
LDVNVRQPKRGAKKDLLLLAHKNAKLALKEKFSLIERDEERTIGAIEKLGKALDIYTPYRIEAFDNSNIQGTDPVSAMVV
FLDGKPHKKEYRKYKIKTVEGPDDYGSMREVIRRRYTRVLKENLPLPDLILIDGGKGQVSAALDVLENELGLDVPVAGLV
KDDKHRTSNLLIGDPLEIVQLERNSQEFYLLQRIQDEVHRFAISFHRQLRGKSAFQSVLDGIPGVGEQRKKLLLKHFGSV
KKMKEASAEDIRKLGIPLKTAQLIEEALKK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=612, Percent_Identity=39.7058823529412, Blast_Score=377, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_BACLD (Q65GF0)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_080142.1
- RefSeq:   YP_092557.1
- ProteinModelPortal:   Q65GF0
- STRING:   Q65GF0
- EnsemblBacteria:   EBBACT00000055960
- EnsemblBacteria:   EBBACT00000059381
- GeneID:   3028507
- GeneID:   3098530
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi02997
- KEGG:   bli:BL00325
- NMPDR:   fig|279010.5.peg.3346
- eggNOG:   COG0322
- GeneTree:   EBGT00050000001864
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   BLIC279010-1:BLI02997-MONOMER
- BioCyc:   BLIC279010:BL00325-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 68399; Mature: 68399

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKIKEKLALLPDQPGCYLMKDRQDTVIYVGKAKILKNRVRSYFSGSHDAKTQRLVSEI
CCHHHHHHHHCCCCCCCEEEEECCCCCEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHH
EDFEYIVTSSNIEALILEMNLIKKYDPKYNVMLKDDKSYPFIKITNERHPKLVVTRKVKK
HHHEEEEECCCCEEEEEEHHHHHHCCCCEEEEEECCCCCCEEEECCCCCCEEEEEEHHHH
DKGRYFGPYPNVQAARETKKLLDRLYPLRKCAKLPDRVCLYYHLGQCLAPCVYDVSEETN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHH
RQLTEEITRFLKGGYNEVKKELEAKMLEASENLQFERAKEFRDQIAHIESTMEKQKMMLN
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DMVDRDVFAYSYDKGWMCVQVFFIRQGKLIERDVSMFPLYREADEEFLTFIGQFYSKNNH
HHHHCCCEEEECCCCCEEEEEEHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
FLPKEILVPDSVDKDMIEELLDVNVRQPKRGAKKDLLLLAHKNAKLALKEKFSLIERDEE
CCCHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCHH
RTIGAIEKLGKALDIYTPYRIEAFDNSNIQGTDPVSAMVVFLDGKPHKKEYRKYKIKTVE
HHHHHHHHHCCCEECCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHEEEEEEEC
GPDDYGSMREVIRRRYTRVLKENLPLPDLILIDGGKGQVSAALDVLENELGLDVPVAGLV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCHHCC
KDDKHRTSNLLIGDPLEIVQLERNSQEFYLLQRIQDEVHRFAISFHRQLRGKSAFQSVLD
CCCCCCCCCEEECCCHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
GIPGVGEQRKKLLLKHFGSVKKMKEASAEDIRKLGIPLKTAQLIEEALKK
CCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNKKIKEKLALLPDQPGCYLMKDRQDTVIYVGKAKILKNRVRSYFSGSHDAKTQRLVSEI
CCHHHHHHHHCCCCCCCEEEEECCCCCEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHH
EDFEYIVTSSNIEALILEMNLIKKYDPKYNVMLKDDKSYPFIKITNERHPKLVVTRKVKK
HHHEEEEECCCCEEEEEEHHHHHHCCCCEEEEEECCCCCCEEEECCCCCCEEEEEEHHHH
DKGRYFGPYPNVQAARETKKLLDRLYPLRKCAKLPDRVCLYYHLGQCLAPCVYDVSEETN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHH
RQLTEEITRFLKGGYNEVKKELEAKMLEASENLQFERAKEFRDQIAHIESTMEKQKMMLN
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DMVDRDVFAYSYDKGWMCVQVFFIRQGKLIERDVSMFPLYREADEEFLTFIGQFYSKNNH
HHHHCCCEEEECCCCCEEEEEEHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
FLPKEILVPDSVDKDMIEELLDVNVRQPKRGAKKDLLLLAHKNAKLALKEKFSLIERDEE
CCCHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCHH
RTIGAIEKLGKALDIYTPYRIEAFDNSNIQGTDPVSAMVVFLDGKPHKKEYRKYKIKTVE
HHHHHHHHHCCCEECCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHEEEEEEEC
GPDDYGSMREVIRRRYTRVLKENLPLPDLILIDGGKGQVSAALDVLENELGLDVPVAGLV
CCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCHHCC
KDDKHRTSNLLIGDPLEIVQLERNSQEFYLLQRIQDEVHRFAISFHRQLRGKSAFQSVLD
CCCCCCCCCEEECCCHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
GIPGVGEQRKKLLLKHFGSVKKMKEASAEDIRKLGIPLKTAQLIEEALKK
CCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA