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The map label for this gene is relA [H]

Identifier: 52786619

GI number: 52786619

Start: 2776003

End: 2778204

Strand: Reverse

Name: relA [H]

Synonym: BLi02887

Alternate gene names: 52786619

Gene position: 2778204-2776003 (Counterclockwise)

Preceding gene: 52786620

Following gene: 52786618

Centisome position: 65.79

GC content: 46.37

Gene sequence:

>2202_bases
ATGGCGAACGAACAAGTATTAACCGCTGAGCAAGTCATTGAGAAGGCGAAAAGTTACCTTTCCGATGAACATGTTGCTTT
TATAAAAAAGGCTTATCAGTACGCGGAAGACGCACATCGCGAACAATACCGCAAATCGGGCGAGCCGTATATTATCCATC
CGATCCAGGTCGCGGGAATCCTCGTCGATTTAGAAATGGACCCCGCCACAATAGCGGGAGGATTTCTCCATGATGTGGTG
GAAGATACGAGCGTAACGCTTGAAGATTTAAAGGAAGCATTCAACGAAGAAGTTGCGATGCTTGTCGACGGCGTCACGAA
GCTTGGGAAAATTAAATATAAATCACAGGAAGAACAGCAGGCAGAAAATCATCGGAAAATGTTTGTGGCTATGGCTCAGG
ACATCCGCGTCATTTTGATCAAGCTGGCGGACCGCCTTCACAACATGAGAACCCTGAAGCATCTGCCGCAGGAAAAGCAG
CGCAGAATTTCAAATGAGACGCTTGAAATATTTGCTCCGCTGGCTCATCGCCTTGGGATTTCAAAAATAAAGTGGGAGCT
TGAGGATACCGCTTTACGGTATTTAAATCCGCAGCAATATTACCGGATCGTCAATTTGATGAAGAAAAAGCGGGCCGAAA
GGGAATTGTACGTCGAAGAGGTCGTAAACGAAGTGAAAAGCCGCGTCGAAGAGGTCAATATTAAAGCGGACTTTTCCGGC
CGGCCGAAGCATATTTACAGCATCTACAGAAAAATGGCGATGCAAAACAAGCAATTCAACGAAATTTACGACTTGCTCGC
AGTCCGGATCCTCGTCAACAGCATCAAGGACTGCTACGCGGTTTTAGGCATCATTCATACGTGCTGGAAGCCGATGCCGG
GCAGATTTAAAGACTATATCGCAATGCCGAAGCCGAACATGTACCAATCGCTCCACACCACGGTCATCGGTCCGAAGGGC
GATCCGCTGGAAGTCCAGATCAGGACGTTTGAAATGCATGAAATTGCGGAGTACGGAATCGCTGCCCACTGGGCTTACAA
AGAAGGCAAAAATGCCAATGAAGATTCAAGCTTTGATAAAAAGCTTTCCTGGTTCCGCGAAATTTTGGAATTTCAGAATG
AGTCGAGCGATGCCGAAGAATTTATGGAATCTCTTAAAATCGATTTGTTTTCGGACATGGTATTCGTTTTTACGCCGAAA
GGGGACGTCATCGAATTGCCGTCAGGATCCGTGCCGATCGACTTTTCGTACCGAATCCATTCAGAAATAGGCAATAAAAC
GATCGGGGCCAAAGTAAACGGCAAAATGGTCACCCTTGATTACAAGCTGCGCACAGGGGATATCGTAGAAATTCTGACGT
CCAAGCATTCGTACGGTCCGAGTCAGGACTGGATCAACCTTGCGCAGACATCTCAAGCGAAGCATAAAATCCGTCAGTTC
TTTAAAAAGCAGCGCAGAGAGGAAAATGTCGAAAAAGGCAGAGAACTGGTTGAAAAAGAAATTAAAAACCTGGACTTTGA
AGTGAAGGACGTCTTAACAGCCGAGAATCTGCAGAAGGTCGCCGACAAATTCAACTTTGCCAATGAAGAAGACATGTATG
CCGCTGTCGGCTATAACGGCATTACAGCCGCTCAAGTTGCAAACCGCCTTACGGAAAAAGAACGGAAGATCAGAGATCAG
GAAGAACAGGTGAAAAGCGTTCAGGACGTAACGCCTGAAGTGAAACCTTACCAAGGGAAGAAACGCGAAGCGGGTGTTCG
CGTCAAAGGCGTTGACAACCTTTTGATCAGGCTGTCAAAATGCTGCAACCCTGTTCCGGGAGATCCGATCGTCGGATTCA
TTACAAAAGGCAGGGGCGTATCCGTCCATCGCGAGGACTGCCCGAATGTTTTAACAAATGAAGCGCTCGACCGGCTCATT
CAAGTAGAATGGGAGCATGAACCGCAGACCCAGCGGAGAAAAGAATATAACGTCGAAATTGAGATTCTCGGCTATGACCG
CCGCGGTCTTCTTAATGAAGTTCTACAGGCAGTTAATGAGACAAAAACAAATATTTCATCTGTTTCAGGTAAATCGGACC
GCAATAAAGTGGCGACGATCCATATGGCGATCTTCATTCAAAATATTAACCATTTGCATAAAGTAGTTGAACGGATTAAG
CAGATCAAAGATATTTACTCCGTGCGCAGGGTGATGAATTAG

