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The map label for this gene is apt [H]

Identifier: 52786620

GI number: 52786620

Start: 2778375

End: 2778887

Strand: Reverse

Name: apt [H]

Synonym: BLi02888

Alternate gene names: 52786620

Gene position: 2778887-2778375 (Counterclockwise)

Preceding gene: 52786621

Following gene: 52786619

Centisome position: 65.81

GC content: 47.76

Gene sequence:

>513_bases
ATGGATTTGAAGAAGTATGTGACAATTGTGCCGGATTACCCGAAGGAAGGCGTACAATTTAAAGATATTACAACATTGAT
GGACAAAGGCGACGTCTATCGCTACGCGACAGATCAAATTGTAACGTATGCGAAGGAAAAAGAGATCGATCTCGTCGTGG
GACCTGAAGCGAGAGGATTTATCATCGGCTGCCCTGTCGCATATGCGCTTGGGGTAGGGTTTGCGCCTGTCCGCAAAGAA
GGCAAACTGCCGCGCGAAGTCATCAAAGTCGACTACGGATTGGAATATGGAAAAGATGTCCTGACCATCCATAAAGATGC
CATTAAACCGGGGCAGCGCGTCTTGATCACTGACGACCTGCTTGCAACCGGCGGGACGATTGAAGCAACGATCAAGCTTG
TTGAAGAGCTCGGCGGCGTCGTGGCCGGAATCGCTTTCCTGATCGAACTGACATATCTTGAAGGAAGAAATAAACTGGAC
GGATATGATATTTTAACCTTGATGCAATACTAA

Upstream 100 bases:

>100_bases
AGCTCATTTATTCTTCGGCGGATGAGCTTAAACAGTGGCTGGATAAGCGGATGGCGGAAAAAGCCGGCGCTTATAAAGTA
TGAGGAGGACATGAAGACAG

Downstream 100 bases:

>100_bases
ACAAATTTTATACTATAAAAAGCACTCATAAAAAGCGGGTGCTTTTTTTCCTATTCATAAAAGTATTCCGGGGCCGGCAA
AAGCCCTTTTGAATTTCTTC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MDLKKYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVTYAKEKEIDLVVGPEARGFIIGCPVAYALGVGFAPVRKE
GKLPREVIKVDYGLEYGKDVLTIHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELTYLEGRNKLD
GYDILTLMQY

Sequences:

>Translated_170_residues
MDLKKYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVTYAKEKEIDLVVGPEARGFIIGCPVAYALGVGFAPVRKE
GKLPREVIKVDYGLEYGKDVLTIHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELTYLEGRNKLD
GYDILTLMQY
>Mature_170_residues
MDLKKYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVTYAKEKEIDLVVGPEARGFIIGCPVAYALGVGFAPVRKE
GKLPREVIKVDYGLEYGKDVLTIHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELTYLEGRNKLD
GYDILTLMQY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=171, Percent_Identity=40.3508771929825, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=40.8, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1786675, Length=158, Percent_Identity=55.6962025316456, Blast_Score=168, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=41.7647058823529, Blast_Score=122, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6323619, Length=172, Percent_Identity=40.1162790697674, Blast_Score=116, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=154, Percent_Identity=33.7662337662338, Blast_Score=82, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17136334, Length=162, Percent_Identity=43.8271604938272, Blast_Score=135, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 18804; Mature: 18804

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKKYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVTYAKEKEIDLVVGPEARGF
CCCCCEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEHHHHHHHHCCCCEEEEECCCCCCE
IIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLTIHKDAIKPGQRVLITDDL
EEECHHHHHHHCCCCCCCCCCCCCHHHHEECCCCCCCCCEEEEEHHHCCCCCEEEEECCH
LATGGTIEATIKLVEELGGVVAGIAFLIELTYLEGRNKLDGYDILTLMQY
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MDLKKYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVTYAKEKEIDLVVGPEARGF
CCCCCEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEHHHHHHHHCCCCEEEEECCCCCCE
IIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLTIHKDAIKPGQRVLITDDL
EEECHHHHHHHCCCCCCCCCCCCCHHHHEECCCCCCCCCEEEEEHHHCCCCCEEEEECCH
LATGGTIEATIKLVEELGGVVAGIAFLIELTYLEGRNKLDGYDILTLMQY
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA