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The map label for this gene is dxs

Identifier: 52786336

GI number: 52786336

Start: 2517659

End: 2519560

Strand: Reverse

Name: dxs

Synonym: BLi02598

Alternate gene names: 52786336

Gene position: 2519560-2517659 (Counterclockwise)

Preceding gene: 52786337

Following gene: 52786335

Centisome position: 59.67

GC content: 49.68

Gene sequence:

>1902_bases
TTGGATCTGTTATCGATAAAGGACCCTGCATTTTTGAAGAACCTTTCAAATGAAGAACTGGAAAGCTTGAGCGCTGAAAT
TCGCCGTTTTTTAATTGAAACGCTTTCTGAATCCGGAGGGCACATTGGTCCGAATCTCGGCGTTGTCGAGCTTACCATTG
CATTGCATAAAGAATTTGACAGCCCGAAAGATAAGTTCTTGTGGGATGTGGGGCATCAATCGTATGTTCATAAACTGTTG
ACCGGCCGCGGAAAGGACTTCGCCACGCTGCGCCAGCATAAAGGGCTGTGCGGTTTTCCAAAGCGGAATGAAAGCGAACA
TGATGTCTGGGAAACGGGCCACAGCTCGACTTCTCTCTCCGGTGCGATGGGGATGGCGGCTGCGAGAGACTTAAAAGGCA
CAAACGAATATATCATCCCGATCATCGGAGACGGTGCACTGACCGGCGGCATGGCTCTTGAAGCGCTTAACCATATCGGC
CATGAACAAAAAGATATGATTGTCATTTTGAATGACAACGAAATGAGCATCGCTCCAAACGTCGGAGCGATTCATTCCAT
GCTCGGAAGGCTGCGTACAGCCGGAAAATACCAATGGGTCAAAGATGAGCTCGAGTATTTGTTCAAGCGGATTCCTGCTG
TTGGCGGAAAGCTTGCCGCTACAGCCGAACGGATTAAAGACAGCCTTAAATATCTGCTCGTATCCGGGATGTTCTTTGAA
GAGCTTGGATTTACGTATTTAGGGCCTGTAGACGGCCATTCCTACGATGAACTGTTTGAGAACTTGCAGTATGCGAAGAA
AACGAAAGGCCCGGTACTCCTCCATGTTATTACGAAAAAAGGAAAAGGCTACAAGCCTGCGGAAACTGATAAAACCGGAA
CATGGCACGGAACCGGCCCATATAAAATCGATACCGGTGACTTTGTCAAACCGAAAGCTGCTGCACCATCATGGAGCTCG
CTCGTAAGCGAAACGGTCAGGAAGCTTGCCCGCGAGGATGAACGGATTGTGGCCATTACTCCGGCCATGCCTGTCGGTTC
AAAACTTGAAGGGTTTGCGAGCGAATTTCCGGAGCGCATGTTTGATGTCGGCATTGCGGAACAGCATGCGGCAACGATGG
CGGCGGGACTTGCGACACAGAATATGAAGCCGTTTCTGGCGATCTATTCGACATTTCTTCAGCGCGCCTATGACCAGGTT
GTCCATGATATCTGCCGGCAAAATCTAAATGTATTTATCGGCATTGACAGAGCAGGTCTCGTCGGCGCCGACGGGGAAAC
ACACCAGGGCGTGTTTGACATTGCTTTTTTACGGCATATTCCGAATTTGGTTCTCATGATGCCAAAAGACGAAAACGAAG
GCCAGCACATGGTCAACACGGCTGTCAAATACGACGACGGCCCGATTGCCATGCGCTTTCCGCGCGGAAACGGACTCGGC
GTCAAAATGGATAAAGAATTAAAAACGATCCCGATCGGAACGTGGGAAGTGCTGCGACCTGGGACAGACGCGGTCATTTT
AACGTTCGGCACCACCATTCCGATGGCGCTTGCTGCCGCGGAGGAGCTGCAAAAAGAAGGCCGTTCGGTCAGAGTGGTAA
ACGCCCGTTTTATCAAGCCGCTCGATGAAAACATGCTGAAGGAAATCCTGAACGAGGGGCTTCCGATTTTAACGATCGAA
GAGGCTGTGCTTCAAGGCGGATTCGGCAGCTCGATCCTTGAGTTTGCCCATGAACATCAGTCTTACAGTCCGATCATTGA
CAGAATGGGGATACCTGATCAATTTATTGAACACGGCAGCGTCGCCAAGCTTCTGGAAGAGATCGGAATGACAAAAGAAG
ACGTCATCAGACGAATAAGACTTTTGACGCCCGTAAAGACTCATAAAGGAATTGGATCATGA

Upstream 100 bases:

>100_bases
CGCATGGGGATGAATTCATCATATAATAATTCAAGCTGAAAACCTAAAACGAAGCAAGGCGCATACTTGCAGAAATCATG
CTGAAAGTGAGTTGATCCGA

Downstream 100 bases:

>100_bases
CAGGAAAAAAAGAACGGCTCGACGTTTTATTAGTAGAAAGAGGGTTAATGGAAACGCGGGAAAAAGCGAAAAGAGCCATC
ATGGCCGGCATTGTCTATAC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MDLLSIKDPAFLKNLSNEELESLSAEIRRFLIETLSESGGHIGPNLGVVELTIALHKEFDSPKDKFLWDVGHQSYVHKLL
TGRGKDFATLRQHKGLCGFPKRNESEHDVWETGHSSTSLSGAMGMAAARDLKGTNEYIIPIIGDGALTGGMALEALNHIG
HEQKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKRIPAVGGKLAATAERIKDSLKYLLVSGMFFE
ELGFTYLGPVDGHSYDELFENLQYAKKTKGPVLLHVITKKGKGYKPAETDKTGTWHGTGPYKIDTGDFVKPKAAAPSWSS
LVSETVRKLAREDERIVAITPAMPVGSKLEGFASEFPERMFDVGIAEQHAATMAAGLATQNMKPFLAIYSTFLQRAYDQV
VHDICRQNLNVFIGIDRAGLVGADGETHQGVFDIAFLRHIPNLVLMMPKDENEGQHMVNTAVKYDDGPIAMRFPRGNGLG
VKMDKELKTIPIGTWEVLRPGTDAVILTFGTTIPMALAAAEELQKEGRSVRVVNARFIKPLDENMLKEILNEGLPILTIE
EAVLQGGFGSSILEFAHEHQSYSPIIDRMGIPDQFIEHGSVAKLLEEIGMTKEDVIRRIRLLTPVKTHKGIGS

Sequences:

>Translated_633_residues
MDLLSIKDPAFLKNLSNEELESLSAEIRRFLIETLSESGGHIGPNLGVVELTIALHKEFDSPKDKFLWDVGHQSYVHKLL
TGRGKDFATLRQHKGLCGFPKRNESEHDVWETGHSSTSLSGAMGMAAARDLKGTNEYIIPIIGDGALTGGMALEALNHIG
HEQKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKRIPAVGGKLAATAERIKDSLKYLLVSGMFFE
ELGFTYLGPVDGHSYDELFENLQYAKKTKGPVLLHVITKKGKGYKPAETDKTGTWHGTGPYKIDTGDFVKPKAAAPSWSS
LVSETVRKLAREDERIVAITPAMPVGSKLEGFASEFPERMFDVGIAEQHAATMAAGLATQNMKPFLAIYSTFLQRAYDQV
VHDICRQNLNVFIGIDRAGLVGADGETHQGVFDIAFLRHIPNLVLMMPKDENEGQHMVNTAVKYDDGPIAMRFPRGNGLG
VKMDKELKTIPIGTWEVLRPGTDAVILTFGTTIPMALAAAEELQKEGRSVRVVNARFIKPLDENMLKEILNEGLPILTIE
EAVLQGGFGSSILEFAHEHQSYSPIIDRMGIPDQFIEHGSVAKLLEEIGMTKEDVIRRIRLLTPVKTHKGIGS
>Mature_633_residues
MDLLSIKDPAFLKNLSNEELESLSAEIRRFLIETLSESGGHIGPNLGVVELTIALHKEFDSPKDKFLWDVGHQSYVHKLL
TGRGKDFATLRQHKGLCGFPKRNESEHDVWETGHSSTSLSGAMGMAAARDLKGTNEYIIPIIGDGALTGGMALEALNHIG
HEQKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKRIPAVGGKLAATAERIKDSLKYLLVSGMFFE
ELGFTYLGPVDGHSYDELFENLQYAKKTKGPVLLHVITKKGKGYKPAETDKTGTWHGTGPYKIDTGDFVKPKAAAPSWSS
LVSETVRKLAREDERIVAITPAMPVGSKLEGFASEFPERMFDVGIAEQHAATMAAGLATQNMKPFLAIYSTFLQRAYDQV
VHDICRQNLNVFIGIDRAGLVGADGETHQGVFDIAFLRHIPNLVLMMPKDENEGQHMVNTAVKYDDGPIAMRFPRGNGLG
VKMDKELKTIPIGTWEVLRPGTDAVILTFGTTIPMALAAAEELQKEGRSVRVVNARFIKPLDENMLKEILNEGLPILTIE
EAVLQGGFGSSILEFAHEHQSYSPIIDRMGIPDQFIEHGSVAKLLEEIGMTKEDVIRRIRLLTPVKTHKGIGS