Upstream 100 bases:

>100_bases
GGGCCGGCAAAAGCCCTTTTGAATTTCTTCTCTTTACATCTGTGACATTTTTCTTGATAATAATTACAATACAGTTTTCA
ATTATAAAAAAGGTGATTCC

Downstream 100 bases:

>100_bases
GAGGAAAAGCGTCATGAGATTAGTTGTTCAGCGCGTCACAGATGCAAGCGTTTCGGTAGGAGGCGAGACTGTCGGCGAAA
TCGGCCTCGGCTTGATGGTG

Product: RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 733; Mature: 732

Protein sequence:

>733_residues
MANEQVLTAEQVIEKAKSYLSDEHVAFIKKAYQYAEDAHREQYRKSGEPYIIHPIQVAGILVDLEMDPATIAGGFLHDVV
EDTSVTLEDLKEAFNEEVAMLVDGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ
RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYVEEVVNEVKSRVEEVNIKADFSG
RPKHIYSIYRKMAMQNKQFNEIYDLLAVRILVNSIKDCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKG
DPLEVQIRTFEMHEIAEYGIAAHWAYKEGKNANEDSSFDKKLSWFREILEFQNESSDAEEFMESLKIDLFSDMVFVFTPK
GDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDYKLRTGDIVEILTSKHSYGPSQDWINLAQTSQAKHKIRQF
FKKQRREENVEKGRELVEKEIKNLDFEVKDVLTAENLQKVADKFNFANEEDMYAAVGYNGITAAQVANRLTEKERKIRDQ
EEQVKSVQDVTPEVKPYQGKKREAGVRVKGVDNLLIRLSKCCNPVPGDPIVGFITKGRGVSVHREDCPNVLTNEALDRLI
QVEWEHEPQTQRRKEYNVEIEILGYDRRGLLNEVLQAVNETKTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIK
QIKDIYSVRRVMN

Sequences:

>Translated_733_residues
MANEQVLTAEQVIEKAKSYLSDEHVAFIKKAYQYAEDAHREQYRKSGEPYIIHPIQVAGILVDLEMDPATIAGGFLHDVV
EDTSVTLEDLKEAFNEEVAMLVDGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ
RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYVEEVVNEVKSRVEEVNIKADFSG
RPKHIYSIYRKMAMQNKQFNEIYDLLAVRILVNSIKDCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKG
DPLEVQIRTFEMHEIAEYGIAAHWAYKEGKNANEDSSFDKKLSWFREILEFQNESSDAEEFMESLKIDLFSDMVFVFTPK
GDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDYKLRTGDIVEILTSKHSYGPSQDWINLAQTSQAKHKIRQF
FKKQRREENVEKGRELVEKEIKNLDFEVKDVLTAENLQKVADKFNFANEEDMYAAVGYNGITAAQVANRLTEKERKIRDQ
EEQVKSVQDVTPEVKPYQGKKREAGVRVKGVDNLLIRLSKCCNPVPGDPIVGFITKGRGVSVHREDCPNVLTNEALDRLI
QVEWEHEPQTQRRKEYNVEIEILGYDRRGLLNEVLQAVNETKTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIK
QIKDIYSVRRVMN
>Mature_732_residues
ANEQVLTAEQVIEKAKSYLSDEHVAFIKKAYQYAEDAHREQYRKSGEPYIIHPIQVAGILVDLEMDPATIAGGFLHDVVE
DTSVTLEDLKEAFNEEVAMLVDGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQR
RISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYVEEVVNEVKSRVEEVNIKADFSGR
PKHIYSIYRKMAMQNKQFNEIYDLLAVRILVNSIKDCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGD
PLEVQIRTFEMHEIAEYGIAAHWAYKEGKNANEDSSFDKKLSWFREILEFQNESSDAEEFMESLKIDLFSDMVFVFTPKG
DVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDYKLRTGDIVEILTSKHSYGPSQDWINLAQTSQAKHKIRQFF
KKQRREENVEKGRELVEKEIKNLDFEVKDVLTAENLQKVADKFNFANEEDMYAAVGYNGITAAQVANRLTEKERKIRDQE
EQVKSVQDVTPEVKPYQGKKREAGVRVKGVDNLLIRLSKCCNPVPGDPIVGFITKGRGVSVHREDCPNVLTNEALDRLIQ
VEWEHEPQTQRRKEYNVEIEILGYDRRGLLNEVLQAVNETKTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQ
IKDIYSVRRVMN

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=718, Percent_Identity=39.5543175487465, Blast_Score=572, Evalue=1e-164,
Organism=Escherichia coli, GI1789147, Length=692, Percent_Identity=38.150289017341, Blast_Score=531, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI25143118, Length=129, Percent_Identity=37.2093023255814, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24650996, Length=128, Percent_Identity=36.71875, Blast_Score=71, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84599; Mature: 84468

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANEQVLTAEQVIEKAKSYLSDEHVAFIKKAYQYAEDAHREQYRKSGEPYIIHPIQVAGI
CCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEE
LVDLEMDPATIAGGFLHDVVEDTSVTLEDLKEAFNEEVAMLVDGVTKLGKIKYKSQEEQQ
EEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
AENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQRRISNETLEIFAPLAHRLGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHCCH
SKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYVEEVVNEVKSRVEEVNIKADFSG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCC
RPKHIYSIYRKMAMQNKQFNEIYDLLAVRILVNSIKDCYAVLGIIHTCWKPMPGRFKDYI
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHC
AMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHEIAEYGIAAHWAYKEGKNANEDSSFDK
CCCCCHHHHHHHHEEECCCCCCEEEEEEEEHHHHHHHHCHHHEEEHHCCCCCCCCCHHHH
KLSWFREILEFQNESSDAEEFMESLKIDLFSDMVFVFTPKGDVIELPSGSVPIDFSYRIH
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCEEECCCCCCCEEEEEEEH
SEIGNKTIGAKVNGKMVTLDYKLRTGDIVEILTSKHSYGPSQDWINLAQTSQAKHKIRQF
HHCCCCEECCEECCEEEEEEEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
FKKQRREENVEKGRELVEKEIKNLDFEVKDVLTAENLQKVADKFNFANEEDMYAAVGYNG
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCC
ITAAQVANRLTEKERKIRDQEEQVKSVQDVTPEVKPYQGKKREAGVRVKGVDNLLIRLSK
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECHHHHHHHHHH
CCNPVPGDPIVGFITKGRGVSVHREDCPNVLTNEALDRLIQVEWEHEPQTQRRKEYNVEI
HCCCCCCCCEEEEEECCCCCEECHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEE
EILGYDRRGLLNEVLQAVNETKTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIK
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QIKDIYSVRRVMN
HHHHHHHHHHHCC
>Mature Secondary Structure 
ANEQVLTAEQVIEKAKSYLSDEHVAFIKKAYQYAEDAHREQYRKSGEPYIIHPIQVAGI
CCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEE
LVDLEMDPATIAGGFLHDVVEDTSVTLEDLKEAFNEEVAMLVDGVTKLGKIKYKSQEEQQ
EEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
AENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQRRISNETLEIFAPLAHRLGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHCCH
SKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYVEEVVNEVKSRVEEVNIKADFSG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCC
RPKHIYSIYRKMAMQNKQFNEIYDLLAVRILVNSIKDCYAVLGIIHTCWKPMPGRFKDYI
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHC
AMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHEIAEYGIAAHWAYKEGKNANEDSSFDK
CCCCCHHHHHHHHEEECCCCCCEEEEEEEEHHHHHHHHCHHHEEEHHCCCCCCCCCHHHH
KLSWFREILEFQNESSDAEEFMESLKIDLFSDMVFVFTPKGDVIELPSGSVPIDFSYRIH
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCEEECCCCCCCEEEEEEEH
SEIGNKTIGAKVNGKMVTLDYKLRTGDIVEILTSKHSYGPSQDWINLAQTSQAKHKIRQF
HHCCCCEECCEECCEEEEEEEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
FKKQRREENVEKGRELVEKEIKNLDFEVKDVLTAENLQKVADKFNFANEEDMYAAVGYNG
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCC
ITAAQVANRLTEKERKIRDQEEQVKSVQDVTPEVKPYQGKKREAGVRVKGVDNLLIRLSK
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECHHHHHHHHHH
CCNPVPGDPIVGFITKGRGVSVHREDCPNVLTNEALDRLIQVEWEHEPQTQRRKEYNVEI
HCCCCCCCCEEEEEECCCCCEECHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEE
EILGYDRRGLLNEVLQAVNETKTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIK
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QIKDIYSVRRVMN
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]