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=424, Percent_Identity=26.6509433962264, Blast_Score=103, Evalue=7e-22,
Organism=Homo sapiens, GI4507521, Length=424, Percent_Identity=26.6509433962264, Blast_Score=103, Evalue=7e-22,
Organism=Homo sapiens, GI225637463, Length=304, Percent_Identity=28.6184210526316, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI225637461, Length=304, Percent_Identity=28.6184210526316, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI225637459, Length=304, Percent_Identity=28.6184210526316, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI133778974, Length=427, Percent_Identity=25.7611241217799, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1786622, Length=609, Percent_Identity=45.4844006568145, Blast_Score=537, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17539652, Length=377, Percent_Identity=25.9946949602122, Blast_Score=89, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6319698, Length=342, Percent_Identity=26.6081871345029, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24666278, Length=532, Percent_Identity=24.6240601503759, Blast_Score=113, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24645119, Length=512, Percent_Identity=25.5859375, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45551847, Length=512, Percent_Identity=25.5859375, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45550715, Length=512, Percent_Identity=25.5859375, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21358145, Length=244, Percent_Identity=25.4098360655738, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24650940, Length=244, Percent_Identity=25.4098360655738, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_BACLD (Q65HJ2)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_079751.2
- RefSeq:   YP_092165.1
- ProteinModelPortal:   Q65HJ2
- STRING:   Q65HJ2
- EnsemblBacteria:   EBBACT00000055534
- EnsemblBacteria:   EBBACT00000058504
- GeneID:   3029280
- GeneID:   3099865
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi02598
- KEGG:   bli:BL01523
- NMPDR:   fig|279010.5.peg.441
- eggNOG:   COG1154
- GeneTree:   EBGT00070000031844
- HOGENOM:   HBG571647
- ProtClustDB:   PRK05444
- BioCyc:   BLIC279010-1:BLI02598-MONOMER
- BioCyc:   BLIC279010:BL01523-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 69789; Mature: 69789

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLLSIKDPAFLKNLSNEELESLSAEIRRFLIETLSESGGHIGPNLGVVELTIALHKEFD
CCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHCC
SPKDKFLWDVGHQSYVHKLLTGRGKDFATLRQHKGLCGFPKRNESEHDVWETGHSSTSLS
CCHHHHEECCCHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCCH
GAMGMAAARDLKGTNEYIIPIIGDGALTGGMALEALNHIGHEQKDMIVILNDNEMSIAPN
HHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCC
VGAIHSMLGRLRTAGKYQWVKDELEYLFKRIPAVGGKLAATAERIKDSLKYLLVSGMFFE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ELGFTYLGPVDGHSYDELFENLQYAKKTKGPVLLHVITKKGKGYKPAETDKTGTWHGTGP
HCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCC
YKIDTGDFVKPKAAAPSWSSLVSETVRKLAREDERIVAITPAMPVGSKLEGFASEFPERM
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
FDVGIAEQHAATMAAGLATQNMKPFLAIYSTFLQRAYDQVVHDICRQNLNVFIGIDRAGL
HHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCE
VGADGETHQGVFDIAFLRHIPNLVLMMPKDENEGQHMVNTAVKYDDGPIAMRFPRGNGLG
ECCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHEEECCCCEEEEECCCCCCC
VKMDKELKTIPIGTWEVLRPGTDAVILTFGTTIPMALAAAEELQKEGRSVRVVNARFIKP
EEECCCCCEECCCCHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEHHHHCCC
LDENMLKEILNEGLPILTIEEAVLQGGFGSSILEFAHEHQSYSPIIDRMGIPDQFIEHGS
HHHHHHHHHHHCCCCEEEEHHHHHCCCCCHHHHHHHHHCCCCCHHHHHCCCCHHHHCCCH
VAKLLEEIGMTKEDVIRRIRLLTPVKTHKGIGS
HHHHHHHHCCCHHHHHHHHHHHCCHHHCCCCCC
>Mature Secondary Structure
MDLLSIKDPAFLKNLSNEELESLSAEIRRFLIETLSESGGHIGPNLGVVELTIALHKEFD
CCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHCC
SPKDKFLWDVGHQSYVHKLLTGRGKDFATLRQHKGLCGFPKRNESEHDVWETGHSSTSLS
CCHHHHEECCCHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHCCCCCCCCH
GAMGMAAARDLKGTNEYIIPIIGDGALTGGMALEALNHIGHEQKDMIVILNDNEMSIAPN
HHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCC
VGAIHSMLGRLRTAGKYQWVKDELEYLFKRIPAVGGKLAATAERIKDSLKYLLVSGMFFE
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ELGFTYLGPVDGHSYDELFENLQYAKKTKGPVLLHVITKKGKGYKPAETDKTGTWHGTGP
HCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCC
YKIDTGDFVKPKAAAPSWSSLVSETVRKLAREDERIVAITPAMPVGSKLEGFASEFPERM
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
FDVGIAEQHAATMAAGLATQNMKPFLAIYSTFLQRAYDQVVHDICRQNLNVFIGIDRAGL
HHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCE
VGADGETHQGVFDIAFLRHIPNLVLMMPKDENEGQHMVNTAVKYDDGPIAMRFPRGNGLG
ECCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHEEECCCCEEEEECCCCCCC
VKMDKELKTIPIGTWEVLRPGTDAVILTFGTTIPMALAAAEELQKEGRSVRVVNARFIKP
EEECCCCCEECCCCHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEHHHHCCC
LDENMLKEILNEGLPILTIEEAVLQGGFGSSILEFAHEHQSYSPIIDRMGIPDQFIEHGS
HHHHHHHHHHHCCCCEEEEHHHHHCCCCCHHHHHHHHHCCCCCHHHHHCCCCHHHHCCCH
VAKLLEEIGMTKEDVIRRIRLLTPVKTHKGIGS
HHHHHHHHCCCHHHHHHHHHHHCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA